The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytoplasmic side of plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q64729-1", "Q62312-2" ], "evidence": [ { "id": "R-MMU-170835", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-170835" } ] }, { "id": "R-MMU-170843", "name": "TGFBR2 phosphorylates TGFBR1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q64729-1", "Q62312-2" ], "evidence": [ { "id": "R-MMU-170843", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-170843" } ] }, { "id": "R-MMU-170846", "name": "TGFBR2 recruits TGFBR1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q64729-1", "P26883-1", "Q62312-2" ], "evidence": [ { "id": "R-MMU-170846", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-170846" } ] }, { "id": "R-MMU-170850", "name": "Phosphorylated SMAD2/3 dissociates from TGFBR", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "early endosome", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q64729-1", "Q62312-2" ], "evidence": [ { "id": "R-MMU-170850", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-170850" } ] }, { "id": "R-MMU-170861", "name": "Dimeric TGF-beta-1 binds to the receptor", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62312-2" ], "evidence": [ { "id": "R-MMU-170861", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-170861" } ] }, { "id": "R-MMU-170868", "name": "Activated type I receptor phosphorylates SMAD2/3 directly", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "early endosome membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q64729-1", "Q62312-2" ], "evidence": [ { "id": "R-MMU-170868", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-170868" } ] }, { "id": "R-MMU-173483", "name": "BAMBI interferes with the interaction of type I receptor with type II receptor", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q64729-1", "Q62312-2" ], "evidence": [ { "id": "R-MMU-173483", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-173483" } ] }, { "id": "R-MMU-173512", "name": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytoplasmic side of plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q64729-1", "Q62312-2" ], "evidence": [ { "id": "R-MMU-173512", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-173512" } ] }, { "id": "R-MMU-2128994", "name": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q64729-1", "Q62312-2" ], "evidence": [ { "id": "R-MMU-2128994", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2128994" } ] }, { "id": "R-MMU-2160931", "name": "Disassembly of tight junctions", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cell junction", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9QUI0-1", "Q64729-1", "Q62312-2", "Q02956-1", "Q9CUN6-1" ], "evidence": [ { "id": "R-MMU-2160931", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2160931" } ] }, { "id": "R-MMU-2160932", "name": "SMURF1 binds phosphorylated PARD6A", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cell junction, cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9QUI0-1", "Q64729-1", "Q62312-2", "Q02956-1", "Q9CUN6-1" ], "evidence": [ { "id": "R-MMU-2160932", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2160932" } ] }, { "id": "R-MMU-2160935", "name": "SMURF1 ubiquitinates RHOA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cell junction, cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9QUI0-1", "Q64729-1", "Q62312-2", "Q02956-1", "Q9CUN6-1" ], "evidence": [ { "id": "R-MMU-2160935", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2160935" } ] }, { "id": "R-MMU-2169046", "name": "Degradation of TGF-beta receptor complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q64729-1", "Q62312-2" ], "evidence": [ { "id": "R-MMU-2169046", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2169046" } ] }, { "id": "R-MMU-4332235", "name": "CBL binds TGFBR2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62312-2", "P22682-1" ], "evidence": [ { "id": "R-MMU-4332235", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-4332235" } ] }, { "id": "R-MMU-4332236", "name": "CBL neddylates TGFBR2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62312-2", "P22682-1", "P61082-1" ], "evidence": [ { "id": "R-MMU-4332236", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-4332236" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0B4KG59", "gene_name": "put", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "A0A0B4KG59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4KG59" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "A0A0B4KG59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4KG59" } ] } ] }, { "uniprot_ac": "A0A8I5ZJI2", "gene_name": "Bmpr1b", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "A0A8I5ZJI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZJI2" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "A0A8I5ZJI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZJI2" } ] } ] }, { "uniprot_ac": "F1LQC5", "gene_name": "Bmpr2", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "F1LQC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LQC5" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "F1LQC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LQC5" } ] } ] }, { "uniprot_ac": "O00238", "gene_name": "BMPR1B", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "O00238", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00238" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "O00238", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00238" } ] } ] }, { "uniprot_ac": "O35607", "gene_name": "Bmpr2", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "O35607", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35607" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "O35607", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35607" } ] } ] }, { "uniprot_ac": "P22682", "gene_name": "Cbl", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P22682", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22682" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P22682", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22682" } ] } ] }, { "uniprot_ac": "P26883", "gene_name": "Fkbp1a", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P26883", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26883" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P26883", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26883" } ] } ] }, { "uniprot_ac": "P27037", "gene_name": "ACVR2A", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "P27037", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27037" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "P27037", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27037" } ] } ] }, { "uniprot_ac": "P27038", "gene_name": "Acvr2a", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "P27038", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27038" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "P27038", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27038" } ] } ] }, { "uniprot_ac": "P27040", "gene_name": "Acvr2b", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "P27040", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27040" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "P27040", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27040" } ] } ] }, { "uniprot_ac": "P36894", "gene_name": "BMPR1A", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "P36894", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36894" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "P36894", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36894" } ] } ] }, { "uniprot_ac": "P36895", "gene_name": "Bmpr1a", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "P36895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36895" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "P36895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36895" } ] } ] }, { "uniprot_ac": "P36896", "gene_name": "ACVR1B", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "P36896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36896" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "P36896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36896" } ] } ] }, { "uniprot_ac": "P36897", "gene_name": "TGFBR1", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "P36897", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36897" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "P36897", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36897" } ] } ] }, { "uniprot_ac": "P36898", "gene_name": "Bmpr1b", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "P36898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36898" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "P36898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36898" } ] } ] }, { "uniprot_ac": "P37023", "gene_name": "ACVRL1", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "P37023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P37023" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "P37023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P37023" } ] } ] }, { "uniprot_ac": "P37172", "gene_name": "Acvr1", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "P37172", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P37172" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "P37172", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P37172" } ] } ] }, { "uniprot_ac": "P37173", "gene_name": "TGFBR2", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "P37173", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P37173" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "P37173", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P37173" } ] } ] }, { "uniprot_ac": "P38438", "gene_name": "Tgfbr2", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "P38438", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38438" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "P38438", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38438" } ] } ] }, { "uniprot_ac": "P38444", "gene_name": "Acvr2a", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "P38444", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38444" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "P38444", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38444" } ] } ] }, { "uniprot_ac": "P38445", "gene_name": "Acvr2b", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "P38445", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38445" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "P38445", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38445" } ] } ] }, { "uniprot_ac": "P61082", "gene_name": "Ube2m", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "P61082", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61082" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "P61082", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61082" } ] } ] }, { "uniprot_ac": "P70539", "gene_name": "Acvr1c", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "P70539", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70539" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "P70539", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70539" } ] } ] }, { "uniprot_ac": "P80201", "gene_name": "Acvr1", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "P80201", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P80201" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "P80201", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P80201" } ] } ] }, { "uniprot_ac": "P80202", "gene_name": "Acvr1b", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "P80202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P80202" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "P80202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P80202" } ] } ] }, { "uniprot_ac": "P80203", "gene_name": "Acvrl1", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "P80203", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P80203" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "P80203", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P80203" } ] } ] }, { "uniprot_ac": "P80204", "gene_name": "Tgfbr1", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "P80204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P80204" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "P80204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P80204" } ] } ] }, { "uniprot_ac": "Q02956", "gene_name": "Prkcz", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q02956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02956" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "Q02956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02956" } ] } ] }, { "uniprot_ac": "Q04771", "gene_name": "ACVR1", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "Q04771", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04771" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "Q04771", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04771" } ] } ] }, { "uniprot_ac": "Q13705", "gene_name": "ACVR2B", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "Q13705", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13705" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "Q13705", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13705" } ] } ] }, { "uniprot_ac": "Q13873", "gene_name": "BMPR2", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "Q13873", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13873" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "Q13873", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13873" } ] } ] }, { "uniprot_ac": "Q16671", "gene_name": "AMHR2", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "Q16671", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16671" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "Q16671", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16671" } ] } ] }, { "uniprot_ac": "Q61271", "gene_name": "Acvr1b", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "Q61271", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61271" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "Q61271", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61271" } ] } ] }, { "uniprot_ac": "Q61288", "gene_name": "Acvrl1", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "Q61288", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61288" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "Q61288", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61288" } ] } ] }, { "uniprot_ac": "Q62312", "gene_name": "Tgfbr2", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "Q62312", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62312" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "Q62312", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62312" } ] } ] }, { "uniprot_ac": "Q62893", "gene_name": "Amhr2", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "Q62893", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62893" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "Q62893", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62893" } ] } ] }, { "uniprot_ac": "Q64729", "gene_name": "Tgfbr1", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "Q64729", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64729" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "Q64729", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64729" } ] } ] }, { "uniprot_ac": "Q78EA7", "gene_name": "Bmpr1a", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "Q78EA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q78EA7" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "Q78EA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q78EA7" } ] } ] }, { "uniprot_ac": "Q8K348", "gene_name": "Acvr1c", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "Q8K348", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K348" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "Q8K348", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K348" } ] } ] }, { "uniprot_ac": "Q8K592", "gene_name": "Amhr2", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "Q8K592", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K592" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "Q8K592", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K592" } ] } ] }, { "uniprot_ac": "Q8NER5", "gene_name": "ACVR1C", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "Q8NER5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NER5" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "Q8NER5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NER5" } ] } ] }, { "uniprot_ac": "Q9CUN6", "gene_name": "Smurf1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9CUN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q9CUN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ] } ] }, { "uniprot_ac": "Q9QUI0", "gene_name": "Rhoa", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "Q9QUI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QUI0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q9QUI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QUI0" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 2 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 2 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 7 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }