The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9Z1K5-1", "Q62077-1", "Q6Q899-1", "P52482-1", "Q9QZU9-1", "P52332-1", "Q63844-1", "Q03963-1", "Q61510-1" ], "evidence": [ { "id": "R-MMU-1169406", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1169406" } ] }, { "id": "R-MMU-1524182", "name": "Activated PLC gamma dissociates from the PDGF receptor", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P26618-1", "P05622-1", "Q62077-1" ], "evidence": [ { "id": "R-MMU-1524182", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1524182" } ] }, { "id": "R-MMU-1524186", "name": "Phosphorylation of PLCgamma by PDGFR", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P26618-1", "P05622-1", "Q62077-1" ], "evidence": [ { "id": "R-MMU-1524186", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1524186" } ] }, { "id": "R-MMU-1678841", "name": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1", "Q6Q899-1", "Q9WTV6-1", "P52482-1", "P52332-1", "Q63844-1", "Q03963-1" ], "evidence": [ { "id": "R-MMU-1678841", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1678841" } ] }, { "id": "R-MMU-1855221", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A2AP18-1", "Q8K4S1-1", "Q8R3B1-1", "Q62077-1", "Q8CIH5-1", "Q4KWH5-1", "Q8K2J0-1" ], "evidence": [ { "id": "R-MMU-1855221", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1855221" } ] }, { "id": "R-MMU-186765", "name": "PLC-gamma binds to the active receptor", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P26618-1", "P05622-1", "Q62077-1" ], "evidence": [ { "id": "R-MMU-186765", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-186765" } ] }, { "id": "R-MMU-202212", "name": "Recruitment of PLC-gamma1 to LAT", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1" ], "evidence": [ { "id": "R-MMU-202212", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-202212" } ] }, { "id": "R-MMU-202248", "name": "Phosphorylation of PLC-gamma1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06240-1", "Q03526-1", "Q62077-1", "P43404-1" ], "evidence": [ { "id": "R-MMU-202248", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-202248" } ] }, { "id": "R-MMU-202331", "name": "Recruitment of PLC-gamma1 to SLP-76", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1" ], "evidence": [ { "id": "R-MMU-202331", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-202331" } ] }, { "id": "R-MMU-202354", "name": "Translocation of PLC-gamma1 to PIP2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1" ], "evidence": [ { "id": "R-MMU-202354", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-202354" } ] }, { "id": "R-MMU-202407", "name": "PLC-gamma1 hydrolyses PIP2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1", "Q8CIH5-1" ], "evidence": [ { "id": "R-MMU-202407", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-202407" } ] }, { "id": "R-MMU-2029268", "name": "Phosphorylation and activation of PLCG", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P48025-1", "Q62077-1", "Q8CIH5-1" ], "evidence": [ { "id": "R-MMU-2029268", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2029268" } ] }, { "id": "R-MMU-2029270", "name": "Recruitment of PLCgamma to membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P48025-1", "Q62077-1", "Q8CIH5-1" ], "evidence": [ { "id": "R-MMU-2029270", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2029270" } ] }, { "id": "R-MMU-2029272", "name": "Release of PLCG from FCGR", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P48025-1", "Q62077-1", "Q8CIH5-1" ], "evidence": [ { "id": "R-MMU-2029272", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2029272" } ] }, { "id": "R-MMU-210283", "name": "Interaction of PECAM-1 and PLC gamma1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1" ], "evidence": [ { "id": "R-MMU-210283", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-210283" } ] }, { "id": "R-MMU-212706", "name": "Phospholipase C-gamma1 binds to the activated EGF receptor", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1", "Q01279-1" ], "evidence": [ { "id": "R-MMU-212706", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-212706" } ] }, { "id": "R-MMU-212710", "name": "EGFR activates PLC-gamma1 by phosphorylation", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1", "Q01279-1" ], "evidence": [ { "id": "R-MMU-212710", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-212710" } ] }, { "id": "R-MMU-212713", "name": "Active PLC-gamma1 dissociates from EGFR", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1", "Q01279-1" ], "evidence": [ { "id": "R-MMU-212713", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-212713" } ] }, { "id": "R-MMU-213406", "name": "Disassociation of PLC-gamma1 from LAT", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1" ], "evidence": [ { "id": "R-MMU-213406", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-213406" } ] }, { "id": "R-MMU-213407", "name": "Disassociation of PLC-gamma1 from SLP-76", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1" ], "evidence": [ { "id": "R-MMU-213407", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-213407" } ] }, { "id": "R-MMU-2396594", "name": "Phosphorylation of SLP-76 by p-SYK", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06240-1", "P48025-1", "Q62077-1", "Q8CIH5-1", "P39688-1" ], "evidence": [ { "id": "R-MMU-2396594", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2396594" } ] }, { "id": "R-MMU-2396606", "name": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1", "Q8CIH5-1" ], "evidence": [ { "id": "R-MMU-2396606", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2396606" } ] }, { "id": "R-MMU-2424476", "name": "Activation of RAC1 by VAV2/3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1", "P35991-1", "Q8CIH5-1", "P63001-1" ], "evidence": [ { "id": "R-MMU-2424476", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2424476" } ] }, { "id": "R-MMU-2424481", "name": "Recruitment of VAV and BTK to p-SLP-76", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1", "P35991-1", "Q8CIH5-1" ], "evidence": [ { "id": "R-MMU-2424481", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2424481" } ] }, { "id": "R-MMU-2424484", "name": "Phosphorylation of BTK by p-SYK", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06240-1", "P48025-1", "Q62077-1", "P35991-1", "Q8CIH5-1", "P39688-1" ], "evidence": [ { "id": "R-MMU-2424484", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2424484" } ] }, { "id": "R-MMU-2424485", "name": "Release of p-PLCG1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1", "P35991-1", "Q8CIH5-1" ], "evidence": [ { "id": "R-MMU-2424485", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2424485" } ] }, { "id": "R-MMU-2424486", "name": "Phosphorylation and activation of VAV2/VAV3 by SYK", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06240-1", "P48025-1", "Q62077-1", "P35991-1", "Q8CIH5-1", "P39688-1" ], "evidence": [ { "id": "R-MMU-2424486", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2424486" } ] }, { "id": "R-MMU-2424487", "name": "Phosphorylation of PLC-gamma by p-BTK/p-SYK", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06240-1", "P48025-1", "Q62077-1", "P35991-1", "Q8CIH5-1", "P39688-1" ], "evidence": [ { "id": "R-MMU-2424487", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2424487" } ] }, { "id": "R-MMU-2730833", "name": "Phosphorylation of TEC kinases by p-SYK", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P48025-1", "Q03526-1", "Q62077-1", "P35991-1", "Q8CIH5-1", "P24604-1", "P42682-1", "P25911-1" ], "evidence": [ { "id": "R-MMU-2730833", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2730833" } ] }, { "id": "R-MMU-2730840", "name": "Activation of RAC1 by VAV", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1", "Q8CIH5-1", "P63001-1" ], "evidence": [ { "id": "R-MMU-2730840", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2730840" } ] }, { "id": "R-MMU-2730841", "name": "Phosphorylation and activation of VAV", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1", "Q8CIH5-1" ], "evidence": [ { "id": "R-MMU-2730841", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2730841" } ] }, { "id": "R-MMU-2730847", "name": "Hydrolysis of PIP2 by PLCG", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q03526-1", "Q62077-1", "P35991-1", "Q8CIH5-1", "P24604-1", "P42682-1" ], "evidence": [ { "id": "R-MMU-2730847", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2730847" } ] }, { "id": "R-MMU-2730851", "name": "Phosphorylation of SLP-76 by p-SYK", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P48025-1", "Q62077-1", "Q8CIH5-1", "P25911-1" ], "evidence": [ { "id": "R-MMU-2730851", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2730851" } ] }, { "id": "R-MMU-2730856", "name": "Autophosphorylation of PAK", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1", "Q8CIH5-1", "Q8CIN4-1", "O88643-1", "P63001-1" ], "evidence": [ { "id": "R-MMU-2730856", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2730856" } ] }, { "id": "R-MMU-2730858", "name": "Autophosphorylation of BTK/ITK", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q03526-1", "Q62077-1", "P35991-1", "Q8CIH5-1", "P24604-1", "P42682-1" ], "evidence": [ { "id": "R-MMU-2730858", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2730858" } ] }, { "id": "R-MMU-2730889", "name": "Recruitment of PAK to the membrane by binding active RAC1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1", "Q8CIH5-1", "Q8CIN4-1", "O88643-1", "P63001-1" ], "evidence": [ { "id": "R-MMU-2730889", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2730889" } ] }, { "id": "R-MMU-2730892", "name": "Recruitment of VAV to p-SLP-76", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1", "Q8CIH5-1" ], "evidence": [ { "id": "R-MMU-2730892", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2730892" } ] }, { "id": "R-MMU-4420121", "name": "SFKs phosphorylate PLCG1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P05480-2", "Q62077-1", "P35918-1" ], "evidence": [ { "id": "R-MMU-4420121", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-4420121" } ] }, { "id": "R-MMU-4420153", "name": "p-6Y-VEGFR2 binds PLCG1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1", "P35918-1" ], "evidence": [ { "id": "R-MMU-4420153", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-4420153" } ] }, { "id": "R-MMU-4420202", "name": "PLCG1 disassociates from VEGFR2 and translocate to PM", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1", "P35918-1" ], "evidence": [ { "id": "R-MMU-4420202", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-4420202" } ] }, { "id": "R-MMU-5621346", "name": "Plcg1 binds p-Y348,352,525,526-Syk", "equation": "", "summary": "Phospholipase C-gamma (PLCG) binds to phosphorylated Tyr-348 (Tyr-342 in mouse) and Tyr-352 (Tyr-346 in mouse) in SYK with its C-terminal SH2 domain (Law et al. 1996). PLCG2 functions downstream of CLEC6A/Dectin-2 and triggers cytokine production in response to the infection by Candida albicans. PLCG2 deficiency results in the defective production of NF-kB and significantly reduced production of reactive oxygen species (ROS) following infection (Gorjestani et al. 2011).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P48025-1", "Q62077-1" ], "evidence": [ { "id": "R-MMU-5621346", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5621346" } ] }, { "id": "R-MMU-5654147", "name": "Activated FGFR2 phosphorylates PLCG1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1", "P21803-1" ], "evidence": [ { "id": "R-MMU-5654147", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5654147" } ] }, { "id": "R-MMU-5654148", "name": "p-4Y-PLCG1 dissociates from activated FGFR3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1", "Q61851-1" ], "evidence": [ { "id": "R-MMU-5654148", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5654148" } ] }, { "id": "R-MMU-5654149", "name": "Activated FGFR1 phosphorylates PLCG1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O35082-1", "Q62077-1", "P16092-1" ], "evidence": [ { "id": "R-MMU-5654149", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5654149" } ] }, { "id": "R-MMU-5654151", "name": "Activated FGFR4 phosphorylates PLCG1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1", "Q03142-1" ], "evidence": [ { "id": "R-MMU-5654151", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5654151" } ] }, { "id": "R-MMU-5654157", "name": "p-4Y-PLCG1 dissociates from activated FGFR2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1", "P21803-1" ], "evidence": [ { "id": "R-MMU-5654157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5654157" } ] }, { "id": "R-MMU-5654159", "name": "Activated FGFR2 binds PLCG1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1", "P21803-1" ], "evidence": [ { "id": "R-MMU-5654159", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5654159" } ] }, { "id": "R-MMU-5654163", "name": "Activated FGFR4 binds PLCG1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1", "Q03142-1" ], "evidence": [ { "id": "R-MMU-5654163", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5654163" } ] }, { "id": "R-MMU-5654165", "name": "p-4Y-PLCG1 dissociates from activated FGFR1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O35082-1", "Q62077-1", "P16092-1" ], "evidence": [ { "id": "R-MMU-5654165", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5654165" } ] }, { "id": "R-MMU-5654167", "name": "Activated FGFR1 binds PLCG1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O35082-1", "Q62077-1", "P16092-1" ], "evidence": [ { "id": "R-MMU-5654167", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5654167" } ] }, { "id": "R-MMU-5654169", "name": "p-4Y-PLCG1 dissociates from activated FGFR4", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1", "Q03142-1" ], "evidence": [ { "id": "R-MMU-5654169", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5654169" } ] }, { "id": "R-MMU-5654222", "name": "Activated FGFR3 phosphorylates PLCG1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1", "Q61851-1" ], "evidence": [ { "id": "R-MMU-5654222", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5654222" } ] }, { "id": "R-MMU-5654224", "name": "Activated FGFR3 binds PLCG1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1", "Q61851-1" ], "evidence": [ { "id": "R-MMU-5654224", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5654224" } ] }, { "id": "R-MMU-8853755", "name": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1", "P35546-1" ], "evidence": [ { "id": "R-MMU-8853755", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8853755" } ] }, { "id": "R-MMU-9026894", "name": "Activated PCLG1 dissociates from NTRK2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P15209-1", "Q62077-1" ], "evidence": [ { "id": "R-MMU-9026894", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9026894" } ] }, { "id": "R-MMU-9027429", "name": "Lyn phosphorylates Plcg1,2 in Epo:phospho-Epor:phospho-Jak2:Lyn:Irs2:Plcg1,2", "equation": "", "summary": "Plcg1 (Phospholipase C gamma1) or Plcg2 bound to the activated Epor is phosphorylated on tyrosine residues (Mason-Garcia et al. 1992, Boudot et al. 1999, Boudot et al. 2002, Tong et al. 2004, Halupa et al. 2005, Schnoder et al. 2015) by the kinase LYN (Boudot et al. 2003).", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62120-1", "Q62077-1", "Q8CIH5-1", "P25911-1" ], "evidence": [ { "id": "R-MMU-9027429", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9027429" } ] }, { "id": "R-MMU-9027436", "name": "Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 binds Plcg1,2", "equation": "", "summary": "Plcg1 (Phospholipase C gamma1) or Plcg2 binds phosphotyrosine-432 and phosphotyrosine-479 of Epor (Boudot et al. 1999, Boudot et al. 2002, Tong et al. 2004, Halupa et al. 2005, Schnoder et al. 2015). After binding, Plcg1,2 is phosphorylated (Boudot et al. 1999).", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62120-1", "Q62077-1", "Q8CIH5-1", "P25911-1" ], "evidence": [ { "id": "R-MMU-9027436", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9027436" } ] }, { "id": "R-MMU-9032476", "name": "Epor-associated Plcg hydrolyzes 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate", "equation": "", "summary": "Phospholipase C gamma (Plcg1 or Plcg2) bound to the phosphorylated cytoplasmic domain of the EPO receptor (Epor) hydrolyzes 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to yield the second messengers diacylglycerol and 1D-myo-inositol 1,4,5-trisphosphate (Beckman et al. 1996, and inferred from human homologs). Erythropoietin also activates the hydrolysis of phosphatidylcholine and phosphatidylethanolamine (Beckman et al. 1996),", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62120-1", "Q62077-1", "Q8CIH5-1", "P25911-1" ], "evidence": [ { "id": "R-MMU-9032476", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9032476" } ] }, { "id": "R-MMU-9034855", "name": "Activated PCLG1 dissociates from NTRK3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q62077-1", "Q6VNS1-1" ], "evidence": [ { "id": "R-MMU-9034855", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9034855" } ] }, { "id": "R-MMU-9700149", "name": "Active ALK binds PLCG1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P97793-1", "Q62077-1" ], "evidence": [ { "id": "R-MMU-9700149", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9700149" } ] }, { "id": "R-MMU-9700171", "name": "Active ALK phosphorylates PLCG1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P97793-1", "Q62077-1" ], "evidence": [ { "id": "R-MMU-9700171", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9700171" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A096MJW8", "gene_name": "Plch1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "A0A096MJW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A096MJW8" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A0A096MJW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A096MJW8" } ] } ] }, { "uniprot_ac": "A0A8I5ZPH5", "gene_name": "Plch2", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "A0A8I5ZPH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZPH5" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A0A8I5ZPH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZPH5" } ] } ] }, { "uniprot_ac": "A2AP18", "gene_name": "Plch2", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "A2AP18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AP18" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A2AP18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AP18" } ] } ] }, { "uniprot_ac": "A3KGF7", "gene_name": "Plcb2", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "A3KGF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A3KGF7" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A3KGF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A3KGF7" } ] } ] }, { "uniprot_ac": "D4A978", "gene_name": "Plcd3", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "D4A978", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A978" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "D4A978", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A978" } ] } ] }, { "uniprot_ac": "F1M324", "gene_name": "Plcl2", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "F1M324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M324" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "F1M324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M324" } ] } ] }, { "uniprot_ac": "O35082", "gene_name": "Kl", "activity": [ { "ec_number": "3.2.1.31", "activity": "a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate.", "evidence": [ { "id": "O35082", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35082" } ] }, { "ec_number": "3.2.1.31", "activity": "", "evidence": [ { "id": "O35082", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35082" } ] } ] }, { "uniprot_ac": "O75038", "gene_name": "PLCH2", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "O75038", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75038" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "O75038", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75038" } ] } ] }, { "uniprot_ac": "O88643", "gene_name": "Pak1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O88643", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88643" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O88643", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88643" } ] } ] }, { "uniprot_ac": "O89040", "gene_name": "Plcb2", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "O89040", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O89040" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "O89040", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O89040" } ] } ] }, { "uniprot_ac": "P05480", "gene_name": "Src", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P05480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05480" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P05480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05480" } ] } ] }, { "uniprot_ac": "P05622", "gene_name": "Pdgfrb", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P05622", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05622" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P05622", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05622" } ] } ] }, { "uniprot_ac": "P06240", "gene_name": "Lck", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P06240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06240" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P06240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06240" } ] } ] }, { "uniprot_ac": "P10686", "gene_name": "Plcg1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P10686", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10686" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P10686", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10686" } ] } ] }, { "uniprot_ac": "P10687", "gene_name": "Plcb1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P10687", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10687" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P10687", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10687" } ] } ] }, { "uniprot_ac": "P10688", "gene_name": "Plcd1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P10688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10688" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P10688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10688" } ] } ] }, { "uniprot_ac": "P13217", "gene_name": "norpA", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P13217", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13217" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P13217", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13217" } ] } ] }, { "uniprot_ac": "P15209", "gene_name": "Ntrk2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P15209", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15209" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P15209", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15209" } ] } ] }, { "uniprot_ac": "P16092", "gene_name": "Fgfr1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16092", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16092" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P16092", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16092" } ] } ] }, { "uniprot_ac": "P16885", "gene_name": "PLCG2", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P16885", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16885" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P16885", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16885" } ] } ] }, { "uniprot_ac": "P19174", "gene_name": "PLCG1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P19174", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19174" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P19174", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19174" } ] } ] }, { "uniprot_ac": "P21803", "gene_name": "Fgfr2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P21803", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21803" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P21803", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21803" } ] } ] }, { "uniprot_ac": "P24135", "gene_name": "Plcg2", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P24135", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24135" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P24135", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24135" } ] } ] }, { "uniprot_ac": "P24604", "gene_name": "Tec", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P24604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24604" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P24604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24604" } ] } ] }, { "uniprot_ac": "P25455", "gene_name": "Plc21C", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P25455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25455" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P25455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25455" } ] } ] }, { "uniprot_ac": "P25911", "gene_name": "Lyn", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P25911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25911" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P25911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25911" } ] } ] }, { "uniprot_ac": "P26618", "gene_name": "Pdgfra", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P26618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26618" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P26618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26618" } ] } ] }, { "uniprot_ac": "P32383", "gene_name": "PLC1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P32383", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32383" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P32383", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32383" } ] } ] }, { "uniprot_ac": "P35546", "gene_name": "Ret", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35546", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35546" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35546", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35546" } ] } ] }, { "uniprot_ac": "P35918", "gene_name": "Kdr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35918", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35918" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35918", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35918" } ] } ] }, { "uniprot_ac": "P35991", "gene_name": "Btk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35991", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35991" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P35991", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35991" } ] } ] }, { "uniprot_ac": "P39688", "gene_name": "Fyn", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P39688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39688" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P39688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39688" } ] } ] }, { "uniprot_ac": "P42682", "gene_name": "Txk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42682", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42682" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42682", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42682" } ] } ] }, { "uniprot_ac": "P43404", "gene_name": "Zap70", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P43404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43404" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P43404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43404" } ] } ] }, { "uniprot_ac": "P48025", "gene_name": "Syk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P48025", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48025" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P48025", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48025" } ] } ] }, { "uniprot_ac": "P51178", "gene_name": "PLCD1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P51178", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51178" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P51178", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51178" } ] } ] }, { "uniprot_ac": "P51432", "gene_name": "Plcb3", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P51432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51432" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P51432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51432" } ] } ] }, { "uniprot_ac": "P52332", "gene_name": "Jak1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P52332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52332" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P52332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52332" } ] } ] }, { "uniprot_ac": "P52482", "gene_name": "Ube2e1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P52482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52482" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P52482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52482" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P52482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52482" } ] } ] }, { "uniprot_ac": "P63001", "gene_name": "Rac1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P63001", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63001" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P63001", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63001" } ] } ] }, { "uniprot_ac": "P97793", "gene_name": "Alk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P97793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97793" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P97793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97793" } ] } ] }, { "uniprot_ac": "Q00722", "gene_name": "PLCB2", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "Q00722", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00722" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q00722", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00722" } ] } ] }, { "uniprot_ac": "Q01279", "gene_name": "Egfr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q01279", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01279" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q01279", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01279" } ] } ] }, { "uniprot_ac": "Q01970", "gene_name": "PLCB3", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "Q01970", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01970" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q01970", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01970" } ] } ] }, { "uniprot_ac": "Q02158", "gene_name": "plc", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "Q02158", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02158" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q02158", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02158" } ] } ] }, { "uniprot_ac": "Q03142", "gene_name": "Fgfr4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03142", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03142" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q03142", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03142" } ] } ] }, { "uniprot_ac": "Q03526", "gene_name": "Itk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03526" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q03526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03526" } ] } ] }, { "uniprot_ac": "Q03963", "gene_name": "Eif2ak2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03963", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03963" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q03963", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03963" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q03963", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03963" } ] } ] }, { "uniprot_ac": "Q15111", "gene_name": "PLCL1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "Q15111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15111" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q15111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15111" } ] } ] }, { "uniprot_ac": "Q15147", "gene_name": "PLCB4", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "Q15147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15147" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q15147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15147" } ] } ] }, { "uniprot_ac": "Q4KWH5", "gene_name": "Plch1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "Q4KWH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KWH5" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q4KWH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KWH5" } ] } ] }, { "uniprot_ac": "Q4KWH8", "gene_name": "PLCH1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "Q4KWH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KWH8" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q4KWH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KWH8" } ] } ] }, { "uniprot_ac": "Q5FX52", "gene_name": "Plcz1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "Q5FX52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FX52" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q5FX52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FX52" } ] } ] }, { "uniprot_ac": "Q61510", "gene_name": "Trim25", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q61510", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61510" } ] }, { "ec_number": "6.3.2.n3", "activity": "ATP + [ISG15] + [protein]-lysine = AMP + diphosphate + [protein]-N-ISGyllysine.", "evidence": [ { "id": "Q61510", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61510" } ] }, { "ec_number": "6.3.2.n3", "activity": "", "evidence": [ { "id": "Q61510", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61510" } ] } ] }, { "uniprot_ac": "Q61851", "gene_name": "Fgfr3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q61851", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61851" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q61851", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61851" } ] } ] }, { "uniprot_ac": "Q62077", "gene_name": "Plcg1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "Q62077", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62077" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q62077", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62077" } ] } ] }, { "uniprot_ac": "Q62120", "gene_name": "Jak2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62120" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q62120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62120" } ] } ] }, { "uniprot_ac": "Q62688", "gene_name": "Plcl1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "Q62688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62688" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q62688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62688" } ] } ] }, { "uniprot_ac": "Q62711", "gene_name": "Plcd4", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "Q62711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62711" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q62711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62711" } ] } ] }, { "uniprot_ac": "Q63844", "gene_name": "Mapk3", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63844" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q63844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63844" } ] } ] }, { "uniprot_ac": "Q640M6", "gene_name": "Gdpd5", "activity": [ { "ec_number": "3.1.4.2", "activity": "H2O + sn-glycerol 3-phosphocholine 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