{
    "uniprot_canonical_ac": "Q61702-1",
    "uniprot_ac": "Q61702",
    "uniprot_id": "ITIH1_MOUSE",
    "mass": {
        "chemical_mass": 101067.0,
        "monoisotopic_mass": 101067.0
    },
    "refseq": {
        "ac": "NP_001293007",
        "name": "inter-alpha-trypsin inhibitor heavy chain H1 isoform 2 precursor",
        "summary": "This gene encodes a heavy chain of inter-alpha trypsin inhibitor (IaI) family of plasma serine protease inhibitors. IaI proteins are protein-glycosaminoglycan-protein complexes comprised of two heavy chains and a light chain. The encoded protein covalently associates with the light chain via a chondroitin sulfate moiety. Intravenous administration of the encoded protein improved survival of mice after infection with Escherichia coli. This gene is located adjacent to two other IaI heavy chain genes. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature protein. [provided by RefSeq, Oct 2015].",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001293007"
    },
    "gene_names": [
        {
            "name": "Itih1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q61702",
            "id": "Q61702"
        },
        {
            "name": "Intin1; ITI-HC1; Itih-1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001293007",
            "id": "NP_001293007"
        },
        {
            "name": "Itih1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001293007",
            "id": "NP_001293007"
        }
    ],
    "protein_names": [
        {
            "name": "Inter-alpha-trypsin inhibitor heavy chain H1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q61702"
        },
        {
            "name": "ITI heavy chain H1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q61702"
        },
        {
            "name": "ITI-HC1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q61702"
        },
        {
            "name": "Inter-alpha-inhibitor heavy chain 1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q61702"
        },
        {
            "name": "inter-alpha-trypsin inhibitor heavy chain H1 isoform 2 precursor",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001293007",
            "id": "NP_001293007"
        },
        {
            "name": "inter-alpha-trypsin inhibitor heavy chain H1; inter-alpha (globulin) inhibitor, H1 polypeptide",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001293007",
            "id": "NP_001293007"
        }
    ],
    "function": [
        {
            "annotation": "May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q61702",
                    "url": "https://www.uniprot.org/uniprot/Q61702#function"
                }
            ]
        },
        {
            "annotation": "This gene encodes a heavy chain of inter-alpha trypsin inhibitor (IaI) family of plasma serine protease inhibitors. IaI proteins are protein-glycosaminoglycan-protein complexes comprised of two heavy chains and a light chain. The encoded protein covalently associates with the light chain via a chondroitin sulfate moiety. Intravenous administration of the encoded protein improved survival of mice after infection with Escherichia coli. This gene is located adjacent to two other IaI heavy chain genes. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature protein. [provided by RefSeq, Oct 2015].",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001293007",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001293007"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q61702",
                    "url": "https://www.uniprot.org/uniprot/Q61702"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Itih1",
            "url": "https://www.uniprot.org/uniprot/Q61702",
            "locus": {
                "chromosome": "14",
                "start_pos": 30651137,
                "end_pos": 30665246,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000006529",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000006529"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000006529",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000006529",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd01461",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01461",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "16424",
            "url": "https://www.ncbi.nlm.nih.gov/gene/16424",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "GPDB0002824",
            "url": "https://acgg.asia/db/gpdb/symbol/GPDB0002824",
            "database": "GlycoProtDB",
            "categories": [
                "Glycoproteomics"
            ]
        },
        {
            "id": "GPDB0005515",
            "url": "https://acgg.asia/db/gpdb/symbol/GPDB0005515",
            "database": "GlycoProtDB",
            "categories": [
                "Glycoproteomics"
            ]
        },
        {
            "id": "Q61702",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q61702*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR002035",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002035",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR010600",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR010600",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR013694",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013694",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036465",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036465",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:16424",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:16424",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "96618",
            "url": "http://www.informatics.jax.org/marker/MGI:96618",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "Q61702",
            "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q61702",
            "database": "O-GlcNAc Database",
            "categories": [
                "Glycoproteomics"
            ]
        },
        {
            "id": "QEFRTTC",
            "url": "https://omabrowser.org/oma/group/QEFRTTC/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "608326at2759",
            "url": "http://www.orthodb.org/?query=608326at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10338",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10338",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10338:SF106",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10338:SF106",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00092",
            "url": "http://pfam.xfam.org/family/PF00092",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF06668",
            "url": "http://pfam.xfam.org/family/PF06668",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF08487",
            "url": "http://pfam.xfam.org/family/PF08487",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q61702",
            "url": "http://purl.obolibrary.org/obo/PR_Q61702",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_001293007",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001293007",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F8WJ05",
            "url": "https://www.uniprot.org/uniprot/F8WJ05",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F8WJ05-1",
            "url": "https://www.uniprot.org/uniprot/F8WJ05-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q61702",
            "url": "https://www.uniprot.org/uniprot/Q61702",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q61702-1",
            "url": "https://www.uniprot.org/uniprot/Q61702-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MEGATGLRVLLCLLPLLTLQARPALGLATGRPRGSEKRHAVDTSVNGVSIKSLKVNCKVTSRFAHYVITSQVVNNADKAREVAFDVEIPKTAFISDFAITSDGKAFIGDIKDKVTAWKQYRKAAVLGESAGLVRASGRNMEQFTIHITVGAQSKATFRLTYEEVLKRRLMQYDITIKVRPKQLVQHFEIDVDIFEPQGISKLDAQASFLSEELAAQTIKKSFSGKKGHVLFRPTVSQQQSCPTCSTSLLNGEFKVTYDVNRDKLCDLLVANNYFTHFFAPKNLTNMSKNLVFVIDISGSMEGQKVRQTKEALLKILEDMRPVDNFDLVLFGSKVQSWKGSLVPASNANLQAAQDFVRRFSLAGATNLNGGLLRGIEILNKAQGSHPELSSPASILIMLTDGEPTEGETDRSQILKNVRNAIRGRFPLYNLGFGHDLDFSFLEVMSTENNGWAQRIYEDHDATQQLQGFYNQVANPLLTDVELQYPQDAVLALTQHRHKQYYDGSEIVVAGRIANHKLNTFKADVRARGEKQEFRATCLVDEEEMKKLLRERGHVLENHVERLWAYLTIQELLAKRMKTEGEERANLSSQVLKMSLDYHFVTPLTSLTIRGLTDEDGLEPTIDKPLEDSQPLEMVGPRRTFVLSAIQPSPTAHPIDSKLPLRVTGVDTDPHFIIYVPSKEDSLCFNINEEPGVILNLVQDPDTGFTVNGQLIGNKASSPGQHESTYFGRLGISSPTSDFQLEVTPQNITLNPSSSGSMFSWRDQAVLQKDGVVVTINKKRNLVVSVDDGATFEIVLHRTWKGSAVHQDFLGFYVLDSFRMSARTKGLLGQFFSPLDFEVFDLHPGSDPTKTDATMVVKNRQLTVTRGLQKDYSKDPRHGAEVPCWFVHDNGAGLIDGVHTDYVVSDIF",
        "length": 907,
        "header": "sp|Q61702-1|ITIH1_MOUSE Isoform 1 of Inter-alpha-trypsin inhibitor heavy chain H1  OS=Mus musculus OX=10090 GN=Itih1 PE=1 SV=2 CANONICAL=Q61702-1"
    },
    "isoforms": [
        {
            "isoform_ac": "F8WJ05-1",
            "url": "",
            "sequence": {
                "sequence": "MEGATGLRVLLCLLPLLTLQARPALGLATGRPRGSEKRHAVDTYYLQSVNGVSIKSLKVNCKVTSRFAHYVITSQVVNNADKAREVAFDVEIPKTAFISDFAITSDGKAFIGDIKDKVTAWKQYRKAAVLGESAGLVRASGRNMEQFTIHITVGAQSKATFRLTYEEVLKRRLMQYDITIKVRPKQLVQHFEIDVDIFEPQGISKLDAQASFLSEELAAQTIKKSFSGKKGHVLFRPTVSQQQSCPTCSTSLLNGEFKVTYDVNRDKLCDLLVANNYFTHFFAPKNLTNMSKNLVFVIDISGSMEGQKVRQTKEALLKILEDMRPVDNFDLVLFGSKVQSWKGSLVPASNANLQAAQDFVRRFSLAGATNLNGGLLRGIEILNKAQGSHPELSSPASILIMLTDGEPTEGETDRSQILKNVRNAIRGRFPLYNLGFGHDLDFSFLEVMSTENNGWAQRIYEDHDATQQLQGFYNQVANPLLTDVELQYPQDAVLALTQHRHKQYYDGSEIVVAGRIANHKLNTFKADVRARGEKQEFRATCLVDEEEMKKLLRERGHVLENHVERLWAYLTIQELLAKRMKTEGEERANLSSQVLKMSLDYHFVTPLTSLTIRGLTDEDGLEPTIDKPLEDSQPLEMVGPRRTFVLSAIQPSPTAHPIDSKLPLRVTGVDTDPHFIIYVPSKEDSLCFNINEEPGVILNLVQDPDTGFTVNGQLIGNKASSPGQHESTYFGRLGISSPTSDFQLEVTPQNITLNPSSSGSMFSWRDQAVLQKDGVVVTINKKRNLVVSVDDGATFEIVLHRTWKGSAVHQDFLGFYVLDSFRMSARTKGLLGQFFSPLDFEVFDLHPGSDPTKTDATMVVKNRQLTVTRGLQKDYSKDPRHGAEVPCWFVHDNGAGLIDGVHTDYVVSDIF",
                "length": 911,
                "header": "tr|F8WJ05-1|ITIH1_MOUSE Computationally mapped isoform of Inter-alpha-trypsin inhibitor heavy chain H1  OS=Mus musculus OX=10090 GN=Itih1 PE=1 SV=1 CANONICAL=Q61702-1"
            },
            "locus": {
                "chromosome": "14",
                "start_pos": 30665223,
                "end_pos": 30651470,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000006704.17",
                        "url": "https://www.ensembl.org/id/ENSMUST00000006704.17"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000006704.8",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000006704.8"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q61702-1",
            "url": "",
            "sequence": {
                "sequence": "MEGATGLRVLLCLLPLLTLQARPALGLATGRPRGSEKRHAVDTSVNGVSIKSLKVNCKVTSRFAHYVITSQVVNNADKAREVAFDVEIPKTAFISDFAITSDGKAFIGDIKDKVTAWKQYRKAAVLGESAGLVRASGRNMEQFTIHITVGAQSKATFRLTYEEVLKRRLMQYDITIKVRPKQLVQHFEIDVDIFEPQGISKLDAQASFLSEELAAQTIKKSFSGKKGHVLFRPTVSQQQSCPTCSTSLLNGEFKVTYDVNRDKLCDLLVANNYFTHFFAPKNLTNMSKNLVFVIDISGSMEGQKVRQTKEALLKILEDMRPVDNFDLVLFGSKVQSWKGSLVPASNANLQAAQDFVRRFSLAGATNLNGGLLRGIEILNKAQGSHPELSSPASILIMLTDGEPTEGETDRSQILKNVRNAIRGRFPLYNLGFGHDLDFSFLEVMSTENNGWAQRIYEDHDATQQLQGFYNQVANPLLTDVELQYPQDAVLALTQHRHKQYYDGSEIVVAGRIANHKLNTFKADVRARGEKQEFRATCLVDEEEMKKLLRERGHVLENHVERLWAYLTIQELLAKRMKTEGEERANLSSQVLKMSLDYHFVTPLTSLTIRGLTDEDGLEPTIDKPLEDSQPLEMVGPRRTFVLSAIQPSPTAHPIDSKLPLRVTGVDTDPHFIIYVPSKEDSLCFNINEEPGVILNLVQDPDTGFTVNGQLIGNKASSPGQHESTYFGRLGISSPTSDFQLEVTPQNITLNPSSSGSMFSWRDQAVLQKDGVVVTINKKRNLVVSVDDGATFEIVLHRTWKGSAVHQDFLGFYVLDSFRMSARTKGLLGQFFSPLDFEVFDLHPGSDPTKTDATMVVKNRQLTVTRGLQKDYSKDPRHGAEVPCWFVHDNGAGLIDGVHTDYVVSDIF",
                "length": 907,
                "header": "sp|Q61702-1|ITIH1_MOUSE Isoform 1 of Inter-alpha-trypsin inhibitor heavy chain H1  OS=Mus musculus OX=10090 GN=Itih1 PE=1 SV=2 CANONICAL=Q61702-1"
            },
            "locus": {
                "chromosome": "14",
                "start_pos": 30665223,
                "end_pos": 30651470,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000163118",
                        "url": "https://www.ensembl.org/id/ENSMUST00000163118"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000126449",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000126449"
                    }
                ]
            }
        }
    ],
    "glycosylation": [
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 282,
            "start_aa": "Asn",
            "end_pos": 282,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn282",
            "evidence": [
                {
                    "id": "Q61702",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/Q61702#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 285,
            "start_aa": "Asn",
            "end_pos": 285,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn285",
            "evidence": [
                {
                    "id": "Q61702",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/Q61702#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "S-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "C",
            "relation": "attached",
            "comment": "S-linked (Hex...) cysteine",
            "start_pos": 57,
            "start_aa": "Cys",
            "end_pos": 57,
            "end_aa": "Cys",
            "residue": "Cys",
            "site_lbl": "Cys57",
            "evidence": [
                {
                    "id": "Q61702",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/Q61702#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "reported",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 585,
            "start_aa": "Asn",
            "end_pos": 585,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn585",
            "evidence": [
                {
                    "id": "Q61702",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/Q61702#ptm_processing"
                },
                {
                    "id": "17330941",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/17330941"
                },
                {
                    "id": "16944957",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/16944957"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "O-linked",
            "subtype": "O-GalNAcylation",
            "site_category": "predicted",
            "site_seq": "T",
            "relation": "attached",
            "comment": "O-linked (GalNAc...) threonine O-GalNAcylation",
            "start_pos": 650,
            "start_aa": "Thr",
            "end_pos": 650,
            "end_aa": "Thr",
            "residue": "Thr",
            "site_lbl": "Thr650",
            "evidence": [
                {
                    "id": "Q61702",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/Q61702#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "G49108TO",
            "type": "O-linked",
            "subtype": "O-GlcNAcylation",
            "site_category": "reported_with_glycan",
            "site_seq": "",
            "relation": "attached",
            "comment": "O-GlcNAcylation",
            "evidence": [
                {
                    "id": "Q61702",
                    "database": "O-GlcNAc Database",
                    "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q61702"
                },
                {
                    "id": "31597753",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/31597753"
                }
            ]
        }
    ],
    "phosphorylation": [
        {
            "start_pos": 399,
            "end_pos": 399,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "Phosphothreonine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q61702",
                    "url": "https://www.uniprot.org/uniprot/Q61702"
                }
            ],
            "site_lbl": "Thr399"
        },
        {
            "start_pos": 404,
            "end_pos": 404,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "Phosphothreonine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q61702",
                    "url": "https://www.uniprot.org/uniprot/Q61702"
                }
            ],
            "site_lbl": "Thr404"
        }
    ],
    "glycation": [],
    "keywords": [
        "glycoprotein",
        "glycoprotein_predicted",
        "glycoprotein_reported",
        "glycoprotein_reported_with_glycan"
    ],
    "publication": [
        {
            "title": "Proteome-wide characterization of N-glycosylation events by diagonal chromatography.",
            "journal": "Journal of proteome research",
            "date": "2006",
            "authors": "Ghesquiere B, Van Damme J, Martens L, Vandekerckhove J, Gevaert K",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q61702",
                    "url": "https://www.uniprot.org/uniprot/Q61702#ptm_processing"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q61702",
                    "url": "https://www.uniprot.org/uniprot/Q61702"
                }
            ],
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                {
                    "type": "PubMed",
                    "id": "16944957",
                    "url": "https://glygen.org/publication/PubMed/16944957"
                }
            ]
        },
        {
            "title": "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides.",
            "journal": "Journal of proteome research",
            "date": "2007",
            "authors": "Bernhard OK, Kapp EA, Simpson RJ",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q61702",
                    "url": "https://www.uniprot.org/uniprot/Q61702#ptm_processing"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q61702",
                    "url": "https://www.uniprot.org/uniprot/Q61702"
                }
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                {
                    "type": "PubMed",
                    "id": "17330941",
                    "url": "https://glygen.org/publication/PubMed/17330941"
                }
            ]
        },
        {
            "title": "Overproduction of inter-alpha-trypsin inhibitor heavy chain 1 after loss of Galpha13 in liver exacerbates systemic insulin resistance in mice.",
            "journal": "Science translational medicine",
            "date": "2019",
            "authors": "Kim TH, Koo JH, Heo MJ, Han CY, Kim YI, Park SY, Cho IJ, Lee CH, Choi CS, Lee JW, Kim W, Cho JY, Kim SG",
            "evidence": [
                {
                    "database": "O-GlcNAc Database",
                    "id": "Q61702",
                    "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q61702"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31597753",
                    "url": "https://glygen.org/publication/PubMed/31597753"
                }
            ]
        },
        {
            "title": "The three heavy-chain precursors for the inter-alpha-inhibitor family in mouse: new members of the multicopper oxidase protein group with differential transcription in liver and brain.",
            "journal": "Biochem. J.",
            "date": "1995",
            "authors": "Chan P, Risler JL, Raguenez G, Salier JP",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q61702",
                    "url": "https://www.uniprot.org/uniprot/Q61702"
                }
            ],
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                {
                    "type": "PubMed",
                    "id": "7534067",
                    "url": "https://glygen.org/publication/PubMed/7534067"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:16424",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:16424",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "P19827-1",
            "protein_name": "Inter-alpha-trypsin inhibitor heavy chain H1",
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            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MDGAMGPRGLLLCMYLVSLLILQAMPALGSATGRSKSSEKRQAVDTAVDGVFIRSLKVNCKVTSRFAHYVVTSQVVNTANEAREVAFDLEIPKTAFISDFAVTADGNAFIGDIKDKVTAWKQYRKAAISGENAGLVRASGRTMEQFTIHLTVNPQSKVTFQLTYEEVLKRNHMQYEIVIKVKPKQLVHHFEIDVDIFEPQGISKLDAQASFLPKELAAQTIKKSFSGKKGHVLFRPTVSQQQSCPTCSTSLLNGHFKVTYDVSRDKICDLLVANNHFAHFFAPQNLTNMNKNVVFVIDISGSMRGQKVKQTKEALLKILGDMQPGDYFDLVLFGTRVQSWKGSLVQASEANLQAAQDFVRGFSLDEATNLNGGLLRGIEILNQVQESLPELSNHASILIMLTDGDPTEGVTDRSQILKNVRNAIRGRFPLYNLGFGHNVDFNFLEVMSMENNGRAQRIYEDHDATQQLQGFYSQVAKPLLVDVDLQYPQDAVLALTQNHHKQYYEGSEIVVAGRIADNKQSSFKADVQAHGEGQEFSITCLVDEEEMKKLLRERGHMLENHVERLWAYLTIQELLAKRMKVDREERANLSSQALQMSLDYGFVTPLTSMSIRGMADQDGLKPTIDKPSEDSPPLEMLGPRRTFVLSALQPSPTHSSSNTQRLPDRVTGVDTDPHFIIHVPQKEDTLCFNINEEPGVILSLVQDPNTGFSVNGQLIGNKARSPGQHDGTYFGRLGIANPATDFQLEVTPQNITLNPGFGGPVFSWRDQAVLRQDGVVVTINKKRNLVVSVDDGGTFEVVLHRVWKGSSVHQDFLGFYVLDSHRMSARTHGLLGQFFHPIGFEVSDIHPGSDPTKPDATMVVRNRRLTVTRGLQKDYSKDPWHGAEVSCWFIHNNGAGLIDGAYTDYIVPDIF",
                "length": 911
            },
            "evidence": [
                {
                    "id": "45235967",
                    "url": "http://www.informatics.jax.org/homology/45235967",
                    "database": "MGI"
                },
                {
                    "id": "Q61702",
                    "url": "https://omabrowser.org/oma/group/Q61702/",
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                }
            ],
            "common_name": "Human"
        }
    ],
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                "name": "Biological Process",
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                    {
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                            }
                        ],
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                    },
                    {
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                            }
                        ],
                        "pmid": ""
                    },
                    {
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                            }
                        ],
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                ]
            },
            {
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                        "id": "GO:0004867",
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                                "id": "Q61702",
                                "url": "https://www.uniprot.org/uniprot/Q61702"
                            }
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                        "pmid": ""
                    },
                    {
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                                "id": "Q61702",
                                "url": "https://www.uniprot.org/uniprot/Q61702"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "hyaluronic acid binding",
                        "id": "GO:0005540",
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                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q61702",
                                "url": "https://www.uniprot.org/uniprot/Q61702"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 3,
                "go_terms": [
                    {
                        "name": "extracellular region",
                        "id": "GO:0005576",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q61702",
                                "url": "https://www.uniprot.org/uniprot/Q61702"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "extracellular matrix",
                        "id": "GO:0031012",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q61702",
                                "url": "https://www.uniprot.org/uniprot/Q61702"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "collagen-containing extracellular matrix",
                        "id": "GO:0062023",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062023",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q61702",
                                "url": "https://www.uniprot.org/uniprot/Q61702"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 282,
            "end_pos": 284,
            "annotation": "n_glycosylation_sequon"
        },
        {
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    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ],
    "section_stats": [
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