{ "uniprot_canonical_ac": "Q61165-1", "uniprot_ac": "Q61165", "uniprot_id": "SL9A1_MOUSE", "mass": { "chemical_mass": 91468.0, "monoisotopic_mass": 91468.0 }, "refseq": { "ac": "NP_058677", "name": "sodium/hydrogen exchanger 1 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058677" }, "gene_names": [ { "name": "Slc9a1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q61165", "id": "Q61165" }, { "name": "Apnh; mir-5122; Mir5122; Nhe1; swe", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058677", "id": "NP_058677" }, { "name": "Nhe1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q61165", "id": "Q61165" }, { "name": "Slc9a1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058677", "id": "NP_058677" } ], "protein_names": [ { "name": "Sodium/hydrogen exchanger 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q61165" }, { "name": "NHE-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q61165" }, { "name": "Na(+)/H(+) exchanger 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q61165" }, { "name": "Na+/H+ antiporter; sodium/hydrogen exchanger 1; solute carrier family 9, member 1; NHE-1; Na(+)/H(+) exchanger 1; slow-wave epilepsy; Na+/H+, amiloride sensitive", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058677", "id": "NP_058677" }, { "name": "Solute carrier family 9 member 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q61165" }, { "name": "sodium/hydrogen exchanger 1 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058677", "id": "NP_058677" } ], "function": [ { "annotation": "Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (By similarity). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival. In addition, can transport lithium Li(+) and functions also as a Na(+)/Li(+) antiporter. SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165#function" }, { "database": "UniProtKB", "id": "P26431", "url": "https://www.uniprot.org/uniprot/P26431#function" }, { "database": "UniProtKB", "id": "P19634", "url": "https://www.uniprot.org/uniprot/P19634#function" } ] }, { "annotation": "Pharmacological Inhibition of NHE1 Protein Increases White Matter Resilience and Neurofunctional Recovery after Ischemic Stroke. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_058677", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058677" }, { "database": "PubMed", "id": "37686096", "url": "https://glygen.org/publication/PubMed/37686096" } ] }, { "annotation": "Slc9a1 plays a vital role in chitosan oligosaccharide transport across the intestinal mucosa of mice.", "evidence": [ { "database": "RefSeq", "id": "NP_058677", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058677" }, { "database": "PubMed", "id": "36876794", "url": "https://glygen.org/publication/PubMed/36876794" } ] } ], "disease": [ { "disease_id": "DOID:0080065", "recommended_name": { "id": "DOID:0080065", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080065", "name": "autosomal recessive spinocerebellar ataxia 19", "description": "An autosomal recessive cerebellar ataxia that is characterized by postnatal onset of severe progressive sensorineural hearing loss and progressive cerebellar ataxia and that has_material_basis_in homozygous mutation in the SLC9A1 gene on chromosome 1p36." }, "synonyms": [ { "id": "DOID:0080065", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080065", "name": "Lichtenstein-Knorr syndrome", "description": "" }, { "id": "DOID:0080065", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080065", "name": "SCAR19", "description": "" }, { "id": "MONDO:0014572", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014572", "name": "Lichtenstein-Knorr syndrome", "description": "" }, { "id": "MONDO:0014572", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014572", "name": "Lichtenstein-Knorr syndrome", "description": "" }, { "id": "MONDO:0014572", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014572", "name": "SCAR19", "description": "" }, { "id": "MONDO:0014572", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014572", "name": "autosomal recessive spinocerebellar ataxia type 19", "description": "" }, { "id": "MONDO:0014572", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014572", "name": "progressive autosomal recessive ataxia-sensorineural hearing loss syndrome", "description": "" }, { "id": "MONDO:0014572", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014572", "name": "LIKNS", "description": "" }, { "id": "MONDO:0014572", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014572", "name": "autosomal recessive spinocerebellar ataxia 19", "description": "" }, { "id": "MONDO:0014572", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014572", "name": "progressive autosomal recessive ataxia-deafness syndrome", "description": "" }, { "id": "MONDO:0014572", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014572", "name": "spinocerebellar ataxia, autosomal recessive 19", "description": "" }, { "id": "MIM:616291", "resource": "MIM", "url": "https://www.omim.org/entry/616291", "name": "Lichtenstein-Knorr syndrome", "description": "Lichtenstein-Knorr syndrome" } ], "evidence": [ { "id": "0080065", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0080065" } ] }, { "disease_id": "DOID:1459", "recommended_name": { "id": "DOID:1459", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1459", "name": "hypothyroidism", "description": "A thyroid gland disease which involves an underproduction of thyroid hormone." }, "synonyms": [ { "id": "DOID:1459", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1459", "name": "Thyroid deficiency", "description": "" }, { "id": "DOID:1459", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1459", "name": "Thyroid insufficiency", "description": "" } ], "evidence": [ { "id": "1459", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1459" } ] }, { "disease_id": "DOID:1591", "recommended_name": { "id": "DOID:1591", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1591", "name": "renovascular hypertension", "description": "" }, "synonyms": [], "evidence": [ { "id": "1591", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1591" } ] }, { "disease_id": "DOID:3525", "recommended_name": { "id": "DOID:3525", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3525", "name": "middle cerebral artery infarction", "description": "" }, "synonyms": [], "evidence": [ { "id": "3525", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3525" } ] }, { "disease_id": "DOID:576", "recommended_name": { "id": "DOID:576", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:576", "name": "proteinuria", "description": "A kidney disease that is characterized by the presence of excess proteins in the urine." }, "synonyms": [], "evidence": [ { "id": "576", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:576" } ] }, { "disease_id": "DOID:585", "recommended_name": { "id": "DOID:585", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:585", "name": "nephrolithiasis", "description": "A kidney disease characterized by the formation of stoney concentrations in the kidneys." }, "synonyms": [ { "id": "DOID:585", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:585", "name": "Stone - kidney/ureter", "description": "" }, { "id": "DOID:585", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:585", "name": "kidney stones", "description": "" } ], "evidence": [ { "id": "585", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:585" } ] }, { "disease_id": "DOID:6000", "recommended_name": { "id": "DOID:6000", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6000", "name": "congestive heart failure", "description": "A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body." }, "synonyms": [ { "id": "DOID:6000", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6000", "name": "CHF", "description": "" }, { "id": "DOID:6000", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6000", "name": "Cardiac Failure Congestive", "description": "" }, { "id": "DOID:6000", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6000", "name": "Congestive heart disease", "description": "" }, { "id": "DOID:6000", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6000", "name": "Weak heart", "description": "" } ], "evidence": [ { "id": "6000", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:6000" } ] }, { "disease_id": "DOID:7998", "recommended_name": { "id": "DOID:7998", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:7998", "name": "hyperthyroidism", "description": "A thyroid gland disease that involves an over production of thyroid hormone." }, "synonyms": [ { "id": "DOID:7998", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:7998", "name": "overactive thyroid", "description": "" } ], "evidence": [ { "id": "7998", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:7998" } ] }, { "disease_id": "DOID:83", "recommended_name": { "id": "DOID:83", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:83", "name": "cataract", "description": "A lens disease characterized by clouding of the lens inside the eye which leads to a decrease in vision." }, "synonyms": [ { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "cataract 1 multiple types", "description": "Any cataract (disease) in which the cause of the disease is a mutation in the GJA8 gene." }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "CTRCT1", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "Duffy linked cataract", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "GJA8 cataract (disease)", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "cataract (disease) caused by mutation in GJA8", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "cataract 1, multiple types, with or without microcornea", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "CAE1", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "CZP1", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "zonular pulverulent cataract 1", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "cataract 1, multiple types", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "cataract, Duffy-linked", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "cataract, zonular pulverulent, 1", "description": "" }, { "id": "MONDO:0011060", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011060", "name": "early-onset non-syndromic cataract", "description": "Early-onset non-syndromic cataract is a rare, genetic, non-syndromic developmental defect of the eye, with high clinical and genetic heterogeneity, most frequently characterized by bilateral, symmetrical, non-progressive cataracts which present at birth or in early-childhood. Additional ocular manifestations (e.g. anterior segment dysgenesis, colobomas, nystagmus, microcornea, microphthalmia, myopia) may be associated, however other organs/systems are usually not affected." }, { "id": "MONDO:0011060", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011060", "name": "cataract, age-related nuclear", "description": "" }, { "id": "MONDO:0011060", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011060", "name": "nuclear sclerosis of the lens", "description": "" }, { "id": "MIM:116200", "resource": "MIM", "url": "https://www.omim.org/entry/116200", "name": "Cataract 1, multiple types", "description": "Cataract 1, multiple types" } ], "evidence": [ { "id": "83", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:83" } ] }, { "disease_id": "DOID:9352", "recommended_name": { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin." }, "synonyms": [ { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "NIDDM", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "non-insulin-dependent diabetes mellitus", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type 2 diabetes", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type II diabetes mellitus", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "insulin resistance", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "diabetes mellitus, noninsulin-dependent, 4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "diabetes mellitus, noninsulin-dependent, 4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "diabetes mellitus, noninsulin-dependent, type 4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "Niddm4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "noninsulin-dependent diabetes mellitus 4", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus", "description": "A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity." }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "NIDDM", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "T2DM - type 2 diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "adult onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "adult-onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitis type 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitis type II", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, association with", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, late onset", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 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"name": "noninsulin dependent diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "noninsulin-dependent diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus non-insulin dependent", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type II diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type II diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, non-insulin-dependent, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2, protection against", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type II, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "hypertension, insulin resistance-related, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "insulin resistance, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "maturity-onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus, susceptibility to", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent, 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent, 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent, type 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "NIDDM1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "noninsulin-dependent diabetes mellitus 1", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "NIDDM2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "noninsulin-dependent diabetes mellitus 2", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, type 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "type 2 diabetes mellitus 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "NIDDM3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "noninsulin-dependent diabetes mellitus 3", "description": "" }, { "id": "MIM:125853", "resource": "MIM", "url": "https://www.omim.org/entry/125853", "name": "Type 2 diabetes mellitus", "description": "Type 2 diabetes mellitus" }, { "id": "MIM:601283", "resource": "MIM", "url": "https://www.omim.org/entry/601283", "name": "Type 2 diabetes mellitus 1", "description": "Type 2 diabetes mellitus 1" } ], "evidence": [ { "id": "9352", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9352" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Slc9a1", "url": "https://www.uniprot.org/uniprot/Q61165", "locus": { "chromosome": "4", "start_pos": 133151013, "end_pos": 133097017, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000028854", "url": "https://www.ensembl.org/id/ENSMUSG00000028854" } ] } } ], "crossref": [ { "id": "ENSMUSG00000028854", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000028854", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "20544", "url": "https://www.ncbi.nlm.nih.gov/gene/20544", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "2723", "url": "https://glyconnect.expasy.org/browser/proteins/2723", "database": "GlyConnect", "categories": [ "Glycan", "Glycoproteomics" ] }, { "id": "Q61165", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q61165*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004709", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004709", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006153", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006153", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032103", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032103", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:20544", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:20544", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "102462", "url": "http://www.informatics.jax.org/marker/MGI:102462", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "TIMTYAV", "url": "https://omabrowser.org/oma/group/TIMTYAV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "1065060at2759", "url": "http://www.orthodb.org/?query=1065060at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10110", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10110", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10110:SF59", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10110:SF59", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00999", "url": "http://pfam.xfam.org/family/PF00999", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16644", "url": "http://pfam.xfam.org/family/PF16644", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q61165", "url": "http://purl.obolibrary.org/obo/PR_Q61165", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-2160916", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2160916", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-425986", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-425986", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_058677", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058677", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29419", "url": "https://www.rhea-db.org/rhea/29419", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "72407", "url": "https://www.rhea-db.org/rhea/72407", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "72415", "url": "https://www.rhea-db.org/rhea/72415", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q61165-1", "url": "https://www.uniprot.org/uniprot/Q61165-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMLRWSGVWGFHPPRIFPSLLVVVALVGLLPVLRSHGLQHSPTASTIRGSEPPRERSIGDVTTAPSEPLHRPDDHNLTNLIIEHGGKPSRKAFPVLDIDYPHVRTPFEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLLYAVCLVGGEQINNIGLLDTLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFASYDSVGISDIFLGFLSFFVVALGGVFVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHQWNWTFVISTLLFCLIARVLGVLVLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKAVTSDRILPALSKDKEEEIRKILRSNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQKITNYLTVPAHKLDSPTLSRARIGSDPLAYEPKADLPVITIDPASPQSPESVDLVNEELKGKVLGLNRGPRVTPEEEEEDEDGIIMIRSKEPSSPGTDDVFTPGSSDSPSSQRIQRCLSDPGPHPEPGEGEPFIPKGQ", "length": 820, "header": "sp|Q61165-1|SL9A1_MOUSE Isoform 1 of Sodium/hydrogen exchanger 1 OS=Mus musculus OX=10090 GN=Slc9a1 PE=1 SV=1 CANONICAL=Q61165-1" }, "isoforms": [ { 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OX=10090 GN=Slc9a1 PE=1 SV=1 CANONICAL=Q61165-1" }, "locus": { "chromosome": "4", "start_pos": 133149635, "end_pos": 133097855, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000030669", "url": "https://www.ensembl.org/id/ENSMUST00000030669" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000030669", "url": "https://www.ensembl.org/id/ENSMUSP00000030669" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G14260UH", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 76, "start_aa": "Asn", "end_pos": 76, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn76", "evidence": [ { "id": "2723", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2723" }, { "id": "30899004", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30899004" } ] } ], "phosphorylation": [ { "start_pos": 381, "end_pos": 381, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q61165", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q61165" }, { "database": "PubMed", "id": "33585583", "url": "https://glygen.org/publication/PubMed/33585583" } ], "site_lbl": "Thr381" }, { "start_pos": 471, "end_pos": 471, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q61165", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q61165" }, { "database": "PubMed", "id": "33585583", "url": "https://glygen.org/publication/PubMed/33585583" } ], "site_lbl": "Tyr471" }, { "start_pos": 561, "end_pos": 561, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q61165", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q61165" }, { "database": "PubMed", "id": "33585583", "url": "https://glygen.org/publication/PubMed/33585583" } ], "site_lbl": "Tyr561" }, { "start_pos": 581, "end_pos": 581, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q61165", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q61165" }, { "database": "PubMed", "id": "33585583", "url": "https://glygen.org/publication/PubMed/33585583" } ], "site_lbl": "Tyr581" }, { "start_pos": 603, "end_pos": 603, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" }, { "database": "phospho.ELM", "id": "Q61165", "url": "http://phospho.elm.eu.org/byAccession/Q61165.html" }, { "database": "iPTMnet", "id": "Q61165", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q61165" } ], "site_lbl": "Ser603" }, { "start_pos": 606, "end_pos": 606, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "phospho.ELM", "id": "Q61165", "url": "http://phospho.elm.eu.org/byAccession/Q61165.html" }, { "database": "iPTMnet", "id": "Q61165", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q61165" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" } ], "site_lbl": "Ser606" }, { "start_pos": 607, "end_pos": 607, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q61165", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q61165" } ], "site_lbl": "Thr607" }, { "start_pos": 609, "end_pos": 609, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" }, { "database": "phospho.ELM", "id": "Q61165", "url": "http://phospho.elm.eu.org/byAccession/Q61165.html" }, { "database": "iPTMnet", "id": "Q61165", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q61165" } ], "site_lbl": "Ser609" }, { "start_pos": 652, "end_pos": 652, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" } ], "site_lbl": "Ser652" }, { "start_pos": 697, "end_pos": 697, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" }, { "database": "PubMed", "id": "19131326", "url": "https://glygen.org/publication/PubMed/19131326" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" }, { "database": "phospho.ELM", "id": "Q61165", "url": "http://phospho.elm.eu.org/byAccession/Q61165.html" }, { "database": "iPTMnet", "id": "Q61165", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q61165" } ], "site_lbl": "Ser697" }, { "start_pos": 701, "end_pos": 701, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q61165", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q61165" } ], "site_lbl": "Ser701" }, { "start_pos": 707, "end_pos": 707, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" }, { "database": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" }, { "database": "phospho.ELM", "id": "Q61165", "url": "http://phospho.elm.eu.org/byAccession/Q61165.html" }, { "database": "iPTMnet", "id": "Q61165", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q61165" }, { "database": "PubMed", "id": "17114649", "url": "https://glygen.org/publication/PubMed/17114649" } ], "site_lbl": "Ser707" }, { "start_pos": 727, "end_pos": 727, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q61165", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q61165" } ], "site_lbl": "Ser727" }, { "start_pos": 730, "end_pos": 730, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q61165", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q61165" } ], "site_lbl": "Ser730" }, { "start_pos": 733, "end_pos": 733, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q61165", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q61165" } ], "site_lbl": "Ser733" }, { "start_pos": 755, "end_pos": 755, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "phospho.ELM", "id": "Q61165", "url": "http://phospho.elm.eu.org/byAccession/Q61165.html" }, { "database": "iPTMnet", "id": "Q61165", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q61165" }, { "database": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" } ], "site_lbl": "Thr755" }, { "start_pos": 784, "end_pos": 784, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": 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"http://research.bioinformatics.udel.edu/iptmnet/entry/Q61165" } ], "site_lbl": "Ser792" }, { "start_pos": 801, "end_pos": 801, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" } ], "site_lbl": "Ser801" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Targeted disruption of the murine Nhe1 locus induces ataxia, growth retardation, and seizures.", "journal": "Am. J. Physiol.", "date": "1999", "authors": "Miller M.L., Bell S.M., Shull G.E., Evans R.L., Schultheis P.J., Schreiner C.M., Vorhees C.V., Scott W.J.", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" } ], "reference": [ { "type": "PubMed", "id": "10199808", "url": "https://glygen.org/publication/PubMed/10199808" } ] }, { "title": "cDNA cloning and expression of the mouse Na/H antiporter (NHE-1) and a potential splice variant.", "journal": "Mol. Biol. Rep.", "date": "2001", "authors": "Dewey M.J., Bowman L.H., Ennis T.M.", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" } ], "reference": [ { "type": "PubMed", "id": "11931388", "url": "https://glygen.org/publication/PubMed/11931388" } ] }, { "title": "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.", "journal": "Mol. Cell. Proteomics", "date": "2007", "authors": "Munton RP, Tweedie-Cullen R, Livingstone-Zatchej M, Weinandy F, Waidelich M, Longo D, Gehrig P, Potthast F, Rutishauser D, Gerrits B, Panse C, Schlapbach R, Mansuy IM", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" }, { "database": "iPTMnet", "id": "Q61165", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q61165" } ], "reference": [ { "type": "PubMed", "id": "17114649", "url": "https://glygen.org/publication/PubMed/17114649" } ] }, { "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007", "authors": "Villen J, Beausoleil SA, Gerber SA, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" }, { "database": "iPTMnet", "id": "Q61165", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q61165" } ], "reference": [ { "type": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" } ] }, { "title": "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Sweet SM, Bailey CM, Cunningham DL, Heath JK, Cooper HJ", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" }, { "database": "iPTMnet", "id": "Q61165", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q61165" } ], "reference": [ { "type": "PubMed", "id": "19131326", "url": "https://glygen.org/publication/PubMed/19131326" } ] }, { "title": "The phagosomal proteome in interferon-gamma-activated macrophages.", "journal": "Immunity", "date": "2009", "authors": "Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" }, { "database": "iPTMnet", "id": "Q61165", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q61165" } ], "reference": [ { "type": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" } ] }, { "title": "Nhe1 is a luminal Na+/H+ exchanger in mouse choroid plexus and is targeted to the basolateral membrane in Ncbe/Nbcn2-null mice.", "journal": "Am. J. Physiol.", "date": "2009", "authors": "Huebner C.A., Damkier H.H., Praetorius J., Prasad V.", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" } ], "reference": [ { "type": "PubMed", "id": "19369449", "url": "https://glygen.org/publication/PubMed/19369449" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" }, { "database": "iPTMnet", "id": "Q61165", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q61165" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis.", "journal": "Nature communications", "date": "2019", "authors": "Riley NM, Hebert AS, Westphall MS, Coon JJ", "evidence": [ { "database": "GlyConnect", "id": "2723", "url": "https://glyconnect.expasy.org/browser/proteins/2723" } ], "reference": [ { "type": "PubMed", "id": "30899004", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "title": "Cardiomyocyte Na+/H+ Exchanger-1 Activity Is Reduced in Hypoxia.", "journal": "Frontiers in cardiovascular medicine", "date": "2020", "authors": "Kandilci Hilmi Burak, Richards Mark A, Fournier Marjorie, \u015eim\u015fek G\u00fcl, Chung Yu Jin, Lakhal-Littleton Samira, Swietach Pawel", "evidence": [ { "database": "iPTMnet", "id": "Q61165", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q61165" } ], "reference": [ { "type": "PubMed", "id": "33585583", "url": "https://glygen.org/publication/PubMed/33585583" } ] }, { "title": "Slc9a1 plays a vital role in chitosan oligosaccharide transport across the intestinal mucosa of mice.", "journal": "Carbohydrate polymers", "date": "2023-01-01", "authors": "Wen Jiaying, Chen Shengwei, Bao Minglong, Hu Canying, Wu Lianyun, Yong Yanhong, Liu Xiaoxi, Li Youquan, Yu Zhichao, Ma Xingbin, Eun Jong-Bang, Shim Jae-Han, Warda Mohamad, Abd El-Aty A M, Ju Xianghong", "evidence": [ { "database": "RefSeq", "id": "NP_058677", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058677" } ], "reference": [ { "type": "PubMed", "id": "36876794", "url": "https://glygen.org/publication/PubMed/36876794" } ] }, { "title": "Pharmacological Inhibition of NHE1 Protein Increases White Matter Resilience and Neurofunctional Recovery after Ischemic Stroke.", "journal": "International journal of molecular sciences", "date": "2023-08-27", "authors": "Metwally Shamseldin Ayman Hassan, Paruchuri Satya Siri, Yu Lauren, Capuk Okan, Pennock Nicholas, Sun Dandan, Song Shanshan", "evidence": [ { "database": "RefSeq", "id": "NP_058677", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058677" } ], "reference": [ { "type": "PubMed", "id": "37686096", "url": "https://glygen.org/publication/PubMed/37686096" } ] }, { "title": "Sodium/hydrogen exchanger gene defect in slow-wave epilepsy mutant mice.", "journal": "Cell", "date": "1997", "authors": "Cox GA, Lutz CM, Yang CL, Biemesderfer D, Bronson RT, Fu A, Aronson PS, Noebels JL, Frankel WN", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" } ], "reference": [ { "type": "PubMed", "id": "9335342", "url": "https://glygen.org/publication/PubMed/9335342" } ] } ], "pathway": [ { "id": "mmu:20544", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:20544", "resource": "KEGG Pathway" }, { "id": "R-MMU-2160916", "name": "Hyaluronan uptake and degradation", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2160916", "resource": "Reactome", "description": "Hyaluronan uptake and degradation" }, { "id": "R-MMU-425986", "name": "Sodium/Proton exchangers", 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{ "name": "positive regulation of cell growth", "id": "GO:0030307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030307", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" } ], "pmid": "" }, { "name": "cellular response to insulin stimulus", "id": "GO:0032869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032869", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" } ], "pmid": "" }, { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" } ], "pmid": "" }, { "name": "stem cell differentiation", "id": "GO:0048863", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048863", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" } ], "pmid": "" }, { "name": "protein complex oligomerization", "id": "GO:0051259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051259", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" } ], "pmid": "" }, { "name": "response to organic cyclic compound", "id": "GO:0014070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014070", "evidence": [ { "database": "UniProtKB", "id": "Q61165", "url": "https://www.uniprot.org/uniprot/Q61165" } ], 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