{ "uniprot_canonical_ac": "Q61056-1", "uniprot_ac": "Q61056", "uniprot_id": "TRPC1_MOUSE", "mass": { "chemical_mass": 91213.0, "monoisotopic_mass": 91213.0 }, "refseq": { "ac": "NP_035773", "name": "short transient receptor potential channel 1 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035773" }, "gene_names": [ { "name": "Trpc1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q61056", "id": "Q61056" }, { "name": "Mtrp1; Trp1; Trrp1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298052", "id": "NP_001298052" }, { "name": "Trp1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q61056", "id": "Q61056" }, { "name": "Trpc1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298052", "id": "NP_001298052" }, { "name": "Trrp1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q61056", "id": "Q61056" } ], "protein_names": [ { "name": "Short transient receptor potential channel 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q61056" }, { "name": "TRP-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q61056" }, { "name": "Transient receptor protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q61056" }, { "name": "Trp-related protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q61056" }, { "name": "TrpC1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q61056" }, { "name": "mTrp1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q61056" }, { "name": "short transient receptor potential channel 1 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035773", "id": "NP_035773" }, { "name": "short transient receptor potential channel 1 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298052", "id": "NP_001298052" }, { "name": "short transient receptor potential channel 1; trp-related protein 1; transient receptor protein 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035773", "id": "NP_035773" } ], "function": [ { "annotation": "Effects of maternal HF diet and absence of TRPC1 gene on mouse placental growth and fetal intrauterine growth retardation (IUGR).", "evidence": [ { "database": "RefSeq", "id": "NP_001298052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298052" }, { "database": "PubMed", "id": "36243380", "url": "https://glygen.org/publication/PubMed/36243380" }, { "database": "RefSeq", "id": "NP_035773", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035773" } ] }, { "annotation": "Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056#function" }, { "database": "UniProtKB", "id": "B7ZMP6", "url": "https://www.uniprot.org/uniprot/B7ZMP6#function" }, { "database": "UniProtKB", "id": "ARBA00003698", "url": "https://www.uniprot.org/uniprot/ARBA00003698#function" }, { "database": "UniProtKB", "id": "B2RPS7", "url": "https://www.uniprot.org/uniprot/B2RPS7#function" } ] } ], "disease": [ { "disease_id": "DOID:0050742", "recommended_name": { "id": "DOID:0050742", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050742", "name": "nicotine dependence", "description": "A substance dependence that is characterized by a physical dependence on nicotine." }, "synonyms": [ { "id": "DOID:0050742", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050742", "name": "tobacco use disorder", "description": "" } ], "evidence": [ { "id": "0050742", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050742" } ] }, { "disease_id": "DOID:0060041", "recommended_name": { "id": "DOID:0060041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060041", "name": "autism spectrum disorder", "description": "A pervasive developmental disorder that is a spectrum of psychological conditions. The disease has_symptom widespread abnormalities of social interactions and communication, has_symptom severely restricted interests and has_symptom highly repetitive behavior." }, "synonyms": [], "evidence": [ { "id": "0060041", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060041" } ] }, { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "evidence": [ { "id": "10534", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:1289", "recommended_name": { "id": "DOID:1289", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1289", "name": "neurodegenerative disease", "description": "A central nervous system disease that results in the progressive deterioration of function or structure of neurons." }, "synonyms": [ { "id": "DOID:1289", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1289", "name": "degenerative disease", "description": "" } ], "evidence": [ { "id": "1289", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1289" } ] }, { "disease_id": "DOID:9352", "recommended_name": { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin." }, "synonyms": [ { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "NIDDM", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "non-insulin-dependent diabetes mellitus", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type 2 diabetes", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type II diabetes mellitus", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "insulin resistance", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "diabetes mellitus, noninsulin-dependent, 4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "diabetes mellitus, noninsulin-dependent, 4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "diabetes mellitus, noninsulin-dependent, type 4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "Niddm4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "noninsulin-dependent diabetes mellitus 4", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus", "description": "A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity." }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "NIDDM", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "T2DM - type 2 diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "adult onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "adult-onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitis type 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitis type II", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, association with", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, late onset", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type II", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes, type 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "insulin resistance, severe, digenic", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "non-insulin dependent diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "non-insulin dependent diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "non-insulin-dependent diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "noninsulin dependent diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "noninsulin-dependent diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus non-insulin dependent", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type II diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type II diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, non-insulin-dependent, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2, protection against", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type II, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "hypertension, insulin resistance-related, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "insulin resistance, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "maturity-onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus, susceptibility to", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent, 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent, 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent, type 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "NIDDM1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "noninsulin-dependent diabetes mellitus 1", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "NIDDM2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "noninsulin-dependent diabetes mellitus 2", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, type 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "type 2 diabetes mellitus 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "NIDDM3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "noninsulin-dependent diabetes mellitus 3", "description": "" }, { "id": "MIM:125853", "resource": "MIM", "url": "https://www.omim.org/entry/125853", "name": "Type 2 diabetes mellitus", "description": "Type 2 diabetes mellitus" }, { "id": "MIM:601283", "resource": "MIM", "url": "https://www.omim.org/entry/601283", "name": "Type 2 diabetes mellitus 1", "description": "Type 2 diabetes mellitus 1" } ], "evidence": [ { "id": "9352", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9352" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Trpc1", "url": "https://www.uniprot.org/uniprot/Q61056", "locus": { "chromosome": "9", "start_pos": 95587135, "end_pos": 95632428, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000032839", "url": "https://www.ensembl.org/id/ENSMUSG00000032839" } ] } } ], "crossref": [ { "id": "ENSMUSG00000032839", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000032839", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "22063", "url": "https://www.ncbi.nlm.nih.gov/gene/22063", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q61056", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q61056*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002153", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002153", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005457", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005457", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013555", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013555", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:22063", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:22063", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "109528", "url": "http://www.informatics.jax.org/marker/MGI:109528", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "SRPTIVX", "url": "https://omabrowser.org/oma/group/SRPTIVX/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5406916at2759", "url": "http://www.orthodb.org/?query=5406916at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10117", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10117", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10117:SF56", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10117:SF56", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00520", "url": "http://pfam.xfam.org/family/PF00520", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF08344", "url": "http://pfam.xfam.org/family/PF08344", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q61056", "url": "http://purl.obolibrary.org/obo/PR_Q61056", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-3295583", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3295583", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-5578775", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5578775", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-983695", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983695", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001298052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298052", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A087WP07", "url": "https://www.uniprot.org/uniprot/A0A087WP07", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A087WP07-1", "url": "https://www.uniprot.org/uniprot/A0A087WP07-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A087WRB2", "url": "https://www.uniprot.org/uniprot/A0A087WRB2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A087WRB2-1", "url": "https://www.uniprot.org/uniprot/A0A087WRB2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A087WSD0", "url": "https://www.uniprot.org/uniprot/A0A087WSD0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A087WSD0-1", "url": "https://www.uniprot.org/uniprot/A0A087WSD0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B2RPS7", "url": "https://www.uniprot.org/uniprot/B2RPS7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B2RPS7-1", "url": "https://www.uniprot.org/uniprot/B2RPS7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B7ZMP6", "url": "https://www.uniprot.org/uniprot/B7ZMP6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B7ZMP6-1", "url": "https://www.uniprot.org/uniprot/B7ZMP6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q61056-1", "url": "https://www.uniprot.org/uniprot/Q61056-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q61056-2", "url": "https://www.uniprot.org/uniprot/Q61056-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMAALYPSTDLSGVSSSSLPSSPSSSSPNEVMALKDVREVKEENTLNEKLFLLACDKGDYYMVKKILEENSSGDLNINCVDVLGRNAVTITIENESLDILQLLLDYGCQSADALLVAIDSEVVGAVDILLNHRPKRSSRPTIVKLMERIQNPEYSTTMDVAPVILAAHRNNYEILTMLLKQDVSLPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYRCLASPALIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASYFTFLLLLNLYSLVYNEDKKNTMGPALERIDYLLILWIIGMIWSDIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVAHNKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDLLGFRTSKYAMFYPRN", "length": 793, "header": "sp|Q61056-1|TRPC1_MOUSE Isoform 1 of Short transient receptor potential channel 1 OS=Mus musculus OX=10090 GN=Trpc1 PE=1 SV=5 CANONICAL=Q61056-1" }, "isoforms": [ { "isoform_ac": "A0A087WP07-1", "url": "", "sequence": { "sequence": "MGAPPPSPGLPPSWAAMMAALYPSTDLSGVSSSSLPSSPSSSSPNEVMALKDVREVKEENTLNEKLFLLACDKETYGTNSESRIFNNDGCRTCYFSCSS", "length": 99, "header": "tr|A0A087WP07-1|A0A087WP07_MOUSE Computationally mapped isoform of Transient receptor potential cation channel, subfamily C, member 1 OS=Mus musculus OX=10090 GN=Trpc1 PE=4 SV=1 CANONICAL=Q61056-1" }, "locus": { "chromosome": "9", "start_pos": 95631940, "end_pos": 95614186, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000190604.7", "url": "https://www.ensembl.org/id/ENSMUST00000190604.7" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000139577.2", "url": "https://www.ensembl.org/id/ENSMUSP00000139577.2" } ] } }, { "isoform_ac": "A0A087WRB2-1", "url": "", "sequence": { "sequence": "MGAPPPSPGLPPSWAAMMAALYPSTDLSGVSSSSLPSSPSSSSPNEVMALKDVREVKEENTLNEKLFLLACDKVRRCTFGGNRL", "length": 84, "header": "tr|A0A087WRB2-1|A0A087WRB2_MOUSE Computationally mapped isoform of Transient receptor potential cation channel, subfamily C, member 1 OS=Mus musculus OX=10090 GN=Trpc1 PE=4 SV=1 CANONICAL=Q61056-1" }, "locus": { "chromosome": "9", "start_pos": 95631940, "end_pos": 95618943, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000190497.2", "url": "https://www.ensembl.org/id/ENSMUST00000190497.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000140550.2", "url": "https://www.ensembl.org/id/ENSMUSP00000140550.2" } ] } }, { "isoform_ac": "A0A087WSD0-1", "url": "", "sequence": { "sequence": "KLMERIQNPEYSTTMDVAPVILAAHRNNYEILTMLLKQDVSLPKPHAVGCECTLCSAKNKKDSLRHSRCLASPALIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASYFTFLLLLNLYS", "length": 255, "header": "tr|A0A087WSD0-1|A0A087WSD0_MOUSE Computationally mapped isoform of Transient receptor potential cation channel, subfamily C, member 1 OS=Mus musculus OX=10090 GN=Trpc1 PE=4 SV=1 CANONICAL=Q61056-1" }, "locus": { "chromosome": "9", "start_pos": 95614262, "end_pos": 95603268, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000186235.2", "url": "https://www.ensembl.org/id/ENSMUST00000186235.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000140994.2", "url": "https://www.ensembl.org/id/ENSMUSP00000140994.2" } ] } }, { "isoform_ac": "B2RPS7-1", "url": "", "sequence": { "sequence": "MGAPPPSPGLPPSWAAMMAALYPSTDLSGVSSSSLPSSPSSSSPNEVMALKDVREVKEENTLNEKLFLLACDKGDYYMVKKILEENSSGDLNINCVDVLGRNAVTITIENESLDILQLLLDYGCQSADALLVAIDSEVVGAVDILLNHRPKRSSRPTIVKLMERIQNPEYSTTMDVAPVILAAHRNNYEILTMLLKQDVSLPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYRCLASPALIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASYFTFLLLLNLYSLVYNEDKKNTMGPALERIDYLLILWIIGMIWSDIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVAHNKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDLLGFRTSKYAMFYPRN", "length": 809, "header": "tr|B2RPS7-1|B2RPS7_MOUSE Computationally mapped isoform of Short transient receptor potential channel 1 OS=Mus musculus OX=10090 GN=Trpc1 PE=1 SV=1 CANONICAL=Q61056-1" }, "locus": { "chromosome": "9", "start_pos": 95631940, "end_pos": 95588796, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000189137.7", "url": "https://www.ensembl.org/id/ENSMUST00000189137.7" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000139672.2", "url": "https://www.ensembl.org/id/ENSMUSP00000139672.2" } ] } }, { "isoform_ac": "B7ZMP6-1", "url": "", "sequence": { "sequence": "MGAPPPSPGLPPSWAAMMAALYPSTDLSGVSSSSLPSSPSSSSPNEVMALKDVREVKEENTLNEKLFLLACDKGDYYMVKKILEENSSGDLNINCVDVLGRNAVTITIENESLDILQLLLDYGCQKLMERIQNPEYSTTMDVAPVILAAHRNNYEILTMLLKQDVSLPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYRCLASPALIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASYFTFLLLLNLYSLVYNEDKKNTMGPALERIDYLLILWIIGMIWSDIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVAHNKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDLLGFRTSKYAMFYPRN", "length": 775, "header": "tr|B7ZMP6-1|B7ZMP6_MOUSE Computationally mapped isoform of Short transient receptor potential channel 1 OS=Mus musculus OX=10090 GN=Trpc1 PE=1 SV=1 CANONICAL=Q61056-1" }, "locus": { "chromosome": "9", "start_pos": 95631940, "end_pos": 95588796, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000053785.10", "url": "https://www.ensembl.org/id/ENSMUST00000053785.10" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000057640.5", "url": "https://www.ensembl.org/id/ENSMUSP00000057640.5" } ] } }, { "isoform_ac": "Q61056-1", "url": "", "sequence": { "sequence": "MMAALYPSTDLSGVSSSSLPSSPSSSSPNEVMALKDVREVKEENTLNEKLFLLACDKGDYYMVKKILEENSSGDLNINCVDVLGRNAVTITIENESLDILQLLLDYGCQSADALLVAIDSEVVGAVDILLNHRPKRSSRPTIVKLMERIQNPEYSTTMDVAPVILAAHRNNYEILTMLLKQDVSLPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYRCLASPALIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASYFTFLLLLNLYSLVYNEDKKNTMGPALERIDYLLILWIIGMIWSDIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVAHNKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDLLGFRTSKYAMFYPRN", "length": 793, "header": "sp|Q61056-1|TRPC1_MOUSE Isoform 1 of Short transient receptor potential channel 1 OS=Mus musculus OX=10090 GN=Trpc1 PE=1 SV=5 CANONICAL=Q61056-1" }, "locus": {} }, { "isoform_ac": "Q61056-2", "url": "", "sequence": { "sequence": "MMAALYPSTDLSGVSSSSLPSSPSSSSPNEVMALKDVREVKEENTLNEKLFLLACDKGDYYMVKKILEENSSGDLNINCVDVLGRNAVTITIENESLDILQLLLDYGCQKLMERIQNPEYSTTMDVAPVILAAHRNNYEILTMLLKQDVSLPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYRCLASPALIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASYFTFLLLLNLYSLVYNEDKKNTMGPALERIDYLLILWIIGMIWSDIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVAHNKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDLLGFRTSKYAMFYPRN", "length": 759, "header": "sp|Q61056-2|TRPC1_MOUSE Isoform 2 of Short transient receptor potential channel 1 OS=Mus musculus OX=10090 GN=Trpc1 PE=1 SV=5 CANONICAL=Q61056-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "TRUSS, TNF-R1, and TRPC ion channels synergistically reverse endoplasmic reticulum Ca2+ storage reduction in response to m1 muscarinic acetylcholine receptor signaling.", "journal": "J. Cell. Physiol.", "date": "2010", "authors": "Mace KE, Lussier MP, Boulay G, Terry-Powers JL, Parfrey H, Perraud AL, Riches DW", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "reference": [ { "type": "PubMed", "id": "20458742", "url": "https://glygen.org/publication/PubMed/20458742" } ] }, { "title": "Effects of maternal HF diet and absence of TRPC1 gene on mouse placental growth and fetal intrauterine growth retardation (IUGR).", "journal": "The Journal of nutritional biochemistry", "date": "2022-10-12", "authors": "Claycombe-Larson Kate, Singh Brij, Bundy Amy N, Brunelle Dale, Bukowski Michael R, Roemmich James N", "evidence": [ { "database": "RefSeq", "id": "NP_035773", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035773" }, { "database": "RefSeq", "id": "NP_001298052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298052" } ], "reference": [ { "type": "PubMed", "id": "36243380", "url": "https://glygen.org/publication/PubMed/36243380" } ] }, { "title": "trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry.", "journal": "Cell", "date": "1996", "authors": "Zhu X, Jiang M, Peyton M, Boulay G, Hurst R, Stefani E, Birnbaumer L", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "reference": [ { "type": "PubMed", "id": "8646775", "url": "https://glygen.org/publication/PubMed/8646775" } ] }, { "title": "Identification of four trp1 gene variants murine pancreatic beta-cells.", "journal": "Diabetologia", "date": "1997", "authors": "Ashcroft F.M., Sakura H.", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "reference": [ { "type": "PubMed", "id": "9165220", "url": "https://glygen.org/publication/PubMed/9165220" } ] } ], "pathway": [ { "id": "mmu:22063", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:22063", "resource": "KEGG Pathway" }, { "id": "R-MMU-3295583", "name": "TRP channels", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3295583", "resource": "Reactome", "description": "TRP channels" }, { "id": "R-MMU-5578775", "name": "Ion homeostasis", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5578775", "resource": "Reactome", "description": "Ion homeostasis" }, { "id": "R-MMU-983695", "name": "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983695", "resource": "Reactome", "description": "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" } ], "orthologs": [ { "uniprot_canonical_ac": "P48995-1", "protein_name": "Short transient receptor potential channel 1", "gene_name": "TRPC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMAALYPSTDLSGASSSSLPSSPSSSSPNEVMALKDVREVKEENTLNEKLFLLACDKGDYYMVKKILEENSSGDLNINCVDVLGRNAVTITIENENLDILQLLLDYGCQSADALLVAIDSEVVGAVDILLNHRPKRSSRPTIVKLMERIQNPEYSTTMDVAPVILAAHRNNYEILTMLLKQDVSLPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYRCLASPALIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASYFTFLLLLNLYSLVYNEDKKNTMGPALERIDYLLILWIIGMIWSDIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVAHNKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDLLGFRTSKYAMFYPRN", "length": 793 }, "evidence": [ { "id": "45229191", "url": "http://www.informatics.jax.org/homology/45229191", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QX01-1", "protein_name": "Short transient receptor potential channel 1", "gene_name": "Trpc1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMAALYPSTDLSGVSSSSLPSSPSSSSPNEVMALKDVREVKEENTLNEKLFLLACDKGDYYMVKKILEENSSGDLNINCVDVLGRNAVTITIENESLDILQLLLDYGCQKLMERIQNPEYSTTMDVAPVILAAHRNNYEILTMLLKQDVALPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYRCLASPALIMLTEEDPILRAFELSADLKELSLVEVEFWNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASYFTFLLLLNLYSLVYNEDKKNTMGPALERIDYLLILWIIGMIWSDIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVAHNKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWVCSHTSKGKVRRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDLLGFRTSKYAMFYPKN", "length": 759 }, "evidence": [ { "id": "45229191", "url": "http://www.informatics.jax.org/homology/45229191", "database": "MGI" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "inositol 1,4,5 trisphosphate binding", "id": "GO:0070679", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070679", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "pmid": "" }, { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "pmid": "" }, { "name": "ATPase binding", "id": "GO:0051117", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051117", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "pmid": "" }, { "name": "transmembrane transporter binding", "id": "GO:0044325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044325", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "pmid": "" }, { "name": "monoatomic cation channel activity", "id": "GO:0005261", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005261", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "pmid": "" }, { "name": "store-operated calcium channel activity", "id": "GO:0015279", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015279", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "pmid": "" }, { "name": "calcium channel activity", "id": "GO:0005262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005262", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 11, "go_terms": [ { "name": "cation channel complex", "id": "GO:0034703", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034703", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "pmid": "" }, { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "pmid": "" }, { "name": "membrane raft", "id": "GO:0045121", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045121", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "pmid": "" }, { "name": "sarcomere", "id": "GO:0030017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030017", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "pmid": "" }, { "name": "costamere", "id": "GO:0043034", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043034", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 11, "go_terms": [ { "name": "phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway", "id": "GO:0007207", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007207", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "pmid": "" }, { "name": "positive regulation of insulin secretion", "id": "GO:0032024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032024", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "pmid": "" }, { "name": "saliva secretion", "id": "GO:0046541", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046541", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "pmid": "" }, { "name": "response to calcium ion", "id": "GO:0051592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051592", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "pmid": "" }, { "name": "regulation of cytosolic calcium ion concentration", "id": "GO:0051480", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051480", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "pmid": "" }, { "name": "phospholipase C-activating G protein-coupled receptor signaling pathway", "id": "GO:0007200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007200", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "pmid": "" }, { "name": "positive regulation of release of sequestered calcium ion into cytosol", "id": "GO:0051281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051281", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "pmid": "" }, { "name": "calcium ion transmembrane transport", "id": "GO:0070588", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070588", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "pmid": "" }, { "name": "melanin biosynthetic process", "id": "GO:0042438", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042438", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "pmid": "" }, { "name": "ion channel modulating, G protein-coupled receptor signaling pathway", "id": "GO:0099105", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099105", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "pmid": "" }, { "name": "ligand-gated ion channel signaling pathway", "id": "GO:1990806", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990806", "evidence": [ { "database": "UniProtKB", "id": "Q61056", "url": "https://www.uniprot.org/uniprot/Q61056" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 287, "end_pos": 289, "annotation": "n_glycosylation_sequon" }, { "start_pos": 306, "end_pos": 308, "annotation": "n_glycosylation_sequon" }, { "start_pos": 581, "end_pos": 583, "annotation": "n_glycosylation_sequon" }, { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" }, { "start_pos": 94, "end_pos": 96, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }