{ "uniprot_canonical_ac": "Q60631-1", "uniprot_ac": "Q60631", "uniprot_id": "GRB2_MOUSE", "mass": { "chemical_mass": 25238.0, "monoisotopic_mass": 25238.0 }, "refseq": { "ac": "NP_001300865", "name": "growth factor receptor-bound protein 2", "summary": "The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Three alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2015].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300865" }, "gene_names": [ { "name": "Grb2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q60631", "id": "Q60631" }, { "name": "Ash", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300865", "id": "NP_001300865" }, { "name": "Grb2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300865", "id": "NP_001300865" } ], "protein_names": [ { "name": "Growth factor receptor-bound protein 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q60631" }, { "name": "Adapter protein GRB2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q60631" }, { "name": "SH2/SH3 adapter GRB2; adapter protein GRB2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300865", "id": "NP_001300865" }, { "name": "SH2/SH3 adapter GRB2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q60631" }, { "name": "growth factor receptor-bound protein 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300865", "id": "NP_001300865" } ], "function": [ { "annotation": "Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631#function" }, { "database": "UniProtKB", "id": "P62993", "url": "https://www.uniprot.org/uniprot/P62993#function" } ] }, { "annotation": "Does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631#function" }, { "database": "UniProtKB", "id": "P62993", "url": "https://www.uniprot.org/uniprot/P62993#function" } ] }, { "annotation": "FRS2-independent GRB2 interaction with FGFR2 is not required for embryonic development.", "evidence": [ { "database": "RefSeq", "id": "NP_001300865", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300865" }, { "database": "PubMed", "id": "37421147", "url": "https://glygen.org/publication/PubMed/37421147" } ] }, { "annotation": "Long noncoding RNA AC092171.4 promotes hepatocellular carcinoma progression by sponging microRNA-1271 and upregulating GRB2.", "evidence": [ { "database": "RefSeq", "id": "NP_001300865", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300865" }, { "database": "PubMed", "id": "32692718", "url": "https://glygen.org/publication/PubMed/32692718" } ] }, { "annotation": "Role of long noncoding RNA MEG3/miR-378/GRB2 axis in neuronal autophagy and neurological functional impairment in ischemic stroke.", "evidence": [ { "database": "RefSeq", "id": "NP_001300865", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300865" }, { "database": "PubMed", "id": "32605923", "url": "https://glygen.org/publication/PubMed/32605923" } ] }, { "annotation": "The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Three alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2015].", "evidence": [ { "database": "RefSeq", "id": "NP_001300865", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300865" } ] } ], "disease": [ { "disease_id": "DOID:0111642", "recommended_name": { "id": "DOID:0111642", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111642", "name": "autosomal recessive nonsyndromic deafness 114", "description": "An autosomal recessive nonsyndromic deafness characterized by congenital profound sensorineural hearing loss that has_material_basis_in homozygous or compound heterozygous mutation in the GRAP gene on chromosome 17p11.2." }, "synonyms": [ { "id": "DOID:0111642", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111642", "name": "DFNB114", "description": "" }, { "id": "DOID:0111642", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111642", "name": "autosomal recessive deafness 114", "description": "" }, { "id": "MONDO:0032761", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032761", "name": "hearing loss, autosomal recessive 114", "description": "" }, { "id": "MONDO:0032761", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032761", "name": "DFNB114", "description": "" }, { "id": "MONDO:0032761", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032761", "name": "deafness, autosomal recessive 114", "description": "" }, { "id": "MIM:618456", "resource": "MIM", "url": "https://www.omim.org/entry/618456", "name": "Deafness, autosomal recessive, 114", "description": "Deafness, autosomal recessive, 114" } ], "evidence": [ { "id": "0111642", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0111642" } ] }, { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": 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Cell. Biol.", "date": "1999", "authors": "Lin P., Muslin A.J., Longmore G.D., Goyal R.K., Kanungo J., Payne A.S.", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "10330178", "url": "https://glygen.org/publication/PubMed/10330178" } ] }, { "title": "Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor.", "journal": "Biochem. J.", "date": "1999", "authors": "Thommes K, Lennartsson J, Carlberg M, Ronnstrand L", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "10377264", "url": "https://glygen.org/publication/PubMed/10377264" } ] }, { "title": "Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.", "journal": "J. Biol. Chem.", "date": "1999", "authors": "Jones N, Master Z, Jones J, Bouchard D, Gunji Y, Sasaki H, Daly R, Alitalo K, Dumont DJ", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "10521483", "url": "https://glygen.org/publication/PubMed/10521483" } ] }, { "title": "Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling.", "journal": "Mol. Cell. Biol.", "date": "2001", "authors": "Ueki K., Kahn C.R., Emkey R., Kriauciunas K.M., Tsuruzoe K.", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "11113178", "url": "https://glygen.org/publication/PubMed/11113178" } ] }, { "title": "MIST functions through distinct domains in immunoreceptor signaling in the presence and absence of LAT.", "journal": "J. Biol. Chem.", "date": "2001", "authors": "Goitsuka R, Tatsuno A, Ishiai M, Kurosaki T, Kitamura D", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "11463797", "url": "https://glygen.org/publication/PubMed/11463797" } ] }, { "title": "Mouse alpha1-syntrophin binding to Grb2: further evidence of a role for syntrophin in cell signaling.", "journal": "Biochemistry", "date": "2001", "authors": "Petrucci T.C., Jarrett H.W., Oak S.A., Russo K.", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "11551227", "url": "https://glygen.org/publication/PubMed/11551227" } ] }, { "title": "PrPC directly interacts with proteins involved in signaling pathways.", "journal": "J. Biol. Chem.", "date": "2001", "authors": "Spielhaupter C, Schatzl HM", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "11571277", "url": "https://glygen.org/publication/PubMed/11571277" } ] }, { "title": "'Srcasm: a novel Src activating and signaling molecule.", "journal": "J. Biol. Chem.", "date": "2002", "authors": "Seykora JT, Mei L, Dotto GP, Stein PL", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "11711534", "url": "https://glygen.org/publication/PubMed/11711534" } ] }, { "title": "EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis.", "journal": "J. Cell Biol.", "date": "2003", "authors": "Vindis C, Cerretti DP, Daniel TO, Huynh-Do U", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "12925710", "url": "https://glygen.org/publication/PubMed/12925710" } ] }, { "title": "LIME, a novel transmembrane adaptor protein, associates with p56lck and mediates T cell activation.", "journal": "J. Exp. Med.", "date": "2003", "authors": "Hur EM, Son M, Lee OH, Choi YB, Park C, Lee H, Yun Y", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "14610044", "url": "https://glygen.org/publication/PubMed/14610044" } ] }, { "title": "Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL.", "journal": "J. Exp. Med.", "date": "2004", "authors": "Volna P, Lebduska P, Draberova L, Simova S, Heneberg P, Boubelik M, Bugajev V, Malissen B, Wilson BS, Horejsi V, Malissen M, Draber P", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "15477348", "url": "https://glygen.org/publication/PubMed/15477348" } ] }, { "title": "Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL.", "journal": "J. Exp. Med.", "date": "2004", "authors": "Zhu M, Liu Y, Koonpaew S, Granillo O, Zhang W", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "15477350", "url": "https://glygen.org/publication/PubMed/15477350" } ] }, { "title": "LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation.", "journal": "Blood", "date": "2006", "authors": "Ahn E, Lee H, Yun Y", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "16249387", "url": "https://glygen.org/publication/PubMed/16249387" } ] }, { "title": "NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells.", "journal": "Nat. Immunol.", "date": "2006", "authors": "Upshaw JL, Arneson LN, Schoon RA, Dick CJ, Billadeau DD, Leibson PJ", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "16582911", "url": "https://glygen.org/publication/PubMed/16582911" } ] }, { "title": "Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF.", "journal": "J. Biol. Chem.", "date": "2006", "authors": "Lamalice L, Houle F, Huot J", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "16966330", "url": "https://glygen.org/publication/PubMed/16966330" } ] }, { "title": "Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection.", "journal": "Nat. Immunol.", "date": "2009", "authors": "Johnson AL, Aravind L, Shulzhenko N, Morgun A, Choi SY, Crockford TL, Lambe T, Domaschenz H, Kucharska EM, Zheng L, Vinuesa CG, Lenardo MJ, Goodnow CC, Cornall RJ, Schwartz RH", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "19597497", "url": "https://glygen.org/publication/PubMed/19597497" } ] }, { "title": "Themis, a T cell-specific protein important for late thymocyte development.", "journal": "Nat. Immunol.", "date": "2009", "authors": "Lesourne R, Uehara S, Lee J, Song KD, Li L, Pinkhasov J, Zhang Y, Weng NP, Wildt KF, Wang L, Bosselut R, Love PE", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "19597498", "url": "https://glygen.org/publication/PubMed/19597498" } ] }, { "title": "Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2009", "authors": "Patrick MS, Oda H, Hayakawa K, Sato Y, Eshima K, Kirikae T, Iemura S, Shirai M, Abe T, Natsume T, Sasazuki T, Suzuki H", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "19805304", "url": "https://glygen.org/publication/PubMed/19805304" } ] }, { "title": "Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn.", "journal": "Genes Cells", "date": "2010", "authors": "Murata Y, Mori M, Kotani T, Supriatna Y, Okazawa H, Kusakari S, Saito Y, Ohnishi H, Matozaki T", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "20398064", "url": "https://glygen.org/publication/PubMed/20398064" } ] }, { "title": "Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage Toll-like receptor signaling and cytokine production.", "journal": "PLoS ONE", "date": "2010", "authors": "Peirce MJ, Brook M, Morrice N, Snelgrove R, Begum S, Lanfrancotti A, Notley C, Hussell T, Cope AP, Wait R", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "20644716", "url": "https://glygen.org/publication/PubMed/20644716" } ] }, { "title": "Rab13-dependent trafficking of RhoA is required for directional migration and angiogenesis.", "journal": "J. Biol. Chem.", "date": "2011", "authors": "Wu C, Agrawal S, Vasanji A, Drazba J, Sarkaria S, Xie J, Welch CM, Liu M, Anand-Apte B, Horowitz A", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "21543326", "url": "https://glygen.org/publication/PubMed/21543326" } ] }, { "title": "SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling.", "journal": "Mol. Cell. Biol.", "date": "2011", "authors": "Draber P, Vonkova I, Stepanek O, Hrdinka M, Kucova M, Skopcova T, Otahal P, Angelisova P, Horejsi V, Yeung M, Weiss A, Brdicka T", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "21930792", "url": "https://glygen.org/publication/PubMed/21930792" } ] }, { "title": "Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling.", "journal": "Nat. Immunol.", "date": "2012", "authors": "Wang D, Zheng M, Lei L, Ji J, Yao Y, Qiu Y, Ma L, Lou J, Ouyang C, Zhang X, He Y, Chi J, Wang L, Kuang Y, Wang J, Cao X, Lu L", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "22561606", "url": "https://glygen.org/publication/PubMed/22561606" } ] }, { "title": "SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages.", "journal": "Nat. Commun.", "date": "2017", "authors": "Luo L, Bokil NJ, Wall AA, Kapetanovic R, Lansdaal NM, Marceline F, Burgess BJ, Tong SJ, Guo Z, Alexandrov K, Ross IL, Hibbs ML, Stow JL, Sweet MJ", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "28098138", "url": "https://glygen.org/publication/PubMed/28098138" } ] }, { "title": "Development of SH2 probes and pull-down assays to detect pathogen-induced, site-specific tyrosine phosphorylation of the TLR adaptor SCIMP.", "journal": "Immunol. Cell Biol.", "date": "2017", "authors": "Luo L, Tong SJ, Wall AA, Khromykh T, Sweet MJ, Stow JL", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "28290451", "url": "https://glygen.org/publication/PubMed/28290451" } ] }, { "title": "Role of long noncoding RNA MEG3/miR-378/GRB2 axis in neuronal autophagy and neurological functional impairment in ischemic stroke.", "journal": "The Journal of biological chemistry", "date": "2020", "authors": "Luo HC, Yi TZ, Huang FG, Wei Y, Luo XP, Luo QS", "evidence": [ { "database": "RefSeq", "id": "NP_001300865", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300865" } ], "reference": [ { "type": "PubMed", "id": "32605923", "url": "https://glygen.org/publication/PubMed/32605923" } ] }, { "title": "Long noncoding RNA AC092171.4 promotes hepatocellular carcinoma progression by sponging microRNA-1271 and upregulating GRB2.", "journal": "Aging", "date": "2020", "authors": "Sun C, Huang S, Hou Y, Li Z, Xia D, Zhang L, Zhang Y, Cai Y, Wang Z, Zhou Q, He X, Wu L", "evidence": [ { "database": "RefSeq", "id": "NP_001300865", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300865" } ], "reference": [ { "type": "PubMed", "id": "32692718", "url": "https://glygen.org/publication/PubMed/32692718" } ] }, { "title": "FRS2-independent GRB2 interaction with FGFR2 is not required for embryonic development.", "journal": "Biology open", "date": "2023-07-15", "authors": "Clark James F, Soriano Philippe", "evidence": [ { "database": "RefSeq", "id": "NP_001300865", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300865" } ], "reference": [ { "type": "PubMed", "id": "37421147", "url": "https://glygen.org/publication/PubMed/37421147" } ] }, { "title": "Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors.", "journal": "Mol. Cell. Biol.", "date": "1993", "authors": "Pawson T., Barbacid M., Bustelo X.R., Suen K.", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "7689150", "url": "https://glygen.org/publication/PubMed/7689150" } ] }, { "title": "Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase.", "journal": "Nature", "date": "1994", "authors": "Schlaepfer DD, Hanks SK, Hunter T, van der Geer P", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "7997267", "url": "https://glygen.org/publication/PubMed/7997267" } ] }, { "title": "Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation.", "journal": "Mol. Cell. Biol.", "date": "1996", "authors": "Bazenet CE, Gelderloos JA, Kazlauskas A", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "8943348", "url": "https://glygen.org/publication/PubMed/8943348" } ] }, { "title": "Solution structure of the Grb2 N-terminal SH3 domain complexed with a ten-residue peptide derived from SOS: direct refinement against NOEs, J-couplings and 1H and 13C chemical shifts.", "journal": "J. Mol. Biol.", "date": "1997", "authors": "Mapelli C., Mueller L., Lee V., Friedrichs M.S., Goldfarb V., Meyers C.A., Wittekind M.", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "9135122", "url": "https://glygen.org/publication/PubMed/9135122" } ] }, { "title": "Sequential activation of phoshatidylinositol 3-kinase and phospholipase C-gamma2 by the M-CSF receptor is necessary for differentiation signaling.", "journal": "EMBO J.", "date": "1997", "authors": "Bourette RP, Myles GM, Choi JL, Rohrschneider LR", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "9312046", "url": "https://glygen.org/publication/PubMed/9312046" } ] }, { "title": "An eps homology (EH) domain protein that binds to the ral-GTPase target, RalBP1.", "journal": "J. Biol. Chem.", "date": "1997", "authors": "Yamaguchi A, Urano T, Goi T, Feig LA", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "9395447", "url": "https://glygen.org/publication/PubMed/9395447" } ] }, { "title": "Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2.", "journal": "Oncogene", "date": "1998", "authors": "Tang B., Xu X.X., Lambeth J.D., Yi T.", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "9569023", "url": "https://glygen.org/publication/PubMed/9569023" } ] }, { "title": "Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules.", "journal": "J. Biol. Chem.", "date": "1998", "authors": "Ito N, Wernstedt C, Engstrom U, Claesson-Welsh L", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "reference": [ { "type": "PubMed", "id": "9722576", "url": "https://glygen.org/publication/PubMed/9722576" } ] } ], "pathway": [ { "id": "mmu:14784", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:14784", "resource": "KEGG Pathway" }, { "id": "R-MMU-109704", "name": "PI3K Cascade", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-109704", "resource": "Reactome", "description": "PI3K Cascade" }, { "id": "R-MMU-112412", "name": "SOS-mediated signalling", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-112412", "resource": "Reactome", "description": "SOS-mediated signalling" }, { "id": "R-MMU-1250347", "name": "SHC1 events in ERBB4 signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1250347", "resource": "Reactome", "description": "SHC1 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], "pmid": "" }, { "name": "SH3 domain binding", "id": "GO:0017124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017124", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "pmid": "" }, { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "pmid": "" }, { "name": "protein domain specific binding", "id": "GO:0019904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "evidence": [ { "database": "UniProtKB", "id": "Q60631", "url": "https://www.uniprot.org/uniprot/Q60631" } ], "pmid": "" }, { "name": "protein-macromolecule adaptor 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