{
    "uniprot_canonical_ac": "Q5XIV2-1",
    "uniprot_ac": "Q5XIV2",
    "uniprot_id": "MARHA_RAT",
    "mass": {
        "chemical_mass": 87886.0,
        "monoisotopic_mass": 87886.0
    },
    "refseq": {
        "ac": "XP_017452826",
        "name": "probable E3 ubiquitin-protein ligase MARCHF10 isoform X1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017452826"
    },
    "gene_names": [
        {
            "name": "March10",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q5XIV2",
            "id": "Q5XIV2"
        },
        {
            "name": "Marchf10",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q5XIV2",
            "id": "Q5XIV2"
        },
        {
            "name": "MARCH-X; March10; RGD1311692; Rnf190",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017452826",
            "id": "XP_017452826"
        },
        {
            "name": "March10",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q5XIV2",
            "id": "Q5XIV2"
        },
        {
            "name": "Marchf10",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017452826",
            "id": "XP_017452826"
        },
        {
            "name": "Marchf10",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q5XIV2",
            "id": "Q5XIV2"
        },
        {
            "name": "Rnf190",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q5XIV2",
            "id": "Q5XIV2"
        }
    ],
    "protein_names": [
        {
            "name": "Probable E3 ubiquitin-protein ligase MARCHF10",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q5XIV2"
        },
        {
            "name": "2.3.2.27",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q5XIV2"
        },
        {
            "name": "MARCH-X",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q5XIV2"
        },
        {
            "name": "Membrane-associated RING finger protein 10",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q5XIV2"
        },
        {
            "name": "Membrane-associated RING-CH protein X",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q5XIV2"
        },
        {
            "name": "RING finger protein 190",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q5XIV2"
        },
        {
            "name": "RING-type E3 ubiquitin transferase MARCHF10",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q5XIV2"
        },
        {
            "name": "probable E3 ubiquitin-protein ligase MARCHF10 isoform X1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017452826",
            "id": "XP_017452826"
        },
        {
            "name": "probable E3 ubiquitin-protein ligase MARCHF10 isoform X4",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017452829",
            "id": "XP_017452829"
        }
    ],
    "function": [
        {
            "annotation": "E3 ubiquitin-protein ligase (Probable). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q5XIV2",
                    "url": "https://www.uniprot.org/uniprot/Q5XIV2#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q5XIV2",
                    "url": "https://www.uniprot.org/uniprot/Q5XIV2"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Marchf10",
            "url": "https://www.uniprot.org/uniprot/Q5XIV2",
            "locus": {
                "chromosome": "10",
                "start_pos": 90332784,
                "end_pos": 90421588,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000007084",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000007084"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000007084",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000007084",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "303596",
            "url": "https://www.ncbi.nlm.nih.gov/gene/303596",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR011016",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011016",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR013083",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:303596",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:303596",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "MWASDTK",
            "url": "https://omabrowser.org/oma/group/MWASDTK/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "1342875at2759",
            "url": "http://www.orthodb.org/?query=1342875at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR14471",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14471",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR14471:SF5",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14471:SF5",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF12906",
            "url": "http://pfam.xfam.org/family/PF12906",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q5XIV2",
            "url": "http://purl.obolibrary.org/obo/PR_Q5XIV2",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "XP_017452826",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017452826",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1311692",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311692",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A6HJY3",
            "url": "https://www.uniprot.org/uniprot/A6HJY3",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A6HJY3-1",
            "url": "https://www.uniprot.org/uniprot/A6HJY3-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q5XIV2",
            "url": "https://www.uniprot.org/uniprot/Q5XIV2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q5XIV2-1",
            "url": "https://www.uniprot.org/uniprot/Q5XIV2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MLHEARDRQKFVSDVQYLRDMQHKVDSEYQACLKRQEHKKEPNEKKQEQLWGKDTSDRSRFSSGSSCKQSSGEEDSLSEARLATKAPTAKCEPKLPAIDQTSVKQKHKGTMTLKKPEKVSPSKPSAVAQATKILSRKRRPNLGRLTVSPEMHSPRLSGERSRQKAQLSTKTSGLLGADPVVQQDSLLSANEMKLKRPAREKRNLAPSSQLVRVAGKAPLERQKKGDPSARPQNEPHTALSQTFQPMSGSQVLTESSVPPFLPATVVGPRRAPFRFHDEDFYSALSLNNEQENYDTEEETRTEEELLLAGMRSPPSYKRSRFLGTSAAQNRNVEENAENLRGNSLRRSEPNPGSPRKTSVTEPTTKQSSPGQRMLQDTRLPRELAKDNPSGDQDEKTPVPGDAKSDGVTQVSAEDVSNNCAVEDRSAVHNCERDWQRYLSGSRNSFDCLLSGRPTAPRASVNPSYNAHGSLFHSAVIDDIPASLSVSSILVPSAELEENLRFNVRRPLSPIRNRNPSAASESHSEDTQGEEERASTSQAQESPLLSDLPNPQSSMALGDSPSSPTRRHLQGHFYMPGSLQENIPFTFFAVSDFASQNDNGTSVRVSGVMDEKATEIKADPEKLRKLQESLLEEDSEEEGDLCRICQIAGGSPANPLLEPCGCVGSLQFVHQECLKKWLKVKITSGADLSTVKTCEMCKQGLLVDLDDFNMTEFYHKHQQSRAQSELMNSGLYLVLLLHLYEQRFAELMTLNYRRASRERMSRNYPQPRPEESESSESGDGNESNVYPGRVI",
        "length": 790,
        "header": "sp|Q5XIV2-1|MARHA_RAT Isoform 1 of Probable E3 ubiquitin-protein ligase MARCHF10  OS=Rattus norvegicus OX=10116 GN=Marchf10 PE=1 SV=1 CANONICAL=Q5XIV2-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A6HJY3-1",
            "url": "",
            "sequence": {
                "sequence": "MLHEARDRQKFVSDVQYLRDMQHKVDSEYQACLKRQEHKKEPNEKKQEQLWGKDTSDRSRFSSGSSCKQSSGEEDSLSEARLATKAPTAKCEPKLPAIDQTSVKQKHKGTMTLKKPEKVSPSKPSAGDSGEQPLFCVEYSPFCSVFAFTPAQQPSTKYCCLLLPLVPPASQGAQSPSTSLPPVIFPPFTSPPSGPPSPLPGSPASLCYFPVSQPTPAETPVLCLPGPRRPSKIYLMW",
                "length": 237,
                "header": "tr|A6HJY3-1|A6HJY3_RAT Computationally mapped isoform of Microtubule-associated E3 ubiquitin ligase isoform 2  OS=Rattus norvegicus OX=10116 GN=March10 PE=1 SV=1 CANONICAL=Q5XIV2-1"
            },
            "locus": {
                "chromosome": "10",
                "start_pos": 90417603,
                "end_pos": 90372344,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000090662.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000090662.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000072446.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000072446.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q5XIV2-1",
            "url": "",
            "sequence": {
                "sequence": "MLHEARDRQKFVSDVQYLRDMQHKVDSEYQACLKRQEHKKEPNEKKQEQLWGKDTSDRSRFSSGSSCKQSSGEEDSLSEARLATKAPTAKCEPKLPAIDQTSVKQKHKGTMTLKKPEKVSPSKPSAVAQATKILSRKRRPNLGRLTVSPEMHSPRLSGERSRQKAQLSTKTSGLLGADPVVQQDSLLSANEMKLKRPAREKRNLAPSSQLVRVAGKAPLERQKKGDPSARPQNEPHTALSQTFQPMSGSQVLTESSVPPFLPATVVGPRRAPFRFHDEDFYSALSLNNEQENYDTEEETRTEEELLLAGMRSPPSYKRSRFLGTSAAQNRNVEENAENLRGNSLRRSEPNPGSPRKTSVTEPTTKQSSPGQRMLQDTRLPRELAKDNPSGDQDEKTPVPGDAKSDGVTQVSAEDVSNNCAVEDRSAVHNCERDWQRYLSGSRNSFDCLLSGRPTAPRASVNPSYNAHGSLFHSAVIDDIPASLSVSSILVPSAELEENLRFNVRRPLSPIRNRNPSAASESHSEDTQGEEERASTSQAQESPLLSDLPNPQSSMALGDSPSSPTRRHLQGHFYMPGSLQENIPFTFFAVSDFASQNDNGTSVRVSGVMDEKATEIKADPEKLRKLQESLLEEDSEEEGDLCRICQIAGGSPANPLLEPCGCVGSLQFVHQECLKKWLKVKITSGADLSTVKTCEMCKQGLLVDLDDFNMTEFYHKHQQSRAQSELMNSGLYLVLLLHLYEQRFAELMTLNYRRASRERMSRNYPQPRPEESESSESGDGNESNVYPGRVI",
                "length": 790,
                "header": "sp|Q5XIV2-1|MARHA_RAT Isoform 1 of Probable E3 ubiquitin-protein ligase MARCHF10  OS=Rattus norvegicus OX=10116 GN=Marchf10 PE=1 SV=1 CANONICAL=Q5XIV2-1"
            },
            "locus": {
                "chromosome": "10",
                "start_pos": 90417603,
                "end_pos": 90333138,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000009316",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000009316"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000009316",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000009316"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 78,
            "end_pos": 78,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q5XIV2",
                    "url": "https://www.uniprot.org/uniprot/Q5XIV2"
                },
                {
                    "database": "PubMed",
                    "id": "22673903",
                    "url": "https://glygen.org/publication/PubMed/22673903"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q5XIV2",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5XIV2"
                }
            ],
            "site_lbl": "Ser78"
        }
    ],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [
        {
            "title": "Membrane-associated RING-CH 10 (MARCH10 protein) is a microtubule-associated E3 ubiquitin ligase of the spermatid flagella.",
            "journal": "J. Biol. Chem.",
            "date": "2011",
            "authors": "Iyengar PV, Hirota T, Hirose S, Nakamura N",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A6HJY3",
                    "url": "https://www.uniprot.org/uniprot/A6HJY3"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21937444",
                    "url": "https://glygen.org/publication/PubMed/21937444"
                }
            ]
        },
        {
            "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.",
            "journal": "Nature communications",
            "date": "2012",
            "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q5XIV2",
                    "url": "https://www.uniprot.org/uniprot/Q5XIV2"
                },
                {
                    "database": "UniProtKB",
                    "id": "A6HJY3",
                    "url": "https://www.uniprot.org/uniprot/A6HJY3"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q5XIV2",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5XIV2"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "22673903",
                    "url": "https://glygen.org/publication/PubMed/22673903"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:303596",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:303596",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "E9PX79-1",
            "protein_name": "Membrane associated ring-CH-type finger 10",
            "gene_name": "Marchf10",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MLHETRDRQKFVSDVQYLRDMQHKVDSEYQACLKRQENKKEPNEKKQEQLWVRDTSDRSRFSSGSSCKQSSCEEDSRSEARLSTKTSSAKCEPRLPAIDQASVKQKHKGTMTLKKSEKVSPSKPSPVAPKILSRKRRPNLGRLTVSPEMHSPRASAERSRQKPQLSTKASGLLGADPVVQQESLLCANETKLKKPARERRKLAPSSQLMRTAGKPREKQKKGDLSAHPQNEPHTALSQTFQPMNGSQMLNESLGPSLLPATVVGPRRTPFRFHDEDFYSAISLNNEQESYDTEEETHMEEELLLSGMRSPPSYKRSRFLGTSTAQNRNVEENAENLRGNSLRWSEPSPGSPRKTSTTEPATKQPSPGQRMLQDTRLPSELAKENPSGDQDEKTPVLGDAKSDGVIQVSADDVSSGGTVEDRSAVQNHERDWQHYYSGSRTSFDCLLSGRPTAPRSSMNPPYSAHGSLLHSALIDDIPANLSMSSILVPSSDLEENLRFNVRRPLSPIRNRNPLAAAEGRSDEAQGTQEMASTSHIQEPPLLADLPNPQSSVALGDSPSSPTRRHLQGHFYMPGSLQENIPFTFFAVSDFANQNDNGTTVRVSGVMDEKATEIKADPEKLRKLQESLLEEDSEEEEGDLCRICQIAGGSPANPLLEPCGCVGSLQFVHQECLKKWLKVKITSGADLGTVKTCEMCKQGLLVDLDDFNMTEFYHKHQQSRAQSELMNSGLYLVLLLHLYEQRFAELMALNYRRASRERLSRNYPQPRPEENESSESGDGNASNIYPGRVI",
                "length": 788
            },
            "evidence": [
                {
                    "id": "45242020",
                    "url": "http://www.informatics.jax.org/homology/45242020",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q8NA82-1",
            "protein_name": "Probable E3 ubiquitin-protein ligase MARCHF10",
            "gene_name": "MARCHF10",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MLHDARDRQKFFSDVQYLRDMQHKVDSEYQACLRRQEYRRDPNEKKRDQFWGQETSFERSRFSSRSSSKQSSSEEDALTEPRSSIKISAFKCDSKLPAIDQTSVKQKHKSTMTVRKAEKVDPSEPSPADQAPMVLLRKRKPNLRRFTVSPESHSPRASGDRSRQKQQWPAKVPVPRGADQVVQQEGLMCNTKLKRPNQERRNLVPSSQPMTENAPDRAKKGDPSAPSQSELHPALSQAFQGKNSPQVLSEFSGPPLTPTTVGGPRKASFRFRDEDFYSILSLNSRRESDDTEEETQSEECLWVGVRSPCSPSHHKRSRFGGTSTPQAKNKNFEENAENCRGHSSRRSEPSHGSLRISNAMEPATERPSAGQRLSQDPGLPDRESATEKDRGGSENAKKSPLSWDTKSEPRQEVGVNAENVWSDCISVEHRPGTHDSEGYWKDYLNSSQNSLDYFISGRPISPRSSVNSSYNPPASFMHSALRDDIPVDLSMSSTSVHSSDSEGNSGFHVCQPLSPIRNRTPFASAENHNYFPVNSAHEFAVREAEDTTLTSQPQGAPLYTDLLLNPQGNLSLVDSSSSSPSRMNSEGHLHVSGSLQENTPFTFFAVSHFPNQNDNGSRMAASGFTDEKETSKIKADPEKLKKLQESLLEEDSEEEGDLCRICQIAGGSPSNPLLEPCGCVGSLQFVHQECLKKWLKVKITSGADLGAVKTCEMCKQGLLVDLGDFNMIEFYQKHQQSQAQNELMNSGLYLVLLLHLYEQRFAELMRLNHNQVERERLSRNYPQPRTEENENSELGDGNEGSISQSQVV",
                "length": 808
            },
            "evidence": [
                {
                    "id": "45242020",
                    "url": "http://www.informatics.jax.org/homology/45242020",
                    "database": "MGI"
                },
                {
                    "id": "Q5XIV2",
                    "url": "https://omabrowser.org/oma/group/Q5XIV2/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "zinc ion binding",
                        "id": "GO:0008270",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIV2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIV2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "transferase activity",
                        "id": "GO:0016740",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016740",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIV2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIV2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ligase activity",
                        "id": "GO:0016874",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016874",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIV2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIV2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 1,
                "go_terms": [
                    {
                        "name": "protein ubiquitination",
                        "id": "GO:0016567",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIV2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIV2"
                            }
                        ],
                        "pmid": ""
                    }
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