{
    "uniprot_canonical_ac": "Q5XIR2-1",
    "uniprot_ac": "Q5XIR2",
    "uniprot_id": "Q5XIR2_RAT",
    "mass": {
        "chemical_mass": 69197.0,
        "monoisotopic_mass": 69197.0
    },
    "refseq": {
        "ac": "NP_001007002",
        "name": "intraflagellar transport protein 74 homolog",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007002"
    },
    "gene_names": [
        {
            "name": "Ift74",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q5XIR2",
            "id": "Q5XIR2"
        },
        {
            "name": "Ccdc2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007002",
            "id": "NP_001007002"
        },
        {
            "name": "Ift74",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007002",
            "id": "NP_001007002"
        }
    ],
    "protein_names": [
        {
            "name": "Intraflagellar transport 74",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q5XIR2"
        },
        {
            "name": "coiled-coil domain containing 2; intraflagellar transport 74 homolog",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007002",
            "id": "NP_001007002"
        },
        {
            "name": "intraflagellar transport protein 74 homolog",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007002",
            "id": "NP_001007002"
        }
    ],
    "function": [],
    "disease": [
        {
            "disease_id": "DOID:0050545",
            "recommended_name": {
                "id": "DOID:0050545",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0050545",
                "name": "visceral heterotaxy",
                "description": "A physical disorder characterized by the abnormal distribution of the major visceral organs within the chest and abdomen."
            },
            "synonyms": [
                {
                    "id": "DOID:0050545",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0050545",
                    "name": "heterotaxia",
                    "description": ""
                },
                {
                    "id": "DOID:0050545",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0050545",
                    "name": "situs ambiguus",
                    "description": ""
                },
                {
                    "id": "MONDO:0011546",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011546",
                    "name": "heterotaxy, visceral, 2, autosomal",
                    "description": ""
                },
                {
                    "id": "MONDO:0011546",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011546",
                    "name": "DTGA2",
                    "description": ""
                },
                {
                    "id": "MONDO:0011546",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011546",
                    "name": "heterotaxy, visceral, 2, autosomal",
                    "description": ""
                },
                {
                    "id": "MONDO:0011546",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011546",
                    "name": "transposition of the great arteries, dextro-looped 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0011546",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011546",
                    "name": "HTX2",
                    "description": ""
                },
                {
                    "id": "MONDO:0011546",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011546",
                    "name": "Htx",
                    "description": ""
                },
                {
                    "id": "MONDO:0011659",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011659",
                    "name": "heterotaxy, visceral, 3, autosomal",
                    "description": ""
                },
                {
                    "id": "MONDO:0011659",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011659",
                    "name": "HTX3",
                    "description": ""
                },
                {
                    "id": "MONDO:0011659",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011659",
                    "name": "heterotaxy, visceral, 3, autosomal",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "heterotaxy, visceral, 1, X-linked",
                    "description": "X-linked visceral heterotaxy type 1 is a very rare form of heterotaxy that has only been reported in a few families. Heterotaxy is the right/left transposition of thoracic and/or abdominal organs. This condition is caused by mutations in the ZIC3 gene, is inherited in an X-linked recessive fashion, and is usually seen in males. Physical features include heart abnormalities such as dextrocardia, transposition of great vessels, ventricular septal defect, patent ductus arteriosus, pulmonic stenosis ; situs inversus, and missing (asplenia) and/or extra spleens (polysplenia).Affected individualscan also experience abnormalities in the development of the midline of the body, which can cause holoprosencephaly, myelomeningocele, urological anomalies, widely spaced eyes (hypertelorism), cleft palate, and abnormalities of the sacral spine and anus. Heterotaxia with recurrent respiratory infections are called primary ciliary dyskinesia."
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "ZIC3 visceral heterotaxy",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "congenital heart defects, nonsyndromic, 1, X-linked, X-linked recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "heterotaxy, visceral, 1, X-linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "heterotaxy, visceral, 1, X-linked, X-linked recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "visceral heterotaxy caused by mutation in ZIC3",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "HTX1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "X-linked visceral heterotaxy 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "congenital heart defects, multiple types, 1, X-linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "dextrocardia with Other Cardiac malformations",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "heterotaxy, visceral, X-linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "laterality, X-linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "situs inversus, Complex Cardiac defects, and splenic defects, X-linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0013887",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013887",
                    "name": "heterotaxy, visceral, 6, autosomal",
                    "description": ""
                },
                {
                    "id": "MONDO:0013887",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013887",
                    "name": "heterotaxy, visceral, 6, autosomal",
                    "description": ""
                },
                {
                    "id": "MONDO:0013887",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013887",
                    "name": "heterotaxy, visceral, 6, autosomal recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0013887",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013887",
                    "name": "HTX6",
                    "description": ""
                },
                {
                    "id": "MONDO:0013403",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013403",
                    "name": "heterotaxy, visceral, 4, autosomal",
                    "description": "Any visceral heterotaxy in which the cause of the disease is a mutation in the ACVR2B gene."
                },
                {
                    "id": "MONDO:0013403",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013403",
                    "name": "ACVR2B visceral heterotaxy",
                    "description": ""
                },
                {
                    "id": "MONDO:0013403",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013403",
                    "name": "heterotaxy, visceral, 4, autosomal",
                    "description": ""
                },
                {
                    "id": "MONDO:0013403",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013403",
                    "name": "visceral heterotaxy caused by mutation in ACVR2B",
                    "description": ""
                },
                {
                    "id": "MONDO:0013403",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013403",
                    "name": "HTX4",
                    "description": ""
                },
                {
                    "id": "MIM:605376",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/605376",
                    "name": "Heterotaxy, visceral, 2, autosomal",
                    "description": "Heterotaxy, visceral, 2, autosomal"
                },
                {
                    "id": "MIM:306955",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/306955",
                    "name": "Heterotaxy, visceral, 1, X-linked",
                    "description": "Heterotaxy, visceral, 1, X-linked"
                },
                {
                    "id": "MIM:614779",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/614779",
                    "name": "Heterotaxy, visceral, 6, autosomal",
                    "description": "Heterotaxy, visceral, 6, autosomal"
                },
                {
                    "id": "MIM:613751",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/613751",
                    "name": "Heterotaxy, visceral, 4, autosomal",
                    "description": "Heterotaxy, visceral, 4, autosomal"
                }
            ],
            "evidence": [
                {
                    "id": "0050545",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050545"
                }
            ]
        },
        {
            "disease_id": "DOID:0050777",
            "recommended_name": {
                "id": "DOID:0050777",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0050777",
                "name": "Joubert syndrome",
                "description": "A ciliopathy that is characterized by congenital malformation of the brainstem and agenesis or hypoplasia of the cerebellar vermis leading to an abnormal respiratory pattern, nystagmus, hypotonia, ataxia, and delay in achieving motor milestones."
            },
            "synonyms": [
                {
                    "id": "DOID:0050777",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0050777",
                    "name": "JBTS",
                    "description": ""
                },
                {
                    "id": "MONDO:0008944",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008944",
                    "name": "Joubert syndrome 1",
                    "description": "Any Joubert syndrome in which the cause of the disease is a mutation in the INPP5E gene."
                },
                {
                    "id": "MONDO:0008944",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008944",
                    "name": "CORS1",
                    "description": ""
                },
                {
                    "id": "MONDO:0008944",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008944",
                    "name": "CPD4",
                    "description": ""
                },
                {
                    "id": "MONDO:0008944",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008944",
                    "name": "INPP5E Joubert syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0008944",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008944",
                    "name": "JBTS1",
                    "description": ""
                },
                {
                    "id": "MONDO:0008944",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008944",
                    "name": "Joubert syndrome 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0008944",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008944",
                    "name": "Joubert syndrome caused by mutation in INPP5E",
                    "description": ""
                },
                {
                    "id": "MONDO:0008944",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008944",
                    "name": "Joubert syndrome type 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0008944",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008944",
                    "name": "cerebellooculorenal syndrome 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0008944",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008944",
                    "name": "Cerebellooculorenal syndrome 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0008944",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008944",
                    "name": "Joubert syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0008944",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008944",
                    "name": "Joubert-Boltshauser syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0008944",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008944",
                    "name": "cerebelloparenchymal disorder 4",
                    "description": ""
                },
                {
                    "id": "MIM:213300",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/213300",
                    "name": "Joubert syndrome 1",
                    "description": "Joubert syndrome 1"
                }
            ],
            "evidence": [
                {
                    "id": "0050777",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050777"
                }
            ]
        },
        {
            "disease_id": "DOID:0081011",
            "recommended_name": {
                "id": "DOID:0081011",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0081011",
                "name": "Bardet-Biedl syndrome 22",
                "description": "A Bardet-Biedl syndrome that is retinitis pigmentosa, obesity, polydactyly, hypogonadism, and intellectual disability has_material_basis_in compound heterozygous or homozygous mutation in the IFT74 gene on chromosome 9p21."
            },
            "synonyms": [
                {
                    "id": "MONDO:0014926",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014926",
                    "name": "Bardet-Biedl syndrome 22",
                    "description": "Any Bardet-Biedl syndrome in which the cause of the disease is a mutation in the IFT74 gene."
                },
                {
                    "id": "MONDO:0014926",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014926",
                    "name": "Bardet-Biedl syndrome caused by mutation in IFT74",
                    "description": ""
                },
                {
                    "id": "MONDO:0014926",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014926",
                    "name": "IFT74 Bardet-Biedl syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0014926",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014926",
                    "name": "BBS20",
                    "description": ""
                },
                {
                    "id": "MONDO:0014926",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014926",
                    "name": "Bardet-Biedl syndrome 20; BBS20",
                    "description": ""
                },
                {
                    "id": "MONDO:0014926",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014926",
                    "name": "Bardet-Biedl syndrome type 20",
                    "description": ""
                },
                {
                    "id": "MIM:617119",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/617119",
                    "name": "Bardet-Biedl syndrome 22",
                    "description": "Bardet-Biedl syndrome 22"
                }
            ],
            "evidence": [
                {
                    "id": "0081011",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0081011"
                }
            ]
        },
        {
            "disease_id": "DOID:0112352",
            "recommended_name": {
                "id": "DOID:0112352",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0112352",
                "name": "spermatogenic failure 58",
                "description": "A spermatogenic failure characterized by multiple morphologic abnormalities of the flagella and immotile or severely reduced progressive motility of sperm that has_material_basis_in homozygous or compound heterozygous mutation in the IFT74 gene on chromosome 9p21.2."
            },
            "synonyms": [
                {
                    "id": "DOID:0112352",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0112352",
                    "name": "SPGF58",
                    "description": ""
                },
                {
                    "id": "MONDO:0030463",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0030463",
                    "name": "spermatogenic failure 58",
                    "description": ""
                },
                {
                    "id": "MONDO:0030463",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0030463",
                    "name": "SPGF58",
                    "description": ""
                },
                {
                    "id": "MIM:619585",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/619585",
                    "name": "Spermatogenic failure 58",
                    "description": "Spermatogenic failure 58"
                }
            ],
            "evidence": [
                {
                    "id": "0112352",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0112352"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q5XIR2",
                    "url": "https://www.uniprot.org/uniprot/Q5XIR2"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Ift74",
            "url": "https://www.uniprot.org/uniprot/Q5XIR2",
            "locus": {
                "chromosome": "5",
                "start_pos": 109563833,
                "end_pos": 109474255,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000008075",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000008075"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000008075",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000008075",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "313365",
            "url": "https://www.ncbi.nlm.nih.gov/gene/313365",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR029602",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR029602",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:313365",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:313365",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "HYDKRAK",
            "url": "https://omabrowser.org/oma/group/HYDKRAK/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "160062at2759",
            "url": "http://www.orthodb.org/?query=160062at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR31432",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31432",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR31432:SF0",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31432:SF0",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-5620924",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5620924",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001007002",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007002",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1359704",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1359704",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A8I6ANR2",
            "url": "https://www.uniprot.org/uniprot/A0A8I6ANR2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6ANR2-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6ANR2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q5XIR2",
            "url": "https://www.uniprot.org/uniprot/Q5XIR2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q5XIR2-1",
            "url": "https://www.uniprot.org/uniprot/Q5XIR2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MASNHKSAAPRPISRGGIGLTGRPPSGIRPPSGTVRVATAMPPATARPGSRGGPLGTGGVLSSQIKVADRPVTQQGLSGMKTGMKGPQRQILDKSYYLGLLRSKISELTTEINKLQKEIEMYNQENSVYLSYEKRAETLAVEIKDFQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSMDVIFTERQAKEKQIRSVEEEVEQEKQAADGIIKNMSPEKQVKYIEMKTTNEKLLQELDTLQQQLDSLNIKKESLETEIAHSQVKQEAVLLYEKLYELESHRDQMIAEDKSMGSPMEERERLLKQVKEDNQEIASMERQLTDIKEKINQFSEEIRQLDMDLEEHQGEMNQKYKELKKREENMDAFIETFEETKNQELERKAQIETSIITLLEHCSRNINRMKQISSITNQELKMMQDDLSFKSTEMQKSQTTARNLTSDSQRLQLDLQKMELLESKMTEEQQSLKNKIKQMTADLETYSDLAALKSSAEEKKKKLHQERTVLSTHRNAFKKIMEKLTTDYEALKTQLQDNETHAQLTNLERKWQHLEQNNFVMKEFIATKSQESDYQPVIKNVMKQIAEYNKTIMDALHSASRS",
        "length": 600,
        "header": "tr|Q5XIR2-1|Q5XIR2_RAT Isoform 1 of Intraflagellar transport 74  OS=Rattus norvegicus OX=10116 GN=Ift74 PE=1 SV=1 CANONICAL=Q5XIR2-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A8I6ANR2-1",
            "url": "",
            "sequence": {
                "sequence": "MASNHKSAAPRPISRGGIGLTGRPPSGIRPPSGTVRVATAMPPATARPGSRGGPLGTGGVLSSQIKVADRPVTQQGLSGMKTGMKGPQRQILDKSYYLGLLRSKISELTTEINKLQKEIEMYNQENSVYLSYEKRAETLAVEIKDFQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSMDVIFTERQAKEKQIRSVEEEVEQEKQAADGIIKNMSPEKQVKYIEMKTTNEKLLQELDTLQQQLDSLNIKKESLETEIAHSQVKQEAVLLYEKLYELESHRDQMIAEDKSMGSPMEERERLLKQVKEDNQEIASMERQLTDIKEKINQFSEEIRQLDMDLEEHQACTTLLLGMVAHILHSSTKDKNRRVSMSLRLLII",
                "length": 385,
                "header": "tr|A0A8I6ANR2-1|A0A8I6ANR2_RAT Computationally mapped isoform of Intraflagellar transport 74  OS=Rattus norvegicus OX=10116 GN=Ift74 PE=4 SV=1 CANONICAL=Q5XIR2-1"
            },
            "locus": {
                "chromosome": "5",
                "start_pos": 109538502,
                "end_pos": 109477678,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000099310.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000099310.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000097814.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000097814.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q5XIR2-1",
            "url": "",
            "sequence": {
                "sequence": "MASNHKSAAPRPISRGGIGLTGRPPSGIRPPSGTVRVATAMPPATARPGSRGGPLGTGGVLSSQIKVADRPVTQQGLSGMKTGMKGPQRQILDKSYYLGLLRSKISELTTEINKLQKEIEMYNQENSVYLSYEKRAETLAVEIKDFQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSMDVIFTERQAKEKQIRSVEEEVEQEKQAADGIIKNMSPEKQVKYIEMKTTNEKLLQELDTLQQQLDSLNIKKESLETEIAHSQVKQEAVLLYEKLYELESHRDQMIAEDKSMGSPMEERERLLKQVKEDNQEIASMERQLTDIKEKINQFSEEIRQLDMDLEEHQGEMNQKYKELKKREENMDAFIETFEETKNQELERKAQIETSIITLLEHCSRNINRMKQISSITNQELKMMQDDLSFKSTEMQKSQTTARNLTSDSQRLQLDLQKMELLESKMTEEQQSLKNKIKQMTADLETYSDLAALKSSAEEKKKKLHQERTVLSTHRNAFKKIMEKLTTDYEALKTQLQDNETHAQLTNLERKWQHLEQNNFVMKEFIATKSQESDYQPVIKNVMKQIAEYNKTIMDALHSASRS",
                "length": 600,
                "header": "tr|Q5XIR2-1|Q5XIR2_RAT Isoform 1 of Intraflagellar transport 74  OS=Rattus norvegicus OX=10116 GN=Ift74 PE=1 SV=1 CANONICAL=Q5XIR2-1"
            },
            "locus": {
                "chromosome": "5",
                "start_pos": 109563669,
                "end_pos": 109477678,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000011336.5",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000011336.5"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000011336.3",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000011336.3"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.",
            "journal": "Nat. Commun.",
            "date": "2012",
            "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q5XIR2",
                    "url": "https://www.uniprot.org/uniprot/Q5XIR2"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "22673903",
                    "url": "https://glygen.org/publication/PubMed/22673903"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:313365",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:313365",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-5620924",
            "name": "Intraflagellar transport",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5620924",
            "resource": "Reactome",
            "description": "Intraflagellar transport"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q8BKE9-1",
            "protein_name": "Intraflagellar transport protein 74 homolog",
            "gene_name": "Ift74",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MASNHKSSAPRPISRGGIGLTGRPPSGIRPPSGNVRVATAMPPTTARPGSRGGPLGTGGVLSSQIKVADRPVTQQGLSGMKTGMKGPQRQILDKSYYLGLLRSKISELTTEINKLQKEIEMYNQENSVYLSYEKRAETLAVEIKDFQGQLADYNMLVDKLNTNTEMEEVMSDYNMLKAQNDRETQSMDVIFTERQAKEKQIRSVEEEVEQEKQAADGIIKNMSPEKQVKYIEMKTTNEKLLQELDTLQQQLDSLNMKKESLETEIAHSQVKQEAVLLYEKLYELESHRDQMIAEDKSMGSPMEERERLLKQVKEDNQEIASMERQLTDIKEKINQFSEEIRQLDMDLEEHQGEMNQKYKELKKREENMDAFIETFEETKNQELERKAQIEASIITLLEHCSRNINRMKQISSITNQELKMMQDDLSFKSTEMQKSQTTARNLTSDSQRLQLDLQKMELLESKMTEEQQSLKNKIKQMTADLETYSDLAALKSSAEEKKKKLHQERTVLSTHRNAFKKIMEKLTSDYDTLKRQLQDNETHAQLTNLERKWQHLEQNNFVMKEFIATKSQESDYQPVIKNVMKQIAEYNKTIMDALHNASRS",
                "length": 600
            },
            "evidence": [
                {
                    "id": "45238943",
                    "url": "http://www.informatics.jax.org/homology/45238943",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q96LB3-1",
            "protein_name": "Intraflagellar transport protein 74 homolog",
            "gene_name": "IFT74",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MASNHKSSAARPVSRGGVGLTGRPPSGIRPLSGNIRVATAMPPGTARPGSRGCPIGTGGVLSSQIKVAHRPVTQQGLTGMKTGTKGPQRQILDKSYYLGLLRSKISELTTEVNKLQKGIEMYNQENSVYLSYEKRAETLAVEIKELQGQLADYNMLVDKLNTNTEMEEVMNDYNMLKAQNDRETQSLDVIFTERQAKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNAFKKIMEKQNIEYEALKTQLQENETHSQLTNLERKWQHLEQNNFAMKEFIATKSQESDYQPIKKNVTKQIAEYNKTIVDALHSTSGN",
                "length": 600
            },
            "evidence": [
                {
                    "id": "45238943",
                    "url": "http://www.informatics.jax.org/homology/45238943",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 2,
                "go_terms": [
                    {
                        "name": "chromatin binding",
                        "id": "GO:0003682",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIR2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIR2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "beta-tubulin binding",
                        "id": "GO:0048487",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048487",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIR2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIR2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 4,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIR2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIR2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "centrosome",
                        "id": "GO:0005813",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIR2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIR2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cilium",
                        "id": "GO:0005929",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIR2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIR2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "intraciliary transport particle B",
                        "id": "GO:0030992",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030992",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIR2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIR2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 13,
                "go_terms": [
                    {
                        "name": "Notch signaling pathway",
                        "id": "GO:0007219",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007219",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIR2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIR2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "heart development",
                        "id": "GO:0007507",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIR2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIR2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of transcription by RNA polymerase II",
                        "id": "GO:0045944",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIR2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIR2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "epidermis development",
                        "id": "GO:0008544",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008544",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIR2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIR2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of epithelial cell proliferation",
                        "id": "GO:0050680",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050680",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIR2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIR2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of cell adhesion mediated by integrin",
                        "id": "GO:0033630",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033630",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIR2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIR2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cilium assembly",
                        "id": "GO:0060271",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIR2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIR2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "keratinocyte development",
                        "id": "GO:0003334",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003334",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIR2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIR2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of keratinocyte proliferation",
                        "id": "GO:0010839",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010839",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIR2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIR2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "determination of left/right symmetry",
                        "id": "GO:0007368",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007368",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIR2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIR2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "intraciliary transport involved in cilium assembly",
                        "id": "GO:0035735",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035735",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIR2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIR2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "non-motile cilium assembly",
                        "id": "GO:1905515",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905515",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIR2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIR2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "keratinocyte proliferation",
                        "id": "GO:0043616",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043616",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIR2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIR2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 221,
            "end_pos": 223,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 441,
            "end_pos": 443,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 536,
            "end_pos": 538,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 587,
            "end_pos": 589,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
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                {
                    "field": "total_sites",
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                {
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                {
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            ],
            "sort_fields": []
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        {
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        {
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        {
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                {
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            ],
            "sort_fields": []
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        {
            "table_id": "glycosylation_automatic_literature_mining",
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                {
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            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
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                {
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            ],
            "sort_fields": []
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        {
            "table_id": "snv",
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                {
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