{
    "uniprot_canonical_ac": "Q5XIF2-1",
    "uniprot_ac": "Q5XIF2",
    "uniprot_id": "Q5XIF2_RAT",
    "mass": {
        "chemical_mass": 28439.0,
        "monoisotopic_mass": 28439.0
    },
    "refseq": {
        "ac": "NP_001012068",
        "name": "uroporphyrinogen-III synthase",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012068"
    },
    "gene_names": [
        {
            "name": "Uros",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q5XIF2",
            "id": "Q5XIF2"
        },
        {
            "name": "Uros",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012068",
            "id": "NP_001012068"
        }
    ],
    "protein_names": [
        {
            "name": "uroporphyrinogen-III synthase",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q5XIF2"
        },
        {
            "name": "4.2.1.75",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q5XIF2"
        },
        {
            "name": "Hydroxymethylbilane hydrolyase [cyclizing]",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q5XIF2"
        },
        {
            "name": "Uroporphyrinogen-III cosynthase",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q5XIF2"
        },
        {
            "name": "urogen III synthase; uroporphyrinogen III co-synthase",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012068",
            "id": "NP_001012068"
        },
        {
            "name": "uroporphyrinogen-III synthase",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012068",
            "id": "NP_001012068"
        }
    ],
    "function": [],
    "disease": [
        {
            "disease_id": "DOID:13270",
            "recommended_name": {
                "id": "DOID:13270",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:13270",
                "name": "erythropoietic protoporphyria",
                "description": "An acute porphyria characterized by a deficiency in the enzyme ferrochelatase, leading to abnormally high levels of protoporphyrin in the tissue."
            },
            "synonyms": [
                {
                    "id": "DOID:13270",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:13270",
                    "name": "EPP",
                    "description": ""
                },
                {
                    "id": "DOID:13270",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:13270",
                    "name": "Protoporphyria",
                    "description": ""
                },
                {
                    "id": "MONDO:0008319",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008319",
                    "name": "protoporphyria, erythropoietic, 1",
                    "description": "Erythropoietic protoporphyria caused by a compound heterozygous or homozygous mutation in the gene encoding ferrochelatase (FECH) on chromosome 18q21."
                },
                {
                    "id": "MONDO:0008319",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008319",
                    "name": "erythropoietic protoporphyria",
                    "description": ""
                },
                {
                    "id": "MONDO:0008319",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008319",
                    "name": "protoporphyria, erythropoietic",
                    "description": ""
                },
                {
                    "id": "MONDO:0008319",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008319",
                    "name": "EPP1",
                    "description": ""
                },
                {
                    "id": "MONDO:0008319",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008319",
                    "name": "ferrochelatase deficiency",
                    "description": ""
                },
                {
                    "id": "MONDO:0008319",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008319",
                    "name": "heme synthetase deficiency",
                    "description": ""
                },
                {
                    "id": "MONDO:0008319",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008319",
                    "name": "protoporphyria, erythropoietic, 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0008319",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008319",
                    "name": "EPP",
                    "description": ""
                },
                {
                    "id": "MONDO:0008319",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008319",
                    "name": "erythrohepatic protoporphyria",
                    "description": ""
                },
                {
                    "id": "MONDO:0010420",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010420",
                    "name": "X-linked erythropoietic protoporphyria",
                    "description": "X-linked form of erythropoietic protoporphyria."
                },
                {
                    "id": "MONDO:0010420",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010420",
                    "name": "X-linked dominant erythropoietic protoporphyria",
                    "description": ""
                },
                {
                    "id": "MONDO:0010420",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010420",
                    "name": "X-linked dominant protoporphyria",
                    "description": ""
                },
                {
                    "id": "MONDO:0010420",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010420",
                    "name": "XLDPP",
                    "description": ""
                },
                {
                    "id": "MONDO:0010420",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010420",
                    "name": "XLP",
                    "description": ""
                },
                {
                    "id": "MONDO:0010420",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010420",
                    "name": "XLPP",
                    "description": ""
                },
                {
                    "id": "MONDO:0010420",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010420",
                    "name": "erythropoietic protoporphyria, X-linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0010420",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010420",
                    "name": "Erythrohepatic protoporphyria, X-linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0010420",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010420",
                    "name": "XLEPP",
                    "description": ""
                },
                {
                    "id": "MONDO:0010420",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010420",
                    "name": "protoporphyria, erythropoietic, X-linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0010420",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010420",
                    "name": "protoporphyria, erythropoietic, X-linked dominant",
                    "description": ""
                },
                {
                    "id": "MIM:177000",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/177000",
                    "name": "Protoporphyria, erythropoietic, 1",
                    "description": "Protoporphyria, erythropoietic, 1"
                },
                {
                    "id": "MIM:300752",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/300752",
                    "name": "Erythropoietic protoporphyria, X-linked dominant",
                    "description": "Erythropoietic protoporphyria, X-linked dominant"
                }
            ],
            "evidence": [
                {
                    "id": "13270",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:13270"
                }
            ]
        },
        {
            "disease_id": "DOID:13271",
            "recommended_name": {
                "id": "DOID:13271",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:13271",
                "name": "cutaneous porphyria",
                "description": ""
            },
            "synonyms": [
                {
                    "id": "DOID:13271",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:13271",
                    "name": "Erythropoietic porphyria",
                    "description": ""
                },
                {
                    "id": "MONDO:0009902",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009902",
                    "name": "cutaneous porphyria",
                    "description": "Congenital erythropoietic porphyria, or Gnther disease, is a form of erythropoietic porphyria characterized by very severe and mutilating photodermatosis."
                },
                {
                    "id": "MONDO:0009902",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009902",
                    "name": "CEP",
                    "description": ""
                },
                {
                    "id": "MONDO:0009902",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009902",
                    "name": "Gnther disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0009902",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009902",
                    "name": "cutaneous porphyria",
                    "description": ""
                },
                {
                    "id": "MONDO:0009902",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009902",
                    "name": "erythropoietic porphyria",
                    "description": ""
                },
                {
                    "id": "MONDO:0009902",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009902",
                    "name": "Cep",
                    "description": ""
                },
                {
                    "id": "MONDO:0009902",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009902",
                    "name": "Gunther disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0009902",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009902",
                    "name": "Uros deficiency",
                    "description": ""
                },
                {
                    "id": "MONDO:0009902",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009902",
                    "name": "congenital erythropoietic porphyria",
                    "description": ""
                },
                {
                    "id": "MONDO:0009902",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009902",
                    "name": "congenital porphyria",
                    "description": ""
                },
                {
                    "id": "MONDO:0009902",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009902",
                    "name": "porphyria, congenital erythropoietic",
                    "description": ""
                },
                {
                    "id": "MONDO:0009902",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009902",
                    "name": "uroporphyrinogen 3 synthase deficiency",
                    "description": ""
                },
                {
                    "id": "MONDO:0009902",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009902",
                    "name": "uroporphyrinogen III synthase, deficiency of",
                    "description": ""
                },
                {
                    "id": "MIM:263700",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/263700",
                    "name": "Congenital erythropoietic porphyria",
                    "description": "Congenital erythropoietic porphyria"
                }
            ],
            "evidence": [
                {
                    "id": "13271",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:13271"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q5XIF2",
                    "url": "https://www.uniprot.org/uniprot/Q5XIF2"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Uros",
            "url": "https://www.uniprot.org/uniprot/Q5XIF2",
            "locus": {
                "chromosome": "1",
                "start_pos": 188490323,
                "end_pos": 188512249,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000017810",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000017810"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000017810",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000017810",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd06578",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06578",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "309070",
            "url": "https://www.ncbi.nlm.nih.gov/gene/309070",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR003754",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003754",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036108",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036108",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR039793",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR039793",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:309070",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:309070",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "IHGADTG",
            "url": "https://omabrowser.org/oma/group/IHGADTG/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "1472480at2759",
            "url": "http://www.orthodb.org/?query=1472480at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12390",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12390",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12390:SF0",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12390:SF0",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF02602",
            "url": "http://pfam.xfam.org/family/PF02602",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-189451",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-189451",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001012068",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012068",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1310396",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310396",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "Q5XIF2",
            "url": "https://www.uniprot.org/uniprot/Q5XIF2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q5XIF2-1",
            "url": "https://www.uniprot.org/uniprot/Q5XIF2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MKVLLLKDAKDDDSGQDPYIQELRLCGLEATLIPVLSFEFMSLPSLSEKLSHPEGFGGLIFTSPRAVEAVKLCLEKDNKTEAWEKSLKDRWNAKSVYVVGSATASLVNKIGLDAEGAGSGNAEKLAEYICSKPSSELPLLFPCGTIKGDTLPKMLRDKGIPMESMHVYQTIPHPGIQGSLESYYENQGIPASITFFSPSGLKYSLEYIQALSGGSFDQIKFVAIGPSTTRAMAAKGLPVSCTAESPTPQALAAGIRKALKPNSCC",
        "length": 265,
        "header": "tr|Q5XIF2-1|Q5XIF2_RAT Isoform 1 of uroporphyrinogen-III synthase  OS=Rattus norvegicus OX=10116 GN=Uros PE=3 SV=1 CANONICAL=Q5XIF2-1"
    },
    "isoforms": [
        {
            "isoform_ac": "Q5XIF2-1",
            "url": "",
            "sequence": {
                "sequence": "MKVLLLKDAKDDDSGQDPYIQELRLCGLEATLIPVLSFEFMSLPSLSEKLSHPEGFGGLIFTSPRAVEAVKLCLEKDNKTEAWEKSLKDRWNAKSVYVVGSATASLVNKIGLDAEGAGSGNAEKLAEYICSKPSSELPLLFPCGTIKGDTLPKMLRDKGIPMESMHVYQTIPHPGIQGSLESYYENQGIPASITFFSPSGLKYSLEYIQALSGGSFDQIKFVAIGPSTTRAMAAKGLPVSCTAESPTPQALAAGIRKALKPNSCC",
                "length": 265,
                "header": "tr|Q5XIF2-1|Q5XIF2_RAT Isoform 1 of uroporphyrinogen-III synthase  OS=Rattus norvegicus OX=10116 GN=Uros PE=3 SV=1 CANONICAL=Q5XIF2-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 188506132,
                "end_pos": 188492334,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000024279.5",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000024279.5"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000024278.3",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000024278.3"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [],
    "pathway": [
        {
            "id": "rno:309070",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:309070",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-189451",
            "name": "Heme biosynthesis",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-189451",
            "resource": "Reactome",
            "description": "Heme biosynthesis"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "P10746-1",
            "protein_name": "Uroporphyrinogen-III synthase",
            "gene_name": "UROS",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLIFTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCGNAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNLNSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKFAAIGPTTARALAAQGLPVSCTAESPTPQALATGIRKALQPHGCC",
                "length": 265
            },
            "evidence": [
                {
                    "id": "45225716",
                    "url": "http://www.informatics.jax.org/homology/45225716",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P51163-1",
            "protein_name": "Uroporphyrinogen-III synthase",
            "gene_name": "Uros",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MKVLLLKDAKEDDSGLDPYIQELRLCGLEATLIPVLSFEFMSLPSLSEKLSHPEGFGGLIFTSPRAVEAVKLCLEKDNKTEAWEKSLKDRWNAKSVYVVGSATASLVNKIGLDAEGAGSGNAEKLAEYICSKPSSELPLLFPCGTIKGDTLPKMLKDKGIPMESMHVYQTVPHPGIQGSLKSYYEDQGIPASITFFSPSGLKYSLEYIQALSGSSFDQIKFIAIGPSTTRAMAAKGLPVSCTAESPTPQALAAGIRNVLKPNHCC",
                "length": 265
            },
            "evidence": [
                {
                    "id": "45225716",
                    "url": "http://www.informatics.jax.org/homology/45225716",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 1,
                "go_terms": [
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIF2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIF2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 7,
                "go_terms": [
                    {
                        "name": "porphyrin-containing compound biosynthetic process",
                        "id": "GO:0006779",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006779",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIF2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIF2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "heme biosynthetic process",
                        "id": "GO:0006783",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006783",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIF2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIF2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protoporphyrinogen IX biosynthetic process",
                        "id": "GO:0006782",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006782",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIF2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIF2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "response to platinum ion",
                        "id": "GO:0070541",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070541",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIF2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIF2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cellular response to arsenic-containing substance",
                        "id": "GO:0071243",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071243",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIF2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIF2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "uroporphyrinogen III biosynthetic process",
                        "id": "GO:0006780",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006780",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIF2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIF2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cellular response to amine stimulus",
                        "id": "GO:0071418",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071418",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIF2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIF2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 2,
                "go_terms": [
                    {
                        "name": "folic acid binding",
                        "id": "GO:0005542",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005542",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIF2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIF2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "uroporphyrinogen-III synthase activity",
                        "id": "GO:0004852",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004852",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIF2",
                                "url": "https://www.uniprot.org/uniprot/Q5XIF2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 78,
            "end_pos": 80,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [
        {
            "id": "R-RNO-189488",
            "name": "UROS transforms HMB to URO3",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q5XIF2-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-189488",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-189488"
                }
            ]
        }
    ],
    "reaction_participants": [],
    "reaction_enzymes": [
        {
            "uniprot_ac": "Q5XIF2",
            "gene_name": "Uros",
            "activity": [
                {
                    "ec_number": "4.2.1.75",
                    "activity": "hydroxymethylbilane = H2O + uroporphyrinogen III.",
                    "evidence": [
                        {
                            "id": "Q5XIF2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5XIF2"
                        }
                    ]
                },
                {
                    "ec_number": "4.2.1.75",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q5XIF2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5XIF2"
                        }
                    ]
                }
            ]
        }
    ],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_disease",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_non_disease",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "publication",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}
