{
    "uniprot_canonical_ac": "Q5XIC4-1",
    "uniprot_ac": "Q5XIC4",
    "uniprot_id": "SPG21_RAT",
    "mass": {
        "chemical_mass": 29576.0,
        "monoisotopic_mass": 29576.0
    },
    "refseq": {
        "ac": "NP_001006988",
        "name": "maspardin isoform 3",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006988"
    },
    "gene_names": [
        {
            "name": "Spg21",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q5XIC4",
            "id": "Q5XIC4"
        }
    ],
    "protein_names": [
        {
            "name": "Maspardin",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q5XIC4"
        },
        {
            "name": "Spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q5XIC4"
        },
        {
            "name": "maspardin isoform 3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006988",
            "id": "NP_001006988"
        },
        {
            "name": "maspardin; spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog; acid cluster protein 33; spastic paraplegia 21 homolog-like; SPG21, maspardin",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006988",
            "id": "NP_001006988"
        }
    ],
    "function": [
        {
            "annotation": "May play a role as a negative regulatory factor in CD4-dependent T-cell activation.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q5XIC4",
                    "url": "https://www.uniprot.org/uniprot/Q5XIC4#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "A0A8I6GKW0",
                    "url": "https://www.uniprot.org/uniprot/A0A8I6GKW0#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "ARBA00002271",
                    "url": "https://www.uniprot.org/uniprot/ARBA00002271#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "A0A8I6AIT6",
                    "url": "https://www.uniprot.org/uniprot/A0A8I6AIT6#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0060245",
            "recommended_name": {
                "id": "DOID:0060245",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0060245",
                "name": "Mast syndrome",
                "description": "A hereditary spastic paraplegia associated with dementia."
            },
            "synonyms": [
                {
                    "id": "DOID:0060245",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0060245",
                    "name": "SPG21",
                    "description": ""
                },
                {
                    "id": "DOID:0060245",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0060245",
                    "name": "autosomal recessive spastic paraplegia 21",
                    "description": ""
                },
                {
                    "id": "DOID:0060245",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0060245",
                    "name": "autosomal recessive spastic paraplegia type 21",
                    "description": ""
                },
                {
                    "id": "DOID:0060245",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0060245",
                    "name": "hereditary spastic paraplegia 21",
                    "description": ""
                },
                {
                    "id": "MONDO:0009568",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009568",
                    "name": "mast syndrome",
                    "description": "Autosomal recessive spastic paraplegia type 21 is a complex type of hereditary spastic paraplegia characterized by an onset in adolescence or adulthood of slowly progressive spastic paraparesis associated with the additional manifestations of apraxia, cognitive and speech decline (leading to dementia and akinetic mutism in some cases), personality disturbances and extrapyramidal (e.g. oromandibular dyskinesia, rigidity) and cerebellar (i.e. dysdiadochokinesia and incoordination) signs. Subtle abnormalities (e.g. developmental delays) may be noted earlier in childhood. A thin corpus callosum and white matter abnormalities are equally reported on magnetic resonance imaging."
                },
                {
                    "id": "MONDO:0009568",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009568",
                    "name": "Mast syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0009568",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009568",
                    "name": "SPG21",
                    "description": ""
                },
                {
                    "id": "MONDO:0009568",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009568",
                    "name": "autosomal recessive spastic paraplegia 21",
                    "description": ""
                },
                {
                    "id": "MONDO:0009568",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009568",
                    "name": "autosomal recessive spastic paraplegia type 21",
                    "description": ""
                },
                {
                    "id": "MONDO:0009568",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009568",
                    "name": "hereditary spastic paraplegia 21",
                    "description": ""
                },
                {
                    "id": "MONDO:0009568",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009568",
                    "name": "mast syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0009568",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009568",
                    "name": "spastic paraplegia 21, autosomal recessive",
                    "description": ""
                },
                {
                    "id": "MIM:248900",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/248900",
                    "name": "Spastic paraplegia 21, autosomal recessive",
                    "description": "Spastic paraplegia 21, autosomal recessive"
                }
            ],
            "evidence": [
                {
                    "id": "0060245",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060245"
                }
            ]
        },
        {
            "disease_id": "DOID:2476",
            "recommended_name": {
                "id": "DOID:2476",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:2476",
                "name": "hereditary spastic paraplegia",
                "description": "A paraplegia that is characterized by progressive stiffness and contraction (spasticity) in the lower limbs."
            },
            "synonyms": [
                {
                    "id": "DOID:2476",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:2476",
                    "name": "French settlement disease",
                    "description": ""
                },
                {
                    "id": "DOID:2476",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:2476",
                    "name": "Strumpell-Lorrain disease",
                    "description": ""
                },
                {
                    "id": "DOID:2476",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:2476",
                    "name": "familial spastic paraplegia",
                    "description": ""
                },
                {
                    "id": "DOID:2476",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:2476",
                    "name": "hereditary spastic paraparesis",
                    "description": ""
                },
                {
                    "id": "MONDO:0010559",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010559",
                    "name": "MASA syndrome",
                    "description": "MASA syndrome (Mental retardation, Aphasia, Spastic paraplegia, Adducted thumbs) is a historical term used to describe a phenotype now considered to be part of the X-linked L1 clinical spectrum (L1 syndrome). MASA is characterized by mild to moderate intellectual deficit, delayed development of speech, hypotonia progressing to spasticity or spastic paraplegia, adducted thumbs, and mild to moderate distension of the cerebral ventricles."
                },
                {
                    "id": "MONDO:0010559",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010559",
                    "name": "Gareis-Mason syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0010559",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010559",
                    "name": "MASA syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0010559",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010559",
                    "name": "X-linked complicated hereditary spastic paraplegia type 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010559",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010559",
                    "name": "X-linked corpus callosum agenesis",
                    "description": ""
                },
                {
                    "id": "MONDO:0010559",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010559",
                    "name": "X-linked spastic paraplegia 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010559",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010559",
                    "name": "hereditary spastic paraplegia 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010559",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010559",
                    "name": "intellectual disability-aphasia-shuffling gait-adducted thumbs syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0010559",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010559",
                    "name": "masa syndrome, X-linked recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0010559",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010559",
                    "name": "spastic paraplegia, X-linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0010559",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010559",
                    "name": "CRASH syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0010559",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010559",
                    "name": "CRASH syndrome, X-linked recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0010559",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010559",
                    "name": "Clasped thumb and intellectual disability",
                    "description": ""
                },
                {
                    "id": "MONDO:0010559",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010559",
                    "name": "Clasped thumb and mental retardation",
                    "description": ""
                },
                {
                    "id": "MONDO:0010559",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010559",
                    "name": "adducted thumb with intellectual disability",
                    "description": ""
                },
                {
                    "id": "MONDO:0010559",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010559",
                    "name": "adducted thumb with mental retardation",
                    "description": ""
                },
                {
                    "id": "MONDO:0010559",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010559",
                    "name": "intellectual disability aphasia shuffling Gait adducted thumbs (MASA)",
                    "description": ""
                },
                {
                    "id": "MONDO:0010559",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010559",
                    "name": "intellectual disability, aphasia, shuffling Gait, and adducted thumbs",
                    "description": ""
                },
                {
                    "id": "MONDO:0010559",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010559",
                    "name": "mental retardation aphasia shuffling Gait adducted thumbs (MASA)",
                    "description": ""
                },
                {
                    "id": "MONDO:0010559",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010559",
                    "name": "mental retardation, aphasia, shuffling Gait, and adducted thumbs",
                    "description": ""
                },
                {
                    "id": "MONDO:0010559",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010559",
                    "name": "spastic paraplegia 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010559",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010559",
                    "name": "spastic paraplegia 1, X-linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0010559",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010559",
                    "name": "thumb congenital clasped with intellectual disability",
                    "description": ""
                },
                {
                    "id": "MONDO:0010559",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010559",
                    "name": "thumb congenital clasped with mental retardation",
                    "description": ""
                },
                {
                    "id": "MONDO:0010559",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010559",
                    "name": "thumb, congenital Clasped, with intellectual disability",
                    "description": ""
                },
                {
                    "id": "MONDO:0010559",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010559",
                    "name": "thumb, congenital Clasped, with mental retardation",
                    "description": ""
                },
                {
                    "id": "MIM:303350",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/303350",
                    "name": "MASA syndrome",
                    "description": "MASA syndrome"
                }
            ],
            "evidence": [
                {
                    "id": "2476",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:2476"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q5XIC4",
                    "url": "https://www.uniprot.org/uniprot/Q5XIC4"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Spg21",
            "url": "https://www.uniprot.org/uniprot/Q5XIC4",
            "locus": {
                "chromosome": "8",
                "start_pos": 66008536,
                "end_pos": 65980962,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000015019",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000015019"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000015019",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000015019",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "300791",
            "url": "https://www.ncbi.nlm.nih.gov/gene/300791",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR000073",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000073",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR026151",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR026151",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR029058",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:300791",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:300791",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "MELDKVH",
            "url": "https://omabrowser.org/oma/group/MELDKVH/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "276364at2759",
            "url": "http://www.orthodb.org/?query=276364at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR15913",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15913",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR15913:SF0",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15913:SF0",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00561",
            "url": "http://pfam.xfam.org/family/PF00561",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q5XIC4",
            "url": "http://purl.obolibrary.org/obo/PR_Q5XIC4",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_001006988",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006988",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1359141",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1359141",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A0G2JW14",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JW14",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0G2JW14-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JW14-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6AIT6",
            "url": "https://www.uniprot.org/uniprot/A0A8I6AIT6",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6AIT6-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6AIT6-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6GKW0",
            "url": "https://www.uniprot.org/uniprot/A0A8I6GKW0",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6GKW0-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6GKW0-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q5XIC4",
            "url": "https://www.uniprot.org/uniprot/Q5XIC4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q5XIC4-1",
            "url": "https://www.uniprot.org/uniprot/Q5XIC4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MGEIKVSPDYNWFRSTVPLKKIIVDDDDSKIWSLYDAGPRSIRCPLIFLPPVSGTADVFFQQILALTGWGYRVIALQYPVYWDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNAFSDTSIFNQTWTANSFWLMPAFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDIHLLQFHGTKYAAIDPSVVSAEELDVQKGQLDLSQEEP",
        "length": 261,
        "header": "sp|Q5XIC4-1|SPG21_RAT Isoform 1 of Maspardin  OS=Rattus norvegicus OX=10116 GN=Spg21 PE=2 SV=1 CANONICAL=Q5XIC4-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0G2JW14-1",
            "url": "",
            "sequence": {
                "sequence": "MGEIKVSPDYNWFRSTVPLKKIIVDDDDSKIWSLYDAGPRSIRCPLIFLPPVSGTADVFFQQILALTGWGYRVIAVHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNAFSDTSIFNQTWTANSFWLMPAFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDVFDQSALSMEAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVNLYVQIHLLQFHGTKYAAIDPSVVSAEELDVQKGQLDLSQEEP",
                "length": 281,
                "header": "tr|A0A0G2JW14-1|A0A0G2JW14_RAT Computationally mapped isoform of SPG21 abhydrolase domain containing, maspardin  OS=Rattus norvegicus OX=10116 GN=Spg21 PE=1 SV=2 CANONICAL=Q5XIC4-1"
            },
            "locus": {
                "chromosome": "8",
                "start_pos": 66008030,
                "end_pos": 65985114,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000077163.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000077163.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000069701.2",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000069701.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I6AIT6-1",
            "url": "",
            "sequence": {
                "sequence": "RSSDESGWHSEDPEEVEYLWLFTIIVDDDDSKIWSLYDAGPRSIRCPLIFLPPVSGTADVFFQQILALTGWGYRVIALQYPVYWDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNAFSDTSIFNQTWTANSFWLMPAFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDVFDQSALSMEAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVNLYVQIHLLQFHGTKYAAIDPSVVSAEELDVQKGQLDLSQEEP",
                "length": 310,
                "header": "tr|A0A8I6AIT6-1|SPG21_RAT Computationally mapped isoform of Maspardin  OS=Rattus norvegicus OX=10116 GN=Spg21 PE=2 SV=1 CANONICAL=Q5XIC4-1"
            },
            "locus": {
                "chromosome": "8",
                "start_pos": 66008030,
                "end_pos": 65986662,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000119542.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000119542.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000092880.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000092880.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I6GKW0-1",
            "url": "",
            "sequence": {
                "sequence": "MGEIKVSPDYNWFRSTVPLKKIIVDDDDSKIWSLYDAGPRSIRCPLIFLPPVSGTADVFFQQILALTGWGYRVIALQYPVYWDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNAFSDTSIFNQTWTANSFWLMPAFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDVFDQSALSMEAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVNLYVQIHLLQFHGTKYAAIDPSVVSAEELDVQKGQLDLSQEEP",
                "length": 308,
                "header": "tr|A0A8I6GKW0-1|A0A8I6GKW0_RAT Computationally mapped isoform of Maspardin  OS=Rattus norvegicus OX=10116 GN=Spg21 PE=1 SV=1 CANONICAL=Q5XIC4-1"
            },
            "locus": {
                "chromosome": "8",
                "start_pos": 66008030,
                "end_pos": 65985114,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000110650.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000110650.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000093920.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000093920.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q5XIC4-1",
            "url": "",
            "sequence": {
                "sequence": "MGEIKVSPDYNWFRSTVPLKKIIVDDDDSKIWSLYDAGPRSIRCPLIFLPPVSGTADVFFQQILALTGWGYRVIALQYPVYWDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNAFSDTSIFNQTWTANSFWLMPAFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDIHLLQFHGTKYAAIDPSVVSAEELDVQKGQLDLSQEEP",
                "length": 261,
                "header": "sp|Q5XIC4-1|SPG21_RAT Isoform 1 of Maspardin  OS=Rattus norvegicus OX=10116 GN=Spg21 PE=2 SV=1 CANONICAL=Q5XIC4-1"
            },
            "locus": {
                "chromosome": "8",
                "start_pos": 66008030,
                "end_pos": 65985114,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000051504",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000051504"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000039361",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000039361"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 257,
            "end_pos": 257,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q5XIC4",
                    "url": "https://www.uniprot.org/uniprot/Q5XIC4"
                }
            ],
            "site_lbl": "Ser257"
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "rno:300791",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:300791",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q9CQC8-1",
            "protein_name": "Maspardin",
            "gene_name": "Spg21",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MGEIKVSPDYNWFRSTVPLKKIIVDDDDSKIWSLYDAGPRSIRCPLIFLPPVSGTADVFFQQILALTGWGYRVIALQYPVYWDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNAFSDTSIFNQTWTANSFWLMPAFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDVFDQSALSTEAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVNLYVQIHLLQFHGTKYAAIDPSVVSAEELEVQKGRLGLSQEEP",
                "length": 308
            },
            "evidence": [
                {
                    "id": "45226648",
                    "url": "http://www.informatics.jax.org/homology/45226648",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
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                                "database": "UniProtKB",
                                "id": "Q5XIC4",
                                "url": "https://www.uniprot.org/uniprot/Q5XIC4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "trans-Golgi network transport vesicle",
                        "id": "GO:0030140",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030140",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIC4",
                                "url": "https://www.uniprot.org/uniprot/Q5XIC4"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "CD4 receptor binding",
                        "id": "GO:0042609",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042609",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5XIC4",
                                "url": "https://www.uniprot.org/uniprot/Q5XIC4"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 144,
            "end_pos": 146,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 167,
            "end_pos": 169,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ],
    "section_stats": [
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                    "field": "n_linked_glycan_sites",
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                    "field": "o_linked_glycans",
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                    "field": "o_linked_glycan_sites",
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}