{ "uniprot_canonical_ac": "Q5U300-1", "uniprot_ac": "Q5U300", "uniprot_id": "UBA1_RAT", "mass": { "chemical_mass": 117788.0, "monoisotopic_mass": 117788.0 }, "refseq": { "ac": "NP_001014102", "name": "ubiquitin-like modifier-activating enzyme 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014102" }, "gene_names": [ { "name": "Uba1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q5U300", "id": "Q5U300" }, { "name": "Uba1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014102", "id": "NP_001014102" }, { "name": "Ube1x", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014102", "id": "NP_001014102" }, { "name": "Ube1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q5U300", "id": "Q5U300" } ], "protein_names": [ { "name": "Ubiquitin-like modifier-activating enzyme 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q5U300" }, { "name": "6.2.1.45", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q5U300" }, { "name": "Ubiquitin-activating enzyme E1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q5U300" }, { "name": "ubiquitin-activating enzyme E1, Chr X", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014102", "id": "NP_001014102" }, { "name": "ubiquitin-like modifier-activating enzyme 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014102", "id": "NP_001014102" } ], "function": [ { "annotation": "Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites.", "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300#function" }, { "database": "UniProtKB", "id": "P22314", "url": "https://www.uniprot.org/uniprot/P22314#function" } ] }, { "annotation": "E1 ligase of the proteasome is inhibitd by ziram and has a role in preventing dopaminergic cell damage", "evidence": [ { "database": "RefSeq", "id": "NP_001014102", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014102" }, { "database": "PubMed", "id": "18818210", "url": "https://glygen.org/publication/PubMed/18818210" } ] }, { "annotation": "UBA1 inhibition effectively suppresses neointimal thickening through its anti-proliferative and anti-inflammatory effects in carotid artery injury.", "evidence": [ { "database": "RefSeq", "id": "NP_001014102", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014102" }, { "database": "PubMed", "id": "26919560", "url": "https://glygen.org/publication/PubMed/26919560" } ] } ], "disease": [ { "disease_id": "DOID:0080828", "recommended_name": { "id": "DOID:0080828", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080828", "name": "VEXAS syndrome", "description": "A syndrome that is characterized by blood clots in veins, recurrent fevers, pulmonary abnormalities and vacuoles in myeloid cells and that has_material_basis_in mutation in the UBA1 gene on chromosome Xp11." }, "synonyms": [ { "id": "DOID:0080828", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080828", "name": "vacuoles, E1 enzyme, X-linked, autoinflammatory and somatic syndrome", "description": "" }, { "id": "MONDO:0026777", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0026777", "name": "VEXAS syndrome", "description": "An adult-onset inflammatory disease that affects only males and is caused by somatic, not germline, mutations. The disorder is characterized by adult onset of rheumatologic symptoms at a mean age of 64 years. Features include recurrent fevers, pulmonary and dermatologic inflammatory manifestations, vasculitis, deep vein thrombosis, arthralgias, and ear and nose chondritis. Laboratory studies indicate hematologic abnormalities, including macrocytic anemia, as well as increased levels of acute-phase reactants; about half of patients have positive autoantibodies. Bone marrow biopsy shows degenerative vacuolization restricted to myeloid and erythroid precursor cells, as well as variable hematopoietic dyspoiesis and dysplasias. The condition does not respond to rheumatologic medications and the features may result in premature death." }, { "id": "MONDO:0026777", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0026777", "name": "VEXAS", "description": "" }, { "id": "MONDO:0026777", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0026777", "name": "VEXAS syndrome, somatic", "description": "" }, { "id": "MONDO:0026777", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0026777", "name": "vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic syndrome", "description": "" }, { "id": "MIM:301054", "resource": "MIM", "url": "https://www.omim.org/entry/301054", "name": "VEXAS syndrome", "description": "VEXAS syndrome" } ], "evidence": [ { "id": "0080828", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0080828" } ] }, { "disease_id": "DOID:0111827", "recommended_name": { "id": "DOID:0111827", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111827", "name": "X-linked spinal muscular atrophy 2", "description": "A spinal muscular atrophy characterized by neonatal onset of severe hypotonia, areflexia, and multiple congenital contractures associated with loss of anterior horn cells and infantile death that has_material_basis_in hemizygous mutation in the UBA1 gene on chromosome Xp11.3." }, "synonyms": [ { "id": "DOID:0111827", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111827", "name": "X-linked distal arthrogryposis multiplex congenita", "description": "" }, { "id": "DOID:0111827", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111827", "name": "SMAX2", "description": "" }, { "id": "DOID:0111827", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111827", "name": "X-linked spinal muscular atrophy type 2", "description": "" }, { "id": "DOID:0111827", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111827", "name": "infantile-onset X-linked spinal muscular atrophy", "description": "" }, { "id": "DOID:0111827", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111827", "name": "spinal muscular atrophy with arthrogryposis", "description": "" }, { "id": "MONDO:0010532", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010532", "name": "infantile-onset X-linked spinal muscular atrophy", "description": "A rare form of spinal muscular atrophy characterized by the neonatal onset of severe hypotonia, areflexia, profound weakness, multiple congenital contractures, facial dysmorphic features (myopathic face with open, tent-shaped mouth), cryptorchidism, and mild skeletal abnormalities (i.e. kyphosis, scoliosis), that is often preceded by polyhydramnios and reduced fetal movements in utero and followed by bone fractures shortly after birth. SMAX2 patients often have a limited life span, often succumbing to the disease within 2 years, as muscle weakness is progressive and chest muscle involvement eventually leads to ventilatory insufficiency and respiratory failure." }, { "id": "MONDO:0010532", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010532", "name": "SMAX2", "description": "" }, { "id": "MONDO:0010532", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010532", "name": "X-linked distal arthrogryposis multiplex congenita", "description": "" }, { "id": "MONDO:0010532", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010532", "name": "X-linked spinal muscular atrophy type 2", "description": "" }, { "id": "MONDO:0010532", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010532", "name": "spinal muscular atrophy with arthrogryposis", "description": "" }, { "id": "MONDO:0010532", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010532", "name": "spinal muscular atrophy, X-linked 2, infantile, X-linked recessive", "description": "" }, { "id": "MONDO:0010532", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010532", "name": "spinal muscular atrophy, X-linked type 2", "description": "" }, { "id": "MONDO:0010532", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010532", "name": "AMC, distal, X-linked", "description": "" }, { "id": "MONDO:0010532", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010532", "name": "arthrogryposis multiplex congenita, distal, X-linked", "description": "" }, { "id": "MONDO:0010532", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010532", "name": "arthrogryposis, X-linked, type 1", "description": "" }, { "id": "MONDO:0010532", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010532", "name": "spinal muscular atrophy, X-linked 2", "description": "" }, { "id": "MONDO:0010532", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010532", "name": "spinal muscular atrophy, X-linked lethal infantile", "description": "" }, { "id": "MONDO:0010532", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010532", "name": "spinal muscular atrophy, infantile X-linked", "description": "" }, { "id": "MIM:301830", "resource": "MIM", "url": "https://www.omim.org/entry/301830", "name": "Spinal muscular atrophy X-linked 2", "description": "Spinal muscular atrophy X-linked 2" } ], "evidence": [ { "id": "0111827", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0111827" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300" } ], "common_name": "Rat" } ], "gene": [ { "name": "Uba1", "url": "https://www.uniprot.org/uniprot/Q5U300", "locus": { "chromosome": "X", "start_pos": 1508666, "end_pos": 1530636, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000019164", "url": "https://www.ensembl.org/id/ENSRNOG00000019164" } ] } } ], "crossref": [ { "id": "ENSRNOG00000019164", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000019164", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01490", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01490", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd01491", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01491", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "314432", "url": "https://www.ncbi.nlm.nih.gov/gene/314432", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000594", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000594", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018074", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018074", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018075", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018075", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019572", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019572", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032418", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032418", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032420", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032420", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033127", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033127", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035985", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035985", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038252", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038252", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042302", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042302", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042449", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042449", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045886", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045886", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:314432", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:314432", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5U300", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q5U300", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "GANLHAF", "url": "https://omabrowser.org/oma/group/GANLHAF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "20494at2759", "url": "http://www.orthodb.org/?query=20494at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10953", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10953", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10953:SF162", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10953:SF162", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00899", "url": "http://pfam.xfam.org/family/PF00899", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF09358", "url": "http://pfam.xfam.org/family/PF09358", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF10585", "url": "http://pfam.xfam.org/family/PF10585", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16190", "url": "http://pfam.xfam.org/family/PF16190", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16191", "url": "http://pfam.xfam.org/family/PF16191", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q5U300", "url": "http://purl.obolibrary.org/obo/PR_Q5U300", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-8866652", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8866652", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001014102", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014102", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1359327", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1359327", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A8I5ZY80", "url": "https://www.uniprot.org/uniprot/A0A8I5ZY80", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZY80-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZY80-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8L2QII5", "url": "https://www.uniprot.org/uniprot/A0A8L2QII5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8L2QII5-1", "url": "https://www.uniprot.org/uniprot/A0A8L2QII5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5U300-1", "url": "https://www.uniprot.org/uniprot/Q5U300-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSSPLSKKRRVSGPDPKPGSNCSSAQSVLSEVSSVPTNGMAKNGSEADIDESLYSRQLYVLGHEAMKMLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTTQWADLSSQFYLREEDIGKNRAEVSQPRLAELNSYVPVTAYTGPLVEDFLSGFQVVVLTNSPLEEQLRVGEFCHSRGIKLVVADTRGLFGQLFCDFGEEMVLTDSNGEQPLSAMVSMVTKDNPGVVTCLDEARHGFETGDFVSFSEVQGMVQLNGCQPIEIKVLGPYTFSICDTSNFSDYIRGGIVSQVKVPKKISFKSLPASLAEPDFVMTDFAKYSRPAQLHIGFQALHQFCAQHNRPPRPRNEEDATELVTLAQAVNARSPPAVQQDNVDEDLIRKLAYVAAGDLAPINAFIGGLAAQEVMKACSGKFMPIMQWLYFDALECLPEDKEALTEDKCLPRQNRYDGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEVVVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMNPYIQVTSHQNRVGPDTERIYDDDFFQNLDGVANALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDEFEGLFKQPAENVNQYLTDSKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQTWGDCVTWACHHWHTQYCNNIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLTFDVNNTLHLDYVMAAANLFAQTYGLTGSQDRAAVASLLQSVQVPEFTPKSGVKIHVSDQELQSANASVDDSRLEELKATLPSPDKLPGFKMYPIDFEKDDDSNFHMDFIVAASNLRAENYDISPADRHKSKLIAGKIIPAIATTTAAVVGLVCLELYKVVQGHQQLDSYKNGFLNLALPFFGFSEPLAAPRHQYYNQEWTLWDRFEVQGLQPNGEEMTLKQFLDYFKTEHKLEITMLSQGVSMLYSFFMPAAKLKERLDQPMTEIVSRVSKRKLGRHVRALVLELCCNDESGEDVEVPYVRYTIR", "length": 1058, "header": "sp|Q5U300-1|UBA1_RAT Isoform 1 of Ubiquitin-like modifier-activating enzyme 1 OS=Rattus norvegicus OX=10116 GN=Uba1 PE=1 SV=1 CANONICAL=Q5U300-1" }, "isoforms": [ { "isoform_ac": "A0A8I5ZY80-1", "url": "", "sequence": { "sequence": "MAKNGSEADIDESLYSRQLYVLGHEAMKMLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTTQWADLSSQFYLREEDIGKNRAEVSQPRLAELNSYVPVTAYTGPLVEDFLSGFQVVVLTNSPLEEQLRVGEFCHSRGIKLVVADTRGLFGQLFCDFGEEMVLTDSNGEQPLSAMVSMVTKDNPGVVTCLDEARHGFETGDFVSFSEVQGMVQLNGCQPIEIKVLGPYTFSICDTSNFSDYIRGGIVSQVKVPKKISFKSLPASLAEPDFVMTDFAKYSRPAQLHIGFQALHQFCAQHNRPPRPRNEEDATELVTLAQAVNARSPPAVQQDNVDEDLIRKLAYVAAGDLAPINAFIGGLAAQEVMKACSGKFMPIMQWLYFDALECLPEDKEALTEDKCLPRQNRYDGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEVVVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMNPYIQVTSHQNRVGPDTERIYDDDFFQNLDGVANALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDEFEGLFKQPAENVNQYLTDSKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQTWGDCVTWACHHWHTQYCNNIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLTFDVNNTLHLDYVMAAANLFAQTYGLTGSQDRAAVASLLQSVQVPEFTPKSGVKIHVSDQELQSANASVDDSRLEELKATLPSPDKLPGFKMYPIDFEKDDDSNFHMDFIVAASNLRAENYDISPADRHKSKLIAGKIIPAIATTTAAVVGLVCLELYKVVQGHQQLDSYKNGFLNLALPFFGFSEPLAAPRHQYYNQEWTLWDRFEVQGLQPNGEEMTLKQFLDYFKTEHKLEITMLSQGVSMLYSFFMPAAKLKERLDQPMTEIVSRVSKRKLGRHVRALVLELCCNDESGEDVEVPYVRYTIR", "length": 1018, "header": "tr|A0A8I5ZY80-1|UBA1_RAT Computationally mapped isoform of Ubiquitin-like modifier-activating enzyme 1 OS=Rattus norvegicus OX=10116 GN=Uba1 PE=1 SV=1 CANONICAL=Q5U300-1" }, "locus": { "chromosome": "X", "start_pos": 1522375, "end_pos": 1508899, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000085338.3", "url": "https://www.ensembl.org/id/ENSRNOT00000085338.3" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000084488.1", "url": "https://www.ensembl.org/id/ENSRNOP00000084488.1" } ] } }, { "isoform_ac": "A0A8L2QII5-1", "url": "", "sequence": { "sequence": "MSSSPLSKKRRVSGPDPKPGSNCSSAQSVLSEVSSVPTNVSIFSLYVLGHEAMKMLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTTQWADLSSQFYLREEDIGKNRAEVSQPRLAELNSYVPVTAYTGPLVEDFLSGFQVVVLTNSPLEEQLRVGEFCHSRGIKLVVADTRGLFGQLFCDFGEEMVLTDSNGEQPLSAMVSMVTKDNPGVVTCLDEARHGFETGDFVSFSEVQGMVQLNGCQPIEIKVLGPYTFSICDTSNFSDYIRGGIVSQVKVPKKISFKSLPASLAEPDFVMTDFAKYSRPAQLHIGFQALHQFCAQHNRPPRPRNEEDATELVTLAQAVNARSPPAVQQDNVDEDLIRKLAYVAAGDLAPINAFIGGLAAQEVMKACSGKFMPIMQWLYFDALECLPEDKEALTEDKCLPRQNRYDGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEVVVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMNPYIQVTSHQNRVGPDTERIYDDDFFQNLDGVANALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDEFEGLFKQPAENVNQYLTDSKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQTWGDCVTWACHHWHTQYCNNIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLTFDVNNTLHLDYVMAAANLFAQTYGLTGSQDRAAVASLLQSVQVPEFTPKSGVKIHVSDQELQSANASVDDSRLEELKATLPSPDKLPGFKMYPIDFEKDDDSNFHMDFIVAASNLRAENYDISPADRHKSKLIAGKIIPAIATTTAAVVGLVCLELYKVVQGHQQLDSYKNGFLNLALPFFGFSEPLAAPRHQYYNQEWTLWDRFEVQGLQPNGEEMTLKQFLDYFKTEHKLEITMLSQGVSMLYSFFMPAAKLKERLDQPMTEIVSRVSKRKLGRHVRALVLELCCNDESGEDVEVPYVRYTIR", "length": 1044, "header": "tr|A0A8L2QII5-1|A0A8L2QII5_RAT Computationally mapped isoform of E1 ubiquitin-activating enzyme OS=Rattus norvegicus OX=10116 GN=Uba1 PE=1 SV=1 CANONICAL=Q5U300-1" }, "locus": { "chromosome": "X", "start_pos": 1522637, "end_pos": 1508899, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000031115.5", "url": "https://www.ensembl.org/id/ENSRNOT00000031115.5" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000033950.3", "url": "https://www.ensembl.org/id/ENSRNOP00000033950.3" } ] } }, { "isoform_ac": "Q5U300-1", "url": "", "sequence": { "sequence": "MSSSPLSKKRRVSGPDPKPGSNCSSAQSVLSEVSSVPTNGMAKNGSEADIDESLYSRQLYVLGHEAMKMLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTTQWADLSSQFYLREEDIGKNRAEVSQPRLAELNSYVPVTAYTGPLVEDFLSGFQVVVLTNSPLEEQLRVGEFCHSRGIKLVVADTRGLFGQLFCDFGEEMVLTDSNGEQPLSAMVSMVTKDNPGVVTCLDEARHGFETGDFVSFSEVQGMVQLNGCQPIEIKVLGPYTFSICDTSNFSDYIRGGIVSQVKVPKKISFKSLPASLAEPDFVMTDFAKYSRPAQLHIGFQALHQFCAQHNRPPRPRNEEDATELVTLAQAVNARSPPAVQQDNVDEDLIRKLAYVAAGDLAPINAFIGGLAAQEVMKACSGKFMPIMQWLYFDALECLPEDKEALTEDKCLPRQNRYDGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEVVVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMNPYIQVTSHQNRVGPDTERIYDDDFFQNLDGVANALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDEFEGLFKQPAENVNQYLTDSKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQTWGDCVTWACHHWHTQYCNNIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLTFDVNNTLHLDYVMAAANLFAQTYGLTGSQDRAAVASLLQSVQVPEFTPKSGVKIHVSDQELQSANASVDDSRLEELKATLPSPDKLPGFKMYPIDFEKDDDSNFHMDFIVAASNLRAENYDISPADRHKSKLIAGKIIPAIATTTAAVVGLVCLELYKVVQGHQQLDSYKNGFLNLALPFFGFSEPLAAPRHQYYNQEWTLWDRFEVQGLQPNGEEMTLKQFLDYFKTEHKLEITMLSQGVSMLYSFFMPAAKLKERLDQPMTEIVSRVSKRKLGRHVRALVLELCCNDESGEDVEVPYVRYTIR", "length": 1058, "header": "sp|Q5U300-1|UBA1_RAT Isoform 1 of Ubiquitin-like modifier-activating enzyme 1 OS=Rattus norvegicus OX=10116 GN=Uba1 PE=1 SV=1 CANONICAL=Q5U300-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "Q5U300", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q5U300" }, { "id": "34502162", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34502162" } ] } ], "phosphorylation": [ { "start_pos": 13, "end_pos": 13, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300" } ], "site_lbl": "Ser13" }, { "start_pos": 21, "end_pos": 21, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300" } ], "site_lbl": "Ser21" }, { "start_pos": 24, "end_pos": 24, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300" } ], "site_lbl": "Ser24" }, { "start_pos": 46, "end_pos": 46, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "Q5U300", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5U300" } ], "site_lbl": "Ser46" }, { "start_pos": 4, "end_pos": 4, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300" } ], "site_lbl": "Ser4" }, { "start_pos": 55, "end_pos": 55, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300" } ], "site_lbl": "Tyr55" }, { "start_pos": 800, "end_pos": 800, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300" } ], "site_lbl": "Thr800" }, { "start_pos": 810, "end_pos": 810, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300" } ], "site_lbl": "Ser810" }, { "start_pos": 816, "end_pos": 816, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300" } ], "site_lbl": "Ser816" }, { "start_pos": 820, "end_pos": 820, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300" } ], "site_lbl": "Ser820" }, { "start_pos": 835, "end_pos": 835, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "Q5U300", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5U300" } ], "site_lbl": "Ser835" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Ziram causes dopaminergic cell damage by inhibiting E1 ligase of the proteasome.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Chou AP, Maidment N, Klintenberg R, Casida JE, Li S, Fitzmaurice AG, Fernagut PO, Mortazavi F, Chesselet MF, Bronstein JM", "evidence": [ { "database": "RefSeq", "id": "NP_001014102", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014102" } ], "reference": [ { "type": "PubMed", "id": "18818210", "url": "https://glygen.org/publication/PubMed/18818210" } ] }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nature communications", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300" }, { "database": "iPTMnet", "id": "Q5U300", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5U300" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] }, { "title": "The ubiquitin-activating enzyme E1 as a novel therapeutic target for the treatment of restenosis.", "journal": "Atherosclerosis", "date": "2016", "authors": "Qin Z, Cui B, Jin J, Song M, Zhou B, Guo H, Qian D, He Y, Huang L", "evidence": [ { "database": "RefSeq", "id": "NP_001014102", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014102" } ], "reference": [ { "type": "PubMed", "id": "26919560", "url": "https://glygen.org/publication/PubMed/26919560" } ] }, { "title": "An O-GlcNAcylomic Approach Reveals ACLY as a Potential Target in Sepsis in the Young Rat.", "journal": "International journal of molecular sciences", "date": "2021", "authors": "Denis M, Dupas T, Persello A, Dontaine J, Bultot L, Betus C, Pele T, Dhot J, Erraud A, Maillard A, Montnach J, Leroux AA, Bigot-Corbel E, Vertommen D, Riviere M, Lebreton J, Tessier A, Waard M, Bertrand L, Rozec B, Lauzier B", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q5U300", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q5U300" } ], "reference": [ { "type": "PubMed", "id": "34502162", "url": "https://glygen.org/publication/PubMed/34502162" } ] } ], "pathway": [ { "id": "rno:314432", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:314432", "resource": "KEGG Pathway" }, { "id": "R-RNO-8866652", "name": "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8866652", "resource": "Reactome", "description": "Synthesis of active ubiquitin: roles of E1 and E2 enzymes" }, { "id": "R-RNO-983168", "name": "Antigen processing: Ubiquitination & Proteasome degradation", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "P22314-1", "protein_name": "Ubiquitin-like modifier-activating enzyme 1", "gene_name": "UBA1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSSPLSKKRRVSGPDPKPGSNCSPAQSVLSEVPSVPTNGMAKNGSEADIDEGLYSRQLYVLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTAQWADLSSQFYLREEDIGKNRAEVSQPRLAELNSYVPVTAYTGPLVEDFLSGFQVVVLTNTPLEDQLRVGEFCHNRGIKLVVADTRGLFGQLFCDFGEEMILTDSNGEQPLSAMVSMVTKDNPGVVTCLDEARHGFESGDFVSFSEVQGMVELNGNQPMEIKVLGPYTFSICDTSNFSDYIRGGIVSQVKVPKKISFKSLVASLAEPDFVVTDFAKFSRPAQLHIGFQALHQFCAQHGRPPRPRNEEDAAELVALAQAVNARALPAVQQNNLDEDLIRKLAYVAAGDLAPINAFIGGLAAQEVMKACSGKFMPIMQWLYFDALECLPEDKEVLTEDKCLQRQNRYDGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEIIVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMNPHIRVTSHQNRVGPDTERIYDDDFFQNLDGVANALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDEFEGLFKQPAENVNQYLTDPKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQTWADCVTWACHHWHTQYSNNIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLTFDVNNPLHLDYVMAAANLFAQTYGLTGSQDRAAVATFLQSVQVPEFTPKSGVKIHVSDQELQSANASVDDSRLEELKATLPSPDKLPGFKMYPIDFEKDDDSNFHMDFIVAASNLRAENYDIPSADRHKSKLIAGKIIPAIATTTAAVVGLVCLELYKVVQGHRQLDSYKNGFLNLALPFFGFSEPLAAPRHQYYNQEWTLWDRFEVQGLQPNGEEMTLKQFLDYFKTEHKLEITMLSQGVSMLYSFFMPAAKLKERLDQPMTEIVSRVSKRKLGRHVRALVLELCCNDESGEDVEVPYVRYTIR", "length": 1058 }, "evidence": [ { "id": "45228598", "url": "http://www.informatics.jax.org/homology/45228598", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q02053-1", "protein_name": "Ubiquitin-like modifier-activating enzyme 1", "gene_name": "Uba1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSSPLSKKRRVSGPDPKPGSNCSPAQSALSEVSSVPTNGMAKNGSEADIDESLYSRQLYVLGHEAMKMLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTTQWADLSSQFYLREEDIGKNRAEVSQPRLAELNSYVPVTAYTGPLVEDFLSSFQVVVLTNSPLEAQLRVGEFCHSRGIKLVVADTRGLFGQLFCDFGEEMVLTDSNGEQPLSAMVSMVTKDNPGVVTCLDEARHGFETGDFVSFSEVQGMIQLNGCQPMEIKVLGPYTFSICDTSNFSDYIRGGIVSQVKVPKKISFKSLPASLVEPDFVMTDFAKYSRPAQLHIGFQALHQFCALHNQPPRPRNEEDATELVGLAQAVNARSPPSVKQNSLDEDLIRKLAYVAAGDLAPINAFIGGLAAQEVMKACSGKFMPIMQWLYFDALECLPEDKEALTEEKCLPRQNRYDGQVAVFGSDFQEKLSKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEVVVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMNPYIQVTSHQNRVGPDTERIYDDDFFQNLDGVANALDNIDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDEFEGLFKQPAENVNQYLTDSKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQTWGDCVTWACHHWHTQYCNNIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLTFDVNNTLHLDYVMAAANLFAQTYGLTGSQDRAAVASLLQSVQVPEFTPKSGVKIHVSDQELQSANASVDDSRLEELKATLPSPDKLPGFKMYPIDFEKDDDSNFHMDFIVAASNLRAENYDISPADRHKSKLIAGKIIPAIATTTAAVVGLVCLELYKVVQGHQQLDSYKNGFLNLALPFFGFSEPLAAPRHQYYNQEWTLWDRFEVQGLQPNGEEMTLKQFLDYFKTEHKLEITMLSQGVSMLYSFFMPAAKLKERLDQPMTEIVSRVSKRKLGRHVRALVLELCCNDESGEDVEVPYVRYTIR", "length": 1058 }, "evidence": [ { "id": "45228598", "url": "http://www.informatics.jax.org/homology/45228598", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300" } ], "pmid": "" }, { "name": "ubiquitin-like modifier activating enzyme activity", "id": "GO:0008641", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008641", "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300" } ], "pmid": "" }, { "name": "ubiquitin activating enzyme activity", "id": "GO:0004839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004839", "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300" } ], "pmid": "" }, { "name": "DNA damage response", "id": "GO:0006974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 10, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300" } ], "pmid": "" }, { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300" } ], "pmid": "" }, { "name": "heterochromatin", "id": "GO:0000792", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000792", "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300" } ], "pmid": "" }, { "name": "desmosome", "id": "GO:0030057", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030057", "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300" } ], "pmid": "" }, { "name": "rough endoplasmic reticulum membrane", "id": "GO:0030867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030867", "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 22, "end_pos": 24, "annotation": "n_glycosylation_sequon" }, { "start_pos": 282, "end_pos": 284, "annotation": "n_glycosylation_sequon" }, { "start_pos": 44, "end_pos": 46, "annotation": "n_glycosylation_sequon" }, { "start_pos": 757, "end_pos": 759, "annotation": "n_glycosylation_sequon" }, { "start_pos": 818, "end_pos": 820, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "ISGylated.", "evidence": [ { "database": "UniProtKB", "id": "Q5U300", "url": "https://www.uniprot.org/uniprot/Q5U300" }, { "database": "PubMed", "id": "P22314", "url": "https://glygen.org/publication/PubMed/P22314" } ] } ], "interactions": [], "reactions": [ { "id": "R-RNO-8852128", "name": "UBA1 adenylates ubiquitin in the nucleoplasm", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-RNO-8852116" ], "output_participant_list": [], "enzyme_list": [ "Q5U300-1" ], "evidence": [ { "id": "R-RNO-8852128", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8852128" } ] }, { "id": "R-RNO-8852129", "name": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "B5DFI8-1", "P62839-1", "D3ZDK2-1", "P62255-1", "Q5U300-1" ], "evidence": [ { "id": "R-RNO-8852129", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8852129" } ] }, { "id": "R-RNO-8852130", "name": "UBA1 conjugates ubiquitin to nuclear E2 enzymes", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P63149-1", "B5DFI8-1", "P62839-1", "Q5U300-1" ], "evidence": [ { "id": "R-RNO-8852130", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8852130" } ] }, { "id": "R-RNO-8852131", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5U300-1" ], "evidence": [ { "id": "R-RNO-8852131", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8852131" } ] }, { "id": "R-RNO-8852132", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5U300-1" ], "evidence": [ { "id": "R-RNO-8852132", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8852132" } ] }, { "id": "R-RNO-8852133", "name": "UBA1 conjugates ubiquitin to UBA1 in the cytosol", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5U300-1" ], "evidence": [ { "id": "R-RNO-8852133", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8852133" } ] }, { "id": "R-RNO-8852134", "name": "UBA1 adenylates ubiquitin in the cytosol", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-RNO-947698" ], "output_participant_list": [], "enzyme_list": [ "Q5U300-1" ], "evidence": [ { "id": "R-RNO-8852134", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8852134" } ] }, { "id": "R-RNO-8852136", "name": "UBA1 conjugates ubiquitin to UBA1 in the nucleus", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5U300-1" ], "evidence": [ { "id": "R-RNO-8852136", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8852136" } ] }, { "id": "R-RNO-983152", "name": "Transfer of ubiquitin from E1 to E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P63149-1", "P61078-1", "B5DFI8-1", "P62839-1", "Q4V8J2-1", "Q99MI7-1", "D3ZDK2-1", "P62255-1", "Q3B7D1-1", "Q5U203-1", "Q5U300-1", "Q9EQX9-1", "D4A8H3-1", "A0A0G2K735-1" ], "evidence": [ { "id": "R-RNO-983152", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983152" } ] }, { "id": "R-RNO-983153", "name": "E1 mediated ubiquitin activation", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q99MI7-1", "Q5U300-1", "D4A8H3-1", "A0A0G2K735-1" ], "evidence": [ { "id": "R-RNO-983153", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983153" } ] } ], "reaction_participants": [ { "participant_id": "R-RNO-8852116", "participant_name": "UBA1 [nucleoplasm]", "crossref": [ { "id": "1359327", "database": "RGD", "url": "" }, { "id": "XP_006256675.2", "database": "RefSeq", "url": "" }, { "id": "Q5U300", "database": "UniProt", "url": "" }, { "id": "XP_006256674.1", "database": "RefSeq", "url": "" }, { "id": "Q5U300", "database": "PRO", "url": "" }, { "id": "NP_001014102.1", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-RNO-947698", "participant_name": "UBA1 [cytosol]", "crossref": [ { "id": "NP_001014102.1", "database": "RefSeq", "url": "" }, { "id": "XP_006256674.1", "database": "RefSeq", "url": "" }, { "id": "Q5U300", "database": "PRO", "url": "" }, { "id": "1359327", "database": "RGD", "url": "" }, { "id": "Q5U300", "database": "UniProt", "url": "" }, { "id": "XP_006256675.2", "database": "RefSeq", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2K735", "gene_name": "Uba7", "activity": [ { "ec_number": "6.2.1.45", "activity": "ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A0G2K735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K735" } ] }, { "ec_number": "6.2.1.45", "activity": "", "evidence": [ { "id": "A0A0G2K735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K735" } ] } ] }, { "uniprot_ac": "B5DFI8", "gene_name": "Ube2s", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "B5DFI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B5DFI8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "B5DFI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B5DFI8" } ] } ] }, { "uniprot_ac": "D3ZDK2", "gene_name": "Ube2d1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3ZDK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDK2" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "D3ZDK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDK2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "D3ZDK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDK2" } ] } ] }, { "uniprot_ac": "D4A8H3", "gene_name": "Uba6", "activity": [ { "ec_number": "6.2.1.45", "activity": "ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.", "evidence": [ { "id": "D4A8H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A8H3" } ] }, { "ec_number": "6.2.1.45", "activity": "", "evidence": [ { "id": "D4A8H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A8H3" } ] } ] }, { "uniprot_ac": "P61078", "gene_name": "Ube2d3", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P61078", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61078" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61078", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61078" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61078", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61078" } ] } ] }, { "uniprot_ac": "P62255", "gene_name": "Ube2g1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62255", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62255" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62255", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62255" } ] } ] }, { "uniprot_ac": "P62839", "gene_name": "Ube2d2", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P62839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62839" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62839" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62839" } ] } ] }, { "uniprot_ac": "P63149", "gene_name": "Ube2b", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P63149", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63149" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P63149", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63149" } ] } ] }, { "uniprot_ac": "Q3B7D1", "gene_name": "Ube2z", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q3B7D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3B7D1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q3B7D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3B7D1" } ] } ] }, { "uniprot_ac": "Q4V8J2", "gene_name": "Ube2l6", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q4V8J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4V8J2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q4V8J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4V8J2" } ] } ] }, { "uniprot_ac": "Q5U203", "gene_name": "Ube2f", "activity": [ { "ec_number": "2.3.2.32", "activity": "S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.", "evidence": [ { "id": "Q5U203", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U203" } ] }, { "ec_number": "2.3.2.32", "activity": "", "evidence": [ { "id": "Q5U203", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U203" } ] } ] }, { "uniprot_ac": "Q5U300", "gene_name": "Uba1", "activity": [ { "ec_number": "6.2.1.45", "activity": "ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.", "evidence": [ { "id": "Q5U300", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U300" } ] }, { "ec_number": "6.2.1.45", "activity": "", "evidence": [ { "id": "Q5U300", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U300" } ] } ] }, { "uniprot_ac": "Q99MI7", "gene_name": "Uba3", "activity": [ { "ec_number": "6.2.1.64", "activity": "ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.", "evidence": [ { "id": "Q99MI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99MI7" } ] }, { "ec_number": "6.2.1.64", "activity": "", "evidence": [ { "id": "Q99MI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99MI7" } ] } ] }, { "uniprot_ac": "Q9EQX9", "gene_name": "Ube2n", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q9EQX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EQX9" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q9EQX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EQX9" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 11 }, { "field": "total_sites", "count": 11 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }