{
    "uniprot_canonical_ac": "Q5M7A4-1",
    "uniprot_ac": "Q5M7A4",
    "uniprot_id": "UBA5_RAT",
    "mass": {
        "chemical_mass": 44895.0,
        "monoisotopic_mass": 44895.0
    },
    "refseq": {
        "ac": "NP_001009669",
        "name": "ubiquitin-like modifier-activating enzyme 5",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009669"
    },
    "gene_names": [
        {
            "name": "Uba5",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q5M7A4",
            "id": "Q5M7A4"
        },
        {
            "name": "Uba5",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009669",
            "id": "NP_001009669"
        },
        {
            "name": "Ube1dc1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009669",
            "id": "NP_001009669"
        }
    ],
    "protein_names": [
        {
            "name": "Ubiquitin-like modifier-activating enzyme 5",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q5M7A4"
        },
        {
            "name": "UFM1-activating enzyme; ubiquitin-activating enzyme 5; ubiquitin-activating enzyme E1 domain-containing protein 1; ubiquitin-activating enzyme E1-domain containing 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009669",
            "id": "NP_001009669"
        },
        {
            "name": "UFM1-activating enzyme",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q5M7A4"
        },
        {
            "name": "Ubiquitin-activating enzyme 5",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q5M7A4"
        },
        {
            "name": "ubiquitin-like modifier-activating enzyme 5",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009669",
            "id": "NP_001009669"
        }
    ],
    "function": [
        {
            "annotation": "E1-like enzyme which specifically catalyzes the first step in ufmylation. Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP. Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer. Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding. Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress (By similarity). Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes (By similarity).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q5M7A4",
                    "url": "https://www.uniprot.org/uniprot/Q5M7A4#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q9GZZ9",
                    "url": "https://www.uniprot.org/uniprot/Q9GZZ9#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q8VE47",
                    "url": "https://www.uniprot.org/uniprot/Q8VE47#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0050709",
            "recommended_name": {
                "id": "DOID:0050709",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0050709",
                "name": "early infantile epileptic encephalopathy",
                "description": "A neonatal period electroclinical syndrome that is characterized by tonic spasms and partial seizures."
            },
            "synonyms": [
                {
                    "id": "DOID:0050709",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0050709",
                    "name": "Early Infantile Epileptic Encephalopathy with Burst-Suppression",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "0050709",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050709"
                }
            ]
        },
        {
            "disease_id": "DOID:0080424",
            "recommended_name": {
                "id": "DOID:0080424",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0080424",
                "name": "developmental and epileptic encephalopathy 44",
                "description": "A developmental and epileptic encephalopathy characterized by onset in the first year of life of refractory infantile spasms or myoclonus with developmental stagnation and severe neurologic impairment after seizure onset that has_material_basis_in homozygous or compound heterozygous mutation in the UBA5 gene on chromosome 3q22."
            },
            "synonyms": [
                {
                    "id": "DOID:0080424",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0080424",
                    "name": "early infantile epileptic encephalopathy 44",
                    "description": ""
                },
                {
                    "id": "DOID:0080424",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0080424",
                    "name": "DEE44",
                    "description": ""
                },
                {
                    "id": "MONDO:0014933",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014933",
                    "name": "developmental and epileptic encephalopathy, 44",
                    "description": "Any early infantile epileptic encephalopathy in which the cause of the disease is a mutation in the UBA5 gene."
                },
                {
                    "id": "MONDO:0014933",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014933",
                    "name": "DEE44",
                    "description": ""
                },
                {
                    "id": "MONDO:0014933",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014933",
                    "name": "EIEE44",
                    "description": ""
                },
                {
                    "id": "MONDO:0014933",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014933",
                    "name": "UBA5 early infantile epileptic encephalopathy",
                    "description": ""
                },
                {
                    "id": "MONDO:0014933",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014933",
                    "name": "developmental and epileptic encephalopathy 44",
                    "description": ""
                },
                {
                    "id": "MONDO:0014933",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014933",
                    "name": "early infantile epileptic encephalopathy caused by mutation in UBA5",
                    "description": ""
                },
                {
                    "id": "MONDO:0014933",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014933",
                    "name": "epileptic encephalopathy, early infantile, 44",
                    "description": ""
                },
                {
                    "id": "MONDO:0014933",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014933",
                    "name": "epileptic encephalopathy, early infantile, 44; EIEE44",
                    "description": ""
                },
                {
                    "id": "MONDO:0014933",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014933",
                    "name": "epileptic encephalopathy, early infantile, type 44",
                    "description": ""
                },
                {
                    "id": "MIM:617132",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/617132",
                    "name": "Developmental and epileptic encephalopathy 44",
                    "description": "Developmental and epileptic encephalopathy 44"
                }
            ],
            "evidence": [
                {
                    "id": "0080424",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080424"
                }
            ]
        },
        {
            "disease_id": "DOID:0111615",
            "recommended_name": {
                "id": "DOID:0111615",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0111615",
                "name": "autosomal recessive spinocerebellar ataxia 24",
                "description": "An autosomal recessive cerebellar ataxia that has_material_basis_in homozygous or compound heterozygous mutation in the UBA5 gene on chromosome 3q22.1."
            },
            "synonyms": [
                {
                    "id": "DOID:0111615",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111615",
                    "name": "SCAR24",
                    "description": ""
                },
                {
                    "id": "MONDO:0014934",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014934",
                    "name": "spinocerebellar ataxia, autosomal recessive 24",
                    "description": "Any autosomal dominant cerebellar ataxia in which the cause of the disease is a mutation in the UBA5 gene."
                },
                {
                    "id": "MONDO:0014934",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014934",
                    "name": "SCAR24",
                    "description": ""
                },
                {
                    "id": "MONDO:0014934",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014934",
                    "name": "UBA5 autosomal dominant cerebellar ataxia",
                    "description": ""
                },
                {
                    "id": "MONDO:0014934",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014934",
                    "name": "autosomal dominant cerebellar ataxia caused by mutation in UBA5",
                    "description": ""
                },
                {
                    "id": "MONDO:0014934",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014934",
                    "name": "spinocerebellar ataxia, autosomal recessive 24",
                    "description": ""
                },
                {
                    "id": "MONDO:0014934",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014934",
                    "name": "spinocerebellar ataxia, autosomal recessive 24; SCAR24",
                    "description": ""
                },
                {
                    "id": "MONDO:0014934",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014934",
                    "name": "spinocerebellar ataxia, autosomal recessive type 24",
                    "description": ""
                },
                {
                    "id": "MIM:617133",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/617133",
                    "name": "Spinocerebellar ataxia, autosomal recessive, 24",
                    "description": "Spinocerebellar ataxia, autosomal recessive, 24"
                }
            ],
            "evidence": [
                {
                    "id": "0111615",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0111615"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q5M7A4",
                    "url": "https://www.uniprot.org/uniprot/Q5M7A4"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Uba5",
            "url": "https://www.uniprot.org/uniprot/Q5M7A4",
            "locus": {
                "chromosome": "8",
                "start_pos": 104665046,
                "end_pos": 104680894,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000011027",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000011027"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000011027",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000011027",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd00757",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00757",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "300968",
            "url": "https://www.ncbi.nlm.nih.gov/gene/300968",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR000594",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000594",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR029752",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR029752",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR035985",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR035985",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR045886",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR045886",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:300968",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:300968",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "FTPDQAG",
            "url": "https://omabrowser.org/oma/group/FTPDQAG/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "315430at2759",
            "url": "http://www.orthodb.org/?query=315430at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10953",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10953",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10953:SF9",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10953:SF9",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00899",
            "url": "http://pfam.xfam.org/family/PF00899",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q5M7A4",
            "url": "http://purl.obolibrary.org/obo/PR_Q5M7A4",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-RNO-983168",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001009669",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009669",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1311702",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311702",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A8I6GAV1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6GAV1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6GAV1-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6GAV1-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q5M7A4",
            "url": "https://www.uniprot.org/uniprot/Q5M7A4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q5M7A4-1",
            "url": "https://www.uniprot.org/uniprot/Q5M7A4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MAESVERLLQRVEELEQELARERSRRIAGDGHCGRTRIQKMSDEVVDSNPYSRLMALKRMGVVSDYEKIRTYAVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLFFQPYQAGMSKVQAAEHTLRSINPDVLFEVHNYNITTVEHFEHFMNRISNGGLEEGQPVDLVLSCVDNFEARMAINTACNELGQTWMESGVSENAVSGHIQLMVPGESACFACAPPLVVASNIDEKTLKREGVCAASLPTTMGVVAGILVQNVLKFLLKFGTVSFYLGYNAMQDFFPTMFMKPNPQCDDKNCRKQQEEYKKRAPAQPTQETAPQEEEEVVHEDNEWGIELVSEVSEEELKNSSGPVPTLPEGITVAYTVPKKREDSVSEVTVEDSGESLEDLMARMKKM",
        "length": 403,
        "header": "sp|Q5M7A4-1|UBA5_RAT Isoform 1 of Ubiquitin-like modifier-activating enzyme 5  OS=Rattus norvegicus OX=10116 GN=Uba5 PE=1 SV=1 CANONICAL=Q5M7A4-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A8I6GAV1-1",
            "url": "",
            "sequence": {
                "sequence": "MAESVERLLQRVEELEQELARERSRRIAGDGHCGRTRIQKMSDEVVDSNPYSRLMALKRMGVVSDYEKIRTYAVAIVGVGGVGSVTAEMLTRCGIGKVKRFLFALTVLLPQPLRAEQINVFCILLFFKYNLFSFCSNGGLEEGQPVDLVLSCVDNFEARMAINTACNELGQTWMESGVSENAVSGHIQLMVPGESACFACAPPLVVASNIDEKTLKREGVCAASLPTTMGVVAGILVQNVLKFLLKFGTVSFYLGYNAMQDFFPTMFMKPNPQCDDKNCRKQQEEYKKRAPAQPTQETAPQEEEEVVHEDNEWGIELVSEVSEEELKNSSGPVPTLPEGITVAYTVPKKREDSVSEVTVEDSGESLEDLMARMKKM",
                "length": 376,
                "header": "tr|A0A8I6GAV1-1|A0A8I6GAV1_RAT Computationally mapped isoform of Ubiquitin-like modifier activating enzyme 5  OS=Rattus norvegicus OX=10116 GN=Uba5 PE=1 SV=1 CANONICAL=Q5M7A4-1"
            },
            "locus": {
                "chromosome": "8",
                "start_pos": 104680721,
                "end_pos": 104666188,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000105523.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000105523.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000083523.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000083523.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q5M7A4-1",
            "url": "",
            "sequence": {
                "sequence": "MAESVERLLQRVEELEQELARERSRRIAGDGHCGRTRIQKMSDEVVDSNPYSRLMALKRMGVVSDYEKIRTYAVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLFFQPYQAGMSKVQAAEHTLRSINPDVLFEVHNYNITTVEHFEHFMNRISNGGLEEGQPVDLVLSCVDNFEARMAINTACNELGQTWMESGVSENAVSGHIQLMVPGESACFACAPPLVVASNIDEKTLKREGVCAASLPTTMGVVAGILVQNVLKFLLKFGTVSFYLGYNAMQDFFPTMFMKPNPQCDDKNCRKQQEEYKKRAPAQPTQETAPQEEEEVVHEDNEWGIELVSEVSEEELKNSSGPVPTLPEGITVAYTVPKKREDSVSEVTVEDSGESLEDLMARMKKM",
                "length": 403,
                "header": "sp|Q5M7A4-1|UBA5_RAT Isoform 1 of Ubiquitin-like modifier-activating enzyme 5  OS=Rattus norvegicus OX=10116 GN=Uba5 PE=1 SV=1 CANONICAL=Q5M7A4-1"
            },
            "locus": {
                "chromosome": "8",
                "start_pos": 104680721,
                "end_pos": 104666188,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000015240",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000015240"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000015240",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000015240"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 357,
            "end_pos": 357,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q5M7A4",
                    "url": "https://www.uniprot.org/uniprot/Q5M7A4"
                }
            ],
            "site_lbl": "Ser357"
        },
        {
            "start_pos": 392,
            "end_pos": 392,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q5M7A4",
                    "url": "https://www.uniprot.org/uniprot/Q5M7A4"
                }
            ],
            "site_lbl": "Ser392"
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.",
            "journal": "Nat. Commun.",
            "date": "2012",
            "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q5M7A4",
                    "url": "https://www.uniprot.org/uniprot/Q5M7A4"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "22673903",
                    "url": "https://glygen.org/publication/PubMed/22673903"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:300968",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:300968",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-983168",
            "name": "Antigen processing: Ubiquitination & Proteasome degradation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168",
            "resource": "Reactome",
            "description": "Antigen processing: Ubiquitination & Proteasome degradation"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q8VE47-1",
            "protein_name": "Ubiquitin-like modifier-activating enzyme 5",
            "gene_name": "Uba5",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MADSVERLRQRVEELEQELARERTRRSGGDGHCGRTRIQEMSDEVLDSNPYSRLMALKRMGIVSDYKKIRTYAVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLFFQPYQAGLSKVHAAEHTLRNINPDVLFEVHNYNITTVEHFEHFMNRISNGGLEEGQPVDLVLSCVDNFEARMAINTACNELGQTWMESGVSENAVSGHIQLMIPGESACFACAPPLVVASNIDEKTLKREGVCAASLPTTMGVVAGILVQNVLKFLLKFGTVSFYLGYNAMQDFFPTMFMKPNPQCDDKNCRKQQEEYKKRAAALPTQEAEPQEEAEVVHEDNEWGIELVSEVSEEELKNSSGPVPTLPEGITVAYTVPKKTEDSASEVTVEDSGESLEDLMARMKNM",
                "length": 403
            },
            "evidence": [
                {
                    "id": "45226099",
                    "url": "http://www.informatics.jax.org/homology/45226099",
                    "database": "MGI"
                },
                {
                    "id": "Q5M7A4",
                    "url": "https://omabrowser.org/oma/group/Q5M7A4/",
                    "database": "OMA"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q9GZZ9-1",
            "protein_name": "Ubiquitin-like modifier-activating enzyme 5",
            "gene_name": "UBA5",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MAESVERLQQRVQELERELAQERSLQVPRSGDGGGGRVRIEKMSSEVVDSNPYSRLMALKRMGIVSDYEKIRTFAVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLFFQPHQAGLSKVQAAEHTLRNINPDVLFEVHNYNITTVENFQHFMDRISNGGLEEGKPVDLVLSCVDNFEARMTINTACNELGQTWMESGVSENAVSGHIQLIIPGESACFACAPPLVVAANIDEKTLKREGVCAASLPTTMGVVAGILVQNVLKFLLNFGTVSFYLGYNAMQDFFPTMSMKPNPQCDDRNCRKQQEEYKKKVAALPKQEVIQEEEEIIHEDNEWGIELVSEVSEEELKNFSGPVPDLPEGITVAYTIPKKQEDSVTELTVEDSGESLEDLMAKMKNM",
                "length": 404
            },
            "evidence": [
                {
                    "id": "45226099",
                    "url": "http://www.informatics.jax.org/homology/45226099",
                    "database": "MGI"
                },
                {
                    "id": "Q5M7A4",
                    "url": "https://omabrowser.org/oma/group/Q5M7A4/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9VYY3-1",
            "protein_name": "Ubiquitin-like modifier-activating enzyme 5",
            "gene_name": "Uba5",
            "tax_id": 7227,
            "organism": "Drosophila melanogaster",
            "sequence": {
                "sequence": "MSHAIDELQAIIADLKTELETEPKSSGGVASNSRLARDRIDRMSAEVVDSNPYSRLMALQRMNIVKDYERIRYKAVAIVGVGGVGSVTADMLTRCGIGKLILFDYDKVELANMNRLFFTPDQAGLSKVAAAAATLSFINPDVEIETHNYNITTVENFDRFLDTISQGGRIAGQPVDLVLSCVDNFEARMAINAACNERNLNWFESGVSENAVSGHIQFIRPGDTACFACAPPLVVAENIDEKTLKREGVCAASLPTTMGITAGFLVQNALKYLLNFGEVSDYLGYNALSDFFPKMTLKPNPQCDDRNCLVRQKEFQARPKPVLIEEKAVSEEPLHATNEWGIELVAEDAPESNTTPAETPVMGEGLRLAYEAPEKSSETSEETVSAATADETSLEDLMAQMKSM",
                "length": 404
            },
            "evidence": [
                {
                    "id": "Q5M7A4",
                    "url": "https://omabrowser.org/oma/group/Q5M7A4/",
                    "database": "OMA"
                }
            ],
            "common_name": "Fruit fly"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 10,
                "go_terms": [
                    {
                        "name": "megakaryocyte differentiation",
                        "id": "GO:0030219",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030219",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5M7A4",
                                "url": "https://www.uniprot.org/uniprot/Q5M7A4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "neuromuscular process",
                        "id": "GO:0050905",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050905",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5M7A4",
                                "url": "https://www.uniprot.org/uniprot/Q5M7A4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "erythrocyte differentiation",
                        "id": "GO:0030218",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030218",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5M7A4",
                                "url": "https://www.uniprot.org/uniprot/Q5M7A4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "response to endoplasmic reticulum stress",
                        "id": "GO:0034976",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034976",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5M7A4",
                                "url": "https://www.uniprot.org/uniprot/Q5M7A4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein ufmylation",
                        "id": "GO:0071569",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071569",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5M7A4",
                                "url": "https://www.uniprot.org/uniprot/Q5M7A4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "reticulophagy",
                        "id": "GO:0061709",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061709",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5M7A4",
                                "url": "https://www.uniprot.org/uniprot/Q5M7A4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein K69-linked ufmylation",
                        "id": "GO:1990592",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990592",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5M7A4",
                                "url": "https://www.uniprot.org/uniprot/Q5M7A4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of intracellular estrogen receptor signaling pathway",
                        "id": "GO:0033146",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033146",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5M7A4",
                                "url": "https://www.uniprot.org/uniprot/Q5M7A4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "localization",
                        "id": "GO:0051179",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051179",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5M7A4",
                                "url": "https://www.uniprot.org/uniprot/Q5M7A4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "selective autophagy",
                        "id": "GO:0061912",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061912",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5M7A4",
                                "url": "https://www.uniprot.org/uniprot/Q5M7A4"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 5,
                "go_terms": [
                    {
                        "name": "UFM1 activating enzyme activity",
                        "id": "GO:0071566",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071566",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5M7A4",
                                "url": "https://www.uniprot.org/uniprot/Q5M7A4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ATP binding",
                        "id": "GO:0005524",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5M7A4",
                                "url": "https://www.uniprot.org/uniprot/Q5M7A4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "zinc ion binding",
                        "id": "GO:0008270",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5M7A4",
                                "url": "https://www.uniprot.org/uniprot/Q5M7A4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein homodimerization activity",
                        "id": "GO:0042803",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5M7A4",
                                "url": "https://www.uniprot.org/uniprot/Q5M7A4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ubiquitin-like modifier activating enzyme activity",
                        "id": "GO:0008641",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008641",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5M7A4",
                                "url": "https://www.uniprot.org/uniprot/Q5M7A4"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 5,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5M7A4",
                                "url": "https://www.uniprot.org/uniprot/Q5M7A4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5M7A4",
                                "url": "https://www.uniprot.org/uniprot/Q5M7A4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "Golgi apparatus",
                        "id": "GO:0005794",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5M7A4",
                                "url": "https://www.uniprot.org/uniprot/Q5M7A4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5M7A4",
                                "url": "https://www.uniprot.org/uniprot/Q5M7A4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endoplasmic reticulum membrane",
                        "id": "GO:0005789",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5M7A4",
                                "url": "https://www.uniprot.org/uniprot/Q5M7A4"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 148,
            "end_pos": 150,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 355,
            "end_pos": 357,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
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                },
                {
                    "field": "total_sites",
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                {
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                },
                {
                    "field": "n_linked_glycan_sites",
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                },
                {
                    "field": "o_linked_glycans",
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                },
                {
                    "field": "o_linked_glycan_sites",
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                }
            ],
            "sort_fields": []
        },
        {
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        {
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        {
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                {
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                {
                    "field": "o_linked_glycan_sites",
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                }
            ],
            "sort_fields": []
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        {
            "table_id": "glycosylation_automatic_literature_mining",
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            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
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                    "field": "total",
                    "count": 2
                },
                {
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            ],
            "sort_fields": [
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                "kinase_uniprot_canonical_ac",
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        {
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            ],
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        {
            "table_id": "snv_disease",
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        {
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            "sort_fields": [
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        }
    ]
}