{
    "uniprot_canonical_ac": "Q5KU39-1",
    "uniprot_ac": "Q5KU39",
    "uniprot_id": "VPS41_MOUSE",
    "mass": {
        "chemical_mass": 98602.0,
        "monoisotopic_mass": 98602.0
    },
    "refseq": {
        "ac": "NP_742118",
        "name": "vacuolar protein sorting-associated protein 41 homolog",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742118"
    },
    "gene_names": [
        {
            "name": "Vps41",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q5KU39",
            "id": "Q5KU39"
        },
        {
            "name": "Vps41",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742118",
            "id": "NP_742118"
        },
        {
            "name": "mVam2; Vam2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742118",
            "id": "NP_742118"
        }
    ],
    "protein_names": [
        {
            "name": "Vacuolar protein sorting-associated protein 41 homolog",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q5KU39"
        },
        {
            "name": "VAM2 homolog; vacuolar protein sorting 41",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742118",
            "id": "NP_742118"
        },
        {
            "name": "VAM2 homolog",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q5KU39"
        },
        {
            "name": "mVAM2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q5KU39"
        },
        {
            "name": "vacuolar protein sorting-associated protein 41 homolog",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742118",
            "id": "NP_742118"
        }
    ],
    "function": [
        {
            "annotation": "It was found that Vam2, which interacts with BMP type I receptor, is required for the spatiotemporal modulation of BMP signaling, via sequestration of the receptor complex in the late stages of the endocytic pathway.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_742118",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742118"
                },
                {
                    "database": "PubMed",
                    "id": "22698281",
                    "url": "https://glygen.org/publication/PubMed/22698281"
                }
            ]
        },
        {
            "annotation": "Lack of Coxiella burnetii targeting to degradative compartments involves an antagonistic engagement of TLR4 by lipopolysaccharides, lack of p38alpha-MAPK-driven phosphorylation, and block in recruitment of the Vps41 to lipopolysaccharide-containing vesicles.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_742118",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742118"
                },
                {
                    "database": "PubMed",
                    "id": "23245320",
                    "url": "https://glygen.org/publication/PubMed/23245320"
                }
            ]
        },
        {
            "annotation": "Pancreatic beta-Cell-Specific Deletion of VPS41 Causes Diabetes Due to Defects in Insulin Secretion.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_742118",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742118"
                },
                {
                    "database": "PubMed",
                    "id": "33168621",
                    "url": "https://glygen.org/publication/PubMed/33168621"
                }
            ]
        },
        {
            "annotation": "Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo. Required for fusion of autophagosomes with lysosomes. Links the HOPS complex to endosomal via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion (By similarity). Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS (By similarity). Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adapter complex (By similarity). May play a role in HOPS-independent function in the regulated secretory pathway (By similarity).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q5KU39",
                    "url": "https://www.uniprot.org/uniprot/Q5KU39#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "P49754",
                    "url": "https://www.uniprot.org/uniprot/P49754#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "D3ZVH6",
                    "url": "https://www.uniprot.org/uniprot/D3ZVH6#function"
                }
            ]
        },
        {
            "annotation": "VPS41-mediated incomplete autophagy aggravates cadmium-induced apoptosis in mouse hepatocytes.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_742118",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742118"
                },
                {
                    "database": "PubMed",
                    "id": "37562348",
                    "url": "https://glygen.org/publication/PubMed/37562348"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0070410",
            "recommended_name": {
                "id": "DOID:0070410",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0070410",
                "name": "autosomal recessive spinocerebellar ataxia 29",
                "description": "An autosomal recessive cerebellar ataxia characterized by delayed motor development in early infancy followed by difficulty walking due to an ataxic gait or inability to walk, hypotonia, and variably impaired intellectual development that has_material_basis_in homozygous or compound heterozygous mutation in the VPS41 gene on chromosome 7p14."
            },
            "synonyms": [
                {
                    "id": "DOID:0070410",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0070410",
                    "name": "SCAR29",
                    "description": ""
                },
                {
                    "id": "MONDO:0030312",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0030312",
                    "name": "spinocerebellar ataxia, autosomal recessive 29",
                    "description": ""
                },
                {
                    "id": "MONDO:0030312",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0030312",
                    "name": "Barakat-Van Ham-Kaya syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0030312",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0030312",
                    "name": "SCAR29",
                    "description": ""
                },
                {
                    "id": "MONDO:0030312",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0030312",
                    "name": "neurodevelopmental disorder with hypotonia and cerebellar ataxia",
                    "description": ""
                },
                {
                    "id": "MONDO:0030312",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0030312",
                    "name": "spinocerebellar ataxia, autosomal recessive 29",
                    "description": ""
                },
                {
                    "id": "MIM:619389",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/619389",
                    "name": "Spinocerebellar ataxia, autosomal recessive, 29",
                    "description": "Spinocerebellar ataxia, autosomal recessive, 29"
                }
            ],
            "evidence": [
                {
                    "id": "0070410",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070410"
                }
            ]
        },
        {
            "disease_id": "DOID:14330",
            "recommended_name": {
                "id": "DOID:14330",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:14330",
                "name": "Parkinson's disease",
                "description": "A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions."
            },
            "synonyms": [
                {
                    "id": "DOID:14330",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:14330",
                    "name": "Parkinson disease",
                    "description": ""
                },
                {
                    "id": "DOID:14330",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:14330",
                    "name": "paralysis agitans",
                    "description": ""
                },
                {
                    "id": "MONDO:0008199",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008199",
                    "name": "late-onset Parkinson disease",
                    "description": "A Parkinson disease that begins after around the age of 50."
                },
                {
                    "id": "MONDO:0008199",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008199",
                    "name": "LOPD",
                    "description": ""
                },
                {
                    "id": "MONDO:0008199",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008199",
                    "name": "PARK",
                    "description": ""
                },
                {
                    "id": "MONDO:0008199",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008199",
                    "name": "PD",
                    "description": ""
                },
                {
                    "id": "MONDO:0008199",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008199",
                    "name": "Parkinson disease, age of onset, modifier, Multifactorial",
                    "description": ""
                },
                {
                    "id": "MONDO:0008199",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008199",
                    "name": "Parkinson disease, late-onset",
                    "description": ""
                },
                {
                    "id": "MONDO:0008199",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008199",
                    "name": "Parkinson disease, late-onset, susceptibility to, Multifactorial",
                    "description": ""
                },
                {
                    "id": "MONDO:0008199",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008199",
                    "name": "Parkinson disease, susceptibility to, Multifactorial",
                    "description": ""
                },
                {
                    "id": "MONDO:0008199",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008199",
                    "name": "autosomal dominant late-onset Parkinson disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0008199",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008199",
                    "name": "hereditary late onset Parkinson disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0008199",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008199",
                    "name": "hereditary late-onset Parkinson disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0008199",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008199",
                    "name": "late onset Parkinson disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0008199",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008199",
                    "name": "late onset Parkinson's disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0008199",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008199",
                    "name": "late-onset Parkinson disease",
                    "description": ""
                },
                {
                    "id": "MIM:168600",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/168600",
                    "name": "Parkinson disease",
                    "description": "Parkinson disease"
                }
            ],
            "evidence": [
                {
                    "id": "14330",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:14330"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q5KU39",
                    "url": "https://www.uniprot.org/uniprot/Q5KU39"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Vps41",
            "url": "https://www.uniprot.org/uniprot/Q5KU39",
            "locus": {
                "chromosome": "13",
                "start_pos": 19050981,
                "end_pos": 18901456,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000041236",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000041236"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000041236",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000041236",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd16690",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16690",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "218035",
            "url": "https://www.ncbi.nlm.nih.gov/gene/218035",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "Q5KU39",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q5KU39*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR000547",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000547",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR001841",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011990",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR015943",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR016902",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR016902",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036322",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR045111",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR045111",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:218035",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:218035",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1929215",
            "url": "http://www.informatics.jax.org/marker/MGI:1929215",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "KFKYQRI",
            "url": "https://omabrowser.org/oma/group/KFKYQRI/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "8838at2759",
            "url": "http://www.orthodb.org/?query=8838at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12616",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12616",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12616:SF1",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12616:SF1",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00637",
            "url": "http://pfam.xfam.org/family/PF00637",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q5KU39",
            "url": "http://purl.obolibrary.org/obo/PR_Q5KU39",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_742118",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742118",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q5KU39",
            "url": "https://www.uniprot.org/uniprot/Q5KU39",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q5KU39-1",
            "url": "https://www.uniprot.org/uniprot/Q5KU39-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MAEAEEQETESLEESTDESEEESEEEPKLKYERLSNGVTEILQKDAASCMTVHDKFLALGTHYGKVYLLDVQGNITQKFDVSPVKINQISLDDSGEHMGVCSEDGKLQVFGLYSGEEFHETFDCPIKIIAVHPQFVRSSCKQFVTGGKKLLLFERTWMNRWKSSVLHEGEGNIRSVKWRGHLIAWANNMGVKVFDITSKQRISNVPRDDISLRPDMYPCSLCWKDNVTLIIGWGTSIKICSVKERHASEMRDLPSRYVEIVSQFETEFYISGLAPLCDQLVVLSYVKEVSEKTEREYCARPRLDIIQPLPETCEEISSDALTVRGFQENECRDYHLEYSEGESLFYVVSPRDVVVAKERDQDDHIDWLLEKKKYEEALMAAEISQRNIKRHKILDIGLAYVNHLVERGEYDMAARKCQKILGKNASLWEYEVYKFKEIGQLKAISPYLPRGDPVLKPLIYEMILHEFLESDYEGFATLIREWPGDLYNNSVIVQAVRDHLKKDSQNKTLLKTLAELYTYDKNYGNALEIYLTLRHKDVFQLIHKHNLFSSIKDKIVLLMDFDSEKAVDMLLDNEDKISIKKVVEELEDRPELQHVYLHKLFKRDHHKGQRYHEKQISLYAEYDRPNLLPFLRDSTHCPLEKALEICQQRNFVEETVYLLSRMGNSRSALKMIMEELHDVDKAIEFAKEQDDGELWEDLILYSIDKPPFITGLLNNIGTHVDPILLIHRIKEGMEIPNLRDSLVKILQDYNLQILLREGCKKILVADSLSLLKKMHRTQMKGVLVDEENICESCLSPILPTDAAKPFSVVVFHCRHMFHKECLPMPSMNAPAQYCNICSAKNRGPGSAILEMKK",
        "length": 853,
        "header": "sp|Q5KU39-1|VPS41_MOUSE Isoform 1 of Vacuolar protein sorting-associated protein 41 homolog  OS=Mus musculus OX=10090 GN=Vps41 PE=1 SV=1 CANONICAL=Q5KU39-1"
    },
    "isoforms": [
        {
            "isoform_ac": "Q5KU39-1",
            "url": "",
            "sequence": {
                "sequence": "MAEAEEQETESLEESTDESEEESEEEPKLKYERLSNGVTEILQKDAASCMTVHDKFLALGTHYGKVYLLDVQGNITQKFDVSPVKINQISLDDSGEHMGVCSEDGKLQVFGLYSGEEFHETFDCPIKIIAVHPQFVRSSCKQFVTGGKKLLLFERTWMNRWKSSVLHEGEGNIRSVKWRGHLIAWANNMGVKVFDITSKQRISNVPRDDISLRPDMYPCSLCWKDNVTLIIGWGTSIKICSVKERHASEMRDLPSRYVEIVSQFETEFYISGLAPLCDQLVVLSYVKEVSEKTEREYCARPRLDIIQPLPETCEEISSDALTVRGFQENECRDYHLEYSEGESLFYVVSPRDVVVAKERDQDDHIDWLLEKKKYEEALMAAEISQRNIKRHKILDIGLAYVNHLVERGEYDMAARKCQKILGKNASLWEYEVYKFKEIGQLKAISPYLPRGDPVLKPLIYEMILHEFLESDYEGFATLIREWPGDLYNNSVIVQAVRDHLKKDSQNKTLLKTLAELYTYDKNYGNALEIYLTLRHKDVFQLIHKHNLFSSIKDKIVLLMDFDSEKAVDMLLDNEDKISIKKVVEELEDRPELQHVYLHKLFKRDHHKGQRYHEKQISLYAEYDRPNLLPFLRDSTHCPLEKALEICQQRNFVEETVYLLSRMGNSRSALKMIMEELHDVDKAIEFAKEQDDGELWEDLILYSIDKPPFITGLLNNIGTHVDPILLIHRIKEGMEIPNLRDSLVKILQDYNLQILLREGCKKILVADSLSLLKKMHRTQMKGVLVDEENICESCLSPILPTDAAKPFSVVVFHCRHMFHKECLPMPSMNAPAQYCNICSAKNRGPGSAILEMKK",
                "length": 853,
                "header": "sp|Q5KU39-1|VPS41_MOUSE Isoform 1 of Vacuolar protein sorting-associated protein 41 homolog  OS=Mus musculus OX=10090 GN=Vps41 PE=1 SV=1 CANONICAL=Q5KU39-1"
            },
            "locus": {
                "chromosome": "13",
                "start_pos": 19050367,
                "end_pos": 18901486,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000072961",
                        "url": "https://www.ensembl.org/id/ENSMUST00000072961"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000072729",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000072729"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Spatial restriction of bone morphogenetic protein signaling in mouse gastrula through the mVam2-dependent endocytic pathway.",
            "journal": "Developmental cell",
            "date": "2012",
            "authors": "Aoyama M, Sun-Wada GH, Yamamoto A, Yamamoto M, Hamada H, Wada Y",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_742118",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742118"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "22698281",
                    "url": "https://glygen.org/publication/PubMed/22698281"
                }
            ]
        },
        {
            "title": "Impaired stimulation of p38alpha-MAPK/Vps41-HOPS by LPS from pathogenic Coxiella burnetii prevents trafficking to microbicidal phagolysosomes.",
            "journal": "Cell host & microbe",
            "date": "2012",
            "authors": "Barry AO, Boucherit N, Mottola G, Vadovic P, Trouplin V, Soubeyran P, Capo C, Bonatti S, Nebreda A, Toman R, Lemichez E, Mege JL, Ghigo E",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_742118",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742118"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "23245320",
                    "url": "https://glygen.org/publication/PubMed/23245320"
                }
            ]
        },
        {
            "title": "Pancreatic beta-Cell-Specific Deletion of VPS41 Causes Diabetes Due to Defects in Insulin Secretion.",
            "journal": "Diabetes",
            "date": "2021",
            "authors": "Burns CH, Yau B, Rodriguez A, Triplett J, Maslar D, An YS, van der Welle REN, Kossina RG, Fisher MR, Strout GW, Bayguinov PO, Veenendaal T, Chitayat D, Fitzpatrick JAJ, Klumperman J, Kebede MA, Asensio CS",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_742118",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742118"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "33168621",
                    "url": "https://glygen.org/publication/PubMed/33168621"
                }
            ]
        },
        {
            "title": "VPS41-mediated incomplete autophagy aggravates cadmium-induced apoptosis in mouse hepatocytes.",
            "journal": "Journal of hazardous materials",
            "date": "2023-10-05",
            "authors": "Wang Tao, Yan Lianqi, Wang Li, Sun Jian, Qu Huayi, Ma Yonggang, Song Ruilong, Tong Xishuai, Zhu Jiaqiao, Yuan Yan, Gu Jianhong, Bian Jianchun, Liu Zongping, Zou Hui",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_742118",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742118"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "37562348",
                    "url": "https://glygen.org/publication/PubMed/37562348"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:218035",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:218035",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "A0A8I5ZWM9-1",
            "protein_name": "Vacuolar protein sorting-associated protein 41 homolog",
            "gene_name": "Vps41",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MGYSDFPTTKCVFFSNLLSLPCLQETESLEESTDESEEESEEEPKLKYERLSNGVTEILQKDAASCMTVHDKFLALGTHYGKVYLLDVQGNITQKFDVSPVKINQISLDESGEHMGVCSEDGKLQVFGLYSGEEFHETFDCPIKIVAVHPQFVRSSCKQFVTGGKKLLLFERTWMNRWKSSVLHEGEGNIRSVKWRGHLIAWANNMGVKIFDITSKQRITNVPRDDISLRPDMYPCSLCWKDAVTLIIGWGTSIKICSVKERHASEMRDLPSRYVEIVSQFETEFYISGLAPLCDQLVVLSYVKEVSEKTEREYCARPRLDIIQPLPETCEEISSDALTVRGFQENECRDYHLEYSEGESLFYVVSPRDVVVAKERDQDDHIDWLLEKKKYEEALMAAEISHRNIKRHKILEIGLAYVNHLVERGEYDMAARKCQKILGKNASLWEYEVYKFKEIGQLKAISPYLPRGDPVLKPLIYEMILHEFLESDYEGFATLIREWPGDLYNNSVIVQAVRDHLKKDSQNKTLLKTLAELYTYDKNYGNALEIYLTLRHKDVFQLIHKHNLFSSIKDKIVLLMDFDSEKAVDMLLDNEDKISIKKVVEELEDRPELQHVYLHKLFKRDHHKGQRYHEKQISLYAEYDRPNLLPFLRDSTHCPLEKALEICQQRNFVEETVYLLSRMGNSRSALKMIMEELHDVDKAIEFAKEQDDGELWEDLILYSIDKPPFITGLLNNIGTHVDPILLIHRIKEGMEIPNLRDSLVKILQDYNLQILLREGCKKILVADSLSLLKKMHRTQMKGVLVDEENICESCLSPILPTDAAKPFSVVVFHCRHMFHKECLPMPSLNAPAQYCNICSAKNRGPGSAILEMKK",
                "length": 870
            },
            "evidence": [
                {
                    "id": "45235151",
                    "url": "http://www.informatics.jax.org/homology/45235151",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "P49754-1",
            "protein_name": "Vacuolar protein sorting-associated protein 41 homolog",
            "gene_name": "VPS41",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MAEAEEQETGSLEESTDESEEEESEEEPKLKYERLSNGVTEILQKDAASCMTVHDKFLALGTHYGKVYLLDVQGNITQKFDVSPVKINQISLDESGEHMGVCSEDGKVQVFGLYSGEEFHETFDCPIKIIAVHPHFVRSSCKQFVTGGKKLLLFERSWMNRWKSAVLHEGEGNIRSVKWRGHLIAWANNMGVKIFDIISKQRITNVPRDDISLRPDMYPCSLCWKDNVTLIIGWGTSVKVCSVKERHASEMRDLPSRYVEIVSQFETEFYISGLAPLCDQLVVLSYVKEISEKTEREYCARPRLDIIQPLSETCEEISSDALTVRGFQENECRDYHLEYSEGESLFYIVSPRDVVVAKERDQDDHIDWLLEKKKYEEALMAAEISQKNIKRHKILDIGLAYINHLVERGDYDIAARKCQKILGKNAALWEYEVYKFKEIGQLKAISPYLPRGDPVLKPLIYEMILHEFLESDYEGFATLIREWPGDLYNNSVIVQAVRDHLKKDSQNKTLLKTLAELYTYDKNYGNALEIYLTLRHKDVFQLIHKHNLFSSIKDKIVLLMDFDSEKAVDMLLDNEDKISIKKVVEELEDRPELQHVYLHKLFKRDHHKGQRYHEKQISLYAEYDRPNLLPFLRDSTHCPLEKALEICQQRNFVEETVYLLSRMGNSRSALKMIMEELHDVDKAIEFAKEQDDGELWEDLILYSIDKPPFITGLLNNIGTHVDPILLIHRIKEGMEIPNLRDSLVKILQDYNLQILLREGCKKILVADSLSLLKKMHRTQMKGVLVDEENICESCLSPILPSDAAKPFSVVVFHCRHMFHKECLPMPSMNSAAQFCNICSAKNRGPGSAILEMKK",
                "length": 854
            },
            "evidence": [
                {
                    "id": "45235151",
                    "url": "http://www.informatics.jax.org/homology/45235151",
                    "database": "MGI"
                },
                {
                    "id": "Q5KU39",
                    "url": "https://omabrowser.org/oma/group/Q5KU39/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 17,
                "go_terms": [
                    {
                        "name": "HOPS complex",
                        "id": "GO:0030897",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030897",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5KU39",
                                "url": "https://www.uniprot.org/uniprot/Q5KU39"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "early endosome",
                        "id": "GO:0005769",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5KU39",
                                "url": "https://www.uniprot.org/uniprot/Q5KU39"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "Golgi apparatus",
                        "id": "GO:0005794",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5KU39",
                                "url": "https://www.uniprot.org/uniprot/Q5KU39"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "Golgi-associated vesicle",
                        "id": "GO:0005798",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005798",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5KU39",
                                "url": "https://www.uniprot.org/uniprot/Q5KU39"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5KU39",
                                "url": "https://www.uniprot.org/uniprot/Q5KU39"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "membrane",
                        "id": "GO:0016020",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5KU39",
                                "url": "https://www.uniprot.org/uniprot/Q5KU39"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "lysosome",
                        "id": "GO:0005764",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5KU39",
                                "url": "https://www.uniprot.org/uniprot/Q5KU39"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "lysosomal membrane",
                        "id": "GO:0005765",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5KU39",
                                "url": "https://www.uniprot.org/uniprot/Q5KU39"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "microtubule cytoskeleton",
                        "id": "GO:0015630",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015630",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5KU39",
                                "url": "https://www.uniprot.org/uniprot/Q5KU39"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "late endosome membrane",
                        "id": "GO:0031902",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031902",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5KU39",
                                "url": "https://www.uniprot.org/uniprot/Q5KU39"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "early endosome membrane",
                        "id": "GO:0031901",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5KU39",
                                "url": "https://www.uniprot.org/uniprot/Q5KU39"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "late endosome",
                        "id": "GO:0005770",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005770",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5KU39",
                                "url": "https://www.uniprot.org/uniprot/Q5KU39"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endosome membrane",
                        "id": "GO:0010008",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5KU39",
                                "url": "https://www.uniprot.org/uniprot/Q5KU39"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "clathrin-coated vesicle",
                        "id": "GO:0030136",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030136",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5KU39",
                                "url": "https://www.uniprot.org/uniprot/Q5KU39"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "AP-3 adaptor complex",
                        "id": "GO:0030123",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030123",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5KU39",
                                "url": "https://www.uniprot.org/uniprot/Q5KU39"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "clathrin complex",
                        "id": "GO:0071439",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071439",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5KU39",
                                "url": "https://www.uniprot.org/uniprot/Q5KU39"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "lysosomal HOPS complex",
                        "id": "GO:1902501",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902501",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5KU39",
                                "url": "https://www.uniprot.org/uniprot/Q5KU39"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 4,
                "go_terms": [
                    {
                        "name": "microtubule binding",
                        "id": "GO:0008017",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5KU39",
                                "url": "https://www.uniprot.org/uniprot/Q5KU39"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "identical protein binding",
                        "id": "GO:0042802",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5KU39",
                                "url": "https://www.uniprot.org/uniprot/Q5KU39"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "metal ion binding",
                        "id": "GO:0046872",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5KU39",
                                "url": "https://www.uniprot.org/uniprot/Q5KU39"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein self-association",
                        "id": "GO:0043621",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043621",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5KU39",
                                "url": "https://www.uniprot.org/uniprot/Q5KU39"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 9,
                "go_terms": [
                    {
                        "name": "regulated exocytosis",
                        "id": "GO:0045055",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045055",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5KU39",
                                "url": "https://www.uniprot.org/uniprot/Q5KU39"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "macroautophagy",
                        "id": "GO:0016236",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016236",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5KU39",
                                "url": "https://www.uniprot.org/uniprot/Q5KU39"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endosome to lysosome transport",
                        "id": "GO:0008333",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008333",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5KU39",
                                "url": "https://www.uniprot.org/uniprot/Q5KU39"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "vesicle-mediated transport",
                        "id": "GO:0016192",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5KU39",
                                "url": "https://www.uniprot.org/uniprot/Q5KU39"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cellular response to starvation",
                        "id": "GO:0009267",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009267",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5KU39",
                                "url": "https://www.uniprot.org/uniprot/Q5KU39"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endosomal vesicle fusion",
                        "id": "GO:0034058",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034058",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5KU39",
                                "url": "https://www.uniprot.org/uniprot/Q5KU39"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "Golgi vesicle transport",
                        "id": "GO:0048193",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048193",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5KU39",
                                "url": "https://www.uniprot.org/uniprot/Q5KU39"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "late endosome to lysosome transport",
                        "id": "GO:1902774",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902774",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5KU39",
                                "url": "https://www.uniprot.org/uniprot/Q5KU39"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein targeting to vacuole",
                        "id": "GO:0006623",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006623",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5KU39",
                                "url": "https://www.uniprot.org/uniprot/Q5KU39"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 226,
            "end_pos": 228,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 424,
            "end_pos": 426,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 488,
            "end_pos": 490,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 506,
            "end_pos": 508,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 74,
            "end_pos": 76,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
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                },
                {
                    "field": "n_linked_glycans",
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                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
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                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
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                },
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                {
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                },
                {
                    "field": "o_linked_glycan_sites",
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                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
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                {
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            "sort_fields": []
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        {
            "table_id": "glycosylation_predicted",
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                },
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                {
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                {
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                {
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            ],
            "sort_fields": []
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        {
            "table_id": "glycosylation_automatic_literature_mining",
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