{
    "uniprot_canonical_ac": "Q5JCS9-1",
    "uniprot_ac": "Q5JCS9",
    "uniprot_id": "B3GN3_MOUSE",
    "mass": {
        "chemical_mass": 42586.0,
        "monoisotopic_mass": 42586.0
    },
    "refseq": {
        "ac": "NP_082465",
        "name": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3 precursor",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082465"
    },
    "gene_names": [
        {
            "name": "B3gnt3",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q5JCS9",
            "id": "Q5JCS9"
        },
        {
            "name": "2210008L19Rik",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082465",
            "id": "NP_082465"
        },
        {
            "name": "B3gnt3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082465",
            "id": "NP_082465"
        }
    ],
    "protein_names": [
        {
            "name": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q5JCS9"
        },
        {
            "name": "2.4.1.146",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q5JCS9"
        },
        {
            "name": "2.4.1.149",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q5JCS9"
        },
        {
            "name": "BGnT-3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q5JCS9"
        },
        {
            "name": "Beta-1,3-Gn-T3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q5JCS9"
        },
        {
            "name": "Beta-1,3-N-acetylglucosaminyltransferase 3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q5JCS9"
        },
        {
            "name": "Beta3Gn-T3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q5JCS9"
        },
        {
            "name": "Core 1 extending beta-1,3-N-acetylglucosaminyltransferase",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q5JCS9"
        },
        {
            "name": "Core1-beta3GlcNAcT",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q5JCS9"
        },
        {
            "name": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3 precursor",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082465",
            "id": "NP_082465"
        },
        {
            "name": "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q5JCS9"
        },
        {
            "name": "core 1 beta-1,3-N-acetylglucosaminyltransferase; BGnT-3; beta3Gn-T3; beta-1,3-Gn-T3; core1-beta3GlcNAcT; beta-1,3-N-acetylglucosaminyltransferase 3; core 1 extending beta-1,3-N-acetylglucosaminyltransferase; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082465",
            "id": "NP_082465"
        }
    ],
    "function": [
        {
            "annotation": "Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides. Also acts as a core1-1,3-N-acetylglucosaminyltransferase (Core1-beta3GlcNAcT) to form the 6-sulfo sialyl Lewis x on extended core1 O-glycans.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q5JCS9",
                    "url": "https://www.uniprot.org/uniprot/Q5JCS9#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q9Y2A9",
                    "url": "https://www.uniprot.org/uniprot/Q9Y2A9#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q5JCS9",
                    "url": "https://www.uniprot.org/uniprot/Q5JCS9"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "B3gnt3",
            "url": "https://www.uniprot.org/uniprot/Q5JCS9",
            "locus": {
                "chromosome": "8",
                "start_pos": 72143400,
                "end_pos": 72154433,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000031803",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000031803"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000031803",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000031803",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "GT31",
            "url": "http://www.cazy.org/GT31.html",
            "database": "CAZy",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "72297",
            "url": "https://www.ncbi.nlm.nih.gov/gene/72297",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "GPDB0005317",
            "url": "https://acgg.asia/db/gpdb/symbol/GPDB0005317",
            "database": "GlycoProtDB",
            "categories": [
                "Glycoproteomics"
            ]
        },
        {
            "id": "IPR002659",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002659",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:72297",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:72297",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "2152535",
            "url": "http://www.informatics.jax.org/marker/MGI:2152535",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "VSYLQGH",
            "url": "https://omabrowser.org/oma/group/VSYLQGH/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "532757at2759",
            "url": "http://www.orthodb.org/?query=532757at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11214",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11214",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11214:SF370",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11214:SF370",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF01762",
            "url": "http://pfam.xfam.org/family/PF01762",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q5JCS9",
            "url": "http://purl.obolibrary.org/obo/PR_Q5JCS9",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-MMU-2022854",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2022854",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-913709",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-913709",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_082465",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082465",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "14389",
            "url": "https://www.rhea-db.org/rhea/14389",
            "database": "Rhea",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "56220",
            "url": "https://www.rhea-db.org/rhea/56220",
            "database": "Rhea",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "56224",
            "url": "https://www.rhea-db.org/rhea/56224",
            "database": "Rhea",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "Q5JCS9",
            "url": "https://www.uniprot.org/uniprot/Q5JCS9",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q5JCS9-1",
            "url": "https://www.uniprot.org/uniprot/Q5JCS9-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MRLPRQSPYEILLLVLVALLVLLLLLTSKSPPSCSAPERSKEPEDNPGWATGHPRTHPARCRANLSVSSHPDFAGLPLHVRDFLFYRHCRDFPVLREPRVTKCAEPVFLLLAIKSSPANYGRRQMLRTTWARERRVRGAPLRRLFLVGSDRDPQQARKYNRLLELEAQKYGDILQWDFHDSFFNLTLKQVLFLEWQLTYCTNASFVLNGDDDVFAHTDNMVTYLQDHDPDQHLFVGHLIQNVGPIRVPWSKYFIPALVMAEDRYPPYCGGGGFLLSRFTVAALRRAARVLPMFPIDDVFLGMCLQQQGLAPGTHSGVRTAGVFPPSPRVSSFDPCFYRDLLLVHRFLPFEMLLMWDALNQPQLLCGRQSPAY",
        "length": 372,
        "header": "sp|Q5JCS9-1|B3GN3_MOUSE Isoform 1 of N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3  OS=Mus musculus OX=10090 GN=B3gnt3 PE=2 SV=1 CANONICAL=Q5JCS9-1"
    },
    "isoforms": [
        {
            "isoform_ac": "Q5JCS9-1",
            "url": "",
            "sequence": {
                "sequence": "MRLPRQSPYEILLLVLVALLVLLLLLTSKSPPSCSAPERSKEPEDNPGWATGHPRTHPARCRANLSVSSHPDFAGLPLHVRDFLFYRHCRDFPVLREPRVTKCAEPVFLLLAIKSSPANYGRRQMLRTTWARERRVRGAPLRRLFLVGSDRDPQQARKYNRLLELEAQKYGDILQWDFHDSFFNLTLKQVLFLEWQLTYCTNASFVLNGDDDVFAHTDNMVTYLQDHDPDQHLFVGHLIQNVGPIRVPWSKYFIPALVMAEDRYPPYCGGGGFLLSRFTVAALRRAARVLPMFPIDDVFLGMCLQQQGLAPGTHSGVRTAGVFPPSPRVSSFDPCFYRDLLLVHRFLPFEMLLMWDALNQPQLLCGRQSPAY",
                "length": 372,
                "header": "sp|Q5JCS9-1|B3GN3_MOUSE Isoform 1 of N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3  OS=Mus musculus OX=10090 GN=B3gnt3 PE=2 SV=1 CANONICAL=Q5JCS9-1"
            },
            "locus": {
                "chromosome": "8",
                "start_pos": 72146527,
                "end_pos": 72145251,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000034260",
                        "url": "https://www.ensembl.org/id/ENSMUST00000034260"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000034260",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000034260"
                    }
                ]
            }
        }
    ],
    "glycosylation": [
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 184,
            "start_aa": "Asn",
            "end_pos": 184,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn184",
            "evidence": [
                {
                    "id": "Q5JCS9",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/Q5JCS9#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 202,
            "start_aa": "Asn",
            "end_pos": 202,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn202",
            "evidence": [
                {
                    "id": "Q5JCS9",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/Q5JCS9#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 64,
            "start_aa": "Asn",
            "end_pos": 64,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn64",
            "evidence": [
                {
                    "id": "Q5JCS9",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/Q5JCS9#ptm_processing"
                }
            ]
        }
    ],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "enzyme",
        "glycosyltransferase-activity",
        "glycoprotein",
        "glycoprotein_predicted"
    ],
    "publication": [],
    "pathway": [
        {
            "id": "mmu:72297",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:72297",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-2022854",
            "name": "Keratan sulfate biosynthesis",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2022854",
            "resource": "Reactome",
            "description": "Keratan sulfate biosynthesis"
        },
        {
            "id": "R-MMU-913709",
            "name": "O-linked glycosylation of mucins",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-913709",
            "resource": "Reactome",
            "description": "O-linked glycosylation of mucins"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "D3ZX31-1",
            "protein_name": "Hexosyltransferase",
            "gene_name": "B3gnt3",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MRLPRLRPVVSLLLALAALLLLLTCQSPPSCPAPESPTEPKDDPAWAPDLSRAHAAPCRANLSVSAHPAFARLPSHVRDFLLYRHCRDFAVLREPKATKCAQPAFLLLAIKSSPANYGRRQVLRTTWARERRVRGASLRRLFLVGSDRDPQQARKFNRLLELEAKAYGDILQWDFHDSFFNLTLKQVLFLEWQRTHCTNASFVLNGDDDVFAHTDNMVTYLQGRDPDQHLFVGHLIQNVGPIRVPWSKYFIPTLVTAEDKYPPYCGGGGFLLSRFTMAALHRAARVLPIFPIDDVFLGMCLQQQGLAPGAHSGVRTAGVLPPSPRVSSFDPCFYRDLLLVHRFLPFEMLLMWDALSRPQLACGRQSPPLLTGLGGRHP",
                "length": 378
            },
            "evidence": [
                {
                    "id": "45238155",
                    "url": "http://www.informatics.jax.org/homology/45238155",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q9Y2A9-1",
            "protein_name": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3",
            "gene_name": "B3GNT3",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MKYLRHRRPNATLILAIGAFTLLLFSLLVSPPTCKVQEQPPAIPEALAWPTPPTRPAPAPCHANTSMVTHPDFATQPQHVQNFLLYRHCRHFPLLQDVPPSKCAQPVFLLLVIKSSPSNYVRRELLRRTWGRERKVRGLQLRLLFLVGTASNPHEARKVNRLLELEAQTHGDILQWDFHDSFFNLTLKQVLFLQWQETRCANASFVLNGDDDVFAHTDNMVFYLQDHDPGRHLFVGQLIQNVGPIRAFWSKYYVPEVVTQNERYPPYCGGGGFLLSRFTAAALRRAAHVLDIFPIDDVFLGMCLELEGLKPASHSGIRTSGVRAPSQRLSSFDPCFYRDLLLVHRFLPYEMLLMWDALNQPNLTCGNQTQIY",
                "length": 372
            },
            "evidence": [
                {
                    "id": "45238155",
                    "url": "http://www.informatics.jax.org/homology/45238155",
                    "database": "MGI"
                },
                {
                    "id": "Q5JCS9",
                    "url": "https://omabrowser.org/oma/group/Q5JCS9/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "Golgi membrane",
                        "id": "GO:0000139",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5JCS9",
                                "url": "https://www.uniprot.org/uniprot/Q5JCS9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "membrane",
                        "id": "GO:0016020",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5JCS9",
                                "url": "https://www.uniprot.org/uniprot/Q5JCS9"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 2,
                "go_terms": [
                    {
                        "name": "protein O-linked glycosylation",
                        "id": "GO:0006493",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006493",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5JCS9",
                                "url": "https://www.uniprot.org/uniprot/Q5JCS9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "poly-N-acetyllactosamine biosynthetic process",
                        "id": "GO:0030311",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030311",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5JCS9",
                                "url": "https://www.uniprot.org/uniprot/Q5JCS9"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity",
                        "id": "GO:0008532",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008532",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5JCS9",
                                "url": "https://www.uniprot.org/uniprot/Q5JCS9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity",
                        "id": "GO:0008457",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008457",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5JCS9",
                                "url": "https://www.uniprot.org/uniprot/Q5JCS9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity",
                        "id": "GO:0047223",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047223",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q5JCS9",
                                "url": "https://www.uniprot.org/uniprot/Q5JCS9"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 184,
            "end_pos": 186,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 202,
            "end_pos": 204,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 64,
            "end_pos": 66,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [
        {
            "id": "14389",
            "name": "",
            "equation": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP",
            "summary": "",
            "cellular_location": "",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q9Y2A9-1",
                "Q9C0J1-1",
                "Q9NY97-1",
                "Q9Z222-1",
                "Q1RLK6-1",
                "Q5JCS9-1"
            ],
            "evidence": [
                {
                    "id": "14389",
                    "database": "Rhea",
                    "url": "https://www.rhea-db.org/rhea/14389"
                }
            ]
        },
        {
            "id": "56220",
            "name": "",
            "equation": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + H(+) + UDP",
            "summary": "",
            "cellular_location": "",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q9Y2A9-1",
                "Q5JCS9-1"
            ],
            "evidence": [
                {
                    "id": "56220",
                    "database": "Rhea",
                    "url": "https://www.rhea-db.org/rhea/56220"
                }
            ]
        },
        {
            "id": "56224",
            "name": "",
            "equation": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + H(+) + UDP",
            "summary": "",
            "cellular_location": "",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q9Y2A9-1",
                "Q5JCS9-1"
            ],
            "evidence": [
                {
                    "id": "56224",
                    "database": "Rhea",
                    "url": "https://www.rhea-db.org/rhea/56224"
                }
            ]
        },
        {
            "id": "R-MMU-2025724",
            "name": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "Golgi lumen, Golgi membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q8BWP8-1",
                "Q1RLK6-1",
                "Q5JCS9-1",
                "Q8K0J2-1",
                "Q9Z222-1"
            ],
            "evidence": [
                {
                    "id": "R-MMU-2025724",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2025724"
                }
            ]
        },
        {
            "id": "R-MMU-914010",
            "name": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "Golgi lumen, Golgi membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q8R3I9-1",
                "Q3USF0-1",
                "Q1RLK6-1",
                "Q3U129-1",
                "Q5JCS9-1",
                "Q8BGY6-1",
                "Q8K0J2-1",
                "Q8VI16-1",
                "Q9Z222-1"
            ],
            "evidence": [
                {
                    "id": "R-MMU-914010",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-914010"
                }
            ]
        }
    ],
    "reaction_participants": [],
    "reaction_enzymes": [
        {
            "uniprot_ac": "Q1RLK6",
            "gene_name": "B3gnt4",
            "activity": [
                {
                    "ec_number": "2.4.1.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q1RLK6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q1RLK6"
                        }
                    ]
                },
                {
                    "ec_number": "2.4.1.149",
                    "activity": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP.",
                    "evidence": [
                        {
                            "id": "Q1RLK6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q1RLK6"
                        }
                    ]
                },
                {
                    "ec_number": "2.4.1.149",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q1RLK6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q1RLK6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q3U129",
            "gene_name": "B3gntl1",
            "activity": [
                {
                    "ec_number": "2.4.1.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q3U129",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q3U129"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q3USF0",
            "gene_name": "B3gnt6",
            "activity": [
                {
                    "ec_number": "2.4.1.147",
                    "activity": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP.",
                    "evidence": [
                        {
                            "id": "Q3USF0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q3USF0"
                        }
                    ]
                },
                {
                    "ec_number": "2.4.1.147",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q3USF0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q3USF0"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q5JCS9",
            "gene_name": "B3gnt3",
            "activity": [
                {
                    "ec_number": "2.4.1.149",
                    "activity": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP.",
                    "evidence": [
                        {
                            "id": "Q5JCS9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5JCS9"
                        }
                    ]
                },
                {
                    "ec_number": "2.4.1.146",
                    "activity": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + H(+) + UDP.",
                    "evidence": [
                        {
                            "id": "Q5JCS9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5JCS9"
                        }
                    ]
                },
                {
                    "ec_number": "2.4.1.149",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q5JCS9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5JCS9"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8BGY6",
            "gene_name": "B3gnt5",
            "activity": [
                {
                    "ec_number": "2.4.1.206",
                    "activity": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine = a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP.",
                    "evidence": [
                        {
                            "id": "Q8BGY6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8BGY6"
                        }
                    ]
                },
                {
                    "ec_number": "2.4.1.206",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8BGY6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8BGY6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8BWP8",
            "gene_name": "B4gat1",
            "activity": [
                {
                    "ec_number": "2.4.1.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8BWP8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8BWP8"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8K0J2",
            "gene_name": "B3gnt7",
            "activity": [
                {
                    "ec_number": "2.4.1.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8K0J2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8K0J2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8R3I9",
            "gene_name": "B3gnt8",
            "activity": [
                {
                    "ec_number": "2.4.1.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8R3I9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8R3I9"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q8VI16",
            "gene_name": "B3gnt9",
            "activity": [
                {
                    "ec_number": "2.4.1.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q8VI16",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q8VI16"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9C0J1",
            "gene_name": "B3GNT4",
            "activity": [
                {
                    "ec_number": "2.4.1.149",
                    "activity": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP.",
                    "evidence": [
                        {
                            "id": "Q9C0J1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9C0J1"
                        }
                    ]
                },
                {
                    "ec_number": "2.4.1.149",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9C0J1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9C0J1"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9NY97",
            "gene_name": "B3GNT2",
            "activity": [
                {
                    "ec_number": "2.4.1.149",
                    "activity": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP.",
                    "evidence": [
                        {
                            "id": "Q9NY97",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9NY97"
                        }
                    ]
                },
                {
                    "ec_number": "2.4.1.149",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9NY97",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9NY97"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9Y2A9",
            "gene_name": "B3GNT3",
            "activity": [
                {
                    "ec_number": "2.4.1.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9Y2A9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9Y2A9"
                        }
                    ]
                },
                {
                    "ec_number": "2.4.1.149",
                    "activity": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP.",
                    "evidence": [
                        {
                            "id": "Q9Y2A9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9Y2A9"
                        }
                    ]
                },
                {
                    "ec_number": "2.4.1.146",
                    "activity": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + H(+) + UDP.",
                    "evidence": [
                        {
                            "id": "Q9Y2A9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9Y2A9"
                        }
                    ]
                },
                {
                    "ec_number": "2.4.1.149",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9Y2A9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9Y2A9"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9Z222",
            "gene_name": "B3GNT2",
            "activity": [
                {
                    "ec_number": "2.4.1.149",
                    "activity": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP.",
                    "evidence": [
                        {
                            "id": "Q9Z222",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9Z222"
                        }
                    ]
                },
                {
                    "ec_number": "2.4.1.149",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9Z222",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9Z222"
                        }
                    ]
                }
            ]
        }
    ],
    "biomarkers": [],
    "synthesized_glycans": [
        {
            "glytoucan_ac": "G00069YC",
            "type": "O-linked",
            "subtype": "Core 2"
        },
        {
            "glytoucan_ac": "G00164QP",
            "type": "O-linked",
            "subtype": "Core 2"
        },
        {
            "glytoucan_ac": "G00287UD",
            "type": "O-linked",
            "subtype": "Core 1"
        },
        {
            "glytoucan_ac": "G00376RB",
            "type": "O-linked",
            "subtype": "Core 2"
        },
        {
            "glytoucan_ac": "G00560KG",
            "type": "O-linked",
            "subtype": "Core 2"
        },
        {
            "glytoucan_ac": "G00569WM",
            "type": "O-linked",
            "subtype": "Core 3"
        },
        {
            "glytoucan_ac": "G00675GF",
            "type": "Other",
            "subtype": "Other"
        },
        {
            "glytoucan_ac": "G00872ZT",
            "type": "O-linked",
            "subtype": "Core 1"
        },
        {
            "glytoucan_ac": "G00891GP",
            "type": "O-linked",
            "subtype": "Core 1"
        },
        {
            "glytoucan_ac": "G00967VH",
            "type": "O-linked",
            "subtype": "Core 1"
        },
        {
            "glytoucan_ac": "G00979XR",
            "type": "O-linked",
            "subtype": "Core 2"
        },
        {
            "glytoucan_ac": "G01116MS",
            "type": "O-linked",
            "subtype": "Core 1"
        },
        {
            "glytoucan_ac": "G01316HN",
            "type": "O-linked",
            "subtype": "Core 1"
        },
        {
            "glytoucan_ac": "G01450RG",
            "type": "O-linked",
            "subtype": "Core 1"
        },
        {
            "glytoucan_ac": "G01520KE",
            "type": "O-linked",
            "subtype": "Core 2"
        },
        {
            "glytoucan_ac": "G01546PE",
            "type": "O-linked",
            "subtype": "Core 1"
        },
        {
            "glytoucan_ac": "G01666SB",
            "type": "O-linked",
            "subtype": "Core 1"
        },
        {
            "glytoucan_ac": "G01674VT",
            "type": "O-linked",
            "subtype": "Core 2"
        },
        {
            "glytoucan_ac": "G01682LD",
            "type": "O-linked",
            "subtype": "Core 1"
        },
        {
            "glytoucan_ac": "G01802HL",
            "type": "O-linked",
            "subtype": "Core 2"
        },
        {
            "glytoucan_ac": "G01879FC",
            "type": "O-linked",
            "subtype": "Core 2"
        },
        {
            "glytoucan_ac": "G02078ZZ",
            "type": "O-linked",
            "subtype": "Core 2"
        },
        {
            "glytoucan_ac": "G02150AC",
            "type": "O-linked",
            "subtype": "Core 2"
        },
        {
            "glytoucan_ac": "G02297WO",
            "type": "Other",
            "subtype": "Other"
        },
        {
            "glytoucan_ac": "G02353KU",
            "type": "O-linked",
            "subtype": "Core 1"
        },
        {
            "glytoucan_ac": "G02379AH",
            "type": "O-linked",
            "subtype": "Core 2"
        },
        {
            "glytoucan_ac": "G02403ZU",
            "type": "O-linked",
            "subtype": "Core 2"
        },
        {
            "glytoucan_ac": "G02613LD",
            "type": "O-linked",
            "subtype": "Core 1"
        },
        {
            "glytoucan_ac": "G02799CL",
            "type": "O-linked",
            "subtype": "Core 1"
        },
        {
            "glytoucan_ac": "G02844SX",
            "type": "O-linked",
            "subtype": "Core 1"
        },
        {
            "glytoucan_ac": "G02873KW",
            "type": "O-linked",
            "subtype": "Core 1"
        },
        {
            "glytoucan_ac": "G02912JK",
            "type": "O-linked",
            "subtype": "Core 2"
        },
        {
            "glytoucan_ac": "G02990AF",
            "type": "O-linked",
            "subtype": "Core 2"
        },
        {
            "glytoucan_ac": "G03049NB",
            "type": "O-linked",
            "subtype": "Core 1"
        },
        {
            "glytoucan_ac": "G03140AX",
            "type": "O-linked",
            "subtype": "Core 2"
        },
        {
            "glytoucan_ac": "G03505EQ",
            "type": "O-linked",
            "subtype": "Core 1"
        },
        {
            "glytoucan_ac": "G03796EF",
            "type": "O-linked",
            "subtype": "Core 1"
        },
        {
            "glytoucan_ac": "G03989SP",
            "type": "O-linked",
            "subtype": "Core 1"
        },
        {
            "glytoucan_ac": "G04043RM",
            "type": "O-linked",
            "subtype": "Core 2"
        },
        {
            "glytoucan_ac": "G04130SK",
            "type": "O-linked",
            "subtype": "Core 1"
        },
        {
            "glytoucan_ac": "G04185QP",
            "type": "O-linked",
            "subtype": "Core 2"
        },
        {
            "glytoucan_ac": "G04324CR",
            "type": "O-linked",
            "subtype": "Core 2"
        },
        {
            "glytoucan_ac": "G04421LE",
            "type": "O-linked",
            "subtype": "Core 2"
        },
        {
            "glytoucan_ac": "G04478DK",
            "type": "O-linked",
            "subtype": "Core 2"
        },
        {
            "glytoucan_ac": "G04513DL",
            "type": "O-linked",
            "subtype": "Core 1"
        },
        {
            "glytoucan_ac": "G04608YG",
            "type": "O-linked",
            "subtype": "Core 1"
        },
        {
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