{ "uniprot_canonical_ac": "Q5I6B8-1", "uniprot_ac": "Q5I6B8", "uniprot_id": "PI51C_RAT", "mass": { "chemical_mass": 75594.0, "monoisotopic_mass": 75594.0 }, "refseq": { "ac": "NP_001009967", "name": "phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform c", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009967" }, "gene_names": [ { "name": "Pip5k1c", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q5I6B8", "id": "Q5I6B8" }, { "name": "Pip5k1c", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009967", "id": "NP_001009967" } ], "protein_names": [ { "name": "Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q5I6B8" }, { "name": "2.7.1.68", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q5I6B8" }, { "name": "PIP5K1-gamma", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q5I6B8" }, { "name": "PIP5KIgamma; ptdInsPKIgamma; ptdIns(4)P-5-kinase gamma; PIP5K1-gamma; ptdIns(4)P-5-kinase 1 gamma; phosphatidylinositol 4-phosphate 5-kinase type I gamma", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009967", "id": "NP_001009967" }, { "name": "PIP5KIgamma", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q5I6B8" }, { "name": "Phosphatidylinositol 4-phosphate 5-kinase type I gamma", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q5I6B8" }, { "name": "PtdIns(4)P-5-kinase 1 gamma", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q5I6B8" }, { "name": "phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform c", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009967", "id": "NP_001009967" } ], "function": [ { "annotation": "Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility. PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Together with PIP5K1A, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity). Promotes particle attachment by generating the pool of PtdIns(4,5)P2 that induces controlled actin depolymerization to facilitate Fc-gamma-R clustering. Mediates RAC1-dependent reorganization of actin filaments (By similarity). Required for synaptic vesicle transport (By similarity). Controls the plasma membrane pool of PtdIns(4,5)P2 implicated in synaptic vesicle endocytosis and exocytosis. Plays a role in endocytosis mediated by clathrin and AP-2 (adaptor protein complex 2) (PubMed:12847086). Required for clathrin-coated pits assembly at the synapse (PubMed:12847086). Participates in cell junction assembly. Modulates adherens junctions formation by facilitating CDH1/cadherin trafficking. Required for focal adhesion dynamics. Modulates the targeting of talins (TLN1 and TLN2) to the plasma membrane and their efficient assembly into focal adhesions. Regulates the interaction between talins (TLN1 and TLN2) and beta-integrins (By similarity). Required for uropodium formation and retraction of the cell rear during directed migration. Has a role in growth factor-stimulated directional cell migration and adhesion (By similarity). Required for talin assembly into nascent adhesions forming at the leading edge toward the direction of the growth factor (By similarity). Negative regulator of T-cell activation and adhesion. Negatively regulates integrin alpha-L/beta-2 (LFA-1) polarization and adhesion induced by T-cell receptor. Together with PIP5K1A has a role during embryogenesis and together with PIP5K1B may have a role immediately after birth (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8#function" }, { "database": "UniProtKB", "id": "P70182", "url": "https://www.uniprot.org/uniprot/P70182#function" }, { "database": "UniProtKB", "id": "O70161", "url": "https://www.uniprot.org/uniprot/O70161#function" }, { "database": "UniProtKB", "id": "O60331", "url": "https://www.uniprot.org/uniprot/O60331#function" }, { "database": "PubMed", "id": "12847086", "url": "https://glygen.org/publication/PubMed/12847086" } ] } ], "disease": [ { "disease_id": "DOID:0060653", "recommended_name": { "id": "DOID:0060653", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060653", "name": "lethal congenital contracture syndrome 3", "description": "A lethal congenital contracture syndrome that has_material_basis_in homozygous mutation in the PIP5K1C gene on chromosome 19p13." }, "synonyms": [ { "id": "DOID:0060653", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060653", "name": "Israeli Bedouin type B multiple contracture syndrome", "description": "" }, { "id": "MONDO:0012656", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012656", "name": "lethal congenital contracture syndrome 3", "description": "Lethal congenital contracture syndrome type 3 is a rare arthrogryposis syndrome characterized by clinical features identical to Lethal congenital contracture syndrome type 2 (i.e. multiple congenital contactures (typically extended elbows and flexed knees), micrognathia, anterior horn cells degeneration, skeletal muscle atrophy (mainly in the lower limbs), in the absence of hydrops, pterygia or bone fractures), but without bladder enlargement." }, { "id": "MONDO:0012656", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012656", "name": "Israeli Bedouin type B multiple contracture syndrome", "description": "" }, { "id": "MONDO:0012656", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012656", "name": "LCCS3", "description": "" }, { "id": "MONDO:0012656", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012656", "name": "PIP5K1C lethal congenital contracture syndrome", "description": "" }, { "id": "MONDO:0012656", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012656", "name": "lethal congenital contractural syndrome 3", "description": "" }, { "id": "MONDO:0012656", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012656", "name": "lethal congenital contracture syndrome 3", "description": "" }, { "id": "MONDO:0012656", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012656", "name": "lethal congenital contracture syndrome caused by mutation in PIP5K1C", "description": "" }, { "id": "MONDO:0012656", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012656", "name": "lethal congenital contracture syndrome type 3", "description": "" }, { "id": "MONDO:0012656", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012656", "name": "multiple contracture syndrome, Israeli Bedouin type B", "description": "" }, { "id": "MIM:611369", "resource": "MIM", "url": "https://www.omim.org/entry/611369", "name": "Lethal congenital contracture syndrome 3", "description": "Lethal congenital contracture syndrome 3" } ], "evidence": [ { "id": "0060653", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060653" } ] }, { "disease_id": "DOID:162", "recommended_name": { "id": "DOID:162", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:162", "name": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis." }, "synonyms": [ { "id": "DOID:162", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:162", "name": "malignant neoplasm", "description": "" }, { "id": "DOID:162", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:162", "name": "malignant tumor", "description": "" }, { "id": "DOID:162", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:162", "name": "primary cancer", "description": "" } ], "evidence": [ { "id": "162", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:162" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 188, "end_pos": 188, "sequence_org": "K", "sequence_mut": "A", "comment": "Reduces activity by over 99%.", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" }, { "database": "PubMed", "id": "14741049", "url": "https://glygen.org/publication/PubMed/14741049" } ] }, { "start_pos": 316, "end_pos": 316, "sequence_org": "D", "sequence_mut": "K", "comment": "Loss of kinase activity.", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" }, { "database": "PubMed", "id": "14741049", "url": "https://glygen.org/publication/PubMed/14741049" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "common_name": "Rat" } ], "gene": [ { "name": "Pip5k1c", "url": "https://www.uniprot.org/uniprot/Q5I6B8", "locus": { "chromosome": "7", "start_pos": 8397406, "end_pos": 8425988, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000020577", "url": "https://www.ensembl.org/id/ENSRNOG00000020577" } ] } } ], "crossref": [ { "id": "ENSRNOG00000020577", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000020577", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17308", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17308", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "314641", "url": "https://www.ncbi.nlm.nih.gov/gene/314641", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002498", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002498", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023610", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023610", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027484", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027484", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:314641", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:314641", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YKFMSNT", "url": "https://omabrowser.org/oma/group/YKFMSNT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5481504at2759", "url": "http://www.orthodb.org/?query=5481504at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23086", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23086", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23086:SF26", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23086:SF26", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01504", "url": "http://pfam.xfam.org/family/PF01504", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q5I6B8", "url": "http://purl.obolibrary.org/obo/PR_Q5I6B8", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-1660499", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1660499", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-399955", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-399955", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-6811558", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6811558", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-8856828", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8856828", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001009967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009967", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1309938", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1309938", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "14425", "url": "https://www.rhea-db.org/rhea/14425", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40363", "url": "https://www.rhea-db.org/rhea/40363", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40367", "url": "https://www.rhea-db.org/rhea/40367", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40375", "url": "https://www.rhea-db.org/rhea/40375", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40379", "url": "https://www.rhea-db.org/rhea/40379", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40383", "url": "https://www.rhea-db.org/rhea/40383", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40387", "url": "https://www.rhea-db.org/rhea/40387", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0G2JU72", "url": "https://www.uniprot.org/uniprot/A0A0G2JU72", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JU72-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JU72-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5XWP7", "url": "https://www.uniprot.org/uniprot/A0A8I5XWP7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5XWP7-1", "url": "https://www.uniprot.org/uniprot/A0A8I5XWP7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6A3A3", "url": "https://www.uniprot.org/uniprot/A0A8I6A3A3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6A3A3-1", "url": "https://www.uniprot.org/uniprot/A0A8I6A3A3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6ARF9", "url": "https://www.uniprot.org/uniprot/A0A8I6ARF9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6ARF9-1", "url": "https://www.uniprot.org/uniprot/A0A8I6ARF9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1M8H6", "url": "https://www.uniprot.org/uniprot/F1M8H6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1M8H6-1", "url": "https://www.uniprot.org/uniprot/F1M8H6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5I6B8-1", "url": "https://www.uniprot.org/uniprot/Q5I6B8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELEVPDEAESAEAGAVTAEAAWSAESGAAAGMTQKKAILAEAPLVTGQPGPGHGKKLGHRGVDASGETTYKKTTSSTLKGAIQLGIGYTVGNLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSVFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMNNVLPRVVKMHLKFDLKGSTYKRRASKKEKEKSLPTYKDLDFMQDMPEGLLLDSDTFGALVKTLQRDCLVLESFKIMDYSLLLGVHNIDQQERERQAEGAQSKADEKRPVAQKALYSTARESIQGGAARGEAIETDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHDGDTVSVHRPSFYAERFFKFMSSTVFRKSSSLKSSPSKKGRGALLAVKPLGPTAAFSASQIPSEREDVQYDLRGARSYPTLEDEGRPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSDTSEQPRYRRRTQSSGQDGRPQEELHAEDLQKITVQVEPVCGVGVVVPKEQGAGVEVPPSGASAAATVEVDAASQASEPASQASDEEDAPSTDIYFFAHGRYWLFSPRRRRLRAVTPSHTGAPTDGRSWVYSPLHYSARPASDGESDT", "length": 688, "header": "sp|Q5I6B8-1|PI51C_RAT Isoform 1 of Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma OS=Rattus norvegicus OX=10116 GN=Pip5k1c PE=1 SV=1 CANONICAL=Q5I6B8-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JU72-1", "url": "", "sequence": { "sequence": "MELEVPDEAESAEAGAVTAEAAWSAESGAAAGMTQKKAILAEAPLVTGQPGPGHGKKLGHRGVDASGETTYKKTTSSTLKGAIQLGIGYTVGNLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSVFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMNNVLPRVVKMHLKFDLKGSTYKRRASKKEKEKSLPTYKDLDFMQDMPEGLLLDSDTFGALVKTLQRDCLVLESFKIMDYSLLLGVHNIDQQERERQAEGAQSKADEKRPVAQKALYSTAMESIQGGAARGEAIETDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHDGDTVSVHRPSFYAERFFKFMSSTVFRKSSSLKSSPSKKGRGALLAVKPLGPTAAFSASQIPSEREDVQYDLRGARSYPTLEDEGRPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSDTSEQPRYRRRTQSSGQDGRHYRPGRLPEPSDPPASQFQTPAPQRGPLATGPPACSANALQASAGPSGCPRLGPPQARTPREPGIACSSGVGEETEVGPSSAGPRRSCMRKTCRR", "length": 655, "header": "tr|A0A0G2JU72-1|PI51C_RAT Computationally mapped isoform of Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma OS=Rattus norvegicus OX=10116 GN=Pip5k1c PE=1 SV=1 CANONICAL=Q5I6B8-1" }, "locus": { "chromosome": "7", "start_pos": 8425927, "end_pos": 8403308, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000088364.2", "url": "https://www.ensembl.org/id/ENSRNOT00000088364.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000068990.2", "url": "https://www.ensembl.org/id/ENSRNOP00000068990.2" } ] } }, { "isoform_ac": "A0A8I5XWP7-1", "url": "", "sequence": { "sequence": "MELEVPDEAESAEAGAVTAEAAWSAESGAAAGMTQKKAILAEAPLVTGQPGPGHGKKLGHRGVDASGETTYKKTTSSTLKGAIQLGIGYTVGNLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSVFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMNNVLPRVVKMHLKFDLKGSTYKRRASKKEKEKSLPTYKDLDFMQDMPEGLLLDSDTFGALVKTLQRDCLVLESFKIMDYSLLLGVHNIDQQERERQAEGAQSKADEKRPVAQKALYSTAMESIQGGAARGEAIETDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHDGDTVSVHRPSFYAERFFKFMSSTVFRKSSSLKSSPSKKGRGALLAVKPLGPTAAFSASQIPSEREDVQYDLRGARSYPTLEDEGRPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSDTSEQPRYRNCMQPQEELHAEDLQKITVQVEPVCGVGVVVPKEQGAGVEVPPSGASAAATVEVDAASQASEPASQASDEEDAPSTDIYFVSSPKGSRGCGQSQLLLSLV", "length": 649, "header": "tr|A0A8I5XWP7-1|A0A8I5XWP7_RAT Computationally mapped isoform of Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma OS=Rattus norvegicus OX=10116 GN=Pip5k1c PE=1 SV=1 CANONICAL=Q5I6B8-1" }, "locus": { "chromosome": "7", "start_pos": 8425927, "end_pos": 8402254, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000107025.1", "url": "https://www.ensembl.org/id/ENSRNOT00000107025.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000077990.1", "url": "https://www.ensembl.org/id/ENSRNOP00000077990.1" } ] } }, { "isoform_ac": "A0A8I6A3A3-1", "url": "", "sequence": { "sequence": "MCPPSPGMTQKKAILAEAPLVTGQPGPGHGKKLGHRGVDASGETTYKKTTSSTLKGAIQLGIGYTVGNLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSVFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMNNVLPRVVKMHLKFDLKGSTYKRRASKKEKEKSLPTYKDLDFMQDMPEGLLLDSDTFGALVKTLQRDCLVLESFKIMDYSLLLGVHNIDQQERERQAEGAQSKADEKRPVAQKALYSTAMESIQGGAARGEAIETDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHDGDTVSVHRPSFYAERFFKFMSSTVFRKSSSLKSSPSKKGRGALLAVKPLGPTAAFSASQIPSEREDVQYDLRGARSYPTLEDEGRPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSDTSEQPRYRRRTQSSGQDGRPQEELHAEDLQKITVQVEPVCGVGVVVPKEQGAGVEVPPSGASAAATVEVDAASQASEPASQASDEEDAPSTDIYF", "length": 611, "header": "tr|A0A8I6A3A3-1|A0A8I6A3A3_RAT Computationally mapped isoform of Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma OS=Rattus norvegicus OX=10116 GN=Pip5k1c PE=1 SV=1 CANONICAL=Q5I6B8-1" }, "locus": { "chromosome": "7", "start_pos": 8412470, "end_pos": 8402314, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000095691.1", "url": "https://www.ensembl.org/id/ENSRNOT00000095691.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000086276.1", "url": "https://www.ensembl.org/id/ENSRNOP00000086276.1" } ] } }, { "isoform_ac": "A0A8I6ARF9-1", "url": "", "sequence": { "sequence": "MCPPSPGMTQKKAILAEAPLVTGQPGPGHGKKLGHRGVDASGETTYKKTTSSTLKGAIQLGIGYTVGNLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSVFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMNNVLPRVVKMHLKFDLKGSTYKRRASKKEKEKSLPTYKDLDFMQDMPEGLLLDSDTFGALVKTLQRDCLVLESFKIMDYSLLLGVHNIDQQERERQAEGAQSKADEKRPVAQKALYSTAMESIQGGAARGEAIETDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHDGDTVSVHRPSFYAERFFKFMSSTVFRKSSSLKSSPSKKGRGALLAVKPLGPTAAFSASQIPSEREDVQYDLRGARSYPTLEDEGRPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSDTSEQPRYRRRTQSSGQDGRPQEELHAEDLQKITVQVEPVCGVGVVVPKEQGAGVEVPPSGASAAATVEVDAASQASEPASQASDEEDAPSTDIYFPTDERSWVYSPLHYSARPASDGESDT", "length": 637, "header": "tr|A0A8I6ARF9-1|A0A8I6ARF9_RAT Computationally mapped isoform of Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma OS=Rattus norvegicus OX=10116 GN=Pip5k1c PE=1 SV=1 CANONICAL=Q5I6B8-1" }, "locus": { "chromosome": "7", "start_pos": 8412470, "end_pos": 8400019, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000115219.1", "url": "https://www.ensembl.org/id/ENSRNOT00000115219.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000097462.1", "url": "https://www.ensembl.org/id/ENSRNOP00000097462.1" } ] } }, { "isoform_ac": "F1M8H6-1", "url": "", "sequence": { "sequence": "MELEVPDEAESAEAGAVTAEAAWSAESGAAAGMTQKKAILAEAPLVTGQPGPGHGKKLGHRGVDASGETTYKKTTSSTLKGAIQLGIGYTVGNLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSVFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMNNVLPRVVKMHLKFDLKGSTYKRRASKKEKEKSLPTYKDLDFMQDMPEGLLLDSDTFGALVKTLQRDCLVLESFKIMDYSLLLGVHNIDQQERERQAEGAQSKADEKRPVAQKALYSTAMESIQGGAARGEAIETDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHDGDTVSVHRPSFYAERFFKFMSSTVFRKSSSLKSSPSKKGRGALLAVKPLGPTAAFSASQIPSEREDVQYDLRGARSYPTLEDEGRPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSDTSEQPRYRRRTQSSGQDGRPQEELHAEDLQKITVQVEPVCGVGVVVPKEQGAGVEVPPSGASAAATVEVDAASQASEPASQASDEEDAPSTDIYFFAHGRYWLFSPRRRQLRAVTPSHTGAPTDERSWVYSPLHYSARPASDGESDT", "length": 688, "header": "tr|F1M8H6-1|F1M8H6_RAT Computationally mapped isoform of Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma OS=Rattus norvegicus OX=10116 GN=Pip5k1c PE=1 SV=1 CANONICAL=Q5I6B8-1" }, "locus": { "chromosome": "7", "start_pos": 8425927, "end_pos": 8400019, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000061159.5", "url": "https://www.ensembl.org/id/ENSRNOT00000061159.5" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000057873.2", "url": "https://www.ensembl.org/id/ENSRNOP00000057873.2" } ] } }, { "isoform_ac": "Q5I6B8-1", "url": "", "sequence": { "sequence": "MELEVPDEAESAEAGAVTAEAAWSAESGAAAGMTQKKAILAEAPLVTGQPGPGHGKKLGHRGVDASGETTYKKTTSSTLKGAIQLGIGYTVGNLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSVFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMNNVLPRVVKMHLKFDLKGSTYKRRASKKEKEKSLPTYKDLDFMQDMPEGLLLDSDTFGALVKTLQRDCLVLESFKIMDYSLLLGVHNIDQQERERQAEGAQSKADEKRPVAQKALYSTARESIQGGAARGEAIETDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHDGDTVSVHRPSFYAERFFKFMSSTVFRKSSSLKSSPSKKGRGALLAVKPLGPTAAFSASQIPSEREDVQYDLRGARSYPTLEDEGRPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSDTSEQPRYRRRTQSSGQDGRPQEELHAEDLQKITVQVEPVCGVGVVVPKEQGAGVEVPPSGASAAATVEVDAASQASEPASQASDEEDAPSTDIYFFAHGRYWLFSPRRRRLRAVTPSHTGAPTDGRSWVYSPLHYSARPASDGESDT", "length": 688, "header": "sp|Q5I6B8-1|PI51C_RAT Isoform 1 of Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma OS=Rattus norvegicus OX=10116 GN=Pip5k1c PE=1 SV=1 CANONICAL=Q5I6B8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 554, "end_pos": 554, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "Q5I6B8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5I6B8" } ], "site_lbl": "Ser554" }, { "start_pos": 635, "end_pos": 635, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine; by EGFR", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "site_lbl": "Tyr635" }, { "start_pos": 671, "end_pos": 671, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine; by CSK", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "site_lbl": "Tyr671" }, { "start_pos": 672, "end_pos": 672, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by CDK5, MAPK1 and CDK1", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "site_lbl": "Ser672" }, { "start_pos": 682, "end_pos": 682, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "Q5I6B8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5I6B8" } ], "site_lbl": "Ser682" }, { "start_pos": 686, "end_pos": 686, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "Q5I6B8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5I6B8" } ], "site_lbl": "Ser686" }, { "start_pos": 688, "end_pos": 688, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "Q5I6B8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5I6B8" } ], "site_lbl": "Thr688" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma.", "journal": "J. Cell Biol.", "date": "2003", "authors": "Krauss M, Kinuta M, Wenk MR, De Camilli P, Takei K, Haucke V", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "reference": [ { "type": "PubMed", "id": "12847086", "url": "https://glygen.org/publication/PubMed/12847086" } ] }, { "title": "A novel neuronal-specific splice variant of Type I phosphatidylinositol 4-phosphate 5-kinase isoform gamma.", "journal": "Biochem. J.", "date": "2004", "authors": "Giudici ML, Emson PC, Irvine RF", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "reference": [ { "type": "PubMed", "id": "14741049", "url": "https://glygen.org/publication/PubMed/14741049" } ] }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nature communications", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" }, { "database": "UniProtKB", "id": "A0A0G2JU72", "url": "https://www.uniprot.org/uniprot/A0A0G2JU72" }, { "database": "UniProtKB", "id": "F1M8H6", "url": "https://www.uniprot.org/uniprot/F1M8H6" }, { "database": "iPTMnet", "id": "Q5I6B8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q5I6B8" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] } ], "pathway": [ { "id": "rno:314641", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:314641", "resource": "KEGG Pathway" }, { "id": "R-RNO-1660499", "name": "Synthesis of PIPs at the plasma membrane", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1660499", "resource": "Reactome", "description": "Synthesis of PIPs at the plasma membrane" }, { "id": "R-RNO-399955", "name": "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-399955", "resource": "Reactome", "description": "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion" }, { "id": "R-RNO-6811558", "name": "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6811558", "resource": "Reactome", "description": "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling" }, { "id": "R-RNO-8856828", "name": "Clathrin-mediated endocytosis", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8856828", "resource": "Reactome", "description": "Clathrin-mediated endocytosis" } ], "orthologs": [ { "uniprot_canonical_ac": "O60331-1", "protein_name": "Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma", "gene_name": "PIP5K1C", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MELEVPDEAESAEAGAVPSEAAWAAESGAAAGLAQKKAAPTEVLSMTAQPGPGHGKKLGHRGVDASGETTYKKTTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMNNILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLVLESFKIMDYSLLLGVHNIDQHERERQAQGAQSTSDEKRPVGQKALYSTAMESIQGGAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHDGDTVSVHRPSFYAERFFKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTLEDEGRPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVPKEEDAGVEASPAGASAAVEVETASQASDEEGAPASQASDEEDAPATDIYFPTDERSWVYSPLHYSAQAPPASDGESDT", "length": 668 }, "evidence": [ { "id": "45228768", "url": "http://www.informatics.jax.org/homology/45228768", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "O70161-1", "protein_name": "Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma", "gene_name": "Pip5k1c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MELEVPDEAESAEAGAVTAEAAWSAESGAAAGMTQKKAGLAEAPLVTGQPGPGHGKKLGHRGVDASGETTYKKTTSSTLKGAIQLGIGYTVGNLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSVFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMNNVLPRVVKMHLKFDLKGSTYKRRASKKEKEKSLPTYKDLDFMQDMPEGLLLDSDTFGALVKTLQRDCLVLESFKIMDYSLLLGVHNIDQQERERQAEGAQSKADEKRPVAQKALYSTAMESIQGGAARGEAIETDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHDGDTVSVHRPSFYAERFFKFMSSTVFRKSSSLKSSPSKKGRGALLAVKPLGPTAAFSASQIPSEREDVQYDLRGARSYPTLEDEGRPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSDTSEQPRYRRRTQSSGQDGRPQEEPHAEDLQKITVQVEPVCGVGVVPKEEGAGVEVPPCGASAAASVEIDAASQASEPASQASDEEDAPSTDIYFPTDERSWVYSPLHYSARPASDGESDT", "length": 661 }, "evidence": [ { "id": "45228768", "url": "http://www.informatics.jax.org/homology/45228768", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "pmid": "" }, { "name": "kinase activity", "id": "GO:0016301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016301", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "pmid": "" }, { "name": "1-phosphatidylinositol-4-phosphate 5-kinase activity", "id": "GO:0016308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016308", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 11, "go_terms": [ { "name": "phosphorylation", "id": "GO:0016310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016310", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "pmid": "" }, { "name": "phosphatidylinositol phosphate biosynthetic process", "id": "GO:0046854", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046854", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "pmid": "" }, { "name": "chemotaxis", "id": "GO:0006935", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006935", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "pmid": "" }, { "name": "axonogenesis", "id": "GO:0007409", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007409", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "pmid": "" }, { "name": "phagocytosis", "id": "GO:0006909", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006909", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "pmid": "" }, { "name": "platelet aggregation", "id": "GO:0070527", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070527", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "pmid": "" }, { "name": "phosphatidylinositol biosynthetic process", "id": "GO:0006661", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006661", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "pmid": "" }, { "name": "exocytosis", "id": "GO:0006887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006887", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "pmid": "" }, { "name": "phosphatidylinositol metabolic process", "id": "GO:0046488", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046488", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "pmid": "" }, { "name": "regulation of synaptic vesicle endocytosis", "id": "GO:1900242", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900242", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "pmid": "" }, { "name": "regulation of postsynaptic neurotransmitter receptor internalization", "id": "GO:0099149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099149", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 12, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "pmid": "" }, { "name": "presynaptic endocytic zone membrane", "id": "GO:0098835", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098835", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "pmid": "" }, { "name": "phagocytic cup", "id": "GO:0001891", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001891", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "pmid": "" }, { "name": "adherens junction", "id": "GO:0005912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005912", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "pmid": "" }, { "name": "postsynaptic density", "id": "GO:0014069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014069", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "pmid": "" }, { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "pmid": "" }, { "name": "ruffle membrane", "id": "GO:0032587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032587", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "pmid": "" }, { "name": "uropod", "id": "GO:0001931", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001931", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q5I6B8", "url": "https://www.uniprot.org/uniprot/Q5I6B8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 121, "end_pos": 123, "annotation": "n_glycosylation_sequon" }, { "start_pos": 93, "end_pos": 95, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "14425", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5I6B8-1", "Q5CZZ9-1", "D3ZSI8-1", "Q5T9C9-1", "Q99755-1", "O14986-1", "O60331-1", "P70181-1", "P70182-1", "O70161-1", "P38994-1" ], "evidence": [ { "id": "14425", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/14425" } ] }, { "id": "40363", "name": "", "equation": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5I6B8-1", "Q5CZZ9-1", "D3ZSI8-1", "O60331-1", "Q99755-1", "O14986-1", "P70181-1", "P70182-1", "O70161-1" ], "evidence": [ { "id": "40363", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40363" } ] }, { "id": "40367", "name": "", "equation": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP = 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5I6B8-1", "Q5CZZ9-1", "D3ZSI8-1", "O60331-1", "Q99755-1", "O14986-1", "P70181-1", "O70161-1", "P70182-1" ], "evidence": [ { "id": "40367", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40367" } ] }, { "id": "40375", "name": "", "equation": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5I6B8-1", "Q5CZZ9-1", "D3ZSI8-1", "O60331-1", "Q99755-1", "O14986-1", "P70181-1", "P70182-1", "O70161-1" ], "evidence": [ { "id": "40375", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40375" } ] }, { "id": "40379", "name": "", "equation": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP = 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5I6B8-1", "Q5CZZ9-1", "D3ZSI8-1", "O60331-1", "Q99755-1", "O14986-1", "P70181-1", "P70182-1", "O70161-1" ], "evidence": [ { "id": "40379", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40379" } ] }, { "id": "40383", "name": "", "equation": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5I6B8-1", "Q5CZZ9-1", "D3ZSI8-1", "O60331-1", "Q99755-1", "O14986-1", "P70181-1", "O70161-1", "P70182-1" ], "evidence": [ { "id": "40383", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40383" } ] }, { "id": "40387", "name": "", "equation": "1,2-di-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP = 1,2-di(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5I6B8-1", "Q5CZZ9-1", "D3ZSI8-1", "O60331-1", "Q99755-1", "O14986-1", "P70181-1", "P70182-1", "O70161-1" ], "evidence": [ { "id": "40387", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40387" } ] }, { "id": "R-RNO-1675773", "name": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5I6B8-1", "D3ZSI8-1", "Q5CZZ9-1" ], "evidence": [ { "id": "R-RNO-1675773", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1675773" } ] }, { "id": "R-RNO-1676082", "name": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5I6B8-1", "D3ZSI8-1", "Q5CZZ9-1" ], "evidence": [ { "id": "R-RNO-1676082", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1676082" } ] }, { "id": "R-RNO-1676145", "name": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-202247" ], "enzyme_list": [ "Q5I6B8-1", "D3ZSI8-1", "Q5CZZ9-1", "Q9R0I8-1", "O88377-1" ], "evidence": [ { "id": "R-RNO-1676145", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1676145" } ] }, { "id": "R-RNO-399936", "name": "Inhibition of integrin activation by sequestering PIP5KIgamma", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-RNO-396935" ], "output_participant_list": [ "R-RNO-350713" ], "enzyme_list": [ "Q5I6B8-1" ], "evidence": [ { "id": "R-RNO-399936", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-399936" } ] }, { "id": "R-RNO-8868066", "name": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5I6B8-1" ], "evidence": [ { "id": "R-RNO-8868066", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8868066" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-202247", "participant_name": "PI(3,4)P2 [plasma membrane]", "crossref": [ { "id": "16152", "database": "ChEBI", "url": "" }, { "id": "16152", "database": "ChEBI", "url": "" }, { "id": "16152", "database": "ChEBI", "url": "" }, { "id": "16152", "database": "ChEBI", "url": "" }, { "id": "16152", "database": "ChEBI", "url": "" }, { "id": "16152", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-RNO-350713", "participant_name": "Tln1 [cytosol]", "crossref": [ { "id": "G3V852", "database": "UniProt", "url": "" }, { "id": "ENSRNOG00000016630", "database": "Ensembl", "url": "" }, { "id": "NP_001034114.2", "database": "RefSeq", "url": "" }, { "id": "1306247", "database": "RGD", "url": "" }, { "id": "ENSRNOP00000022401", "database": "Ensembl", "url": "" }, { "id": "ENSRNOT00000022400", "database": "Ensembl", "url": "" } ] }, { "participant_id": "R-RNO-396935", "participant_name": "Farp2 [cytosol]", "crossref": [ { "id": "1308003", "database": "RGD", "url": "" }, { "id": "ENSRNOT00000024440", "database": "Ensembl", "url": "" }, { "id": "XP_006245594.1", "database": "RefSeq", "url": "" }, { "id": "ENSRNOG00000018051", "database": "Ensembl", "url": "" }, { "id": "ENSRNOP00000024440", "database": "Ensembl", "url": "" }, { "id": "D3ZFK8", "database": "UniProt", "url": "" }, { "id": "NP_001101703.1", "database": "RefSeq", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "D3ZSI8", "gene_name": "Pip5k1a", "activity": [ { "ec_number": "2.7.1.68", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "D3ZSI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZSI8" } ] }, { "ec_number": "2.7.1.68", "activity": "", "evidence": [ { "id": "D3ZSI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZSI8" } ] } ] }, { "uniprot_ac": "O14986", "gene_name": "PIP5K1B", "activity": [ { "ec_number": "2.7.1.68", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "O14986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14986" } ] }, { "ec_number": "2.7.1.68", "activity": "", "evidence": [ { "id": "O14986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14986" } ] } ] }, { "uniprot_ac": "O60331", "gene_name": "PIP5K1C", "activity": [ { "ec_number": "2.7.1.68", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "O60331", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60331" } ] }, { "ec_number": "2.7.1.68", "activity": "", "evidence": [ { "id": "O60331", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60331" } ] } ] }, { "uniprot_ac": "O70161", "gene_name": "Pip5k1c", "activity": [ { "ec_number": "2.7.1.68", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "O70161", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70161" } ] }, { "ec_number": "2.7.1.68", "activity": "", "evidence": [ { "id": "O70161", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70161" } ] } ] }, { "uniprot_ac": "O88377", "gene_name": "Pip4k2b", "activity": [ { "ec_number": "2.7.1.149", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "O88377", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88377" } ] }, { "ec_number": "2.7.1.149", "activity": "", "evidence": [ { "id": "O88377", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88377" } ] } ] }, { "uniprot_ac": "P38994", "gene_name": "MSS4", "activity": [ { "ec_number": "2.7.1.68", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "P38994", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38994" } ] }, { "ec_number": "2.7.1.68", "activity": "", "evidence": [ { "id": "P38994", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38994" } ] } ] }, { "uniprot_ac": "P70181", "gene_name": "Pip5k1b", "activity": [ { "ec_number": "2.7.1.68", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "P70181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70181" } ] }, { "ec_number": "2.7.1.68", "activity": "", "evidence": [ { "id": "P70181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70181" } ] } ] }, { "uniprot_ac": "P70182", "gene_name": "Pip5k1a", "activity": [ { "ec_number": "2.7.1.68", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "P70182", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70182" } ] }, { "ec_number": "2.7.1.68", "activity": "", "evidence": [ { "id": "P70182", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70182" } ] } ] }, { "uniprot_ac": "Q5CZZ9", "gene_name": "Pip5k1b", "activity": [ { "ec_number": "2.7.1.68", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "Q5CZZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5CZZ9" } ] }, { "ec_number": "2.7.1.68", "activity": "", "evidence": [ { "id": "Q5CZZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5CZZ9" } ] } ] }, { "uniprot_ac": "Q5I6B8", "gene_name": "Pip5k1c", "activity": [ { "ec_number": "2.7.1.68", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "Q5I6B8", "database": "UniProtKB", "url": 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