{
    "uniprot_canonical_ac": "Q5EBB0-1",
    "uniprot_ac": "Q5EBB0",
    "uniprot_id": "Q5EBB0_RAT",
    "mass": {
        "chemical_mass": 27916.0,
        "monoisotopic_mass": 27916.0
    },
    "refseq": {
        "ac": "NP_001013963",
        "name": "stratifin like 1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013963"
    },
    "gene_names": [
        {
            "name": "Sfnl1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q5EBB0",
            "id": "Q5EBB0"
        },
        {
            "name": "LOC298795",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q5EBB0",
            "id": "Q5EBB0"
        },
        {
            "name": "Sfnl1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013963",
            "id": "NP_001013963"
        }
    ],
    "protein_names": [
        {
            "name": "14-3-3 protein sigma-like",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013963",
            "id": "NP_001013963"
        },
        {
            "name": "Similar to 14-3-3 protein sigma",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q5EBB0"
        },
        {
            "name": "stratifin like 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013963",
            "id": "NP_001013963"
        }
    ],
    "function": [
        {
            "annotation": "In the absence of PKG activity, we propose that some ATP synthasebeta precursor dissociates from 14-3-3sigma, resulting in its activation and incorporation into the ATP synthase complex, which results in an increase in ATP and apoptosis",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001013963",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013963"
                },
                {
                    "database": "PubMed",
                    "id": "17303654",
                    "url": "https://glygen.org/publication/PubMed/17303654"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:1059",
            "recommended_name": {
                "id": "DOID:1059",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:1059",
                "name": "intellectual disability",
                "description": "A specific developmental disorder that involves significant limitations both in mental functioning and in adaptive behavior such as communicating, taking care of him or herself, and social skills."
            },
            "synonyms": [],
            "evidence": [
                {
                    "id": "1059",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:1059"
                }
            ]
        },
        {
            "disease_id": "DOID:11054",
            "recommended_name": {
                "id": "DOID:11054",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:11054",
                "name": "urinary bladder cancer",
                "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder."
            },
            "synonyms": [
                {
                    "id": "DOID:11054",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:11054",
                    "name": "bladder cancer",
                    "description": ""
                },
                {
                    "id": "DOID:11054",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:11054",
                    "name": "tumor of the bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "urinary bladder cancer",
                    "description": "A primary or metastatic malignant neoplasm involving the bladder."
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "tumor of the bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "tumour of the bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "bladder cancer, somatic",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "cancer of urinary bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant bladder neoplasm",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant bladder tumor",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant bladder tumour",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant neoplasm of bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant neoplasm of the bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant neoplasm of the urinary bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant neoplasm of urinary bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant neoplasm, bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant neoplasm, urinary bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant tumor of bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant tumor of the bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant tumor of the urinary bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant tumor of urinary bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant tumor, urinary bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant tumour of bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant tumour of the bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant tumour of the urinary bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant tumour of urinary bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant urinary bladder neoplasm",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant urinary bladder tumor",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant urinary bladder tumour",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "urinary bladder cancer",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "urinary bladder malignant neoplasm",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "urinary bladder malignant tumor",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "urinary bladder malignant tumour",
                    "description": ""
                },
                {
                    "id": "MIM:109800",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/109800",
                    "name": "Bladder cancer",
                    "description": "Bladder cancer"
                }
            ],
            "evidence": [
                {
                    "id": "11054",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:11054"
                }
            ]
        },
        {
            "disease_id": "DOID:2101",
            "recommended_name": {
                "id": "DOID:2101",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:2101",
                "name": "vulva squamous cell carcinoma",
                "description": "A vulva carcinoma and has_material_basis_in squamous cells and is located_in the epidermis of the vulvar tissue."
            },
            "synonyms": [
                {
                    "id": "DOID:2101",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:2101",
                    "name": "Vulvar Epidermoid carcinoma",
                    "description": ""
                },
                {
                    "id": "DOID:2101",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:2101",
                    "name": "vulvar squamous cell carcinoma",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "2101",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:2101"
                }
            ]
        },
        {
            "disease_id": "DOID:2394",
            "recommended_name": {
                "id": "DOID:2394",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:2394",
                "name": "ovarian cancer",
                "description": "A female reproductive organ cancer that is located_in the ovary."
            },
            "synonyms": [
                {
                    "id": "DOID:2394",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:2394",
                    "name": "malignant Ovarian tumor",
                    "description": ""
                },
                {
                    "id": "DOID:2394",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:2394",
                    "name": "malignant tumour of ovary",
                    "description": ""
                },
                {
                    "id": "DOID:2394",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:2394",
                    "name": "ovarian neoplasm",
                    "description": ""
                },
                {
                    "id": "DOID:2394",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:2394",
                    "name": "ovary neoplasm",
                    "description": ""
                },
                {
                    "id": "DOID:2394",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:2394",
                    "name": "primary ovarian cancer",
                    "description": ""
                },
                {
                    "id": "DOID:2394",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:2394",
                    "name": "tumor of the Ovary",
                    "description": ""
                },
                {
                    "id": "MONDO:0011931",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                    "name": "ovarian cancer, susceptibility to, 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0011931",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                    "name": "OVCAS1",
                    "description": ""
                },
                {
                    "id": "MONDO:0011931",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                    "name": "ovarian cancer, susceptibility to",
                    "description": ""
                },
                {
                    "id": "MONDO:0011931",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                    "name": "ovarian cancer, susceptibility to, 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0008170",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                    "name": "ovarian cancer",
                    "description": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas."
                },
                {
                    "id": "MONDO:0008170",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                    "name": "ovarian neoplasm",
                    "description": ""
                },
                {
                    "id": "MONDO:0008170",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                    "name": "ovary neoplasm",
                    "description": ""
                },
                {
                    "id": "MONDO:0008170",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                    "name": "tumor of the ovary",
                    "description": ""
                },
                {
                    "id": "MONDO:0008170",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                    "name": "tumour of the ovary",
                    "description": ""
                },
                {
                    "id": "MONDO:0008170",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                    "name": "cancer of ovary",
                    "description": ""
                },
                {
                    "id": "MONDO:0008170",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                    "name": "cancer of the ovary",
                    "description": ""
                },
                {
                    "id": "MONDO:0008170",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                    "name": "malignant neoplasm of ovary",
                    "description": ""
                },
                {
                    "id": "MONDO:0008170",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                    "name": "malignant neoplasm of the ovary",
                    "description": ""
                },
                {
                    "id": "MONDO:0008170",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                    "name": "malignant ovarian neoplasm",
                    "description": ""
                },
                {
                    "id": "MONDO:0008170",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                    "name": "malignant ovarian tumor",
                    "description": ""
                },
                {
                    "id": "MONDO:0008170",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                    "name": "malignant ovarian tumour",
                    "description": ""
                },
                {
                    "id": "MONDO:0008170",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                    "name": "malignant ovary neoplasm",
                    "description": ""
                },
                {
                    "id": "MONDO:0008170",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                    "name": "malignant tumor of ovary",
                    "description": ""
                },
                {
                    "id": "MONDO:0008170",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                    "name": "malignant tumor of the ovary",
                    "description": ""
                },
                {
                    "id": "MONDO:0008170",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                    "name": "malignant tumour of ovary",
                    "description": ""
                },
                {
                    "id": "MONDO:0008170",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                    "name": "malignant tumour of the ovary",
                    "description": ""
                },
                {
                    "id": "MONDO:0008170",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                    "name": "ovarian cancer",
                    "description": ""
                },
                {
                    "id": "MONDO:0008170",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                    "name": "ovarian cancer, somatic",
                    "description": ""
                },
                {
                    "id": "MONDO:0008170",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                    "name": "ovarian malignant tumor",
                    "description": ""
                },
                {
                    "id": "MONDO:0008170",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                    "name": "ovarian malignant tumour",
                    "description": ""
                },
                {
                    "id": "MONDO:0008170",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                    "name": "ovary cancer",
                    "description": ""
                },
                {
                    "id": "MONDO:0008170",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                    "name": "ovarian cancer, epithelial",
                    "description": ""
                },
                {
                    "id": "MONDO:0008170",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                    "name": "primary ovarian cancer",
                    "description": ""
                },
                {
                    "id": "MIM:167000",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/167000",
                    "name": "Ovarian cancer",
                    "description": "Ovarian cancer"
                }
            ],
            "evidence": [
                {
                    "id": "2394",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:2394"
                }
            ]
        },
        {
            "disease_id": "DOID:2671",
            "recommended_name": {
                "id": "DOID:2671",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:2671",
                "name": "transitional cell carcinoma",
                "description": "A carcinoma that derives_from transitional epithelial cells."
            },
            "synonyms": [
                {
                    "id": "DOID:2671",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:2671",
                    "name": "transitional carcinoma",
                    "description": ""
                },
                {
                    "id": "DOID:2671",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:2671",
                    "name": "transitional cell tumor",
                    "description": ""
                },
                {
                    "id": "DOID:2671",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:2671",
                    "name": "urothelial cell carcinoma",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "2671",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:2671"
                }
            ]
        },
        {
            "disease_id": "DOID:2871",
            "recommended_name": {
                "id": "DOID:2871",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:2871",
                "name": "endometrial carcinoma",
                "description": "A endometrial cancer that is located_in the tissue lining the uterus."
            },
            "synonyms": [
                {
                    "id": "DOID:2871",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:2871",
                    "name": "endometrioid carcinoma of female Reproductive system",
                    "description": ""
                },
                {
                    "id": "DOID:2871",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:2871",
                    "name": "carcinoma of the Endometrium",
                    "description": ""
                },
                {
                    "id": "DOID:2871",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:2871",
                    "name": "endometrioid carcinoma",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "2871",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:2871"
                }
            ]
        },
        {
            "disease_id": "DOID:8719",
            "recommended_name": {
                "id": "DOID:8719",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:8719",
                "name": "in situ carcinoma",
                "description": "A carcinoma that is an early development defined by the absence of invasion of surrounding tissues."
            },
            "synonyms": [],
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            "title": "Progesterone maintains basal intracellular adenosine triphosphate levels and viability of spontaneously immortalized granulosa cells by promoting an interaction between 14-3-3sigma and ATP synthase beta/precursor through a protein kinase G-dependent mechanism.",
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                    "type": "PubMed",
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