{ "uniprot_canonical_ac": "Q5BJX1-1", "uniprot_ac": "Q5BJX1", "uniprot_id": "RM41_RAT", "mass": { "chemical_mass": 15193.0, "monoisotopic_mass": 15193.0 }, "refseq": { "ac": "NP_001013444", "name": "large ribosomal subunit protein mL41 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013444" }, "gene_names": [ { "name": "Mrpl41", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q5BJX1", "id": "Q5BJX1" }, { "name": "Mrpl41", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013444", "id": "NP_001013444" } ], "protein_names": [ { "name": "Large ribosomal subunit protein mL41", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q5BJX1" }, { "name": "39S ribosomal protein L41, mitochondrial; L41mt; MRP-L41; large ribosomal subunit protein mL41", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013444", "id": "NP_001013444" }, { "name": "39S ribosomal protein L41, mitochondrial", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q5BJX1" }, { "name": "L41mt", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q5BJX1" }, { "name": "MRP-L41", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q5BJX1" }, { "name": "large ribosomal subunit protein mL41 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013444", "id": "NP_001013444" } ], "function": [ { "annotation": "Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.", "evidence": [ { "database": "UniProtKB", "id": "Q5BJX1", "url": "https://www.uniprot.org/uniprot/Q5BJX1#function" }, { "database": "UniProtKB", "id": "Q8IXM3", "url": "https://www.uniprot.org/uniprot/Q8IXM3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "Q5BJX1", "url": "https://www.uniprot.org/uniprot/Q5BJX1" } ], "common_name": "Rat" } ], "gene": [ { "name": "Mrpl41", "url": "https://www.uniprot.org/uniprot/Q5BJX1", "locus": { "chromosome": "3", "start_pos": 7779143, "end_pos": 7782818, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000063489", "url": "https://www.ensembl.org/id/ENSRNOG00000063489" } ] } } ], "crossref": [ { "id": "ENSRNOG00000029875", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000029875", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "296551", "url": "https://www.ncbi.nlm.nih.gov/gene/296551", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q5BJX1", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q5BJX1*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR019189", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019189", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:296551", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:296551", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KFVQVKE", "url": "https://omabrowser.org/oma/group/KFVQVKE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "9263at2759", "url": "http://www.orthodb.org/?query=9263at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21338", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21338", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21338:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21338:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09809", "url": "http://pfam.xfam.org/family/PF09809", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q5BJX1", "url": "http://purl.obolibrary.org/obo/PR_Q5BJX1", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-5389840", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5389840", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5419276", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001013444", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013444", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1310241", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310241", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "Q5BJX1", "url": "https://www.uniprot.org/uniprot/Q5BJX1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5BJX1-1", "url": "https://www.uniprot.org/uniprot/Q5BJX1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGFLTAVTQGLVRGADRMSKWTSKRGPRTFTKSRGAKKTGFYTNRKFVQIKEMVPEFVVPDLTGFKLKPYVNYRAPAGIDTPLTAKALFLETVAPAIEKDFKEGTFDANNLEKYGFEPTQEGKLFQLYPKNFPR", "length": 134, "header": "sp|Q5BJX1-1|RM41_RAT Isoform 1 of Large ribosomal subunit protein mL41 OS=Rattus norvegicus OX=10116 GN=Mrpl41 PE=1 SV=1 CANONICAL=Q5BJX1-1" }, "isoforms": [ { "isoform_ac": "Q5BJX1-1", "url": "", "sequence": { "sequence": "MGFLTAVTQGLVRGADRMSKWTSKRGPRTFTKSRGAKKTGFYTNRKFVQIKEMVPEFVVPDLTGFKLKPYVNYRAPAGIDTPLTAKALFLETVAPAIEKDFKEGTFDANNLEKYGFEPTQEGKLFQLYPKNFPR", "length": 134, "header": "sp|Q5BJX1-1|RM41_RAT Isoform 1 of Large ribosomal subunit protein mL41 OS=Rattus norvegicus OX=10116 GN=Mrpl41 PE=1 SV=1 CANONICAL=Q5BJX1-1" }, "locus": { "chromosome": "3", "start_pos": 7781193, "end_pos": 7780792, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000110175", "url": "https://www.ensembl.org/id/ENSRNOT00000110175" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000095947", "url": "https://www.ensembl.org/id/ENSRNOP00000095947" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences.", "journal": "J. Biol. Chem.", "date": "1998", "authors": "Goldschmidt-Reisin S, Kitakawa M, Herfurth E, Wittmann-Liebold B, Grohmann L, Graack HR", "evidence": [ { "database": "UniProtKB", "id": "Q5BJX1", "url": "https://www.uniprot.org/uniprot/Q5BJX1" } ], "reference": [ { "type": "PubMed", "id": "9857009", "url": "https://glygen.org/publication/PubMed/9857009" } ] } ], "pathway": [ { "id": "rno:296551", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:296551", "resource": "KEGG Pathway" }, { "id": "R-RNO-5389840", "name": "Mitochondrial translation elongation", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5389840", "resource": "Reactome", "description": "Mitochondrial translation elongation" }, { "id": "R-RNO-5419276", "name": "Mitochondrial translation termination", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5419276", "resource": "Reactome", "description": "Mitochondrial translation termination" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZH23-1", "protein_name": "Similar to mitochondrial ribosomal protein L41", "gene_name": "RGD1560917", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGFLTAVTQGLVRGADRMSKWTSKQGPRTFTKSRGAKKTGFYTNRKFVQIKEMVPEFVVPDLTGFKLKPYVNYRAPAGIDTPLTAKALFLETVAPAIEKDFKEGTFDTNNLEKYGFEPTQEGKLFQLYPKNFPR", "length": 134 }, "evidence": [ { "id": "45233738", "url": "http://www.informatics.jax.org/homology/45233738", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8IXM3-1", "protein_name": "Large ribosomal subunit protein mL41", "gene_name": "MRPL41", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGVLAAAARCLVRGADRMSKWTSKRGPRSFRGRKGRGAKGIGFLTSGWRFVQIKEMVPEFVVPDLTGFKLKPYVSYLAPESEETPLTAAQLFSEAVAPAIEKDFKDGTFDPDNLEKYGFEPTQEGKLFQLYPRNFLR", "length": 137 }, "evidence": [ { "id": "45233738", "url": "http://www.informatics.jax.org/homology/45233738", "database": "MGI" }, { "id": "Q5BJX1", "url": "https://omabrowser.org/oma/group/Q5BJX1/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CQN7-1", "protein_name": "Large ribosomal subunit protein mL41", "gene_name": "Mrpl41", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGFLTAVTQGLVRGADRMSKWTSKRGPRTFTKSRGAKKTGIYTSDRKFVQIKEMVPEFVVPDLTGFKLKPYVNYRAPAGIDTPLTAKALFQETVAPAIEKDFKEGTFDANNLEKYGFEPTQEGKLFQLYPKNFPR", "length": 135 }, "evidence": [ { "id": "45233738", "url": "http://www.informatics.jax.org/homology/45233738", "database": "MGI" }, { "id": "Q5BJX1", "url": "https://omabrowser.org/oma/group/Q5BJX1/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial large ribosomal subunit", "id": "GO:0005762", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005762", "evidence": [ { "database": "UniProtKB", "id": "Q5BJX1", "url": "https://www.uniprot.org/uniprot/Q5BJX1" } ], "pmid": "" }, { "name": "ribonucleoprotein 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