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"UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZSX8-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZSX8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q566R0", "url": "https://www.uniprot.org/uniprot/Q566R0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q566R0-1", "url": "https://www.uniprot.org/uniprot/Q566R0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRSCAMRLRTLGATPARRPEATRRLFSSEEVVCKDYALPNPSWTKDLRLLFDQFMKKCEDGSWKRLPSYRQNPPQALQEFQTHFVDSKFKKEEQMSKAQQFTRSLEEGLGFEYAMFYNKAEKRIVCLFQGGLHLQGMPGFVHGGAIATIIDITAGMCAFSEGIVMTANLNIDYKKPIPLLSVVVVNSQLQKIEGRKLFVSCTIQSTDEKTLHTQATALFIKLDPDKPLT", "length": 230, "header": "sp|Q566R0-1|THEM4_RAT Isoform 1 of Acyl-coenzyme A thioesterase THEM4 OS=Rattus norvegicus OX=10116 GN=Them4 PE=2 SV=1 CANONICAL=Q566R0-1" }, "isoforms": [ { "isoform_ac": "A0A8I5ZSX8-1", "url": "", "sequence": { "sequence": "MLRSCAMRLRTLGATPARRPEATRRLFSSEEVVCKDYALPNPSWTKDLRLLFDQFMKKCEDGSWKRLPSYRQNPPQALQEFQTHFVDSKFKKEEQMSKAQQFTRSLEEGLGFEYAMFYNKAEKRIVCLFQGGLHLQGMPGFVHGGAIATIIDITAGMCAFSEGIVMTANLNIDYKKPIPLLSVVVVNSQLQKIEGRKLFVSCTIQSTDEKTLHTQATGKKLPLPICQYP", "length": 229, "header": "tr|A0A8I5ZSX8-1|THEM4_RAT Computationally mapped isoform of Acyl-coenzyme A thioesterase THEM4 OS=Rattus norvegicus OX=10116 GN=Them4 PE=2 SV=1 CANONICAL=Q566R0-1" }, "locus": { "chromosome": "2", "start_pos": 181972799, "end_pos": 181953628, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000111836.1", "url": "https://www.ensembl.org/id/ENSRNOT00000111836.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000082042.1", "url": "https://www.ensembl.org/id/ENSRNOP00000082042.1" } ] } }, { "isoform_ac": "Q566R0-1", "url": "", "sequence": { "sequence": "MLRSCAMRLRTLGATPARRPEATRRLFSSEEVVCKDYALPNPSWTKDLRLLFDQFMKKCEDGSWKRLPSYRQNPPQALQEFQTHFVDSKFKKEEQMSKAQQFTRSLEEGLGFEYAMFYNKAEKRIVCLFQGGLHLQGMPGFVHGGAIATIIDITAGMCAFSEGIVMTANLNIDYKKPIPLLSVVVVNSQLQKIEGRKLFVSCTIQSTDEKTLHTQATALFIKLDPDKPLT", "length": 230, "header": "sp|Q566R0-1|THEM4_RAT Isoform 1 of Acyl-coenzyme A thioesterase THEM4 OS=Rattus norvegicus OX=10116 GN=Them4 PE=2 SV=1 CANONICAL=Q566R0-1" }, "locus": { "chromosome": "2", "start_pos": 181973745, "end_pos": 181953628, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000028260", "url": "https://www.ensembl.org/id/ENSRNOT00000028260" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000028260", "url": "https://www.ensembl.org/id/ENSRNOP00000028260" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 28, "end_pos": 28, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q566R0", "url": "https://www.uniprot.org/uniprot/Q566R0" } ], "site_lbl": "Ser28" }, { "start_pos": 29, "end_pos": 29, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q566R0", "url": "https://www.uniprot.org/uniprot/Q566R0" } ], "site_lbl": "Ser29" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "The endogenous inhibitor of Akt, CTMP, is critical to ischemia-induced neuronal death.", "journal": "Nature neuroscience", "date": "2009", "authors": "Miyawaki T, Ofengeim D, Noh KM, Latuszek-Barrantes A, Hemmings BA, Follenzi A, Zukin RS", "evidence": [ { "database": "RefSeq", "id": "NP_001020188", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020188" } ], "reference": [ { "type": "PubMed", "id": "19349976", "url": "https://glygen.org/publication/PubMed/19349976" } ] } ], "pathway": [ { "id": "rno:361992", "name": "", "url": 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"url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5218920", "resource": "Reactome", "description": "VEGFR2 mediated vascular permeability" }, { "id": "R-RNO-77289", "name": "Mitochondrial Fatty Acid Beta-Oxidation", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-77289", "resource": "Reactome", "description": "Mitochondrial Fatty Acid Beta-Oxidation" } ], "orthologs": [ { "uniprot_canonical_ac": "Q3UUI3-1", "protein_name": "Acyl-coenzyme A thioesterase THEM4", "gene_name": "Them4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLRNCAMRLRTLGATPARRPGAARRLFSSEKVIRKDYALPNPSWTKDLRLLFDQFMKKCEDGSWKRMPSHRQNPTRAIQEFQTLFVDSKFKKEEQMSKAQQFTRSFEEGLGFEYAMFYNKVEKRTVSLFQGGLHLQGVPGFVHGGAIATIIDVTTGTCAISEGVAMTANLNITYKKPIPLLSVVVVNSQLQKIEGRKLFVSCTIQSIDEKTLYTEATALFIKLDPEKPLT", "length": 230 }, "evidence": [ { "id": "45239236", "url": "http://www.informatics.jax.org/homology/45239236", "database": "MGI" }, { "id": "Q566R0", "url": "https://omabrowser.org/oma/group/Q566R0/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5T1C6-1", "protein_name": "Acyl-coenzyme A thioesterase THEM4", "gene_name": "THEM4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLRSCAARLRTLGALCLPPVGRRLPGSEPRPELRSFSSEEVILKDCSVPNPSWNKDLRLLFDQFMKKCEDGSWKRLPSYKRTPTEWIQDFKTHFLDPKLMKEEQMSQAQLFTRSFDDGLGFEYVMFYNDIEKRMVCLFQGGPYLEGPPGFIHGGAIATMIDATVGMCAMMAGGIVMTANLNINYKRPIPLCSVVMINSQLDKVEGRKFFVSCNVQSVDEKTLYSEATSLFIKLNPAKSLT", "length": 240 }, "evidence": [ { "id": "45239236", "url": "http://www.informatics.jax.org/homology/45239236", "database": "MGI" }, { "id": "Q566R0", "url": "https://omabrowser.org/oma/group/Q566R0/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": 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activity", "id": "GO:0016290", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016290", "evidence": [ { "database": "UniProtKB", "id": "Q566R0", "url": "https://www.uniprot.org/uniprot/Q566R0" } ], "pmid": "" }, { "name": "myristoyl-CoA hydrolase activity", "id": "GO:0102991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102991", "evidence": [ { "database": "UniProtKB", "id": "Q566R0", "url": "https://www.uniprot.org/uniprot/Q566R0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [ { "annotation": "Phosphorylated.", "evidence": [ { "database": "UniProtKB", "id": "Q566R0", "url": "https://www.uniprot.org/uniprot/Q566R0" }, { "database": "PubMed", "id": "Q5T1C6", "url": "https://glygen.org/publication/PubMed/Q5T1C6" } ] } ], "interactions": [], "reactions": [ { "id": "16645", "name": "", "equation": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q566R0-1", "O88267-1", "O55171-1", "Q63276-1", "Q8VHK0-1", "Q64559-2", "P80250-1", "P13437-1", "P97570-1", "P08635-1", "P49753-1", "O14734-1", "Q86TX2-1", "Q8N9L9-1", "Q8WXI4-1", "Q8N1Q8-1", "Q6ZUV0-1", "O00154-1", "Q14032-1", "Q5T1C6-1", "P42765-1", "Q9NPJ3-1", "O60733-1", "Q9NV23-1", "Q68D91-1", "Q8VHQ9-1", "Q9CQJ0-1", "Q9QYR7-1", "P58137-1", "O55137-1", "Q6Q2Z6-1", "Q9QYR9-1", "Q91V12-1", "Q91X34-1", "Q8BWT1-1", "Q3UUI3-1", "Q8BL86-1", "P97819-1", "Q8R197-1", "Q9CQR4-1", "P41903-1" ], "evidence": [ { "id": "16645", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16645" } ] }, { "id": "30135", "name": "", "equation": "dodecanoyl-CoA + H2O = CoA + dodecanoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q566R0-1", "O88267-1", "O55171-1", "Q63276-1", "Q8VHK0-1", "Q64559-2", "P13437-1", "P08635-1", "P49753-1", "O14734-1", "Q86TX2-1", "Q8N9L9-1", "Q8WXI4-1", "O00154-1", "Q14032-1", "Q5T1C6-1", "P42765-1", "Q9NPJ3-1", "Q9NV23-1", "Q68D91-1", "Q8VHQ9-1", "Q9QYR7-1", "P58137-1", "O55137-1", "Q6Q2Z6-1", "Q9QYR9-1", "Q91V12-1", "Q91X34-1", "Q8BWT1-1", "Q3UUI3-1", "Q8BL86-1", "Q8R197-1", "Q9CQR4-1" ], "evidence": [ { "id": "30135", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/30135" } ] }, { "id": "30143", "name": "", "equation": "H2O + octanoyl-CoA = CoA + H(+) + octanoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q566R0-1", "Q8VHK0-1", "Q64559-2", "P13437-1", "O14734-1", "O00154-1", "Q5T1C6-1", "P42765-1", "Q9NPJ3-1", "P58137-1", "Q6Q2Z6-1", "Q91V12-1", "Q8BWT1-1", "Q3UUI3-1", "Q9CQR4-1" ], "evidence": [ { "id": "30143", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/30143" } ] }, { "id": "40059", "name": "", "equation": "decanoyl-CoA + H2O = CoA + decanoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q566R0-1", "O88267-1", "O55171-1", "Q8VHK0-1", "Q64559-2", "P13437-1", "P08635-1", "P49753-1", "O14734-1", "Q86TX2-1", "Q8N9L9-1", "O00154-1", "Q5T1C6-1", "P42765-1", "Q9NPJ3-1", "Q9NV23-1", "Q9QYR7-1", "P58137-1", "O55137-1", "Q6Q2Z6-1", "Q9QYR9-1", "Q91V12-1", "Q8BWT1-1", "Q3UUI3-1", "Q8R197-1", "Q9CQR4-1" ], "evidence": [ { "id": "40059", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40059" } ] }, { "id": "40119", "name": "", "equation": "H2O + tetradecanoyl-CoA = CoA + H(+) + tetradecanoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q566R0-1", "O88267-1", "O55171-1", "Q63276-1", "Q8VHK0-1", "Q64559-2", "P13437-1", "P08635-1", "P49753-1", "O14734-1", "Q86TX2-1", "Q8N9L9-1", "Q8WXI4-1", "Q8N1Q8-1", "O00154-1", "Q14032-1", "Q5T1C6-1", "P42765-1", "Q9NPJ3-1", "Q9NV23-1", "Q68D91-1", "Q8VHQ9-1", "Q9CQJ0-1", "Q9QYR7-1", "P58137-1", "O55137-1", "Q6Q2Z6-1", "Q9QYR9-1", "Q91V12-1", "Q91X34-1", "Q8BWT1-1", "Q3UUI3-1", "Q8BL86-1", "Q8R197-1", "Q9CQR4-1" ], "evidence": [ { "id": "40119", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40119" } ] }, { "id": "40139", "name": "", "equation": "(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q566R0-1", "O88267-1", "O55171-1", "Q8VHK0-1", "Q64559-2", "P49753-1", "O14734-1", "Q86TX2-1", "Q8N9L9-1", "Q8N1Q8-1", "O00154-1", "Q5T1C6-1", "Q9NPJ3-1", "Q9CQJ0-1", "Q9QYR7-1", "P58137-1", "O55137-1", "Q6Q2Z6-1", "Q9QYR9-1", "Q91V12-1", "Q3UUI3-1", "Q9CQR4-1" ], "evidence": [ { "id": "40139", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40139" } ] }, { "id": "40151", "name": "", "equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q566R0-1", "Q8VHK0-1", "O14734-1", "Q8N9L9-1", "Q8N1Q8-1", "Q5T1C6-1", "Q9NPJ3-1", "Q9CQJ0-1", "Q9QYR7-1", "P58137-1", "Q6Q2Z6-1", "Q3UUI3-1" ], "evidence": [ { "id": "40151", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40151" } ] }, { "id": "R-RNO-109700", "name": "AKT2 binds PIP3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P47197-1", "Q566R0-1" ], "evidence": [ { "id": "R-RNO-109700", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-109700" } ] }, { "id": "R-RNO-198640", "name": "TORC2 (mTOR) phosphorylates AKT at S473", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P42346-1", "P47196-1", "P47197-1", "Q63484-1", "Q566R0-1" ], "evidence": [ { "id": "R-RNO-198640", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-198640" } ] }, { "id": "R-RNO-199443", "name": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P47196-1", "P47197-1", "Q63484-1", "Q566R0-1" ], "evidence": [ { "id": "R-RNO-199443", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-199443" } ] }, { "id": "R-RNO-5690066", "name": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O88267-1", "O55171-1", "Q566R0-1" ], "evidence": [ { "id": "R-RNO-5690066", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5690066" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "O00154", "gene_name": "ACOT7", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O00154", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00154" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "O00154", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00154" } ] } ] }, { "uniprot_ac": "O14734", "gene_name": "ACOT8", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.11", "activity": "acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+).", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.3", "activity": "H2O + succinyl-CoA = CoA + H(+) + succinate.", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.5", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.1", "activity": "", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.3", "activity": "", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.5", "activity": "", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.11", "activity": "", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] } ] }, { "uniprot_ac": "O55137", "gene_name": "Acot1", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "O55137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55137" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O55137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55137" } ] } ] }, { "uniprot_ac": "O55171", "gene_name": "Acot2", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O55171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55171" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "O55171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55171" } ] } ] }, { "uniprot_ac": "O60733", "gene_name": "PLA2G6", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] } ] }, { "uniprot_ac": "O88267", "gene_name": "Acot1", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "O88267", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88267" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O88267", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88267" } ] } ] }, { "uniprot_ac": "P08635", "gene_name": "Olah", "activity": [ { "ec_number": "3.1.2.14", "activity": "(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H(+) + holo-[ACP].", "evidence": [ { "id": "P08635", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08635" } ] }, { "ec_number": "3.1.2.14", "activity": "", "evidence": [ { "id": "P08635", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08635" } ] } ] }, { "uniprot_ac": "P13437", "gene_name": "Acaa2", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "P13437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13437" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P13437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13437" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "P13437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13437" } ] }, { "ec_number": "2.3.1.16", "activity": "acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA.", "evidence": [ { "id": "P13437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13437" } ] }, { "ec_number": "2.3.1.9", "activity": "2 acetyl-CoA = acetoacetyl-CoA + CoA.", "evidence": [ { "id": "P13437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13437" } ] }, { "ec_number": "2.3.1.16", "activity": "", "evidence": [ { "id": "P13437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13437" } ] } ] }, { "uniprot_ac": "P41903", "gene_name": "TES1", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P41903", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41903" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "P41903", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41903" } ] } ] }, { "uniprot_ac": "P42346", "gene_name": "Mtor", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P42346", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42346" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P42346", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42346" } ] } ] }, { "uniprot_ac": "P42765", "gene_name": "ACAA2", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "P42765", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42765" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P42765", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42765" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "P42765", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42765" } ] }, { "ec_number": "2.3.1.16", "activity": "acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA.", "evidence": [ { "id": "P42765", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42765" } ] }, { "ec_number": "2.3.1.9", "activity": "2 acetyl-CoA = acetoacetyl-CoA + CoA.", "evidence": [ { "id": "P42765", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42765" } ] }, { "ec_number": "2.3.1.16", "activity": "", "evidence": [ { "id": "P42765", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42765" } ] } ] }, { "uniprot_ac": "P47196", "gene_name": "Akt1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P47196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47196" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P47196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47196" } ] } ] }, { "uniprot_ac": "P47197", "gene_name": "Akt2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P47197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47197" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P47197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47197" } ] } ] }, { "uniprot_ac": "P49753", "gene_name": "ACOT2", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P49753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49753" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "P49753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49753" } ] } ] }, { "uniprot_ac": "P58137", "gene_name": "Acot8", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.11", "activity": "acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+).", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.3", "activity": "H2O + succinyl-CoA = CoA + H(+) + succinate.", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.5", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.1", "activity": "", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.3", "activity": "", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.5", "activity": "", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.11", "activity": "", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] } ] }, { "uniprot_ac": "P80250", "gene_name": "", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P80250", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P80250" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "P80250", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P80250" } ] } ] }, { "uniprot_ac": "P97570", "gene_name": "Pla2g6", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] } ] }, { "uniprot_ac": "P97819", "gene_name": "Pla2g6", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] } ] }, { "uniprot_ac": "Q14032", "gene_name": "BAAT", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q14032", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14032" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "Q14032", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14032" } ] }, { "ec_number": "2.3.1.65", "activity": "choloyl-CoA + glycine = CoA + glycocholate + H(+).", "evidence": [ { "id": "Q14032", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14032" } ] }, { "ec_number": "2.3.1.65", "activity": "", "evidence": [ { "id": "Q14032", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14032" } ] } ] }, { "uniprot_ac": "Q3UUI3", "gene_name": "Them4", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q3UUI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UUI3" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q3UUI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UUI3" } ] } ] }, { "uniprot_ac": "Q566R0", "gene_name": "Them4", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q566R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q566R0" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q566R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q566R0" } ] } ] }, { "uniprot_ac": "Q5T1C6", "gene_name": "THEM4", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q5T1C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5T1C6" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q5T1C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5T1C6" } ] } ] }, { "uniprot_ac": "Q63276", "gene_name": "Baat", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q63276", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63276" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "Q63276", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63276" } ] }, { "ec_number": "2.3.1.65", "activity": "choloyl-CoA + glycine = CoA + glycocholate + H(+).", "evidence": [ { "id": "Q63276", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63276" } ] }, { "ec_number": "2.3.1.65", "activity": "", "evidence": [ { "id": "Q63276", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63276" } ] } ] }, { "uniprot_ac": "Q63484", "gene_name": "Akt3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63484" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q63484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63484" } ] } ] }, { "uniprot_ac": "Q64559", "gene_name": "Acot7", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q64559", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64559" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q64559", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64559" } ] } ] }, { "uniprot_ac": "Q68D91", "gene_name": "MBLAC2", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q68D91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68D91" } ] }, { "ec_number": "3.5.2.6", "activity": "a beta-lactam + H2O = a substituted beta-amino acid.", "evidence": [ { "id": "Q68D91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68D91" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q68D91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68D91" } ] } ] }, { "uniprot_ac": "Q6Q2Z6", "gene_name": "Acot5", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q6Q2Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Q2Z6" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q6Q2Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Q2Z6" } ] } ] }, { "uniprot_ac": "Q6ZUV0", "gene_name": "ACOT7L", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q6ZUV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZUV0" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q6ZUV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZUV0" } ] } ] }, { "uniprot_ac": "Q86TX2", "gene_name": "ACOT1", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q86TX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86TX2" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q86TX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86TX2" } ] } ] }, { "uniprot_ac": "Q8BL86", "gene_name": "Mblac2", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q8BL86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BL86" } ] }, { "ec_number": "3.5.2.6", "activity": "a beta-lactam + H2O = a substituted beta-amino acid.", "evidence": [ { "id": "Q8BL86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BL86" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q8BL86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BL86" } ] } ] }, { "uniprot_ac": "Q8BWT1", "gene_name": "Acaa2", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q8BWT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWT1" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q8BWT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWT1" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "Q8BWT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWT1" } ] }, { "ec_number": "2.3.1.16", "activity": "acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA.", "evidence": [ { "id": "Q8BWT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWT1" } ] }, { "ec_number": "2.3.1.9", "activity": "2 acetyl-CoA = acetoacetyl-CoA + CoA.", "evidence": [ { "id": "Q8BWT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWT1" } ] }, { "ec_number": "2.3.1.16", "activity": "", "evidence": [ { "id": "Q8BWT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWT1" } ] } ] }, { "uniprot_ac": "Q8N1Q8", "gene_name": "THEM5", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q8N1Q8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N1Q8" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q8N1Q8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N1Q8" } ] } ] }, { "uniprot_ac": "Q8N9L9", "gene_name": "ACOT4", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q8N9L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N9L9" } ] }, { "ec_number": "3.1.2.3", "activity": "H2O + succinyl-CoA = CoA + H(+) + succinate.", "evidence": [ { "id": "Q8N9L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N9L9" } ] }, { "ec_number": "3.1.2.3", "activity": "", "evidence": [ { "id": "Q8N9L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N9L9" } ] } ] }, { "uniprot_ac": "Q8R197", "gene_name": "Olah", "activity": [ { "ec_number": "3.1.2.14", "activity": "(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H(+) + holo-[ACP].", "evidence": [ { "id": "Q8R197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R197" } ] }, { "ec_number": "3.1.2.14", "activity": "", "evidence": [ { "id": "Q8R197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R197" } ] } ] }, { "uniprot_ac": "Q8VHK0", "gene_name": "Acot8", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.11", "activity": "acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+).", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.3", "activity": "H2O + succinyl-CoA = CoA + H(+) + succinate.", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.5", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.11", "activity": "", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.5", "activity": "", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.3", "activity": "", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.1", "activity": "", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] } ] }, { "uniprot_ac": "Q8VHQ9", "gene_name": "Acot11", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q8VHQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHQ9" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q8VHQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHQ9" } ] } ] }, { "uniprot_ac": "Q8WXI4", "gene_name": "ACOT11", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q8WXI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WXI4" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q8WXI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WXI4" } ] } ] }, { "uniprot_ac": "Q91V12", "gene_name": "Acot7", "activity": [ { "ec_number": "3.1.2.2", 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