{ "uniprot_canonical_ac": "Q55AP1-1", "uniprot_ac": "Q55AP1", "uniprot_id": "GRLA_DICDI", "mass": { "chemical_mass": 89613.0, "monoisotopic_mass": 89613.0 }, "refseq": { "ac": "XP_645481", "name": "G-protein-coupled receptor family 3 protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_645481" }, "gene_names": [ { "name": "grlA", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q55AP1", "id": "Q55AP1" }, { "name": "DDB_G0271684", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q55AP1", "id": "Q55AP1" }, { "name": "grlA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_645481", "id": "XP_645481" } ], "protein_names": [ { "name": "Metabotropic glutamate receptor-like protein A", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q55AP1" }, { "name": "G-protein-coupled receptor family 3 protein 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_645481", "id": "XP_645481" } ], "function": [ { "annotation": "May play an important role in the terminal differentiation.", "evidence": [ { "database": "UniProtKB", "id": "Q55AP1", "url": "https://www.uniprot.org/uniprot/Q55AP1#function" }, { "database": "PubMed", "id": "17950724", "url": "https://glygen.org/publication/PubMed/17950724" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "Q55AP1", "url": "https://www.uniprot.org/uniprot/Q55AP1" } ], "common_name": "Dictyostelium discoideum" } ], "gene": [ { "name": "grlA", "url": "https://www.uniprot.org/uniprot/Q55AP1", "locus": {} } ], "crossref": [ { "id": "cd15047", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15047", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "DDB_G0271684", "url": "", "database": "", "categories": [ "Organism-specific" ] }, { "id": "8618109", "url": "https://www.ncbi.nlm.nih.gov/gene/8618109", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003760", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003760", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017978", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017978", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028082", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028082", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ddi:DDB_G0271684", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0271684", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CRSRIWL", "url": "https://omabrowser.org/oma/group/CRSRIWL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR46924", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46924", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46924:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46924:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00003", "url": "http://pfam.xfam.org/family/PF00003", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02608", "url": "http://pfam.xfam.org/family/PF02608", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q55AP1", "url": "http://purl.obolibrary.org/obo/PR_Q55AP1", "database": "PRO", "categories": [ "Protein" ] }, { "id": "XP_645481", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_645481", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q55AP1", "url": "https://www.uniprot.org/uniprot/Q55AP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q55AP1-1", "url": "https://www.uniprot.org/uniprot/Q55AP1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNKLKFLIILFITFLFNLKYINSLKQCKISVLLSGDWSDMGYNYQMNNARIKAESALNLEMSLCYKNLEVSIDLAKQAIEDSIKKGANFIVISSSVHTSIGYEYARLHRDKDIYWLIRGRGRPVPDDLPKVAVINFNTHLLHYTLGLVSGYLTTSGTVGFISPGPQILALANSNSFYLGALASRKNVTFLNAYTGSWYNPEVAYKASQMLISNGADFIGMSQDDMSVQKALMDSGKMALGITGFSNRLIWGSDIALSYITDWSDVFIKYAGHILNDTWPEYTDYYTTLAEGGSLLFDTFSYRVPSEVQKLVSLEIEKLKNSSYQPFRCNPMYSQINLNFDSNGCANDMEFKNTKLLLKGTDISKTINLGLYTIPIEFVDYSNSMKLGLTIVSGFCILFCIISMVLVIMFRHAKIIKSASPIFCLLILFGCIIIFSGCIIFSLSPTDGICGARVWLLSIGYTIFLGSLLVKNWRIWLLFDNPKLKKRSITNWKLYPFVAGILAADVLILALWQGLGDIRSESRIGIDSLTKYQYANVCSSNDQGSVALYILLVFHGIKLLAACFISFKIKAVDIEEFNESKPIASSIYIITFCLFIVIPLMVSPQSVASQVITIVVCAIVTTLISISLLFGSKFYMMATQGLALNQTFATNTKSSSFSLSLEKQKSKSNGLEFEDSDESEEKLPQIKNYSNSEIPNLQHNHSRLAHFSSDSCTSAEQDSKLDLENQNDENEIENNQNNQNNIVEDCQKVEKLEKDENLEKDENLEKDENLEKDNENQSIIQKKRLSKNFNQSEIDPDDV", "length": 798, "header": "sp|Q55AP1-1|GRLA_DICDI Isoform 1 of Metabotropic glutamate receptor-like protein A OS=Dictyostelium discoideum OX=44689 GN=grlA PE=2 SV=1 CANONICAL=Q55AP1-1" }, "isoforms": [ { "isoform_ac": "Q55AP1-1", "url": "", "sequence": { "sequence": "MNKLKFLIILFITFLFNLKYINSLKQCKISVLLSGDWSDMGYNYQMNNARIKAESALNLEMSLCYKNLEVSIDLAKQAIEDSIKKGANFIVISSSVHTSIGYEYARLHRDKDIYWLIRGRGRPVPDDLPKVAVINFNTHLLHYTLGLVSGYLTTSGTVGFISPGPQILALANSNSFYLGALASRKNVTFLNAYTGSWYNPEVAYKASQMLISNGADFIGMSQDDMSVQKALMDSGKMALGITGFSNRLIWGSDIALSYITDWSDVFIKYAGHILNDTWPEYTDYYTTLAEGGSLLFDTFSYRVPSEVQKLVSLEIEKLKNSSYQPFRCNPMYSQINLNFDSNGCANDMEFKNTKLLLKGTDISKTINLGLYTIPIEFVDYSNSMKLGLTIVSGFCILFCIISMVLVIMFRHAKIIKSASPIFCLLILFGCIIIFSGCIIFSLSPTDGICGARVWLLSIGYTIFLGSLLVKNWRIWLLFDNPKLKKRSITNWKLYPFVAGILAADVLILALWQGLGDIRSESRIGIDSLTKYQYANVCSSNDQGSVALYILLVFHGIKLLAACFISFKIKAVDIEEFNESKPIASSIYIITFCLFIVIPLMVSPQSVASQVITIVVCAIVTTLISISLLFGSKFYMMATQGLALNQTFATNTKSSSFSLSLEKQKSKSNGLEFEDSDESEEKLPQIKNYSNSEIPNLQHNHSRLAHFSSDSCTSAEQDSKLDLENQNDENEIENNQNNQNNIVEDCQKVEKLEKDENLEKDENLEKDENLEKDNENQSIIQKKRLSKNFNQSEIDPDDV", "length": 798, "header": "sp|Q55AP1-1|GRLA_DICDI Isoform 1 of Metabotropic glutamate receptor-like protein A OS=Dictyostelium discoideum OX=44689 GN=grlA PE=2 SV=1 CANONICAL=Q55AP1-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 186, "start_aa": "Asn", "end_pos": 186, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn186", "evidence": [ { "id": "Q55AP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55AP1#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 275, "start_aa": "Asn", "end_pos": 275, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn275", "evidence": [ { "id": "Q55AP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55AP1#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 320, "start_aa": "Asn", "end_pos": 320, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn320", "evidence": [ { "id": "Q55AP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55AP1#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.", "journal": "Nature", "date": "2002", "authors": "Gloeckner G., Kumpf K., Lehmann R., Platzer M., Rosenthal A., Bankier A.T., Dear P.H., Szafranski K., Guigo R., Parra G., Noegel A.A., Glockner G., Tunggal B., Abril J.F., Cox E., Eichinger L., Quail M.A., Cox E.C., Baumgart C., Pachebat J.A.", "evidence": [ { "database": "UniProtKB", "id": "Q55AP1", "url": "https://www.uniprot.org/uniprot/Q55AP1" } ], "reference": [ { "type": "PubMed", "id": "12097910", "url": "https://glygen.org/publication/PubMed/12097910" } ] }, { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Chen G., Gibbs R.A., Gloeckner G., Hernandez J., Johnson D., Knights A., Lehmann R., Loulseged H., Ma J., Muzny D.M., Oliver K., Platzer M., Rosenthal A., Saito T., Sodergren E., Steffen D., Sugano S., Walker D., Weinstock G., Lu M., Muzny D., Tanaka Y., Song J., Sodergren E.J., Xu Q., Bankier A.T., Barrell B.G., Williams J., Fey P., Nie X., Gibbs R., Dear P.H., Szafranski K., Davies R., Price C., James K., Noegel A.A., Glockner G., Cooper J., Morio T., Davis P., Williams J.G., Kay R.R., Cronin A., Schleicher M., Olsen R., Kummerfeld S., Sharp S., Hauser H., Weinstock G.M., White B., Quiles M., Rost R., Tunggal B., Pain A., Madan Babu M., Madera M., Rivero F., Saunders D., Eichinger L., Sanders M., Kohara Y., Chisholm R.L., Barrell B., Churcher C.M., Hamlin N., Rajandream M.A., Thangavelu M., Quail M.A., Anjard C., Cox E.C., Haydock S., Kuspa A., Loomis W.F., Shaulsky G., Sucgang R., Urushihara H., Bason N., Berriman M., Buchrieser C., Churcher C., Desany B., Farbrother P., Felder M., Gaudet P., Goodhead I., Hall N., Harper D., Hemphill L., James K.D., Just E., Kerhornou A., Konfortov B.A., Lindsay R., Mourier T., Mungall K., Mungall K.L., Pachebat J.A., Pilcher K., Rabbinowitsch E., Simmonds M., Simmonds M.N., Spiegler S., Tivey A., Wardroper A., Winckler T., Woodward J., Woodward J.R., van Driessche N.", "evidence": [ { "database": "UniProtKB", "id": "Q55AP1", "url": "https://www.uniprot.org/uniprot/Q55AP1" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] }, { "title": "The Dictyostelium repertoire of seven transmembrane domain receptors.", "journal": "Eur. J. Cell Biol.", "date": "2006", "authors": "Prabhu Y., Eichinger L.", "evidence": [ { "database": "UniProtKB", "id": "Q55AP1", "url": "https://www.uniprot.org/uniprot/Q55AP1" } ], "reference": [ { "type": "PubMed", "id": "16735079", "url": "https://glygen.org/publication/PubMed/16735079" } ] }, { "title": "GrlJ, a Dictyostelium GABAB-like receptor with roles in post-aggregation development.", "journal": "BMC Dev. Biol.", "date": "2007", "authors": "Prabhu Y., Mueller R., Noegel A.A., Anjard C.", "evidence": [ { "database": "UniProtKB", "id": "Q55AP1", "url": "https://www.uniprot.org/uniprot/Q55AP1" } ], "reference": [ { "type": "PubMed", "id": "17501984", "url": "https://glygen.org/publication/PubMed/17501984" } ] }, { "title": "A GPCR involved in post aggregation events in Dictyostelium discoideum.", "journal": "Dev. Biol.", "date": "2007", "authors": "Prabhu Y., Noegel A.A., Eichinger L., Mondal S.", "evidence": [ { "database": "UniProtKB", "id": "Q55AP1", "url": "https://www.uniprot.org/uniprot/Q55AP1" } ], "reference": [ { "type": "PubMed", "id": "17950724", "url": "https://glygen.org/publication/PubMed/17950724" } ] } ], "pathway": [ { "id": "ddi:DDB_G0271684", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0271684", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "Q55AP1", "url": "https://www.uniprot.org/uniprot/Q55AP1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nuclear envelope", "id": "GO:0005635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005635", "evidence": [ { "database": "UniProtKB", "id": "Q55AP1", "url": "https://www.uniprot.org/uniprot/Q55AP1" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q55AP1", "url": "https://www.uniprot.org/uniprot/Q55AP1" } ], "pmid": "" }, { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "Q55AP1", "url": "https://www.uniprot.org/uniprot/Q55AP1" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "Q55AP1", "url": "https://www.uniprot.org/uniprot/Q55AP1" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q55AP1", "url": "https://www.uniprot.org/uniprot/Q55AP1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "sporulation resulting in formation of a cellular spore", "id": "GO:0030435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030435", "evidence": [ { "database": "UniProtKB", "id": "Q55AP1", "url": "https://www.uniprot.org/uniprot/Q55AP1" } ], "pmid": "" }, { "name": "sorocarp development", "id": "GO:0030587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030587", "evidence": [ { "database": "UniProtKB", "id": "Q55AP1", "url": "https://www.uniprot.org/uniprot/Q55AP1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 186, "end_pos": 188, "annotation": "n_glycosylation_sequon" }, { "start_pos": 275, "end_pos": 277, "annotation": "n_glycosylation_sequon" }, { "start_pos": 320, "end_pos": 322, "annotation": "n_glycosylation_sequon" }, { "start_pos": 577, "end_pos": 579, "annotation": "n_glycosylation_sequon" }, { "start_pos": 644, "end_pos": 646, "annotation": "n_glycosylation_sequon" }, { "start_pos": 687, "end_pos": 689, "annotation": "n_glycosylation_sequon" }, { "start_pos": 699, "end_pos": 701, "annotation": "n_glycosylation_sequon" }, { "start_pos": 775, "end_pos": 777, "annotation": "n_glycosylation_sequon" }, { "start_pos": 789, "end_pos": 791, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 3 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": 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}, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 5 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }