{ "uniprot_canonical_ac": "Q54XP3-1", "uniprot_ac": "Q54XP3", "uniprot_id": "ADAT1_DICDI", "mass": { "chemical_mass": 62484.0, "monoisotopic_mass": 62484.0 }, "refseq": { "ac": "XP_641987", "name": "adenosine deaminase acting on tRNA 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_641987" }, "gene_names": [ { "name": "adat1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q54XP3", "id": "Q54XP3" }, { "name": "DDB_G0278943", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q54XP3", "id": "Q54XP3" } ], "protein_names": [ { "name": "tRNA-specific adenosine deaminase 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q54XP3" }, { "name": "3.5.4.34", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q54XP3" }, { "name": "adenosine deaminase acting on tRNA 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_641987", "id": "XP_641987" }, { "name": "tRNA-specific adenosine-37 deaminase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q54XP3" } ], "function": [ { "annotation": "Specifically deaminates adenosine-37 to inosine in tRNA-Ala.", "evidence": [ { "database": "UniProtKB", "id": "Q54XP3", "url": "https://www.uniprot.org/uniprot/Q54XP3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "Q54XP3", "url": "https://www.uniprot.org/uniprot/Q54XP3" } ], "common_name": "Dictyostelium discoideum" } ], "gene": [ { "name": "adat1", "url": "https://www.uniprot.org/uniprot/Q54XP3", "locus": {} } ], "crossref": [ { "id": "DDB_G0278943", "url": "", "database": "", "categories": [ "Organism-specific" ] }, { "id": "8621719", "url": "https://www.ncbi.nlm.nih.gov/gene/8621719", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002466", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002466", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ddi:DDB_G0278943", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0278943", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PVNQTHP", "url": "https://omabrowser.org/oma/group/PVNQTHP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR46516", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46516", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46516:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46516:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02137", "url": "http://pfam.xfam.org/family/PF02137", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q54XP3", "url": "http://purl.obolibrary.org/obo/PR_Q54XP3", "database": "PRO", "categories": [ "Protein" ] }, { "id": "XP_641987", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_641987", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "50968", "url": "https://www.rhea-db.org/rhea/50968", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q54XP3", "url": "https://www.uniprot.org/uniprot/Q54XP3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q54XP3-1", "url": "https://www.uniprot.org/uniprot/Q54XP3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSWKLDKQFSDKICNFSHDFFNKKLIKKGKPISGEWTVLATLVLVVENTSSYEIKQVLSLGTGNRCLGKSSLSNQGDVLNDSHAEIICKRSFQKFCYNEILNLLQSKYYNSILFNIEYHDSNNNNKDNDNNGSLPTISIKKGHSLHFYVNQTPCGDCSIFPFKKETQPENFIEKEKLEKDGKDKIENHEKKEQKDIIKQVDKDKDEENYEDEESKRKLKKVKDDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNINNNNNQYDDIQRTGAKTVFGEPEDKKLIGVDYHQIGVLRVKPGRGDPTVSMSCSDKIARWNVLGIQGSLLSHFIKEQIFLSSITIGDLFNHSSIYRGLIGRLLPNPTTTTTETSSSSSSSSSSSNTIPNFKLNSDLEIFSTNIQFQFSKLLLESDQQNNNKSTSSGLAISFCYPNQHEVTIAINGKKMGTNQKNFNAISQRSSICKFNLFKLFHQLVLIIKNKNSNEENEKNNQIVLIDSLFNYYECKHLSKKYYQEYEKLKEFKFKNWLTNSSDLENFVLDN", "length": 545, "header": "sp|Q54XP3-1|ADAT1_DICDI Isoform 1 of tRNA-specific adenosine deaminase 1 OS=Dictyostelium discoideum OX=44689 GN=adat1 PE=3 SV=1 CANONICAL=Q54XP3-1" }, "isoforms": [ { "isoform_ac": "Q54XP3-1", "url": "", "sequence": { "sequence": "MSWKLDKQFSDKICNFSHDFFNKKLIKKGKPISGEWTVLATLVLVVENTSSYEIKQVLSLGTGNRCLGKSSLSNQGDVLNDSHAEIICKRSFQKFCYNEILNLLQSKYYNSILFNIEYHDSNNNNKDNDNNGSLPTISIKKGHSLHFYVNQTPCGDCSIFPFKKETQPENFIEKEKLEKDGKDKIENHEKKEQKDIIKQVDKDKDEENYEDEESKRKLKKVKDDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNINNNNNQYDDIQRTGAKTVFGEPEDKKLIGVDYHQIGVLRVKPGRGDPTVSMSCSDKIARWNVLGIQGSLLSHFIKEQIFLSSITIGDLFNHSSIYRGLIGRLLPNPTTTTTETSSSSSSSSSSSNTIPNFKLNSDLEIFSTNIQFQFSKLLLESDQQNNNKSTSSGLAISFCYPNQHEVTIAINGKKMGTNQKNFNAISQRSSICKFNLFKLFHQLVLIIKNKNSNEENEKNNQIVLIDSLFNYYECKHLSKKYYQEYEKLKEFKFKNWLTNSSDLENFVLDN", "length": 545, "header": "sp|Q54XP3-1|ADAT1_DICDI Isoform 1 of tRNA-specific adenosine deaminase 1 OS=Dictyostelium discoideum OX=44689 GN=adat1 PE=3 SV=1 CANONICAL=Q54XP3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Chen G., Gibbs R.A., Gloeckner G., Hernandez J., Johnson D., Knights A., Lehmann R., Loulseged H., Ma J., Muzny D.M., Oliver K., Platzer M., Rosenthal A., Saito T., Sodergren E., Steffen D., Sugano S., Walker D., Weinstock G., Lu M., Muzny D., Tanaka Y., Song J., Sodergren E.J., Xu Q., Bankier A.T., Barrell B.G., Williams J., Fey P., Nie X., Gibbs R., Dear P.H., Szafranski K., Davies R., Price C., James K., Noegel A.A., Glockner G., Cooper J., Morio T., Davis P., Williams J.G., Kay R.R., Cronin A., Schleicher M., Olsen R., Kummerfeld S., Sharp S., Hauser H., Weinstock G.M., White B., Quiles M., Rost R., Tunggal B., Pain A., Madan Babu M., Madera M., Rivero F., Saunders D., Eichinger L., Sanders M., Kohara Y., Chisholm R.L., Barrell B., Churcher C.M., Hamlin N., Rajandream M.A., Thangavelu M., Quail M.A., Anjard C., Cox E.C., Haydock S., Kuspa A., Loomis W.F., Shaulsky G., Sucgang R., Urushihara H., Bason N., Berriman M., Buchrieser C., Churcher C., Desany B., Farbrother P., Felder M., Gaudet P., Goodhead I., Hall N., Harper D., Hemphill L., James K.D., Just E., Kerhornou A., Konfortov B.A., Lindsay R., Mourier T., Mungall K., Mungall K.L., Pachebat J.A., Pilcher K., Rabbinowitsch E., Simmonds M., Simmonds M.N., Spiegler S., Tivey A., Wardroper A., Winckler T., Woodward J., Woodward J.R., van Driessche N.", "evidence": [ { "database": "UniProtKB", "id": "Q54XP3", "url": "https://www.uniprot.org/uniprot/Q54XP3" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] } ], "pathway": [ { "id": "ddi:DDB_G0278943", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0278943", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q54XP3", "url": "https://www.uniprot.org/uniprot/Q54XP3" } ], "pmid": "" }, { "name": "tRNA-specific adenosine deaminase activity", "id": "GO:0008251", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008251", "evidence": [ { "database": "UniProtKB", "id": "Q54XP3", "url": "https://www.uniprot.org/uniprot/Q54XP3" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q54XP3", "url": "https://www.uniprot.org/uniprot/Q54XP3" } ], "pmid": "" }, { "name": "tRNA-specific adenosine-37 deaminase activity", "id": "GO:0043829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043829", "evidence": [ { "database": "UniProtKB", "id": "Q54XP3", "url": "https://www.uniprot.org/uniprot/Q54XP3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "tRNA processing", "id": "GO:0008033", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008033", "evidence": [ { "database": "UniProtKB", "id": "Q54XP3", "url": "https://www.uniprot.org/uniprot/Q54XP3" } ], "pmid": "" }, { "name": "tRNA modification", "id": "GO:0006400", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006400", "evidence": [ { "database": "UniProtKB", "id": "Q54XP3", "url": "https://www.uniprot.org/uniprot/Q54XP3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 131, "end_pos": 133, "annotation": "n_glycosylation_sequon" }, { "start_pos": 150, "end_pos": 152, "annotation": "n_glycosylation_sequon" }, { "start_pos": 15, "end_pos": 17, "annotation": "n_glycosylation_sequon" }, { "start_pos": 352, "end_pos": 354, "annotation": "n_glycosylation_sequon" }, { "start_pos": 422, "end_pos": 424, "annotation": "n_glycosylation_sequon" }, { "start_pos": 48, "end_pos": 50, "annotation": "n_glycosylation_sequon" }, { "start_pos": 534, "end_pos": 536, "annotation": "n_glycosylation_sequon" }, { "start_pos": 80, "end_pos": 82, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "50968", "name": "", "equation": "adenosine(37) in tRNA(Ala) + H(+) + H2O = inosine(37) in tRNA(Ala) + NH4(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9BUB4-1", "Q9JHI2-1", "P53065-1", "Q54XP3-1", "Q9V3R6-1" ], "evidence": [ { "id": "50968", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/50968" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "P53065", "gene_name": "TAD1", "activity": [ { "ec_number": "3.5.4.34", "activity": "adenosine(37) in tRNA(Ala) + H(+) + H2O = inosine(37) in tRNA(Ala) + NH4(+).", "evidence": [ { "id": "P53065", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53065" } ] }, { "ec_number": "3.5.4.34", "activity": "", "evidence": [ { "id": "P53065", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53065" } ] } ] }, { "uniprot_ac": "Q54XP3", "gene_name": "adat1", "activity": [ { "ec_number": "3.5.4.34", "activity": "adenosine(37) in tRNA(Ala) + H(+) + H2O = inosine(37) in tRNA(Ala) + NH4(+).", "evidence": [ { "id": "Q54XP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54XP3" } ] }, { "ec_number": "3.5.4.34", "activity": "", "evidence": [ { "id": "Q54XP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54XP3" } ] } ] }, { "uniprot_ac": "Q9BUB4", "gene_name": "ADAT1", "activity": [ { "ec_number": "3.5.4.34", "activity": "adenosine(37) in tRNA(Ala) + H(+) + H2O = inosine(37) in tRNA(Ala) + NH4(+).", "evidence": [ { "id": "Q9BUB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BUB4" } ] }, { "ec_number": "3.5.4.34", "activity": "", "evidence": [ { "id": "Q9BUB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BUB4" } ] } ] }, { "uniprot_ac": "Q9JHI2", "gene_name": "Adat1", "activity": [ { "ec_number": "3.5.4.34", "activity": "adenosine(37) in tRNA(Ala) + H(+) + H2O = inosine(37) in tRNA(Ala) + NH4(+).", "evidence": [ { "id": "Q9JHI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JHI2" } ] }, { "ec_number": "3.5.4.34", "activity": "", "evidence": [ { "id": "Q9JHI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JHI2" } ] } ] }, { "uniprot_ac": "Q9V3R6", "gene_name": "Adat1", "activity": [ { "ec_number": "3.5.4.34", "activity": "adenosine(37) in tRNA(Ala) + H(+) + H2O = inosine(37) in tRNA(Ala) + NH4(+).", "evidence": [ { "id": "Q9V3R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V3R6" } ] }, { "ec_number": "3.5.4.34", "activity": "", "evidence": [ { "id": "Q9V3R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V3R6" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }