{ "uniprot_canonical_ac": "Q54VG0-1", "uniprot_ac": "Q54VG0", "uniprot_id": "DHTK1_DICDI", "mass": { "chemical_mass": 101831.0, "monoisotopic_mass": 101831.0 }, "refseq": { "ac": "XP_641395", "name": "2-oxoglutarate dehydrogenase E1 component", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_641395" }, "gene_names": [ { "name": "odhA", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q54VG0", "id": "Q54VG0" }, { "name": "DDB_G0280353", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q54VG0", "id": "Q54VG0" }, { "name": "odhA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_641395", "id": "XP_641395" } ], "protein_names": [ { "name": "Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q54VG0" }, { "name": "1.2.4.2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q54VG0" }, { "name": "2-oxoglutarate dehydrogenase E1 component", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_641395", "id": "XP_641395" }, { "name": "Oxoglutarate dehydrogenase A", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q54VG0" }, { "name": "alpha-ketoglutarate dehydrogenase; oxoglutarate dehydrogenase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_641395", "id": "XP_641395" } ], "function": [ { "annotation": "The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q54VG0", "url": "https://www.uniprot.org/uniprot/Q54VG0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "Q54VG0", "url": "https://www.uniprot.org/uniprot/Q54VG0" } ], "common_name": "Dictyostelium discoideum" } ], "gene": [ { "name": "odhA", "url": "https://www.uniprot.org/uniprot/Q54VG0", "locus": {} } ], "crossref": [ { "id": "cd02016", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02016", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "DDB_G0280353", "url": "", "database": "", "categories": [ "Organism-specific" ] }, { "id": "8622529", "url": "https://www.ncbi.nlm.nih.gov/gene/8622529", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001017", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001017", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005475", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005475", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011603", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011603", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029061", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029061", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031717", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031717", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ddi:DDB_G0280353", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0280353", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GMAIDNP", "url": "https://omabrowser.org/oma/group/GMAIDNP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR23152", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23152", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23152:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23152:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00676", "url": "http://pfam.xfam.org/family/PF00676", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02779", "url": "http://pfam.xfam.org/family/PF02779", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16870", "url": "http://pfam.xfam.org/family/PF16870", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q54VG0", "url": "http://purl.obolibrary.org/obo/PR_Q54VG0", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DDI-389661", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-389661", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_641395", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_641395", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "12188", "url": "https://www.rhea-db.org/rhea/12188", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q54VG0", "url": "https://www.uniprot.org/uniprot/Q54VG0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q54VG0-1", "url": "https://www.uniprot.org/uniprot/Q54VG0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIGLRSISKNKQTINSISKSFYCTSSPSSSSVKLSVTRLIDGYRAHGHLAANIDPLARMERIRSQLLDLDRYNLVKGQSIPSTIDLINQDLTNLDQVVSFLENAYCNDVTAQFDHIESIEEKAWLYEKFEQLQHQNPSKSEKINILKNLIKSEIFDQFMQKKFPTFKRYGLEGNESMMVSCDSIFRESAKNQLKNVVIGMPHRGRLNLLVQMCNYPAKDFFWKVKGNSEFSEGILGVGDVTSHIAVSTDLQFNNNKESVHVSLIHNPSHLEAVDPVAAGKTRAKQFYEKNEGGSESLCLMLHGDAAVAGQGVVTETLQLSQLSGFNIGGCVHVIVNNQIGFTTVPTNGRSNRYSSDIGKFIGAPIIVVNSQSPEQVEKVSRLAVEYRQKFKKDIIIDLIGWRKFGHNEVDEPSFTQPTMYQNIRKRQSIPQKYATQIISQGIFSEQELLEFTQKEQAILEEQFQLSTPENFKYSPMDHLQGKWSGLIQSKHIADDSKLDTGYSVEELSEIANDSVKVPSDFQVHQRLLRSFSNARLEKLKQNQADWATAESMAVGSLMKQGYNVRISGQDVGRGTFSQRHFNLTEQNSDRIYQPLNNMGAKGELDVVNSNLSEFAVLCYEYGYSLESPDTLPIWEAQFGDFINGAQIAIDQFVTSGESKWLRQSGIVILLPHGFDGAGPEHSSCRIERFLQLSDTEAVNVKDDTLINQETNFYFINPSTPANYFHALRRQMIRNYRKPLIVAGPKVLLRHPNCFSTLNEMAPGTHFQTVLSDPDTINNASTIKRVIFCSGKVFYDLQEERKAKNFNDVAIIRLEQIAPFPYQRIQEEINRYSNATKFAWVQEEQQNGGCWSFVEPRFKQRYPQTSQIKYIGRPPLAASAIGISSIHKKEVSQLLIDAFNF", "length": 900, "header": "sp|Q54VG0-1|DHTK1_DICDI Isoform 1 of Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial OS=Dictyostelium discoideum OX=44689 GN=odhA PE=3 SV=1 CANONICAL=Q54VG0-1" }, "isoforms": [ { "isoform_ac": "Q54VG0-1", "url": "", "sequence": { "sequence": "MIGLRSISKNKQTINSISKSFYCTSSPSSSSVKLSVTRLIDGYRAHGHLAANIDPLARMERIRSQLLDLDRYNLVKGQSIPSTIDLINQDLTNLDQVVSFLENAYCNDVTAQFDHIESIEEKAWLYEKFEQLQHQNPSKSEKINILKNLIKSEIFDQFMQKKFPTFKRYGLEGNESMMVSCDSIFRESAKNQLKNVVIGMPHRGRLNLLVQMCNYPAKDFFWKVKGNSEFSEGILGVGDVTSHIAVSTDLQFNNNKESVHVSLIHNPSHLEAVDPVAAGKTRAKQFYEKNEGGSESLCLMLHGDAAVAGQGVVTETLQLSQLSGFNIGGCVHVIVNNQIGFTTVPTNGRSNRYSSDIGKFIGAPIIVVNSQSPEQVEKVSRLAVEYRQKFKKDIIIDLIGWRKFGHNEVDEPSFTQPTMYQNIRKRQSIPQKYATQIISQGIFSEQELLEFTQKEQAILEEQFQLSTPENFKYSPMDHLQGKWSGLIQSKHIADDSKLDTGYSVEELSEIANDSVKVPSDFQVHQRLLRSFSNARLEKLKQNQADWATAESMAVGSLMKQGYNVRISGQDVGRGTFSQRHFNLTEQNSDRIYQPLNNMGAKGELDVVNSNLSEFAVLCYEYGYSLESPDTLPIWEAQFGDFINGAQIAIDQFVTSGESKWLRQSGIVILLPHGFDGAGPEHSSCRIERFLQLSDTEAVNVKDDTLINQETNFYFINPSTPANYFHALRRQMIRNYRKPLIVAGPKVLLRHPNCFSTLNEMAPGTHFQTVLSDPDTINNASTIKRVIFCSGKVFYDLQEERKAKNFNDVAIIRLEQIAPFPYQRIQEEINRYSNATKFAWVQEEQQNGGCWSFVEPRFKQRYPQTSQIKYIGRPPLAASAIGISSIHKKEVSQLLIDAFNF", "length": 900, "header": "sp|Q54VG0-1|DHTK1_DICDI Isoform 1 of Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial OS=Dictyostelium discoideum OX=44689 GN=odhA PE=3 SV=1 CANONICAL=Q54VG0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Chen G., Gibbs R.A., Gloeckner G., Hernandez J., Johnson D., Knights A., Lehmann R., Loulseged H., Ma J., Muzny D.M., Oliver K., Platzer M., Rosenthal A., Saito T., Sodergren E., Steffen D., Sugano S., Walker D., Weinstock G., Lu M., Muzny D., Tanaka Y., Song J., Sodergren E.J., Xu Q., Bankier A.T., Barrell B.G., Williams J., Fey P., Nie X., Gibbs R., Dear P.H., Szafranski K., Davies R., Price C., James K., Noegel A.A., Glockner G., Cooper J., Morio T., Davis P., Williams J.G., Kay R.R., Cronin A., Schleicher M., Olsen R., Kummerfeld S., Sharp S., Hauser H., Weinstock G.M., White B., Quiles M., Rost R., Tunggal B., Pain A., Madan Babu M., Madera M., Rivero F., Saunders D., Eichinger L., Sanders M., Kohara Y., Chisholm R.L., Barrell B., Churcher C.M., Hamlin N., Rajandream M.A., Thangavelu M., Quail M.A., Anjard C., Cox E.C., Haydock S., Kuspa A., Loomis W.F., Shaulsky G., Sucgang R., Urushihara H., Bason N., Berriman M., Buchrieser C., Churcher C., Desany B., Farbrother P., Felder M., Gaudet P., Goodhead I., Hall N., Harper D., Hemphill L., James K.D., Just E., Kerhornou A., Konfortov B.A., Lindsay R., Mourier T., Mungall K., Mungall K.L., Pachebat J.A., Pilcher K., Rabbinowitsch E., Simmonds M., Simmonds M.N., Spiegler S., Tivey A., Wardroper A., Winckler T., Woodward J., Woodward J.R., van Driessche N.", "evidence": [ { "database": "UniProtKB", "id": "Q54VG0", "url": "https://www.uniprot.org/uniprot/Q54VG0" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] } ], "pathway": [ { "id": "ddi:DDB_G0280353", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0280353", "resource": "KEGG Pathway" }, { "id": "R-DDI-389661", "name": "Glyoxylate metabolism and glycine degradation", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-389661", "resource": "Reactome", "description": "Glyoxylate metabolism and glycine degradation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q54VG0", "url": "https://www.uniprot.org/uniprot/Q54VG0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "tricarboxylic acid cycle", "id": "GO:0006099", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006099", "evidence": [ { "database": "UniProtKB", "id": "Q54VG0", "url": "https://www.uniprot.org/uniprot/Q54VG0" } ], "pmid": "" }, { "name": "glycolytic process", "id": "GO:0006096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006096", "evidence": [ { "database": "UniProtKB", "id": "Q54VG0", "url": "https://www.uniprot.org/uniprot/Q54VG0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "thiamine pyrophosphate binding", "id": "GO:0030976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030976", "evidence": [ { "database": "UniProtKB", "id": "Q54VG0", "url": "https://www.uniprot.org/uniprot/Q54VG0" } ], "pmid": "" }, { "name": "oxoglutarate dehydrogenase (succinyl-transferring) activity", "id": "GO:0004591", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004591", "evidence": [ { "database": "UniProtKB", "id": "Q54VG0", "url": "https://www.uniprot.org/uniprot/Q54VG0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 174, "end_pos": 176, "annotation": "n_glycosylation_sequon" }, { "start_pos": 512, "end_pos": 514, "annotation": "n_glycosylation_sequon" }, { "start_pos": 582, "end_pos": 584, "annotation": "n_glycosylation_sequon" }, { "start_pos": 610, "end_pos": 612, "annotation": "n_glycosylation_sequon" }, { "start_pos": 778, "end_pos": 780, "annotation": "n_glycosylation_sequon" }, { "start_pos": 833, "end_pos": 835, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "12188", "name": "", "equation": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5XI78-1", "D3ZQD3-1", "Q02218-1", "Q9ULD0-1", "B2RXT3-1", "Q60597-1", "P20967-1", "Q54JE4-1", "Q54VG0-1", "Q9VA02-1" ], "evidence": [ { "id": "12188", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12188" } ] }, { "id": "R-DDI-6792572", "name": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54KY1-1", "Q54TR7-1", "Q54JE4-1", "Q54M22-1", "Q54VG0-1", "Q55FN7-1", "Q86HX0-1", "P36413-1", "Q54C70-1", "Q54EW8-1", "Q869Y7-1" ], "evidence": [ { "id": "R-DDI-6792572", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6792572" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "B2RXT3", "gene_name": "Ogdhl", "activity": [ { "ec_number": "1.2.4.2", "activity": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2.", "evidence": [ { "id": "B2RXT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RXT3" } ] }, { "ec_number": "1.2.4.2", "activity": "", "evidence": [ { "id": "B2RXT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RXT3" } ] } ] }, { "uniprot_ac": "D3ZQD3", "gene_name": "Ogdhl", "activity": [ { "ec_number": "1.2.4.2", "activity": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2.", "evidence": [ { "id": "D3ZQD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQD3" } ] }, { "ec_number": "1.2.4.2", "activity": "", "evidence": [ { "id": "D3ZQD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQD3" } ] } ] }, { "uniprot_ac": "P20967", "gene_name": "KGD1", "activity": [ { "ec_number": "1.2.4.2", "activity": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2.", "evidence": [ { "id": "P20967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20967" } ] }, { "ec_number": "1.2.4.2", "activity": "", "evidence": [ { "id": "P20967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20967" } ] } ] }, { "uniprot_ac": "P36413", "gene_name": "pdhC", "activity": [ { "ec_number": "2.3.1.12", "activity": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA.", "evidence": [ { "id": "P36413", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36413" } ] }, { "ec_number": "2.3.1.12", "activity": "", "evidence": [ { "id": "P36413", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36413" } ] } ] }, { "uniprot_ac": "Q02218", "gene_name": "OGDH", "activity": [ { "ec_number": "1.2.4.2", "activity": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2.", "evidence": [ { "id": "Q02218", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02218" } ] }, { "ec_number": "1.2.4.2", "activity": "", "evidence": [ { "id": "Q02218", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02218" } ] } ] }, { "uniprot_ac": "Q54C70", "gene_name": "pdhA", "activity": [ { "ec_number": "1.2.4.1", "activity": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2.", "evidence": [ { "id": "Q54C70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54C70" } ] }, { "ec_number": "1.2.4.1", "activity": "", "evidence": [ { "id": "Q54C70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54C70" } ] } ] }, { "uniprot_ac": "Q54EW8", "gene_name": "lpd", "activity": [ { "ec_number": "1.8.1.4", "activity": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH.", "evidence": [ { "id": "Q54EW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54EW8" } ] }, { "ec_number": "1.8.1.4", "activity": "", "evidence": [ { "id": "Q54EW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54EW8" } ] } ] }, { "uniprot_ac": "Q54JE4", "gene_name": "ogdh", "activity": [ { "ec_number": "1.2.4.2", "activity": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2.", "evidence": [ { "id": "Q54JE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54JE4" } ] }, { "ec_number": "1.2.4.2", "activity": "", "evidence": [ { "id": "Q54JE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54JE4" } ] } ] }, { "uniprot_ac": "Q54KY1", "gene_name": "", "activity": [ { "ec_number": "6.3.1.20", "activity": "(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+).", "evidence": [ { "id": "Q54KY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54KY1" } ] }, { "ec_number": "6.3.1.20", "activity": "", "evidence": [ { "id": "Q54KY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54KY1" } ] } ] }, { "uniprot_ac": "Q54M22", "gene_name": "bkdA", "activity": [ { "ec_number": "1.2.4.4", "activity": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + 3-methyl-2-oxobutanoate + H(+) = (R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + CO2.", "evidence": [ { "id": "Q54M22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54M22" } ] }, { "ec_number": "1.2.4.4", "activity": "", "evidence": [ { "id": "Q54M22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54M22" } ] } ] }, { "uniprot_ac": "Q54TR7", "gene_name": "bkdC", "activity": [ { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q54TR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54TR7" } ] } ] }, { "uniprot_ac": "Q54VG0", "gene_name": "odhA", "activity": [ { "ec_number": "1.2.4.2", "activity": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2.", "evidence": [ { "id": "Q54VG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54VG0" } ] }, { "ec_number": "1.2.4.2", "activity": "", "evidence": [ { "id": "Q54VG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54VG0" } ] } ] }, { "uniprot_ac": "Q55FN7", "gene_name": "bkdB", "activity": [ { "ec_number": "1.2.4.4", "activity": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + 3-methyl-2-oxobutanoate + H(+) = (R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + CO2.", "evidence": [ { "id": "Q55FN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55FN7" } ] }, { "ec_number": "1.2.4.4", "activity": "", "evidence": [ { "id": "Q55FN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55FN7" } ] } ] }, { "uniprot_ac": "Q5XI78", "gene_name": "Ogdh", "activity": [ { "ec_number": "1.2.4.2", "activity": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2.", "evidence": [ { "id": "Q5XI78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XI78" } ] }, { "ec_number": "1.2.4.2", "activity": "", "evidence": [ { "id": 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