{ "uniprot_canonical_ac": "Q54U71-1", "uniprot_ac": "Q54U71", "uniprot_id": "COQ2_DICDI", "mass": { "chemical_mass": 51925.0, "monoisotopic_mass": 51925.0 }, "refseq": { "ac": "XP_640905", "name": "4-hydroxybenzoate nonaprenyltransferase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_640905" }, "gene_names": [ { "name": "coq2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q54U71", "id": "Q54U71" }, { "name": "DDB_G0281241", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q54U71", "id": "Q54U71" }, { "name": "coq2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_640905", "id": "XP_640905" } ], "protein_names": [ { "name": "4-hydroxybenzoate polyprenyltransferase, mitochondrial", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q54U71" }, { "name": "2.5.1.39", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q54U71" }, { "name": "4-HB polyprenyltransferase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q54U71" }, { "name": "4-hydroxybenzoate nonaprenyltransferase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_640905", "id": "XP_640905" }, { "name": "PHB:PPT", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q54U71" }, { "name": "PHB:polyprenyltransferase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q54U71" }, { "name": "Para-hydroxybenzoate--polyprenyltransferase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q54U71" }, { "name": "para-hydroxybenzoate nonaprenyltransferase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_640905", "id": "XP_640905" } ], "function": [ { "annotation": "Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB.", "evidence": [ { "database": "UniProtKB", "id": "Q54U71", "url": "https://www.uniprot.org/uniprot/Q54U71#function" }, { "database": "UniProtKB", "id": "MF_03189", "url": "https://www.uniprot.org/uniprot/MF_03189#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "Q54U71", "url": "https://www.uniprot.org/uniprot/Q54U71" } ], "common_name": "Dictyostelium discoideum" } ], "gene": [ { "name": "coq2", "url": "https://www.uniprot.org/uniprot/Q54U71", "locus": {} } ], "crossref": [ { "id": "cd13959", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13959", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "DDB_G0281241", "url": "", "database": "", "categories": [ "Organism-specific" ] }, { "id": "8622964", "url": "https://www.ncbi.nlm.nih.gov/gene/8622964", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000537", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000537", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006370", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006370", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030470", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030470", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039653", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039653", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044878", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044878", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ddi:DDB_G0281241", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0281241", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VINDMAD", "url": "https://omabrowser.org/oma/group/VINDMAD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11048", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11048", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11048:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11048:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01040", "url": "http://pfam.xfam.org/family/PF01040", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q54U71", "url": "http://purl.obolibrary.org/obo/PR_Q54U71", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DDI-1268020", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-1268020", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-2142789", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-2142789", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_640905", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_640905", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "44504", "url": "https://www.rhea-db.org/rhea/44504", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q54U71", "url": "https://www.uniprot.org/uniprot/Q54U71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q54U71-1", "url": "https://www.uniprot.org/uniprot/Q54U71-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIKSILSLQNFKFIKPCTNSSILKYNNNNNTNNNNNNNGINKYNSTFNNNNSNFSNKNLFSSKQYQQQSICNIPILSTISYHNKNNTNINTIINNNNSSNNNLINLNDKFNNLNNKTSPIIFNKNYSTTVSTLLDDNNSNSNNNNNSNNNKPSTTFVNDWISKFPNSVQPYLRLSRVDKPIGVWLLLYPCCWSISLAAPAGSFPDLKTMLVFGIGAYVMRSAGCVINDMADYKFDSKVERTKTRPIASKQLTHKQSLIFLGGQLLASFGLILSSLNYYTIALCASSLPIVVLYPFMKRFTYYPQFVLGLAFNWGALAGYSAIAGSCNWSIVAPLYLAGISWTMVYDTIYAHQDKRDDILVGVKSTALKFAEKSRIILSVFSGLVISGMFLTGIAANMPLFYYLGTAACSSHLIWQLKTVDFNNPSSCLEKFISNKNFGLYFLLIIIVSKLLQDKENENEIQKK", "length": 463, "header": "sp|Q54U71-1|COQ2_DICDI Isoform 1 of 4-hydroxybenzoate polyprenyltransferase, mitochondrial OS=Dictyostelium discoideum OX=44689 GN=coq2 PE=3 SV=1 CANONICAL=Q54U71-1" }, "isoforms": [ { "isoform_ac": "Q54U71-1", "url": "", "sequence": { "sequence": "MIKSILSLQNFKFIKPCTNSSILKYNNNNNTNNNNNNNGINKYNSTFNNNNSNFSNKNLFSSKQYQQQSICNIPILSTISYHNKNNTNINTIINNNNSSNNNLINLNDKFNNLNNKTSPIIFNKNYSTTVSTLLDDNNSNSNNNNNSNNNKPSTTFVNDWISKFPNSVQPYLRLSRVDKPIGVWLLLYPCCWSISLAAPAGSFPDLKTMLVFGIGAYVMRSAGCVINDMADYKFDSKVERTKTRPIASKQLTHKQSLIFLGGQLLASFGLILSSLNYYTIALCASSLPIVVLYPFMKRFTYYPQFVLGLAFNWGALAGYSAIAGSCNWSIVAPLYLAGISWTMVYDTIYAHQDKRDDILVGVKSTALKFAEKSRIILSVFSGLVISGMFLTGIAANMPLFYYLGTAACSSHLIWQLKTVDFNNPSSCLEKFISNKNFGLYFLLIIIVSKLLQDKENENEIQKK", "length": 463, "header": "sp|Q54U71-1|COQ2_DICDI Isoform 1 of 4-hydroxybenzoate polyprenyltransferase, mitochondrial OS=Dictyostelium discoideum OX=44689 GN=coq2 PE=3 SV=1 CANONICAL=Q54U71-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Chen G., Gibbs R.A., Gloeckner G., Hernandez J., Johnson D., Knights A., Lehmann R., Loulseged H., Ma J., Muzny D.M., Oliver K., Platzer M., Rosenthal A., Saito T., Sodergren E., Steffen D., Sugano S., Walker D., Weinstock G., Lu M., Muzny D., Tanaka Y., Song J., Sodergren E.J., Xu Q., Bankier A.T., Barrell B.G., Williams J., Fey P., Nie X., Gibbs R., Dear P.H., Szafranski K., Davies R., Price C., James K., Noegel A.A., Glockner G., Cooper J., Morio T., Davis P., Williams J.G., Kay R.R., Cronin A., Schleicher M., Olsen R., Kummerfeld S., Sharp S., Hauser H., Weinstock G.M., White B., Quiles M., Rost R., Tunggal B., Pain A., Madan Babu M., Madera M., Rivero F., Saunders D., Eichinger L., Sanders M., Kohara Y., Chisholm R.L., Barrell B., Churcher C.M., Hamlin N., Rajandream M.A., Thangavelu M., Quail M.A., Anjard C., Cox E.C., Haydock S., Kuspa A., Loomis W.F., Shaulsky G., Sucgang R., Urushihara H., Bason N., Berriman M., Buchrieser C., Churcher C., Desany B., Farbrother P., Felder M., Gaudet P., Goodhead I., Hall N., Harper D., Hemphill L., James K.D., Just E., Kerhornou A., Konfortov B.A., Lindsay R., Mourier T., Mungall K., Mungall K.L., Pachebat J.A., Pilcher K., Rabbinowitsch E., Simmonds M., Simmonds M.N., Spiegler S., Tivey A., Wardroper A., Winckler T., Woodward J., Woodward J.R., van Driessche N.", "evidence": [ { "database": "UniProtKB", "id": "Q54U71", "url": "https://www.uniprot.org/uniprot/Q54U71" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] } ], "pathway": [ { "id": "ddi:DDB_G0281241", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0281241", "resource": "KEGG Pathway" }, { "id": "R-DDI-1268020", "name": "Mitochondrial protein import", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-1268020", "resource": "Reactome", "description": "Mitochondrial protein import" }, { "id": "R-DDI-2142789", "name": "Ubiquinol biosynthesis", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-2142789", "resource": "Reactome", "description": "Ubiquinol biosynthesis" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q54U71", "url": "https://www.uniprot.org/uniprot/Q54U71" } ], "pmid": "" }, { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "Q54U71", "url": "https://www.uniprot.org/uniprot/Q54U71" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "ubiquinone biosynthetic process", "id": "GO:0006744", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006744", "evidence": [ { "database": "UniProtKB", "id": "Q54U71", "url": "https://www.uniprot.org/uniprot/Q54U71" } ], "pmid": "" }, { "name": "isoprenoid biosynthetic process", "id": "GO:0008299", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008299", "evidence": [ { "database": "UniProtKB", "id": "Q54U71", "url": "https://www.uniprot.org/uniprot/Q54U71" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "transferase activity, transferring alkyl or aryl (other than methyl) groups", "id": "GO:0016765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016765", "evidence": [ { "database": "UniProtKB", "id": "Q54U71", "url": "https://www.uniprot.org/uniprot/Q54U71" } ], "pmid": "" }, { "name": "4-hydroxybenzoate decaprenyltransferase activity", "id": "GO:0002083", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002083", "evidence": [ { "database": "UniProtKB", "id": "Q54U71", "url": "https://www.uniprot.org/uniprot/Q54U71" } ], "pmid": "" }, { "name": "4-hydroxybenzoate nonaprenyltransferase activity", "id": "GO:0047293", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047293", "evidence": [ { "database": "UniProtKB", "id": "Q54U71", "url": "https://www.uniprot.org/uniprot/Q54U71" } ], "pmid": "" }, { "name": "4-hydroxybenzoate octaprenyltransferase activity", "id": "GO:0008412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008412", "evidence": [ { "database": "UniProtKB", "id": "Q54U71", "url": "https://www.uniprot.org/uniprot/Q54U71" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 115, "end_pos": 117, "annotation": "n_glycosylation_sequon" }, { "start_pos": 125, "end_pos": 127, "annotation": "n_glycosylation_sequon" }, { "start_pos": 137, "end_pos": 139, "annotation": "n_glycosylation_sequon" }, { "start_pos": 145, "end_pos": 147, "annotation": "n_glycosylation_sequon" }, { "start_pos": 19, "end_pos": 21, "annotation": "n_glycosylation_sequon" }, { "start_pos": 29, "end_pos": 31, "annotation": "n_glycosylation_sequon" }, { "start_pos": 327, "end_pos": 329, "annotation": "n_glycosylation_sequon" }, { "start_pos": 44, "end_pos": 46, "annotation": "n_glycosylation_sequon" }, { "start_pos": 50, "end_pos": 52, "annotation": "n_glycosylation_sequon" }, { "start_pos": 53, "end_pos": 55, "annotation": "n_glycosylation_sequon" }, { "start_pos": 85, "end_pos": 87, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" }, { "start_pos": 97, "end_pos": 99, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "44504", "name": "", "equation": "4-hydroxybenzoate + an all-trans-polyprenyl diphosphate = a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q499N4-1", "Q96H96-1", "Q66JT7-1", "P32378-1", "Q54U71-1", "Q9VHS7-1" ], "evidence": [ { "id": "44504", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/44504" } ] }, { "id": "R-DDI-2162192", "name": "PHB and all-E-10PrP2 are combined into DHB by COQ2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane, mitochondrial matrix", "input_participant_list": [ "R-ALL-2162213" ], "output_participant_list": [ "R-ALL-2162207" ], "enzyme_list": [ "Q54U71-1" ], "evidence": [ { "id": "R-DDI-2162192", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-2162192" } ] }, { "id": "R-DDI-8986181", "name": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54U71-1", "Q55CS9-1" ], "evidence": [ { "id": "R-DDI-8986181", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-8986181" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-2162207", "participant_name": "DHB [mitochondrial matrix]", "crossref": [ { "id": "HMDB0006251", "database": "HMDB Metabolite", "url": "" }, { "id": "64136", "database": "ChEBI", "url": "" }, { "id": "000085552713", "database": "ZINC", "url": "" }, { "id": "64136", "database": "ChEBI", "url": "" }, { "id": "000085552713", "database": "ZINC", "url": "" }, { "id": "HMDB0006251", "database": "HMDB Metabolite", "url": "" }, { "id": "64136", "database": "ChEBI", "url": "" }, { "id": "000085552713", "database": "ZINC", "url": "" }, { "id": "HMDB0006251", "database": "HMDB Metabolite", "url": "" }, { "id": "64136", "database": "ChEBI", "url": "" }, { "id": "000085552713", "database": "ZINC", "url": "" }, { "id": "HMDB0006251", "database": "HMDB Metabolite", "url": "" }, { "id": "HMDB0006251", "database": "HMDB Metabolite", "url": "" }, { "id": "64136", "database": "ChEBI", "url": "" }, { "id": "000085552713", "database": "ZINC", "url": "" }, { "id": "64136", "database": "ChEBI", "url": "" }, { "id": "000085552713", "database": "ZINC", "url": "" }, { "id": "HMDB0006251", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-ALL-2162213", "participant_name": "PHB [mitochondrial matrix]", "crossref": [ { "id": "HMDB0000500", "database": "HMDB Metabolite", "url": "" }, { "id": "C00156", "database": "COMPOUND", "url": "" }, { "id": "000000332752", "database": "ZINC", "url": "" }, { "id": "30763", "database": "ChEBI", "url": "" }, { "id": "000000332752", "database": "ZINC", "url": "" }, { "id": "30763", "database": "ChEBI", "url": "" }, { "id": "C00156", "database": "COMPOUND", "url": "" }, { "id": "HMDB0000500", "database": "HMDB Metabolite", "url": "" }, { "id": "HMDB0000500", "database": "HMDB Metabolite", "url": "" }, { "id": "C00156", "database": "COMPOUND", "url": "" }, { "id": "000000332752", "database": "ZINC", "url": "" }, { "id": "30763", "database": "ChEBI", "url": "" }, { "id": "000000332752", "database": "ZINC", "url": "" }, { "id": "30763", "database": "ChEBI", "url": "" }, { "id": "C00156", "database": "COMPOUND", "url": "" }, { "id": "HMDB0000500", "database": "HMDB Metabolite", "url": "" }, { "id": "30763", "database": "ChEBI", "url": "" }, { "id": "HMDB0000500", "database": "HMDB Metabolite", "url": "" }, { "id": "000000332752", "database": "ZINC", "url": "" }, { "id": "C00156", "database": "COMPOUND", "url": "" }, { "id": "HMDB0000500", "database": "HMDB Metabolite", "url": "" }, { "id": "C00156", "database": "COMPOUND", "url": "" }, { "id": "000000332752", "database": "ZINC", "url": "" }, { "id": "30763", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "P32378", "gene_name": "COQ2", "activity": [ { "ec_number": "2.5.1.39", "activity": "4-hydroxybenzoate + all-trans-nonaprenyl diphosphate = 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate.", "evidence": [ { "id": "P32378", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32378" } ] }, { "ec_number": "2.5.1.39", "activity": "", "evidence": [ { "id": "P32378", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32378" } ] } ] }, { "uniprot_ac": "Q499N4", "gene_name": "Coq2", "activity": [ { "ec_number": "2.5.1.39", "activity": "4-hydroxybenzoate + all-trans-nonaprenyl diphosphate = 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate.", "evidence": [ { "id": "Q499N4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q499N4" } ] }, { "ec_number": "2.5.1.39", "activity": "", "evidence": [ { "id": "Q499N4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q499N4" } ] } ] }, { "uniprot_ac": "Q54U71", "gene_name": "coq2", "activity": [ { "ec_number": "2.5.1.39", "activity": "4-hydroxybenzoate + all-trans-nonaprenyl diphosphate = 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate.", "evidence": [ { "id": "Q54U71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54U71" } ] }, { "ec_number": "2.5.1.39", "activity": "", "evidence": [ { "id": "Q54U71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54U71" } ] } ] }, { "uniprot_ac": "Q55CS9", "gene_name": "atp5f1b", "activity": [ { "ec_number": "7.1.2.2", "activity": "ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate.", "evidence": [ { "id": "Q55CS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55CS9" } ] }, { "ec_number": "7.1.2.2", "activity": "", "evidence": [ { "id": "Q55CS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55CS9" } ] } ] }, { "uniprot_ac": "Q66JT7", 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