The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54TI6-1", "Q54QG9-1", "Q55C16-1" ], "evidence": [ { "id": "R-DDI-8951661", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-8951661" } ] }, { "id": "R-DDI-8951751", "name": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54TI6-1", "Q54QG9-1", "Q55C16-1" ], "evidence": [ { "id": "R-DDI-8951751", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-8951751" } ] }, { "id": "R-DDI-8951764", "name": "Transfer of NEDD8 to AcM-UBE2F", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54TI6-1", "Q54QG9-1", "Q55C16-1" ], "evidence": [ { "id": "R-DDI-8951764", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-8951764" } ] }, { "id": "R-DDI-8951766", "name": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54TI6-1", "Q54QG9-1", "Q55C16-1" ], "evidence": [ { "id": "R-DDI-8951766", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-8951766" } ] }, { "id": "R-DDI-8952044", "name": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54TI6-1" ], "evidence": [ { "id": "R-DDI-8952044", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-8952044" } ] }, { "id": "R-DDI-8952618", "name": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54TI6-1", "Q54RP0-1" ], "evidence": [ { "id": "R-DDI-8952618", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-8952618" } ] }, { "id": "R-DDI-8952620", "name": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54TI6-1", "Q54RP0-1" ], "evidence": [ { "id": "R-DDI-8952620", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-8952620" } ] }, { "id": "R-DDI-8952630", "name": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54TI6-1" ], "evidence": [ { "id": "R-DDI-8952630", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-8952630" } ] }, { "id": "R-DDI-8952631", "name": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54TI6-1" ], "evidence": [ { "id": "R-DDI-8952631", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-8952631" } ] }, { "id": "R-DDI-8952638", "name": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54TI6-1" ], "evidence": [ { "id": "R-DDI-8952638", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-8952638" } ] }, { "id": "R-DDI-8952639", "name": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54TI6-1" ], "evidence": [ { "id": "R-DDI-8952639", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-8952639" } ] }, { "id": "R-DDI-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54GG5-1", "Q54IL3-1", "Q54JV0-1", "Q54KP2-1", "Q54QS0-1", "Q54XG4-1", "Q55DC5-1", "C7G034-1", "Q54I43-1", "Q54IW6-1", "Q54JE9-1", "Q54JT8-1", "Q54LP7-1", "Q54QG5-1", "Q54QZ3-1", "Q54TI6-1", "Q54XS6-1", "Q553F3-1", "Q555H8-1", "Q55EY8-1", "Q75JM9-1", "Q86K32-1", "Q8T2Q2-1", "Q54DM4-1", "Q54RP0-1", "Q557E7-1", "Q557I6-1", "Q55C16-1", "Q6T486-1", "Q94490-1" ], "evidence": [ { "id": "R-DDI-983140", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-983140" } ] }, { "id": "R-DDI-983152", "name": "Transfer of ubiquitin from E1 to E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54I43-1", "Q54LP7-1", "Q54TI6-1", "Q54XS6-1", "Q553F3-1", "Q55EY8-1", "Q86K32-1", "Q54QG9-1", "Q55C16-1", "Q94490-1" ], "evidence": [ { "id": "R-DDI-983152", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-983152" } ] }, { "id": "R-DDI-983156", "name": "Polyubiquitination of substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54GG5-1", "Q54IL3-1", "Q54JV0-1", "Q54KP2-1", "Q54QS0-1", "Q54XG4-1", "Q55DC5-1", "C7G034-1", "Q54I43-1", "Q54IW6-1", "Q54JE9-1", "Q54JT8-1", "Q54LP7-1", "Q54QG5-1", "Q54QZ3-1", "Q54TI6-1", "Q54XS6-1", "Q553F3-1", "Q555H8-1", "Q55EY8-1", "Q75JM9-1", "Q86K32-1", "Q8T2Q2-1", "Q54DM4-1", "Q54RP0-1", "Q557E7-1", "Q557I6-1", "Q55C16-1", "Q6T486-1", "Q94490-1" ], "evidence": [ { "id": "R-DDI-983156", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-983156" } ] }, { "id": "R-DDI-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54GG5-1", "Q54IL3-1", "Q54JV0-1", "Q54KP2-1", "Q54QS0-1", "Q54XG4-1", "Q55DC5-1", "C7G034-1", "Q54I43-1", "Q54IW6-1", "Q54JE9-1", "Q54JT8-1", "Q54LP7-1", "Q54QG5-1", "Q54QZ3-1", "Q54TI6-1", "Q54XS6-1", "Q553F3-1", "Q555H8-1", "Q55EY8-1", "Q75JM9-1", "Q86K32-1", "Q8T2Q2-1", "Q54DM4-1", "Q54RP0-1", "Q557E7-1", "Q557I6-1", "Q55C16-1", "Q6T486-1", "Q94490-1" ], "evidence": [ { "id": "R-DDI-983157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-983157" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "C7G034", "gene_name": "", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "C7G034", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C7G034" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "C7G034", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C7G034" } ] } ] }, { "uniprot_ac": "Q54DM4", "gene_name": "", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q54DM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54DM4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q54DM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54DM4" } ] } ] }, { "uniprot_ac": "Q54GG5", "gene_name": "ube3a", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q54GG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54GG5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q54GG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54GG5" } ] } ] }, { "uniprot_ac": "Q54I43", "gene_name": "ube2s", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q54I43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54I43" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q54I43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54I43" } ] } ] }, { "uniprot_ac": "Q54IL3", "gene_name": "", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q54IL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54IL3" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q54IL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54IL3" } ] } ] }, { "uniprot_ac": "Q54IW6", "gene_name": "", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q54IW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54IW6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q54IW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54IW6" } ] } ] }, { "uniprot_ac": "Q54JE9", "gene_name": "", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q54JE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54JE9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q54JE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54JE9" } ] } ] }, { "uniprot_ac": "Q54JT8", "gene_name": "", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q54JT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54JT8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q54JT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54JT8" } ] } ] }, { "uniprot_ac": "Q54JV0", "gene_name": "", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q54JV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54JV0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q54JV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54JV0" } ] } ] }, { "uniprot_ac": "Q54KP2", "gene_name": "", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q54KP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54KP2" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q54KP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54KP2" } ] } ] }, { "uniprot_ac": "Q54LP7", "gene_name": "ube2j2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q54LP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54LP7" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q54LP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54LP7" } ] } ] }, { "uniprot_ac": "Q54QG5", "gene_name": "", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "Q54QG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QG5" } ] } ] }, { "uniprot_ac": "Q54QG9", "gene_name": "uba3", "activity": [ { "ec_number": "6.2.1.64", "activity": "ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.", "evidence": [ { "id": "Q54QG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QG9" } ] }, { "ec_number": "6.2.1.64", "activity": "", "evidence": [ { "id": "Q54QG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QG9" } ] } ] }, { "uniprot_ac": "Q54QS0", "gene_name": "", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "Q54QS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QS0" } ] } ] }, { "uniprot_ac": "Q54QZ3", "gene_name": "", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q54QZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QZ3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q54QZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QZ3" } ] } ] }, { "uniprot_ac": "Q54RP0", "gene_name": "agtA", "activity": [ { "ec_number": "2.4.1.37", "activity": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-alpha-D-galactose = an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP.", "evidence": [ { "id": "Q54RP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54RP0" } ] }, { "ec_number": "2.4.1.37", "activity": "", "evidence": [ { "id": "Q54RP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54RP0" } ] } ] }, { "uniprot_ac": "Q54TI6", "gene_name": "ube2m", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "Q54TI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54TI6" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "Q54TI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54TI6" } ] } ] }, { "uniprot_ac": "Q54XG4", "gene_name": "", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q54XG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54XG4" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q54XG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54XG4" } ] } ] }, { "uniprot_ac": "Q54XS6", "gene_name": "ube2c", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q54XS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54XS6" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q54XS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54XS6" } ] } ] }, { "uniprot_ac": "Q553F3", "gene_name": "ubc2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q553F3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q553F3" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q553F3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q553F3" } ] } ] }, { "uniprot_ac": "Q555H8", "gene_name": "rnf160", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q555H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q555H8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q555H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q555H8" } ] } ] }, { "uniprot_ac": "Q557E7", "gene_name": "cblA-2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q557E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q557E7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q557E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q557E7" } ] } ] }, { "uniprot_ac": "Q557I6", "gene_name": "mip1-2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q557I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q557I6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q557I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q557I6" } ] } ] }, { "uniprot_ac": "Q55C16", "gene_name": "uba1", "activity": [ { "ec_number": "6.2.1.45", "activity": "ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.", "evidence": [ { "id": "Q55C16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55C16" } ] }, { "ec_number": "6.2.1.45", "activity": "", "evidence": [ { "id": "Q55C16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55C16" } ] } ] }, { "uniprot_ac": "Q55DC5", "gene_name": "", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q55DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55DC5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q55DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55DC5" } ] } ] }, { "uniprot_ac": "Q55EY8", "gene_name": "ube2w", "activity": [ { "ec_number": "2.3.2.25", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].", "evidence": [ { "id": "Q55EY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55EY8" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q55EY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55EY8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q55EY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55EY8" } ] } ] }, { "uniprot_ac": "Q6T486", "gene_name": "rbrA", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q6T486", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6T486" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q6T486", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6T486" } ] } ] }, { "uniprot_ac": "Q75JM9", "gene_name": "", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q75JM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q75JM9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q75JM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q75JM9" } ] } ] }, { "uniprot_ac": "Q86K32", "gene_name": "ube2n", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q86K32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86K32" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q86K32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86K32" } ] } ] }, { "uniprot_ac": "Q8T2Q2", "gene_name": "", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q8T2Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8T2Q2" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q8T2Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8T2Q2" } ] } ] }, { "uniprot_ac": "Q94490", "gene_name": "ubcB", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q94490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q94490" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q94490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q94490" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }