{ "uniprot_canonical_ac": "Q54NY7-1", "uniprot_ac": "Q54NY7", "uniprot_id": "MTNB_DICDI", "mass": { "chemical_mass": 26521.0, "monoisotopic_mass": 26521.0 }, "refseq": { "ac": "XP_639930", "name": "class II aldolase/adducin, N-terminal domain-containing protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_639930" }, "gene_names": [ { "name": "DDB_G0284915", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q54NY7", "id": "Q54NY7" } ], "protein_names": [ { "name": "Probable methylthioribulose-1-phosphate dehydratase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q54NY7" }, { "name": "4.2.1.109", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q54NY7" }, { "name": "MTRu-1-P dehydratase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q54NY7" }, { "name": "class II aldolase/adducin, N-terminal domain-containing protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_639930", "id": "XP_639930" } ], "function": [ { "annotation": "Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).", "evidence": [ { "database": "UniProtKB", "id": "Q54NY7", "url": "https://www.uniprot.org/uniprot/Q54NY7#function" }, { "database": "UniProtKB", "id": "MF_03116", "url": "https://www.uniprot.org/uniprot/MF_03116#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "Q54NY7", "url": "https://www.uniprot.org/uniprot/Q54NY7" } ], "common_name": "Dictyostelium discoideum" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprot/Q54NY7", "locus": {} } ], "crossref": [ { "id": "DDB_G0284915", "url": "", "database": "", "categories": [ "Organism-specific" ] }, { "id": "8624842", "url": "https://www.ncbi.nlm.nih.gov/gene/8624842", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001303", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001303", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017714", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017714", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027514", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027514", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036409", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036409", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ddi:DDB_G0284915", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0284915", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IRGHGLY", "url": "https://omabrowser.org/oma/group/IRGHGLY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10640", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10640", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10640:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10640:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00596", "url": "http://pfam.xfam.org/family/PF00596", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q54NY7", "url": "http://purl.obolibrary.org/obo/PR_Q54NY7", "database": "PRO", "categories": [ "Protein" ] }, { "id": "XP_639930", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_639930", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "15549", "url": "https://www.rhea-db.org/rhea/15549", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q54NY7", "url": "https://www.uniprot.org/uniprot/Q54NY7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q54NY7-1", "url": "https://www.uniprot.org/uniprot/Q54NY7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSNFDSEHPRVLIPELCKLFYGNGWVTGTGGGISIKRDKEIYIAASGVQKERILGEDIFVMDENENEISTPPTEKKLKASQCTPLFFNAYKYRDAGAVIHTHSQHAVMVTLLYQTEFIITHQEMIKGILSGHGENAKYLQYFDRLVIPIIENTPHERDLKERMHKAMEKYPNANAVLVRRHGVYVWGPDWVKAKTMCECFDYLFEIAIKMKQMGLDPTEVPHANEECCYDC", "length": 231, "header": "sp|Q54NY7-1|MTNB_DICDI Isoform 1 of Probable methylthioribulose-1-phosphate dehydratase OS=Dictyostelium discoideum OX=44689 GN= PE=3 SV=1 CANONICAL=Q54NY7-1" }, "isoforms": [ { "isoform_ac": "Q54NY7-1", "url": "", "sequence": { "sequence": "MSNFDSEHPRVLIPELCKLFYGNGWVTGTGGGISIKRDKEIYIAASGVQKERILGEDIFVMDENENEISTPPTEKKLKASQCTPLFFNAYKYRDAGAVIHTHSQHAVMVTLLYQTEFIITHQEMIKGILSGHGENAKYLQYFDRLVIPIIENTPHERDLKERMHKAMEKYPNANAVLVRRHGVYVWGPDWVKAKTMCECFDYLFEIAIKMKQMGLDPTEVPHANEECCYDC", "length": 231, "header": "sp|Q54NY7-1|MTNB_DICDI Isoform 1 of Probable methylthioribulose-1-phosphate dehydratase OS=Dictyostelium discoideum OX=44689 GN= PE=3 SV=1 CANONICAL=Q54NY7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Chen G., Gibbs R.A., Gloeckner G., Hernandez J., Johnson D., Knights A., Lehmann R., Loulseged H., Ma J., Muzny D.M., Oliver K., Platzer M., Rosenthal A., Saito T., Sodergren E., Steffen D., Sugano S., Walker D., Weinstock G., Lu M., Muzny D., Tanaka Y., Song J., Sodergren E.J., Xu Q., Bankier A.T., Barrell B.G., Williams J., Fey P., Nie X., Gibbs R., Dear P.H., Szafranski K., Davies R., Price C., James K., Noegel A.A., Glockner G., Cooper J., Morio T., Davis P., Williams J.G., Kay R.R., Cronin A., Schleicher M., Olsen R., Kummerfeld S., Sharp S., Hauser H., Weinstock G.M., White B., Quiles M., Rost R., Tunggal B., Pain A., Madan Babu M., Madera M., Rivero F., Saunders D., Eichinger L., Sanders M., Kohara Y., Chisholm R.L., Barrell B., Churcher C.M., Hamlin N., Rajandream M.A., Thangavelu M., Quail M.A., Anjard C., Cox E.C., Haydock S., Kuspa A., Loomis W.F., Shaulsky G., Sucgang R., Urushihara H., Bason N., Berriman M., Buchrieser C., Churcher C., Desany B., Farbrother P., Felder M., Gaudet P., Goodhead I., Hall N., Harper D., Hemphill L., James K.D., Just E., Kerhornou A., Konfortov B.A., Lindsay R., Mourier T., Mungall K., Mungall K.L., Pachebat J.A., Pilcher K., Rabbinowitsch E., Simmonds M., Simmonds M.N., Spiegler S., Tivey A., Wardroper A., Winckler T., Woodward J., Woodward J.R., van Driessche N.", "evidence": [ { "database": "UniProtKB", "id": "Q54NY7", "url": "https://www.uniprot.org/uniprot/Q54NY7" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] } ], "pathway": [ { "id": "ddi:DDB_G0284915", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0284915", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q54NY7", "url": "https://www.uniprot.org/uniprot/Q54NY7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q54NY7", "url": "https://www.uniprot.org/uniprot/Q54NY7" } ], "pmid": "" }, { "name": "methylthioribulose 1-phosphate dehydratase activity", "id": "GO:0046570", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046570", "evidence": [ { "database": "UniProtKB", "id": "Q54NY7", "url": "https://www.uniprot.org/uniprot/Q54NY7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "L-methionine salvage from methylthioadenosine", "id": "GO:0019509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019509", "evidence": [ { "database": "UniProtKB", "id": "Q54NY7", "url": "https://www.uniprot.org/uniprot/Q54NY7" } ], "pmid": "" }, { "name": "L-methionine salvage from S-adenosylmethionine", "id": "GO:0019284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019284", "evidence": [ { "database": "UniProtKB", "id": "Q54NY7", "url": "https://www.uniprot.org/uniprot/Q54NY7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "15549", "name": "", "equation": "S-methyl-5-thio-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZUI1-1", "Q96GX9-1", "Q9WVQ5-1", "P47095-1", "Q54NY7-1", "Q9VY93-1" ], "evidence": [ { "id": "15549", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15549" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "D3ZUI1", "gene_name": "Apip", "activity": [ { "ec_number": "4.2.1.109", "activity": "S-methyl-5-thio-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O.", "evidence": [ { "id": "D3ZUI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZUI1" } ] }, { "ec_number": "4.2.1.109", "activity": "", "evidence": [ { "id": "D3ZUI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZUI1" } ] } ] }, { "uniprot_ac": "P47095", "gene_name": "MDE1", "activity": [ { "ec_number": "4.2.1.109", "activity": "S-methyl-5-thio-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O.", "evidence": [ { "id": "P47095", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47095" } ] }, { "ec_number": "4.2.1.109", "activity": "", "evidence": [ 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