{ "uniprot_canonical_ac": "Q54MU9-1", "uniprot_ac": "Q54MU9", "uniprot_id": "Q54MU9_DICDI", "mass": { "chemical_mass": 81909.0, "monoisotopic_mass": 81909.0 }, "refseq": { "ac": "XP_638194", "name": "glycoside hydrolase family 20 protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_638194" }, "gene_names": [ { "name": "nagE", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q54MU9", "id": "Q54MU9" }, { "name": "DDB_G0285647", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q54MU9", "id": "Q54MU9" }, { "name": "nagE", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_638194", "id": "XP_638194" } ], "protein_names": [ { "name": "beta-N-acetylhexosaminidase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q54MU9" }, { "name": "3.2.1.52", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q54MU9" }, { "name": "glycoside hydrolase family 20 protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_638194", "id": "XP_638194" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "Q54MU9", "url": "https://www.uniprot.org/uniprot/Q54MU9" } ], "common_name": "Dictyostelium discoideum" } ], "gene": [ { "name": "nagE", "url": "https://www.uniprot.org/uniprot/Q54MU9", "locus": {} } ], "crossref": [ { "id": "DDB_G0285647", "url": "", "database": "", "categories": [ "Organism-specific" ] }, { "id": "8625240", "url": "https://www.ncbi.nlm.nih.gov/gene/8625240", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR015883", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015883", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017853", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017853", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025705", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025705", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029018", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029018", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029019", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029019", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ddi:DDB_G0285647", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0285647", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EACAWEM", "url": "https://omabrowser.org/oma/group/EACAWEM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR22600", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22600", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22600:SF23", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22600:SF23", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00728", "url": "http://pfam.xfam.org/family/PF00728", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF14845", "url": "http://pfam.xfam.org/family/PF14845", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-2022857", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-2022857", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-2024101", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-2024101", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-2160916", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-2160916", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-9840310", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9840310", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_638194", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_638194", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q54MU9", "url": "https://www.uniprot.org/uniprot/Q54MU9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q54MU9-1", "url": "https://www.uniprot.org/uniprot/Q54MU9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKRIITIINYLFLILLLLLLSFINLTFSFNIVNIEDFKIVNNNENLNYIFPKPKFVTFQASRGDPKNINEFDAKRPFIELTNETKIKFQNDEKSSSSSQNKKHWNENDIEHIKKYYQYLFKVYPIREQSNIFKDIIINNKNNYENTTGTTYTIEIIKTPTLSEKDYKSTHKNTIPFGSNENYELLSSQYGITIYVNSKFGVLHALKSLFQSGNLVLSNNNNNNNNNNNNNNNNNNNKRIKKLYFYNYPFSIVDKPRLNYRGLLIDTGRHYLSVEYIKEIITSMSLLKMNALHWHITDDQSFPLEIPEYPLLYRKGSNHLGYIHNFISTTTTSNNNKTNEEEQKKQKQHLNYYKLRDIKEIIKHGEFMGVRIIPEIDLPGHTLSWGKAYPELVCSCPNYLEKRRNPINGEYTFSAPLDPSNDLVYTMIESILKTVKSVFTDPYLHLGFDEIPFDCWIENSELVTKMFQKYNLSSPSKYLSFFLKKVNQILSNLKTNNNDNSILMWEDIIPMLDSIDQDEYLLNNDDDDKRDIIFQLWKGRDEYDRFLLKNKKPFIYSFGNYLDPSYQSCNTFSECLFKQQELIEEFEKSKLLIGMEACAWEMIPYGDIKSIEKDGISKHDRGYPDRVWSRLLGIAEKMWFKPIFSFNETENKQLTQSIKDQIKENSITRAKYFIKILDLIIQNQNLIDSSKLNKII", "length": 695, "header": "tr|Q54MU9-1|Q54MU9_DICDI Isoform 1 of beta-N-acetylhexosaminidase OS=Dictyostelium discoideum OX=44689 GN=nagE PE=3 SV=1 CANONICAL=Q54MU9-1" }, "isoforms": [ { "isoform_ac": "Q54MU9-1", "url": "", "sequence": { "sequence": "MKRIITIINYLFLILLLLLLSFINLTFSFNIVNIEDFKIVNNNENLNYIFPKPKFVTFQASRGDPKNINEFDAKRPFIELTNETKIKFQNDEKSSSSSQNKKHWNENDIEHIKKYYQYLFKVYPIREQSNIFKDIIINNKNNYENTTGTTYTIEIIKTPTLSEKDYKSTHKNTIPFGSNENYELLSSQYGITIYVNSKFGVLHALKSLFQSGNLVLSNNNNNNNNNNNNNNNNNNNKRIKKLYFYNYPFSIVDKPRLNYRGLLIDTGRHYLSVEYIKEIITSMSLLKMNALHWHITDDQSFPLEIPEYPLLYRKGSNHLGYIHNFISTTTTSNNNKTNEEEQKKQKQHLNYYKLRDIKEIIKHGEFMGVRIIPEIDLPGHTLSWGKAYPELVCSCPNYLEKRRNPINGEYTFSAPLDPSNDLVYTMIESILKTVKSVFTDPYLHLGFDEIPFDCWIENSELVTKMFQKYNLSSPSKYLSFFLKKVNQILSNLKTNNNDNSILMWEDIIPMLDSIDQDEYLLNNDDDDKRDIIFQLWKGRDEYDRFLLKNKKPFIYSFGNYLDPSYQSCNTFSECLFKQQELIEEFEKSKLLIGMEACAWEMIPYGDIKSIEKDGISKHDRGYPDRVWSRLLGIAEKMWFKPIFSFNETENKQLTQSIKDQIKENSITRAKYFIKILDLIIQNQNLIDSSKLNKII", "length": 695, "header": "tr|Q54MU9-1|Q54MU9_DICDI Isoform 1 of beta-N-acetylhexosaminidase OS=Dictyostelium discoideum OX=44689 GN=nagE PE=3 SV=1 CANONICAL=Q54MU9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Chen G., Gibbs R.A., Gloeckner G., Hernandez J., Johnson D., Knights A., Lehmann R., Loulseged H., Ma J., Muzny D.M., Oliver K., Platzer M., Rosenthal A., Saito T., Sodergren E., Steffen D., Sugano S., Walker D., Weinstock G., Lu M., Muzny D., Tanaka Y., Song J., Sodergren E.J., Xu Q., Bankier A.T., Barrell B.G., Williams J., Fey P., Nie X., Gibbs R., Dear P.H., Szafranski K., Davies R., Price C., James K., Noegel A.A., Glockner G., Cooper J., Morio T., Davis P., Williams J.G., Kay R.R., Cronin A., Schleicher M., Olsen R., Kummerfeld S., Sharp S., Hauser H., Weinstock G.M., White B., Quiles M., Rost R., Tunggal B., Pain A., Madan Babu M., Madera M., Rivero F., Saunders D., Eichinger L., Sanders M., Kohara Y., Chisholm R.L., Barrell B., Churcher C.M., Hamlin N., Rajandream M.A., Thangavelu M., Quail M.A., Anjard C., Cox E.C., Haydock S., Kuspa A., Loomis W.F., Shaulsky G., Sucgang R., Urushihara H., Bason N., Berriman M., Buchrieser C., Churcher C., Desany B., Farbrother P., Felder M., Gaudet P., Goodhead I., Hall N., Harper D., Hemphill L., James K.D., Just E., Kerhornou A., Konfortov B.A., Lindsay R., Mourier T., Mungall K., Mungall K.L., Pachebat J.A., Pilcher K., Rabbinowitsch E., Simmonds M., Simmonds M.N., Spiegler S., Tivey A., Wardroper A., Winckler T., Woodward J., Woodward J.R., van Driessche N.", "evidence": [ { "database": "UniProtKB", "id": "Q54MU9", "url": "https://www.uniprot.org/uniprot/Q54MU9" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] } ], "pathway": [ { "id": "ddi:DDB_G0285647", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0285647", "resource": "KEGG Pathway" }, { "id": "R-DDI-2022857", "name": "Keratan sulfate degradation", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-2022857", "resource": "Reactome", "description": "Keratan sulfate degradation" }, { "id": "R-DDI-2024101", "name": "CS/DS degradation", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-2024101", "resource": "Reactome", "description": "CS/DS degradation" }, { "id": "R-DDI-2160916", "name": "Hyaluronan uptake and degradation", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-2160916", "resource": "Reactome", "description": "Hyaluronan uptake and degradation" }, { "id": "R-DDI-9840310", "name": "Glycosphingolipid catabolism", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9840310", "resource": "Reactome", "description": "Glycosphingolipid catabolism" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q54MU9", "url": "https://www.uniprot.org/uniprot/Q54MU9" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "Q54MU9", "url": "https://www.uniprot.org/uniprot/Q54MU9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "Q54MU9", "url": "https://www.uniprot.org/uniprot/Q54MU9" } ], "pmid": "" }, { "name": "glycosaminoglycan metabolic process", "id": "GO:0030203", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030203", "evidence": [ { "database": "UniProtKB", "id": "Q54MU9", "url": "https://www.uniprot.org/uniprot/Q54MU9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "N-acetyl-beta-D-galactosaminidase activity", "id": "GO:0102148", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102148", "evidence": [ { "database": "UniProtKB", "id": "Q54MU9", "url": "https://www.uniprot.org/uniprot/Q54MU9" } ], "pmid": "" }, { "name": "beta-N-acetylhexosaminidase activity", "id": "GO:0004563", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004563", "evidence": [ { "database": "UniProtKB", "id": "Q54MU9", "url": "https://www.uniprot.org/uniprot/Q54MU9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 145, "end_pos": 147, "annotation": "n_glycosylation_sequon" }, { "start_pos": 24, "end_pos": 26, "annotation": "n_glycosylation_sequon" }, { "start_pos": 335, "end_pos": 337, "annotation": "n_glycosylation_sequon" }, { "start_pos": 470, "end_pos": 472, "annotation": "n_glycosylation_sequon" }, { "start_pos": 646, "end_pos": 648, "annotation": "n_glycosylation_sequon" }, { "start_pos": 82, "end_pos": 84, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-DDI-1605632", "name": "bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "lysosomal lumen", "input_participant_list": [], "output_participant_list": [ "R-ALL-1605658" ], "enzyme_list": [ "Q54MU9-1", "Q54K55-1", "Q54K56-1", "Q54SC9-1", "P13723-1" ], "evidence": [ { "id": "R-DDI-1605632", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-1605632" } ] }, { "id": "R-DDI-1638053", "name": "HEXA cleaves the terminal GalNAc from keratan sulfate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "lysosomal lumen", "input_participant_list": [ "R-ALL-2105012" ], "output_participant_list": [ "R-ALL-2105010" ], "enzyme_list": [ "Q54MU9-1", "Q54K55-1", "Q54K56-1", "Q54SC9-1", "P13723-1" ], "evidence": [ { "id": "R-DDI-1638053", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-1638053" } ] }, { "id": "R-DDI-2105001", "name": "HEXA cleaves the terminal GalNAc from DS", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "lysosomal lumen", "input_participant_list": [ "R-ALL-2065269" ], "output_participant_list": [ "R-ALL-2105025" ], "enzyme_list": [ "Q54MU9-1", "Q54K55-1", "Q54K56-1", "Q54SC9-1", "P13723-1" ], "evidence": [ { "id": "R-DDI-2105001", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-2105001" } ] }, { "id": "R-DDI-2162225", "name": "HEXA cleaves the terminal GalNAc from small HA fragments", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "lysosomal lumen", "input_participant_list": [ "R-ALL-2162223" ], "output_participant_list": [ "R-ALL-1678743", "R-ALL-2162224" ], "enzyme_list": [ "Q54MU9-1", "Q54K55-1", "Q54K56-1", "Q54SC9-1", "P13723-1" ], "evidence": [ { "id": "R-DDI-2162225", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-2162225" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1605658", "participant_name": "GalNAc [lysosomal lumen]", "crossref": [ { "id": "28037", "database": "ChEBI", "url": "" }, { "id": "G27025MB", "database": "GlyTouCan", "url": "" }, { "id": "000002562219", "database": "ZINC", "url": "" }, { "id": "000003861733", "database": "ZINC", "url": "" }, { "id": "C01132", "database": "COMPOUND", "url": "" }, { "id": "28037", "database": "ChEBI", "url": "" }, { "id": "G27025MB", "database": "GlyTouCan", "url": "" }, { "id": "000002562219", "database": "ZINC", "url": "" }, { "id": "000003861733", "database": "ZINC", "url": "" }, { "id": "C01132", "database": "COMPOUND", "url": "" }, { "id": "28037", "database": "ChEBI", "url": "" }, { "id": "G27025MB", "database": "GlyTouCan", "url": "" }, { "id": "000002562219", "database": "ZINC", "url": "" }, { "id": "000003861733", "database": "ZINC", "url": "" }, { "id": "C01132", "database": "COMPOUND", "url": "" }, { "id": "000002562219", "database": "ZINC", "url": "" }, { "id": "C01132", "database": "COMPOUND", "url": "" }, { "id": "000003861733", "database": "ZINC", "url": "" }, { "id": "28037", "database": "ChEBI", "url": "" }, { "id": "G27025MB", "database": "GlyTouCan", "url": "" }, { "id": "28037", "database": "ChEBI", "url": "" }, { "id": "G27025MB", "database": "GlyTouCan", "url": "" }, { "id": "000002562219", "database": "ZINC", "url": "" }, { "id": "000003861733", "database": "ZINC", "url": "" }, { "id": "C01132", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-1678743", "participant_name": "GlcNAc [lysosomal lumen]", "crossref": [ { "id": "17411", "database": "ChEBI", "url": "" }, { "id": "HMDB0062641", "database": "HMDB Metabolite", "url": "" }, { "id": "C00140", "database": "COMPOUND", "url": "" }, { "id": "000002077807", "database": "ZINC", "url": "" }, { "id": "17411", "database": "ChEBI", "url": "" }, { "id": "HMDB0062641", "database": "HMDB Metabolite", "url": "" }, { "id": "C00140", "database": "COMPOUND", "url": "" }, { "id": "000002077807", "database": "ZINC", "url": "" }, { "id": "17411", "database": "ChEBI", "url": "" }, { "id": "HMDB0062641", "database": "HMDB Metabolite", "url": "" }, { "id": "C00140", "database": "COMPOUND", "url": "" }, { "id": "000002077807", "database": "ZINC", "url": "" }, { "id": "HMDB0062641", "database": "HMDB Metabolite", "url": "" }, { "id": "000002077807", "database": "ZINC", "url": "" }, { "id": "C00140", "database": "COMPOUND", "url": "" }, { "id": "17411", "database": "ChEBI", "url": "" }, { "id": "17411", "database": "ChEBI", "url": "" }, { "id": "HMDB0062641", "database": "HMDB Metabolite", "url": "" }, { "id": "C00140", "database": "COMPOUND", "url": "" }, { "id": "000002077807", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-2065269", "participant_name": "ChEBI:63516 chain [lysosomal lumen]", "crossref": [ { "id": "63516", "database": "ChEBI", "url": "" }, { "id": "63516", "database": "ChEBI", "url": "" }, { "id": "63516", "database": "ChEBI", "url": "" }, { "id": "63516", "database": "ChEBI", "url": "" }, { "id": "63516", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-2105010", "participant_name": "Gal-GlcNAc(S)-Gal [lysosomal lumen]", "crossref": [ { "id": "G08421", "database": "KEGG Glycan", "url": "" }, { "id": "63853", "database": "ChEBI", "url": "" }, { "id": "000087528704", "database": "ZINC", "url": "" }, { "id": "000087528707", "database": "ZINC", "url": "" }, { "id": "G08421", "database": "KEGG Glycan", "url": "" }, { "id": "63853", "database": "ChEBI", "url": "" }, { "id": "000087528704", "database": "ZINC", "url": "" }, { "id": "000087528707", "database": "ZINC", "url": "" }, { "id": "G08421", "database": "KEGG Glycan", "url": "" }, { "id": "63853", "database": "ChEBI", "url": "" }, { "id": "000087528704", "database": "ZINC", "url": "" }, { "id": "000087528707", "database": "ZINC", "url": "" }, { "id": "G08421", "database": "KEGG Glycan", "url": "" }, { "id": "000087528704", "database": "ZINC", "url": "" }, { "id": "000087528707", "database": "ZINC", "url": "" }, { "id": "63853", "database": "ChEBI", "url": "" }, { "id": "G08421", "database": "KEGG Glycan", "url": "" }, { "id": "63853", "database": "ChEBI", "url": "" }, { "id": "000087528704", "database": "ZINC", "url": "" }, { "id": "000087528707", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-2105012", "participant_name": "GlcNAc-Gal-GlcNAc(S)-Gal [lysosomal lumen]", "crossref": [ { "id": "G13033", "database": "KEGG Glycan", "url": "" }, { "id": "63852", "database": "ChEBI", "url": "" }, { "id": "000096085299", "database": "ZINC", "url": "" }, { "id": "000096085300", "database": "ZINC", "url": "" }, { "id": "63852", "database": "ChEBI", "url": "" }, { "id": "000096085300", "database": "ZINC", "url": "" }, { "id": "G13033", "database": "KEGG Glycan", "url": "" }, { "id": "000096085299", "database": "ZINC", "url": "" }, { "id": "G13033", "database": "KEGG Glycan", "url": "" }, { "id": "63852", "database": "ChEBI", "url": "" }, { "id": "000096085299", "database": "ZINC", "url": "" }, { "id": "000096085300", "database": "ZINC", "url": "" }, { "id": "G13033", "database": "KEGG Glycan", "url": "" }, { "id": "63852", "database": "ChEBI", "url": "" }, { "id": "000096085299", "database": "ZINC", "url": "" }, { "id": "000096085300", "database": "ZINC", "url": "" }, { "id": "G13033", "database": "KEGG Glycan", "url": "" }, { "id": "63852", "database": "ChEBI", "url": "" }, { "id": "000096085299", "database": "ZINC", "url": "" }, { "id": "000096085300", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-2105025", "participant_name": "IdoA-GalNAc(4S)-GlcA-Gal-Gal-Xyl [lysosomal lumen]", "crossref": [ { "id": "63873", "database": "ChEBI", "url": "" }, { "id": "63873", "database": "ChEBI", "url": "" }, { "id": "63873", "database": "ChEBI", "url": "" }, { "id": "63873", "database": "ChEBI", "url": "" }, { "id": "63873", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-2162223", "participant_name": "GlcNAc-GlcA-GlcNAc [lysosomal lumen]", "crossref": [ { "id": "63563", "database": "ChEBI", "url": "" }, { "id": "63563", "database": "ChEBI", "url": "" }, { "id": "63563", "database": "ChEBI", "url": "" }, { "id": "63563", "database": "ChEBI", "url": "" }, { "id": "63563", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-2162224", "participant_name": "GlcA-1,3-GlcNAc [lysosomal lumen]", "crossref": [ { "id": "64024", "database": "ChEBI", "url": "" }, { "id": "G35674CY", "database": "GlyTouCan", "url": "" }, { "id": "000031371284", "database": "ZINC", "url": "" }, { "id": "000031371287", "database": "ZINC", "url": "" }, { "id": "64024", "database": "ChEBI", "url": "" }, { "id": "G35674CY", "database": "GlyTouCan", "url": "" }, { "id": "000031371284", "database": "ZINC", "url": "" }, { "id": "000031371287", "database": "ZINC", "url": "" }, { "id": "64024", "database": "ChEBI", "url": "" }, { "id": "G35674CY", "database": "GlyTouCan", "url": "" }, { "id": "000031371284", "database": "ZINC", "url": "" }, { "id": "000031371287", "database": "ZINC", "url": "" }, { "id": "64024", "database": "ChEBI", "url": "" }, { "id": "G35674CY", "database": "GlyTouCan", "url": "" }, { "id": "000031371284", "database": "ZINC", "url": "" }, { "id": "000031371287", "database": "ZINC", "url": "" }, { "id": "64024", "database": "ChEBI", "url": "" }, { "id": "G35674CY", "database": "GlyTouCan", "url": "" }, { "id": "000031371284", "database": "ZINC", "url": "" }, { "id": "000031371287", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "P13723", "gene_name": "hexa1", "activity": [ { "ec_number": "3.2.1.52", "activity": "Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.", "evidence": [ { "id": "P13723", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13723" } ] }, { "ec_number": "3.2.1.52", "activity": "", "evidence": [ { "id": "P13723", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13723" } ] } ] }, { "uniprot_ac": "Q54K55", "gene_name": "hexb1", "activity": [ { "ec_number": "3.2.1.52", "activity": "Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.", "evidence": [ { "id": "Q54K55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54K55" } ] }, { "ec_number": "3.2.1.52", "activity": "", "evidence": [ { "id": "Q54K55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54K55" } ] } ] }, { "uniprot_ac": "Q54K56", "gene_name": "hexb2", "activity": [ { "ec_number": "3.2.1.52", "activity": "Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.", "evidence": [ { "id": "Q54K56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54K56" } ] }, { "ec_number": "3.2.1.52", "activity": "", "evidence": [ { "id": "Q54K56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54K56" } ] } ] }, { "uniprot_ac": "Q54MU9", "gene_name": "nagE", "activity": [ { "ec_number": "3.2.1.52", "activity": "Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.", "evidence": [ { "id": "Q54MU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54MU9" } ] }, { "ec_number": "3.2.1.52", "activity": "", "evidence": [ { "id": "Q54MU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54MU9" } ] } ] }, { "uniprot_ac": "Q54SC9", "gene_name": "hexa2", "activity": [ { "ec_number": "3.2.1.52", "activity": "Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.", "evidence": [ { "id": "Q54SC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54SC9" } ] }, { "ec_number": "3.2.1.52", "activity": "", "evidence": [ { "id": "Q54SC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54SC9" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }