{ "uniprot_canonical_ac": "Q54MH2-1", "uniprot_ac": "Q54MH2", "uniprot_id": "VINC_DICDI", "mass": { "chemical_mass": 92839.0, "monoisotopic_mass": 92839.0 }, "refseq": { "ac": "XP_638018", "name": "vinculin A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_638018" }, "gene_names": [ { "name": "ctnnA", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q54MH2", "id": "Q54MH2" }, { "name": "DDB_G0285939", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q54MH2", "id": "Q54MH2" }, { "name": "vcl", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q54MH2", "id": "Q54MH2" }, { "name": "vinA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_638018", "id": "XP_638018" }, { "name": "vinA", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q54MH2", "id": "Q54MH2" } ], "protein_names": [ { "name": "Probable vinculin", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q54MH2" }, { "name": "Ddalpha-catenin", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q54MH2" }, { "name": "vinculin A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_638018", "id": "XP_638018" } ], "function": [ { "annotation": "Involved in cell adhesion. Thought to play an important role in cytokinesis B, probably by providing substrate adhesion and traction forces. Required to organize and polarize the tip epithelium during cytokinesis. Required for the normal distribution of myosin in the tip epithelium. Involved in the localization of ctxA, ctxB, dcsA, exoc6 and rgaA. Thought to form a complex with ctxA, ctxB, and rgaA which regulates myosin accumulation to the apical plasma membrane.", "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2#function" }, { "database": "PubMed", "id": "21393547", "url": "https://glygen.org/publication/PubMed/21393547" }, { "database": "PubMed", "id": "19065153", "url": "https://glygen.org/publication/PubMed/19065153" }, { "database": "PubMed", "id": "22902739", "url": "https://glygen.org/publication/PubMed/22902739" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2" } ], "common_name": "Dictyostelium discoideum" } ], "gene": [ { "name": "ctnnA", "url": "https://www.uniprot.org/uniprot/Q54MH2", "locus": {} } ], "crossref": [ { "id": "DDB_G0285939", "url": "", "database": "", "categories": [ "Organism-specific" ] }, { "id": "8625369", "url": "https://www.ncbi.nlm.nih.gov/gene/8625369", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006077", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006077", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017997", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017997", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036723", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036723", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ddi:DDB_G0285939", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0285939", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ANNLCEL", "url": "https://omabrowser.org/oma/group/ANNLCEL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR46180", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46180", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46180:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46180:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01044", "url": "http://pfam.xfam.org/family/PF01044", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q54MH2", "url": "http://purl.obolibrary.org/obo/PR_Q54MH2", "database": "PRO", "categories": [ "Protein" ] }, { "id": "XP_638018", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_638018", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q54MH2-1", "url": "https://www.uniprot.org/uniprot/Q54MH2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDEVLEMIADAVSSLVVAITDSEEKNTLFGDMVPGVELIQQAVNGMAEAAEETVSLIDEEFIGQLESTSKQLKNSAGQLYVHAVRAREDPWNRVPQKDAIKAAKQILQNVVLLVLIEEQSNIKVLVNIAKKAAEGVRRIDEIENIKQLDVMIGDVNQLQNELVKRSQRRSEGSHNPELRSKLEDIATMVNILSEQHQASARDVCRNPREETLRSKRSELSSKLLSAIDDLIYTIKLIFENNTKFVDLAFKWKPVRTMAEDEVTRASAVLIDNLRTLPKSIEAGNGPAAAREIVNAANLQISNAIIVANRCQDPVKKKMLLKQIEELKKLTPMLISAMKPVLENPNDQEAQKHLESVIYSTQKASEALATAVVSSPAEIVAASGVSLARDLDSLEEAIASGDKKRAQVILSHIPSAIDKHIELANALLETITDPGQRHQIKQSIERLQTLKPRIIENANRAIANPNDHEARKNLSSDIKEAKKAIGQISQPYEVVSALNTKIHNDLDSLIKCIDEGGPDMQVKGVQYAKDIANSIKKQIEAAEAYAQTITDPDRKKQVLDSIEQLKKLTPQLLEAIRACLANPDDKEARKRLDDVVRRVKEASSNLSQVIQPTADELKEEKRKRNEEIARIEAEEKAKARALLKAAELARIEAEEEKKRLAIIEEEKKRLAAEEEERKRAPKLVVPEGPVNKAVFGAAADVAQALESKVRDGTPLGILVQLSDEIAQQMALIASFAMNGDVKGMITAARKIADTIKQVQTQAKHIADNCTDPRLKQNVLTYCDCGGNFSTQLKILCAVKSNDFNDPTAEEQLVTCAKGLSGAVINLVKSSEAASIKQRKVPQQ", "length": 842, "header": "sp|Q54MH2-1|VINC_DICDI Isoform 1 of Probable vinculin OS=Dictyostelium discoideum OX=44689 GN=ctnnA PE=1 SV=1 CANONICAL=Q54MH2-1" }, "isoforms": [ { "isoform_ac": "Q54MH2-1", "url": "", "sequence": { "sequence": "MDEVLEMIADAVSSLVVAITDSEEKNTLFGDMVPGVELIQQAVNGMAEAAEETVSLIDEEFIGQLESTSKQLKNSAGQLYVHAVRAREDPWNRVPQKDAIKAAKQILQNVVLLVLIEEQSNIKVLVNIAKKAAEGVRRIDEIENIKQLDVMIGDVNQLQNELVKRSQRRSEGSHNPELRSKLEDIATMVNILSEQHQASARDVCRNPREETLRSKRSELSSKLLSAIDDLIYTIKLIFENNTKFVDLAFKWKPVRTMAEDEVTRASAVLIDNLRTLPKSIEAGNGPAAAREIVNAANLQISNAIIVANRCQDPVKKKMLLKQIEELKKLTPMLISAMKPVLENPNDQEAQKHLESVIYSTQKASEALATAVVSSPAEIVAASGVSLARDLDSLEEAIASGDKKRAQVILSHIPSAIDKHIELANALLETITDPGQRHQIKQSIERLQTLKPRIIENANRAIANPNDHEARKNLSSDIKEAKKAIGQISQPYEVVSALNTKIHNDLDSLIKCIDEGGPDMQVKGVQYAKDIANSIKKQIEAAEAYAQTITDPDRKKQVLDSIEQLKKLTPQLLEAIRACLANPDDKEARKRLDDVVRRVKEASSNLSQVIQPTADELKEEKRKRNEEIARIEAEEKAKARALLKAAELARIEAEEEKKRLAIIEEEKKRLAAEEEERKRAPKLVVPEGPVNKAVFGAAADVAQALESKVRDGTPLGILVQLSDEIAQQMALIASFAMNGDVKGMITAARKIADTIKQVQTQAKHIADNCTDPRLKQNVLTYCDCGGNFSTQLKILCAVKSNDFNDPTAEEQLVTCAKGLSGAVINLVKSSEAASIKQRKVPQQ", "length": 842, "header": "sp|Q54MH2-1|VINC_DICDI Isoform 1 of Probable vinculin OS=Dictyostelium discoideum OX=44689 GN=ctnnA PE=1 SV=1 CANONICAL=Q54MH2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Chen G., Gibbs R.A., Gloeckner G., Hernandez J., Johnson D., Knights A., Lehmann R., Loulseged H., Ma J., Muzny D.M., Oliver K., Platzer M., Rosenthal A., Saito T., Sodergren E., Steffen D., Sugano S., Walker D., Weinstock G., Lu M., Muzny D., Tanaka Y., Song J., Sodergren E.J., Xu Q., Bankier A.T., Barrell B.G., Williams J., Fey P., Nie X., Gibbs R., Dear P.H., Szafranski K., Davies R., Price C., James K., Noegel A.A., Glockner G., Cooper J., Morio T., Davis P., Williams J.G., Kay R.R., Cronin A., Schleicher M., Olsen R., Kummerfeld S., Sharp S., Hauser H., Weinstock G.M., White B., Quiles M., Rost R., Tunggal B., Pain A., Madan Babu M., Madera M., Rivero F., Saunders D., Eichinger L., Sanders M., Kohara Y., Chisholm R.L., Barrell B., Churcher C.M., Hamlin N., Rajandream M.A., Thangavelu M., Quail M.A., Anjard C., Cox E.C., Haydock S., Kuspa A., Loomis W.F., Shaulsky G., Sucgang R., Urushihara H., Bason N., Berriman M., Buchrieser C., Churcher C., Desany B., Farbrother P., Felder M., Gaudet P., Goodhead I., Hall N., Harper D., Hemphill L., James K.D., Just E., Kerhornou A., Konfortov B.A., Lindsay R., Mourier T., Mungall K., Mungall K.L., Pachebat J.A., Pilcher K., Rabbinowitsch E., Simmonds M., Simmonds M.N., Spiegler S., Tivey A., Wardroper A., Winckler T., Woodward J., Woodward J.R., van Driessche N.", "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] }, { "title": "Cell adhesion molecules regulate contractile ring-independent cytokinesis in Dictyostelium discoideum.", "journal": "Cell Res.", "date": "2009", "authors": "Nagasaki A., Kanada M., Uyeda T.Q.", "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2" } ], "reference": [ { "type": "PubMed", "id": "19065153", "url": "https://glygen.org/publication/PubMed/19065153" } ] }, { "title": "A polarized epithelium organized by beta- and alpha-catenin predates cadherin and metazoan origins.", "journal": "Science", "date": "2011", "authors": "Weis W.I., Nelson W.J., Dickinson D.J.", "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2" } ], "reference": [ { "type": "PubMed", "id": "21393547", "url": "https://glygen.org/publication/PubMed/21393547" } ] }, { "title": "Alpha-catenin and IQGAP regulate myosin localization to control epithelial tube morphogenesis in Dictyostelium.", "journal": "Dev. Cell", "date": "2012", "authors": "Weis W.I., Nelson W.J., Dickinson D.J., Robinson D.N.", "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2" } ], "reference": [ { "type": "PubMed", "id": "22902739", "url": "https://glygen.org/publication/PubMed/22902739" } ] } ], "pathway": [ { "id": "ddi:DDB_G0285939", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0285939", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "basal cortex", "id": "GO:0045180", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045180", "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2" } ], "pmid": "" }, { "name": "cell-cell junction", "id": "GO:0005911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005911", "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2" } ], "pmid": "" }, { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2" } ], "pmid": "" }, { "name": "cell-cell contact zone", "id": "GO:0044291", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044291", "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 14, "go_terms": [ { "name": "positive regulation of cytoskeleton organization", "id": "GO:0051495", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051495", "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2" } ], "pmid": "" }, { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2" } ], "pmid": "" }, { "name": "actin filament bundle assembly", "id": "GO:0051017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051017", "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2" } ], "pmid": "" }, { "name": "actomyosin structure organization", "id": "GO:0031032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031032", "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2" } ], "pmid": "" }, { "name": "mitotic cytokinesis", "id": "GO:0000281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000281", "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2" } ], "pmid": "" }, { "name": "protein localization", "id": "GO:0008104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008104", "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2" } ], "pmid": "" }, { "name": "protein secretion", "id": "GO:0009306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009306", "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2" } ], "pmid": "" }, { "name": "centrosome localization", "id": "GO:0051642", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051642", "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2" } ], "pmid": "" }, { "name": "Golgi localization", "id": "GO:0051645", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051645", "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2" } ], "pmid": "" }, { "name": "sorocarp stalk development", "id": "GO:0031150", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031150", "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2" } ], "pmid": "" }, { "name": "culmination involved in sorocarp development", "id": "GO:0031154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031154", "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2" } ], "pmid": "" }, { "name": "sorocarp stalk morphogenesis", "id": "GO:0036360", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036360", "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2" } ], "pmid": "" }, { "name": "establishment or maintenance of bipolar cell polarity", "id": "GO:0061245", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061245", "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2" } ], "pmid": "" }, { "name": "epithelium-like organization", "id": "GO:0140509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140509", "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2" } ], "pmid": "" }, { "name": "beta-catenin binding", "id": "GO:0008013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008013", "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2" } ], "pmid": "" }, { "name": "alpha-catenin binding", "id": "GO:0045294", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045294", "evidence": [ { "database": "UniProtKB", "id": "Q54MH2", "url": "https://www.uniprot.org/uniprot/Q54MH2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 240, "end_pos": 242, "annotation": "n_glycosylation_sequon" }, { "start_pos": 472, "end_pos": 474, "annotation": "n_glycosylation_sequon" }, { "start_pos": 604, "end_pos": 606, "annotation": "n_glycosylation_sequon" }, { "start_pos": 767, "end_pos": 769, "annotation": "n_glycosylation_sequon" }, { "start_pos": 786, "end_pos": 788, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", 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