{ "uniprot_canonical_ac": "Q54M56-1", "uniprot_ac": "Q54M56", "uniprot_id": "Q54M56_DICDI", "mass": { "chemical_mass": 56285.0, "monoisotopic_mass": 56285.0 }, "refseq": { "ac": "XP_637775", "name": "hypothetical protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_637775" }, "gene_names": [ { "name": "DDB_G0286199", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q54M56", "id": "Q54M56" } ], "protein_names": [ { "name": "rRNA adenine N(6)-methyltransferase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q54M56" }, { "name": "2.1.1.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q54M56" }, { "name": "hypothetical protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_637775", "id": "XP_637775" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "Q54M56", "url": "https://www.uniprot.org/uniprot/Q54M56" } ], "common_name": "Dictyostelium discoideum" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprot/Q54M56", "locus": {} } ], "crossref": [ { "id": "cd02440", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02440", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "DDB_G0286199", "url": "", "database": "", "categories": [ "Organism-specific" ] }, { "id": "8625489", "url": "https://www.ncbi.nlm.nih.gov/gene/8625489", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001737", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001737", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011530", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011530", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020596", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020596", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023165", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023165", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ddi:DDB_G0286199", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0286199", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "THLMLKW", "url": "https://omabrowser.org/oma/group/THLMLKW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11727", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11727", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11727:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11727:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00398", "url": "http://pfam.xfam.org/family/PF00398", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-163282", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-163282", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_637775", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_637775", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q54M56", "url": "https://www.uniprot.org/uniprot/Q54M56", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q54M56-1", "url": "https://www.uniprot.org/uniprot/Q54M56-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTIKNLTTSLPPMPKIQEIIRIFGLSAKQQLSQNFLIDKNITDKICKKSGGFDDCTVIEVGAGPGGLTRSLLTSGAKKVIAVEMDPRFYPALKMLEESSGGRMSLIMANMMDVDEAKLLRDAGAETTNWKDKSKVKIIGNLPFNVGTHLMLKWIRQIAPRQGLYEFGRVPMYLMFQKELSDRICAQVGSEEYSRLSVMVQQMCQPSIVYSIPGTAFVPPPKVDASVVAIEPRISPLGDEPVKDHHYFEFVCRELFSQRRKKLSNTIKTLGKDAESLLGDDIDPKIRTQNLQIEQFVKITNRYIEFPNKIAIDHLEFENDGKTKRKEEKLKERVNKINTRIEKEKKKQELILEEKKLKKEQREKEKQELKENFEKQEIEIQNLTKFDLEDKIDNEKEEEEEEINNSLLDSYKYQLKEALEKKEKIDLLKQKKLENKDIIDQDQLKNQYHQQNNNNKSYNIDDIDLDDDDDGENIDYDQFLNEHFKK", "length": 485, "header": "tr|Q54M56-1|Q54M56_DICDI Isoform 1 of rRNA adenine N(6)-methyltransferase OS=Dictyostelium discoideum OX=44689 GN= PE=3 SV=1 CANONICAL=Q54M56-1" }, "isoforms": [ { "isoform_ac": "Q54M56-1", "url": "", "sequence": { "sequence": "MTIKNLTTSLPPMPKIQEIIRIFGLSAKQQLSQNFLIDKNITDKICKKSGGFDDCTVIEVGAGPGGLTRSLLTSGAKKVIAVEMDPRFYPALKMLEESSGGRMSLIMANMMDVDEAKLLRDAGAETTNWKDKSKVKIIGNLPFNVGTHLMLKWIRQIAPRQGLYEFGRVPMYLMFQKELSDRICAQVGSEEYSRLSVMVQQMCQPSIVYSIPGTAFVPPPKVDASVVAIEPRISPLGDEPVKDHHYFEFVCRELFSQRRKKLSNTIKTLGKDAESLLGDDIDPKIRTQNLQIEQFVKITNRYIEFPNKIAIDHLEFENDGKTKRKEEKLKERVNKINTRIEKEKKKQELILEEKKLKKEQREKEKQELKENFEKQEIEIQNLTKFDLEDKIDNEKEEEEEEINNSLLDSYKYQLKEALEKKEKIDLLKQKKLENKDIIDQDQLKNQYHQQNNNNKSYNIDDIDLDDDDDGENIDYDQFLNEHFKK", "length": 485, "header": "tr|Q54M56-1|Q54M56_DICDI Isoform 1 of rRNA adenine N(6)-methyltransferase OS=Dictyostelium discoideum OX=44689 GN= PE=3 SV=1 CANONICAL=Q54M56-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Chen G., Gibbs R.A., Gloeckner G., Hernandez J., Johnson D., Knights A., Lehmann R., Loulseged H., Ma J., Muzny D.M., Oliver K., Platzer M., Rosenthal A., Saito T., Sodergren E., Steffen D., Sugano S., Walker D., Weinstock G., Lu M., Muzny D., Tanaka Y., Song J., Sodergren E.J., Xu Q., Bankier A.T., Barrell B.G., Williams J., Fey P., Nie X., Gibbs R., Dear P.H., Szafranski K., Davies R., Price C., James K., Noegel A.A., Glockner G., Cooper J., Morio T., Davis P., Williams J.G., Kay R.R., Cronin A., Schleicher M., Olsen R., Kummerfeld S., Sharp S., Hauser H., Weinstock G.M., White B., Quiles M., Rost R., Tunggal B., Pain A., Madan Babu M., Madera M., Rivero F., Saunders D., Eichinger L., Sanders M., Kohara Y., Chisholm R.L., Barrell B., Churcher C.M., Hamlin N., Rajandream M.A., Thangavelu M., Quail M.A., Anjard C., Cox E.C., Haydock S., Kuspa A., Loomis W.F., Shaulsky G., Sucgang R., Urushihara H., Bason N., Berriman M., Buchrieser C., Churcher C., Desany B., Farbrother P., Felder M., Gaudet P., Goodhead I., Hall N., Harper D., Hemphill L., James K.D., Just E., Kerhornou A., Konfortov B.A., Lindsay R., Mourier T., Mungall K., Mungall K.L., Pachebat J.A., Pilcher K., Rabbinowitsch E., Simmonds M., Simmonds M.N., Spiegler S., Tivey A., Wardroper A., Winckler T., Woodward J., Woodward J.R., van Driessche N.", "evidence": [ { "database": "UniProtKB", "id": "Q54M56", "url": "https://www.uniprot.org/uniprot/Q54M56" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] } ], "pathway": [ { "id": "ddi:DDB_G0286199", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0286199", "resource": "KEGG Pathway" }, { "id": "R-DDI-163282", "name": "Mitochondrial transcription initiation", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-163282", "resource": "Reactome", "description": "Mitochondrial transcription initiation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "rRNA methylation", "id": "GO:0031167", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031167", "evidence": [ { "database": "UniProtKB", "id": "Q54M56", "url": "https://www.uniprot.org/uniprot/Q54M56" } ], "pmid": "" }, { "name": "transcription initiation at mitochondrial promoter", "id": "GO:0006391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006391", "evidence": [ { "database": "UniProtKB", "id": "Q54M56", "url": "https://www.uniprot.org/uniprot/Q54M56" } ], "pmid": "" }, { "name": "DNA-templated transcription initiation", "id": "GO:0006352", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006352", "evidence": [ { "database": "UniProtKB", "id": "Q54M56", "url": "https://www.uniprot.org/uniprot/Q54M56" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q54M56", "url": "https://www.uniprot.org/uniprot/Q54M56" } ], "pmid": "" }, { "name": "rRNA methyltransferase activity", "id": "GO:0008649", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008649", "evidence": [ { "database": "UniProtKB", "id": "Q54M56", "url": "https://www.uniprot.org/uniprot/Q54M56" } ], "pmid": "" }, { "name": "rRNA (adenine-N6,N6-)-dimethyltransferase activity", "id": "GO:0000179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000179", "evidence": [ { "database": "UniProtKB", "id": "Q54M56", "url": "https://www.uniprot.org/uniprot/Q54M56" } ], "pmid": "" }, { "name": "mitochondrial transcription factor activity", "id": "GO:0034246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034246", "evidence": [ { "database": "UniProtKB", "id": "Q54M56", "url": "https://www.uniprot.org/uniprot/Q54M56" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q54M56", "url": "https://www.uniprot.org/uniprot/Q54M56" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "Q54M56", "url": "https://www.uniprot.org/uniprot/Q54M56" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 381, "end_pos": 383, "annotation": "n_glycosylation_sequon" }, { "start_pos": 403, "end_pos": 405, "annotation": "n_glycosylation_sequon" }, { "start_pos": 40, "end_pos": 42, "annotation": "n_glycosylation_sequon" }, { "start_pos": 454, "end_pos": 456, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-DDI-163296", "name": "Association of TFAM:mt promoter complex with POLRMT:TFB2M", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54M56-1", "Q95NZ8-1" ], "evidence": [ { "id": "R-DDI-163296", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-163296" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "Q54M56", "gene_name": "", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "Q54M56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54M56" } ] } ] }, { "uniprot_ac": "Q95NZ8", "gene_name": "rpmA", "activity": [ { "ec_number": "2.7.7.6", "activity": "a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1).", "evidence": [ { "id": "Q95NZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q95NZ8" } ] }, { "ec_number": "2.7.7.6", "activity": "", "evidence": [ { "id": "Q95NZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q95NZ8" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }