{ "uniprot_canonical_ac": "Q54LK1-1", "uniprot_ac": "Q54LK1", "uniprot_id": "Q54LK1_DICDI", "mass": { "chemical_mass": 71053.0, "monoisotopic_mass": 71053.0 }, "refseq": { "ac": "XP_637560", "name": "glucosamine-fructose-6-phosphate aminotransferase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_637560" }, "gene_names": [ { "name": "DDB_G0286603", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q54LK1", "id": "Q54LK1" } ], "protein_names": [ { "name": "glutamine--fructose-6-phosphate transaminase (isomerizing)", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q54LK1" }, { "name": "2.6.1.16", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q54LK1" }, { "name": "glucosamine-fructose-6-phosphate aminotransferase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_637560", "id": "XP_637560" }, { "name": "glutamine-fructose-6-phosphate transaminase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_637560", "id": "XP_637560" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "Q54LK1", "url": "https://www.uniprot.org/uniprot/Q54LK1" } ], "common_name": "Dictyostelium discoideum" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprot/Q54LK1", "locus": {} } ], "crossref": [ { "id": "cd00714", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00714", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd05008", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05008", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd05009", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05009", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "DDB_G0286603", "url": "", "database": "", "categories": [ "Organism-specific" ] }, { "id": "8625700", "url": "https://www.ncbi.nlm.nih.gov/gene/8625700", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005855", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005855", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017932", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017932", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035466", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035466", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035490", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035490", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046348", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046348", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047084", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047084", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ddi:DDB_G0286603", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0286603", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ASEYRYA", "url": "https://omabrowser.org/oma/group/ASEYRYA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10937", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10937", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10937:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10937:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01380", "url": "http://pfam.xfam.org/family/PF01380", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13522", "url": "http://pfam.xfam.org/family/PF13522", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q54LK1", "url": "http://purl.obolibrary.org/obo/PR_Q54LK1", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DDI-446210", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-446210", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_637560", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_637560", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13237", "url": "https://www.rhea-db.org/rhea/13237", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q54LK1", "url": "https://www.uniprot.org/uniprot/Q54LK1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q54LK1-1", "url": "https://www.uniprot.org/uniprot/Q54LK1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNQNTIRRLQVTQRHLLEQQQEQQQYQHNSSDSFDGLESSDTCGIIGFVGKEEAINYLLEGLAILENRGYDSAGVTTISSDNDLVTSKYASLNTTSDAITRLKSVAHLHKGHVIGIAHTRWATHGGKTDKNAHPHLDYKDRVAVIHNGVIENNIILKEELEKKGIVFRSETDTEVIAQLIGLFLDQGLQIVDAIKETQKKLQGTWGIAVVCKDNPDQIVAARNGSPLLIGIGKDRMFIASEPGAFSRHTKEFISMENGEIAVLKADGHSLDLSRIEMAAHETIALSPEPYPHWTIKEIMEQPMSISRALNYGGRISDESRVKLGGLEDAKDLLLPIKNLIITGCGTSFFAAQFGARIMRYLGAFDTVQVFDAAEIIRDTLPHNHAGVLMISQSGETKDVARILTLAEESGIPRFSIVNAVGSLIARSSICGVYLNAGREHAVASTKAFSSQVTVLSLVANWFAQHRGIEEGKRRQLIDSLHRLPTNLGMALRVREQCKAIAQKIYKKNSIFVLGKGFAEPIAFEGALKIKEITYCHAEGYSGGALKHGPFALIEQDTPIILIILDDSNSPLMRVAAEEVKARGAHTIVITNNSTLAKHIAHDTILIPSNGILTALLAAIPLQLLAYEMAICKNIDPDRPKNLAKTVTTD", "length": 649, "header": "tr|Q54LK1-1|Q54LK1_DICDI Isoform 1 of glutamine--fructose-6-phosphate transaminase (isomerizing) OS=Dictyostelium discoideum OX=44689 GN= PE=4 SV=1 CANONICAL=Q54LK1-1" }, "isoforms": [ { "isoform_ac": "Q54LK1-1", "url": "", "sequence": { "sequence": "MNQNTIRRLQVTQRHLLEQQQEQQQYQHNSSDSFDGLESSDTCGIIGFVGKEEAINYLLEGLAILENRGYDSAGVTTISSDNDLVTSKYASLNTTSDAITRLKSVAHLHKGHVIGIAHTRWATHGGKTDKNAHPHLDYKDRVAVIHNGVIENNIILKEELEKKGIVFRSETDTEVIAQLIGLFLDQGLQIVDAIKETQKKLQGTWGIAVVCKDNPDQIVAARNGSPLLIGIGKDRMFIASEPGAFSRHTKEFISMENGEIAVLKADGHSLDLSRIEMAAHETIALSPEPYPHWTIKEIMEQPMSISRALNYGGRISDESRVKLGGLEDAKDLLLPIKNLIITGCGTSFFAAQFGARIMRYLGAFDTVQVFDAAEIIRDTLPHNHAGVLMISQSGETKDVARILTLAEESGIPRFSIVNAVGSLIARSSICGVYLNAGREHAVASTKAFSSQVTVLSLVANWFAQHRGIEEGKRRQLIDSLHRLPTNLGMALRVREQCKAIAQKIYKKNSIFVLGKGFAEPIAFEGALKIKEITYCHAEGYSGGALKHGPFALIEQDTPIILIILDDSNSPLMRVAAEEVKARGAHTIVITNNSTLAKHIAHDTILIPSNGILTALLAAIPLQLLAYEMAICKNIDPDRPKNLAKTVTTD", "length": 649, "header": "tr|Q54LK1-1|Q54LK1_DICDI Isoform 1 of glutamine--fructose-6-phosphate transaminase (isomerizing) OS=Dictyostelium discoideum OX=44689 GN= PE=4 SV=1 CANONICAL=Q54LK1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Chen G., Gibbs R.A., Gloeckner G., Hernandez J., Johnson D., Knights A., Lehmann R., Loulseged H., Ma J., Muzny D.M., Oliver K., Platzer M., Rosenthal A., Saito T., Sodergren E., Steffen D., Sugano S., Walker D., Weinstock G., Lu M., Muzny D., Tanaka Y., Song J., Sodergren E.J., Xu Q., Bankier A.T., Barrell B.G., Williams J., Fey P., Nie X., Gibbs R., Dear P.H., Szafranski K., Davies R., Price C., James K., Noegel A.A., Glockner G., Cooper J., Morio T., Davis P., Williams J.G., Kay R.R., Cronin A., Schleicher M., Olsen R., Kummerfeld S., Sharp S., Hauser H., Weinstock G.M., White B., Quiles M., Rost R., Tunggal B., Pain A., Madan Babu M., Madera M., Rivero F., Saunders D., Eichinger L., Sanders M., Kohara Y., Chisholm R.L., Barrell B., Churcher C.M., Hamlin N., Rajandream M.A., Thangavelu M., Quail M.A., Anjard C., Cox E.C., Haydock S., Kuspa A., Loomis W.F., Shaulsky G., Sucgang R., Urushihara H., Bason N., Berriman M., Buchrieser C., Churcher C., Desany B., Farbrother P., Felder M., Gaudet P., Goodhead I., Hall N., Harper D., Hemphill L., James K.D., Just E., Kerhornou A., Konfortov B.A., Lindsay R., Mourier T., Mungall K., Mungall K.L., Pachebat J.A., Pilcher K., Rabbinowitsch E., Simmonds M., Simmonds M.N., Spiegler S., Tivey A., Wardroper A., Winckler T., Woodward J., Woodward J.R., van Driessche N.", "evidence": [ { "database": "UniProtKB", "id": "Q54LK1", "url": "https://www.uniprot.org/uniprot/Q54LK1" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] } ], "pathway": [ { "id": "ddi:DDB_G0286603", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0286603", "resource": "KEGG Pathway" }, { "id": "R-DDI-446210", "name": "Synthesis of UDP-N-acetyl-glucosamine", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-446210", "resource": "Reactome", "description": "Synthesis of UDP-N-acetyl-glucosamine" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein N-linked glycosylation", "id": "GO:0006487", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006487", "evidence": [ { "database": "UniProtKB", "id": "Q54LK1", "url": "https://www.uniprot.org/uniprot/Q54LK1" } ], "pmid": "" }, { "name": "glutamine metabolic process", "id": "GO:0006541", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006541", "evidence": [ { "database": "UniProtKB", "id": "Q54LK1", "url": "https://www.uniprot.org/uniprot/Q54LK1" } ], "pmid": "" }, { "name": "UDP-N-acetylglucosamine metabolic process", "id": "GO:0006047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006047", "evidence": [ { "database": "UniProtKB", "id": "Q54LK1", "url": "https://www.uniprot.org/uniprot/Q54LK1" } ], "pmid": "" }, { "name": "fructose 6-phosphate metabolic process", "id": "GO:0006002", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006002", "evidence": [ { "database": "UniProtKB", "id": "Q54LK1", "url": "https://www.uniprot.org/uniprot/Q54LK1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "glutamine-fructose-6-phosphate transaminase (isomerizing) activity", "id": "GO:0004360", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004360", "evidence": [ { "database": "UniProtKB", "id": "Q54LK1", "url": "https://www.uniprot.org/uniprot/Q54LK1" } ], "pmid": "" }, { "name": "carbohydrate derivative binding", "id": "GO:0097367", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097367", "evidence": [ { "database": "UniProtKB", "id": "Q54LK1", "url": "https://www.uniprot.org/uniprot/Q54LK1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 223, "end_pos": 225, "annotation": "n_glycosylation_sequon" }, { "start_pos": 29, "end_pos": 31, "annotation": "n_glycosylation_sequon" }, { "start_pos": 591, "end_pos": 593, "annotation": "n_glycosylation_sequon" }, { "start_pos": 592, "end_pos": 594, "annotation": "n_glycosylation_sequon" }, { "start_pos": 93, "end_pos": 95, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13237", "name": "", "equation": "D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q4KMC4-1", "P82808-1", "Q06210-1", "O94808-1", "P47856-1", "Q9Z2Z9-1", "P14742-1", "A2P2R3-1", "Q54LK1-1", "Q7PLC7-1", "Q9VAW3-1" ], "evidence": [ { "id": "13237", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13237" } ] }, { "id": "R-DDI-449715", "name": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-449701" ], "enzyme_list": [ "Q54LK1-1" ], "evidence": [ { "id": "R-DDI-449715", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-449715" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-449701", "participant_name": "GlcN6P [cytosol]", "crossref": [ { "id": "HMDB0001254", "database": "HMDB Metabolite", "url": "" }, { "id": "000004097103", "database": "ZINC", "url": "" }, { "id": "15873", "database": "ChEBI", "url": "" }, { "id": "C00352", "database": "COMPOUND", "url": "" }, { "id": "15873", "database": "ChEBI", "url": "" }, { "id": "HMDB0001254", "database": "HMDB Metabolite", "url": "" }, { "id": "C00352", "database": "COMPOUND", "url": "" }, { "id": "000004097103", "database": "ZINC", "url": "" }, { "id": "15873", "database": "ChEBI", "url": "" }, { "id": "HMDB0001254", "database": "HMDB Metabolite", "url": "" }, { "id": "C00352", "database": "COMPOUND", "url": "" }, { "id": "000004097103", "database": "ZINC", "url": "" }, { "id": "15873", "database": "ChEBI", "url": "" }, { "id": "HMDB0001254", "database": "HMDB Metabolite", "url": "" }, { "id": "C00352", "database": "COMPOUND", "url": "" }, { "id": "000004097103", "database": "ZINC", "url": "" }, { "id": "15873", "database": "ChEBI", "url": "" }, { "id": "HMDB0001254", "database": "HMDB Metabolite", "url": "" }, { "id": "C00352", "database": "COMPOUND", "url": "" }, { "id": "000004097103", "database": "ZINC", "url": "" }, { "id": "15873", "database": "ChEBI", "url": "" }, { "id": "HMDB0001254", "database": "HMDB Metabolite", "url": "" }, { "id": "C00352", "database": "COMPOUND", "url": "" }, { "id": "000004097103", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A2P2R3", "gene_name": "", "activity": [ { "ec_number": "2.6.1.16", "activity": "D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate.", "evidence": [ { "id": "A2P2R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2P2R3" } ] }, { "ec_number": "2.6.1.16", "activity": "", "evidence": [ { "id": "A2P2R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2P2R3" } ] } ] }, { "uniprot_ac": "O94808", "gene_name": "GFPT2", "activity": [ { "ec_number": "2.6.1.16", "activity": "D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate.", "evidence": [ { "id": "O94808", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94808" } ] }, { "ec_number": "2.6.1.16", "activity": "", "evidence": [ { "id": "O94808", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94808" } ] } ] }, { "uniprot_ac": "P14742", "gene_name": "GFA1", "activity": [ { "ec_number": "2.6.1.16", "activity": "D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate.", "evidence": [ { "id": "P14742", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14742" } ] }, { "ec_number": "2.6.1.16", "activity": "", "evidence": [ { "id": "P14742", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14742" } ] } ] }, { "uniprot_ac": "P47856", "gene_name": "Gfpt1", "activity": [ { "ec_number": "2.6.1.16", "activity": "D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate.", "evidence": [ { "id": "P47856", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47856" } ] }, { "ec_number": "2.6.1.16", "activity": "", "evidence": [ { "id": "P47856", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47856" } ] } ] }, { "uniprot_ac": "P82808", "gene_name": "Gfpt1", "activity": [ { "ec_number": "2.6.1.16", "activity": "D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate.", "evidence": [ { "id": "P82808", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P82808" } ] }, { "ec_number": "2.6.1.16", "activity": "", "evidence": [ { "id": "P82808", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P82808" } ] } ] }, { "uniprot_ac": "Q06210", "gene_name": "GFPT1", "activity": [ { "ec_number": "2.6.1.16", "activity": "D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate.", "evidence": [ { "id": "Q06210", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06210" } ] }, { "ec_number": "2.6.1.16", "activity": "", "evidence": [ { "id": "Q06210", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06210" } ] } ] }, { "uniprot_ac": "Q4KMC4", "gene_name": "Gfpt2", "activity": [ { "ec_number": "2.6.1.16", "activity": "D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate.", "evidence": [ { "id": "Q4KMC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KMC4" } ] }, { "ec_number": "2.6.1.16", "activity": "", "evidence": [ { "id": "Q4KMC4", "database": 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