{ "uniprot_canonical_ac": "Q54DN5-1", "uniprot_ac": "Q54DN5", "uniprot_id": "Q54DN5_DICDI", "mass": { "chemical_mass": 132532.0, "monoisotopic_mass": 132532.0 }, "refseq": { "ac": "XP_629837", "name": "SH3 domain-containing protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_629837" }, "gene_names": [ { "name": "DDB_G0291984", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q54DN5", "id": "Q54DN5" } ], "protein_names": [ { "name": "glutaminase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q54DN5" }, { "name": "3.5.1.2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q54DN5" }, { "name": "SH3 domain-containing protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_629837", "id": "XP_629837" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "Q54DN5", "url": "https://www.uniprot.org/uniprot/Q54DN5" } ], "common_name": "Dictyostelium discoideum" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprot/Q54DN5", "locus": {} } ], "crossref": [ { "id": "cd00174", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00174", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06463", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06463", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "DDB_G0291984", "url": "", "database": "", "categories": [ "Organism-specific" ] }, { "id": "8628518", "url": "https://www.ncbi.nlm.nih.gov/gene/8628518", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007052", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007052", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008978", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008978", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012338", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012338", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015868", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015868", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ddi:DDB_G0291984", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0291984", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WFSNTFV", "url": "https://omabrowser.org/oma/group/WFSNTFV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR12544", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12544", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12544:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12544:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00018", "url": "http://pfam.xfam.org/family/PF00018", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF04960", "url": "http://pfam.xfam.org/family/PF04960", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF04969", "url": "http://pfam.xfam.org/family/PF04969", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07653", "url": "http://pfam.xfam.org/family/PF07653", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "XP_629837", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_629837", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "15889", "url": "https://www.rhea-db.org/rhea/15889", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q54DN5", "url": "https://www.uniprot.org/uniprot/Q54DN5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q54DN5-1", "url": "https://www.uniprot.org/uniprot/Q54DN5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFKWHQSNNLVYVTFNIPANVTKQDIHAEITSSSIGLGVKGFGLNCEGTLFSSIKGSKWAIKDDTVQVQMDKQQTGVKWSHLLSEITESNAKAVVLFEYEATSEEELSLIPHQVIDIISKDDSGWWEGSKQQMNGVFPSNFVQEFPTDYQPPEDEDASAEATKEEEISKPISQVSRLGINISLGSMDELKNKLANRKTATYTSADIEEAHNNNNASNEESNSSSSSSSSSNINSSGGFVAVKPSGAVNTQQRQPGKVLLNNRQSTILSGVPPAIQSIPSSNTNTTTTTNTTPAVQPLIQLKPKQTNTEINTSGNSIPATTSKESQSTKEESSSGGNKITSLFKKPLKKITAISALTGSHSSNESSSGGDKNNSGSKTKAKVVYDFESKEPNELNLKKGDIIVVLAKDSSGWWQGINQSTQATGWFSNTFVEEIKEEKLPPPPSSSENKQPLKIVKSPPPKSSSSSQPQTVEAKLQSLSDTPKLETARKAGAAKGRKPPSRVRASYLLSDDEKAEREKLKQSFYSHVVSSQKELSMYDNNEDGGEHLSDDDQPSTPPSISRSGGSFTPTQQQQQQSVDKPIERPSKPPPPKRTAAMNSSLNNINEPPPPSNKPPPPPKSLKPLSTSDGYEPPSPPSSSSTTPITTSGEDTLQKSPTLQRKVAPPPQQQNEQDLPSSLVGKPPPLKPTPKPRAIQTNSESTAPAPTPSHEVNFKANLKPAKPSSPPIGNSQEIPTDTSSPPNATTPQPTPPPLKRVAKPPVQQQQPSNENIENITQFKLKPSPASPTSPSSPTIDPISTTTKPPARPPLKKSAAAAAPPSPPNEEATTTSPPTLAAKPKVALRNGPSSAPTSPLSQPQQPLPPSTHKRNLSNPNTTNNEKPPPPTKKPQLIKPLPQFNDICVEVSNICNEIQERSDNSQETTTTFKHNYPSLIDSFFSVAVCSNDGQFWGNDDQLNDHCVPMFQVIYPFLYSILCEEIGLDEVSKFISDQARPDSYDNQKPLNDQKKSHNPFTLAGQLITANLFTGKYPNAVTRIYQFLNIIQELVNCSSVSCDMVSYLSQKSETSDEILVGHLLKSSGLIKQPDDVLDFFYQINSIQLNSKQVSVLAATLANDGVCPFSQDLKLAPKNIISKTIDLIRICNSTPITSSIFDNNIDNINNSKIIPILSDSGVLMIIIPGLMGVSIISPCNNNNNNNNNNNDNFNHYPNNNHIEFCKKLCSILDQ", "length": 1222, "header": "tr|Q54DN5-1|Q54DN5_DICDI Isoform 1 of glutaminase OS=Dictyostelium discoideum OX=44689 GN= PE=3 SV=1 CANONICAL=Q54DN5-1" }, "isoforms": [ { "isoform_ac": "Q54DN5-1", "url": "", "sequence": { "sequence": "MFKWHQSNNLVYVTFNIPANVTKQDIHAEITSSSIGLGVKGFGLNCEGTLFSSIKGSKWAIKDDTVQVQMDKQQTGVKWSHLLSEITESNAKAVVLFEYEATSEEELSLIPHQVIDIISKDDSGWWEGSKQQMNGVFPSNFVQEFPTDYQPPEDEDASAEATKEEEISKPISQVSRLGINISLGSMDELKNKLANRKTATYTSADIEEAHNNNNASNEESNSSSSSSSSSNINSSGGFVAVKPSGAVNTQQRQPGKVLLNNRQSTILSGVPPAIQSIPSSNTNTTTTTNTTPAVQPLIQLKPKQTNTEINTSGNSIPATTSKESQSTKEESSSGGNKITSLFKKPLKKITAISALTGSHSSNESSSGGDKNNSGSKTKAKVVYDFESKEPNELNLKKGDIIVVLAKDSSGWWQGINQSTQATGWFSNTFVEEIKEEKLPPPPSSSENKQPLKIVKSPPPKSSSSSQPQTVEAKLQSLSDTPKLETARKAGAAKGRKPPSRVRASYLLSDDEKAEREKLKQSFYSHVVSSQKELSMYDNNEDGGEHLSDDDQPSTPPSISRSGGSFTPTQQQQQQSVDKPIERPSKPPPPKRTAAMNSSLNNINEPPPPSNKPPPPPKSLKPLSTSDGYEPPSPPSSSSTTPITTSGEDTLQKSPTLQRKVAPPPQQQNEQDLPSSLVGKPPPLKPTPKPRAIQTNSESTAPAPTPSHEVNFKANLKPAKPSSPPIGNSQEIPTDTSSPPNATTPQPTPPPLKRVAKPPVQQQQPSNENIENITQFKLKPSPASPTSPSSPTIDPISTTTKPPARPPLKKSAAAAAPPSPPNEEATTTSPPTLAAKPKVALRNGPSSAPTSPLSQPQQPLPPSTHKRNLSNPNTTNNEKPPPPTKKPQLIKPLPQFNDICVEVSNICNEIQERSDNSQETTTTFKHNYPSLIDSFFSVAVCSNDGQFWGNDDQLNDHCVPMFQVIYPFLYSILCEEIGLDEVSKFISDQARPDSYDNQKPLNDQKKSHNPFTLAGQLITANLFTGKYPNAVTRIYQFLNIIQELVNCSSVSCDMVSYLSQKSETSDEILVGHLLKSSGLIKQPDDVLDFFYQINSIQLNSKQVSVLAATLANDGVCPFSQDLKLAPKNIISKTIDLIRICNSTPITSSIFDNNIDNINNSKIIPILSDSGVLMIIIPGLMGVSIISPCNNNNNNNNNNNDNFNHYPNNNHIEFCKKLCSILDQ", "length": 1222, "header": "tr|Q54DN5-1|Q54DN5_DICDI Isoform 1 of glutaminase OS=Dictyostelium discoideum OX=44689 GN= PE=3 SV=1 CANONICAL=Q54DN5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Chen G., Gibbs R.A., Gloeckner G., Hernandez J., Johnson D., Knights A., Lehmann R., Loulseged H., Ma J., Muzny D.M., Oliver K., Platzer M., Rosenthal A., Saito T., Sodergren E., Steffen D., Sugano S., Walker D., Weinstock G., Lu M., Muzny D., Tanaka Y., Song J., Sodergren E.J., Xu Q., Bankier A.T., Barrell B.G., Williams J., Fey P., Nie X., Gibbs R., Dear P.H., Szafranski K., Davies R., Price C., James K., Noegel A.A., Glockner G., Cooper J., Morio T., Davis P., Williams J.G., Kay R.R., Cronin A., Schleicher M., Olsen R., Kummerfeld S., Sharp S., Hauser H., Weinstock G.M., White B., Quiles M., Rost R., Tunggal B., Pain A., Madan Babu M., Madera M., Rivero F., Saunders D., Eichinger L., Sanders M., Kohara Y., Chisholm R.L., Barrell B., Churcher C.M., Hamlin N., Rajandream M.A., Thangavelu M., Quail M.A., Anjard C., Cox E.C., Haydock S., Kuspa A., Loomis W.F., Shaulsky G., Sucgang R., Urushihara H., Bason N., Berriman M., Buchrieser C., Churcher C., Desany B., Farbrother P., Felder M., Gaudet P., Goodhead I., Hall N., Harper D., Hemphill L., James K.D., Just E., Kerhornou A., Konfortov B.A., Lindsay R., Mourier T., Mungall K., Mungall K.L., Pachebat J.A., Pilcher K., Rabbinowitsch E., Simmonds M., Simmonds M.N., Spiegler S., Tivey A., Wardroper A., Winckler T., Woodward J., Woodward J.R., van Driessche N.", "evidence": [ { "database": "UniProtKB", "id": "Q54DN5", "url": "https://www.uniprot.org/uniprot/Q54DN5" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] } ], "pathway": [ { "id": "ddi:DDB_G0291984", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0291984", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "glutamine metabolic process", "id": "GO:0006541", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006541", "evidence": [ { "database": "UniProtKB", "id": "Q54DN5", "url": "https://www.uniprot.org/uniprot/Q54DN5" } ], "pmid": "" }, { "name": "cellular component assembly", "id": "GO:0022607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022607", "evidence": [ { "database": "UniProtKB", "id": "Q54DN5", "url": "https://www.uniprot.org/uniprot/Q54DN5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "glutaminase activity", "id": "GO:0004359", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004359", "evidence": [ { "database": "UniProtKB", "id": "Q54DN5", "url": "https://www.uniprot.org/uniprot/Q54DN5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1045, "end_pos": 1047, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1140, "end_pos": 1142, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1157, "end_pos": 1159, "annotation": "n_glycosylation_sequon" }, { "start_pos": 180, "end_pos": 182, "annotation": "n_glycosylation_sequon" }, { "start_pos": 20, "end_pos": 22, "annotation": "n_glycosylation_sequon" }, { "start_pos": 214, "end_pos": 216, "annotation": "n_glycosylation_sequon" }, { "start_pos": 221, "end_pos": 223, "annotation": "n_glycosylation_sequon" }, { "start_pos": 233, "end_pos": 235, "annotation": "n_glycosylation_sequon" }, { "start_pos": 283, "end_pos": 285, "annotation": "n_glycosylation_sequon" }, { "start_pos": 289, "end_pos": 291, "annotation": "n_glycosylation_sequon" }, { "start_pos": 310, "end_pos": 312, "annotation": "n_glycosylation_sequon" }, { "start_pos": 362, "end_pos": 364, "annotation": "n_glycosylation_sequon" }, { "start_pos": 371, "end_pos": 373, "annotation": "n_glycosylation_sequon" }, { "start_pos": 416, "end_pos": 418, "annotation": "n_glycosylation_sequon" }, { "start_pos": 596, "end_pos": 598, "annotation": "n_glycosylation_sequon" }, { "start_pos": 740, "end_pos": 742, "annotation": "n_glycosylation_sequon" }, { "start_pos": 771, "end_pos": 773, "annotation": "n_glycosylation_sequon" }, { "start_pos": 867, "end_pos": 869, "annotation": "n_glycosylation_sequon" }, { "start_pos": 872, "end_pos": 874, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "15889", "name": "", "equation": "H2O + L-glutamine = L-glutamate + NH4(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P28492-1", "P13264-1", "O94925-1", "Q9UI32-1", "D3Z7P3-1", "Q571F8-1", "P33734-1", "Q03144-1", "P43544-1", "P53823-1", "Q54DN5-1", "Q54J48-1", "Q1RL13-1" ], "evidence": [ { "id": "15889", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15889" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "D3Z7P3", "gene_name": "Gls", "activity": [ { "ec_number": "3.5.1.2", "activity": "H2O + L-glutamine = L-glutamate + NH4(+).", "evidence": [ { "id": "D3Z7P3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z7P3" } ] }, { "ec_number": "3.5.1.2", "activity": "", "evidence": [ { "id": "D3Z7P3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z7P3" } ] } ] }, { "uniprot_ac": "O94925", "gene_name": "GLS", "activity": [ { "ec_number": "3.5.1.2", "activity": "H2O + L-glutamine = L-glutamate + NH4(+).", "evidence": [ { "id": "O94925", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94925" } ] }, { "ec_number": "3.5.1.2", "activity": "", "evidence": [ { "id": "O94925", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94925" } ] } ] }, { "uniprot_ac": "P13264", "gene_name": "Gls", "activity": [ { "ec_number": "3.5.1.2", "activity": "H2O + L-glutamine = L-glutamate + NH4(+).", "evidence": [ { "id": "P13264", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13264" } ] }, { "ec_number": "3.5.1.2", "activity": "", "evidence": [ { "id": "P13264", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13264" } ] } ] }, { "uniprot_ac": "P28492", "gene_name": "Gls2", "activity": [ { "ec_number": "3.5.1.2", "activity": "H2O + L-glutamine = L-glutamate + NH4(+).", "evidence": [ { "id": "P28492", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28492" } ] }, { "ec_number": "3.5.1.2", "activity": "", "evidence": [ { "id": "P28492", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28492" } ] } ] }, { "uniprot_ac": "P33734", "gene_name": "HIS7", "activity": [ { "ec_number": "3.5.1.2", "activity": "H2O + L-glutamine = L-glutamate + NH4(+).", "evidence": [ { "id": "P33734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33734" } ] }, { "ec_number": "4.3.2.10", "activity": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate.", "evidence": [ { "id": "P33734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33734" } ] }, { "ec_number": "4.3.2.10", "activity": "", "evidence": [ { "id": "P33734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33734" } ] } ] }, { "uniprot_ac": "P43544", "gene_name": "SNO3", "activity": [ { "ec_number": "3.5.1.2", "activity": "H2O + L-glutamine = L-glutamate + NH4(+).", "evidence": [ { "id": "P43544", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43544" } ] }, { "ec_number": "4.3.3.6", "activity": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate.", "evidence": [ { "id": "P43544", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43544" } ] }, { "ec_number": "4.3.3.6", "activity": "", "evidence": [ { "id": "P43544", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43544" } ] } ] }, { "uniprot_ac": "P53823", "gene_name": "SNO2", "activity": [ { "ec_number": "3.5.1.2", "activity": "H2O + L-glutamine = L-glutamate + NH4(+).", "evidence": [ { "id": "P53823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53823" } ] }, { "ec_number": "4.3.3.6", "activity": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate.", "evidence": [ { "id": "P53823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53823" } ] }, { "ec_number": "4.3.3.6", "activity": "", "evidence": [ { "id": "P53823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53823" } ] } ] }, { "uniprot_ac": "Q03144", "gene_name": "SNO1", "activity": [ { "ec_number": "3.5.1.2", "activity": "H2O + L-glutamine = L-glutamate + NH4(+).", "evidence": [ { "id": "Q03144", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03144" } ] }, { "ec_number": "4.3.3.6", "activity": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate.", "evidence": [ { "id": "Q03144", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03144" } ] }, { "ec_number": "4.3.3.6", "activity": "", "evidence": [ { "id": "Q03144", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03144" } ] } ] }, { "uniprot_ac": "Q1RL13", "gene_name": "GLS", "activity": [ { "ec_number": "3.5.1.2", "activity": "H2O + L-glutamine = L-glutamate + NH4(+).", "evidence": [ { "id": "Q1RL13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1RL13" } ] }, { "ec_number": "3.5.1.2", "activity": "", "evidence": [ { "id": "Q1RL13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1RL13" } ] } ] }, { "uniprot_ac": "Q54DN5", "gene_name": "", "activity": [ { "ec_number": "3.5.1.2", "activity": "H2O + L-glutamine = L-glutamate + NH4(+).", "evidence": [ { "id": "Q54DN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54DN5" } ] }, { "ec_number": "3.5.1.2", "activity": "", "evidence": [ { "id": "Q54DN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54DN5" } ] } ] }, { "uniprot_ac": "Q54J48", "gene_name": "pdx2", "activity": [ { "ec_number": "3.5.1.2", "activity": "H2O + L-glutamine = L-glutamate + NH4(+).", "evidence": [ { "id": "Q54J48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54J48" } ] }, { "ec_number": "4.3.3.6", "activity": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate.", "evidence": [ { "id": "Q54J48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54J48" } ] }, { "ec_number": "4.3.3.6", "activity": "", "evidence": [ { "id": "Q54J48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54J48" } ] } ] }, { "uniprot_ac": "Q571F8", "gene_name": "Gls2", "activity": [ { "ec_number": "3.5.1.2", "activity": "H2O + L-glutamine = L-glutamate + NH4(+).", "evidence": [ { "id": "Q571F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q571F8" } ] }, { "ec_number": "3.5.1.2", "activity": "", "evidence": [ { "id": "Q571F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q571F8" } ] } ] }, { "uniprot_ac": "Q9UI32", "gene_name": "GLS2", "activity": [ { "ec_number": "3.5.1.2", "activity": "H2O + L-glutamine = L-glutamate + NH4(+).", "evidence": [ { "id": "Q9UI32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UI32" } ] }, { 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