{ "uniprot_canonical_ac": "Q53F39-1", "uniprot_ac": "Q53F39", "uniprot_id": "MPPE1_HUMAN", "mass": { "chemical_mass": 45141.0, "monoisotopic_mass": 45141.0 }, "refseq": { "ac": "NP_001317492", "name": "metallophosphoesterase 1 isoform 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317492" }, "gene_names": [ { "name": "MPPE1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q53F39", "id": "Q53F39" }, { "name": "Cdc1; PGAP5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317492", "id": "NP_001317492" }, { "name": "MPPE1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317492", "id": "NP_001317492" }, { "name": "PGAP5", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q53F39", "id": "Q53F39" }, { "name": "PP579", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q53F39", "id": "Q53F39" } ], "protein_names": [ { "name": "Metallophosphoesterase 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q53F39" }, { "name": "3.1.-.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q53F39" }, { "name": "Post-GPI attachment to proteins factor 5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q53F39" }, { "name": "metallo phosphoesterase; post-GPI attachment to proteins factor 5; post-GPI attachment to proteins 5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229833", "id": "NP_001229833" }, { "name": "metallophosphoesterase 1 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229833", "id": "NP_001229833" }, { "name": "metallophosphoesterase 1 isoform 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317492", "id": "NP_001317492" } ], "function": [ { "annotation": "CDNA cloning, genomic organization and expression of the novel human metallophosphoesterase gene MPPE1 on chromosome 18p11.2", "evidence": [ { "database": "RefSeq", "id": "NP_001317492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317492" }, { "database": "PubMed", "id": "11978971", "url": "https://glygen.org/publication/PubMed/11978971" }, { "database": "RefSeq", "id": "NP_001229833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229833" } ] }, { "annotation": "Data demonstrate that glycosylphosphatidylinositol(GPI) glycan acts as an endoplasmic reticulum-exit signal and suggest that glycan remodeling mediated by PGAP5 regulates GPI-anchored proteins transport in the early secretory pathway.", "evidence": [ { "database": "RefSeq", "id": "NP_001317492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317492" }, { "database": "PubMed", "id": "19837036", "url": "https://glygen.org/publication/PubMed/19837036" }, { "database": "RefSeq", "id": "NP_001229833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229833" } ] }, { "annotation": "Metallophosphoesterase 1, a novel candidate gene in hepatocellular carcinoma malignancy and recurrence.", "evidence": [ { "database": "RefSeq", "id": "NP_001317492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317492" }, { "database": "PubMed", "id": "33054568", "url": "https://glygen.org/publication/PubMed/33054568" }, { "database": "RefSeq", "id": "NP_001229833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229833" } ] }, { "annotation": "Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.", "evidence": [ { "database": "UniProtKB", "id": "K7EM03", "url": "https://www.uniprot.org/uniprot/K7EM03#function" }, { "database": "UniProtKB", "id": "ARBA00025587", "url": "https://www.uniprot.org/uniprot/ARBA00025587#function" }, { "database": "UniProtKB", "id": "A0A0C4DH11", "url": "https://www.uniprot.org/uniprot/A0A0C4DH11#function" }, { "database": "UniProtKB", "id": "K7EQ70", "url": "https://www.uniprot.org/uniprot/K7EQ70#function" }, { "database": "UniProtKB", "id": "Q53F39", "url": "https://www.uniprot.org/uniprot/Q53F39#function" }, { "database": "PubMed", "id": "19837036", "url": "https://glygen.org/publication/PubMed/19837036" }, { "database": "PubMed", "id": "29374258", "url": "https://glygen.org/publication/PubMed/29374258" }, { "database": "UniProtKB", "id": "A0A0A0MR93", "url": "https://www.uniprot.org/uniprot/A0A0A0MR93#function" }, { "database": "UniProtKB", "id": "K7EQV4", "url": "https://www.uniprot.org/uniprot/K7EQV4#function" }, { "database": "UniProtKB", "id": "K7ES91", "url": "https://www.uniprot.org/uniprot/K7ES91#function" } ] }, { "annotation": "Observational study of gene-disease association. (HuGE Navigator)", "evidence": [ { "database": "RefSeq", "id": "NP_001317492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317492" }, { "database": "PubMed", "id": "19328558", "url": "https://glygen.org/publication/PubMed/19328558" }, { "database": "RefSeq", "id": "NP_001229833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229833" } ] }, { "annotation": "These results provide evidence of an association between a polymorphism in the MPPE1 gene and bipolar disorder. GeneRIF: Observational study of gene-disease association. (HuGE Navigator)", "evidence": [ { "database": "RefSeq", "id": "NP_001317492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317492" }, { "database": "PubMed", "id": "19859903", "url": "https://glygen.org/publication/PubMed/19859903" }, { "database": "RefSeq", "id": "NP_001229833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229833" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "Q53F39", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q53F39" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 125, "end_pos": 125, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "K", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (KWS->NWS).", "chr_id": "18", "chr_pos": "11893483", "ref_nt": "C", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "K125", "disease": [ { "disease_id": "DOID:11054", "recommended_name": { 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"resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", 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"id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "Q53F39", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q53F39" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q53F39" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "Q53F39", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q53F39" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": 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"Protein" ] }, { "id": "K7ES91-1", "url": "https://www.uniprot.org/uniprot/K7ES91-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7ESB8", "url": "https://www.uniprot.org/uniprot/K7ESB8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7ESB8-1", "url": "https://www.uniprot.org/uniprot/K7ESB8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q53F39", "url": "https://www.uniprot.org/uniprot/Q53F39", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q53F39-1", "url": "https://www.uniprot.org/uniprot/Q53F39-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q53F39-2", "url": "https://www.uniprot.org/uniprot/Q53F39-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q53F39-3", "url": "https://www.uniprot.org/uniprot/Q53F39-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q53F39-4", "url": "https://www.uniprot.org/uniprot/Q53F39-4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q53F39-5", "url": "https://www.uniprot.org/uniprot/Q53F39-5", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAMIELGFGRQNFHPLKRKSSLLLKLIAVVFAVLLFCEFLIYYLAIFQCNWPEVKTTASDGEQTTREPVLKAMFLADTHLLGEFLGHWLDKLRREWQMERAFQTALWLLQPEVVFILGDIFDEGKWSTPEAWADDVERFQKMFRHPSHVQLKVVAGNHDIGFHYEMNTYKVERFEKVFSSERLFSWKGINFVMVNSVALNGDGCGICSETEAELIEVSHRLNCSREARGSSRCGPGPLLPTSAPVLLQHYPLYRRSDANCSGEDAAPAEERDIPFKENYDVLSREASQKLLWWLQPRLVLSGHTHSACEVHHGGRVPELSVPSFSWRNRNNPSFIMGSITPTDYTLSKCYLPREDVVLIIYCGVVGFLVVLTLTHFGLLASPFLSGLNLLGKRKTR", "length": 396, "header": "sp|Q53F39-1|MPPE1_HUMAN Isoform 1 of Metallophosphoesterase 1 OS=Homo sapiens OX=9606 GN=MPPE1 PE=1 SV=2 CANONICAL=Q53F39-1" }, "isoforms": [ { "isoform_ac": "A0A075B777-1", "url": "", "sequence": { "sequence": "MAMIELGFGRQNFHPLKRKSSLLLKL", "length": 26, "header": "tr|A0A075B777-1|A0A075B777_HUMAN Computationally mapped isoform of Metallophosphoesterase 1 OS=Homo sapiens OX=9606 GN=MPPE1 PE=4 SV=1 CANONICAL=Q53F39-1" }, "locus": { "chromosome": "18", "start_pos": 11897264, "end_pos": 11897187, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000593001.5", "url": "https://www.ensembl.org/id/ENST00000593001.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000467599.1", "url": "https://www.ensembl.org/id/ENSP00000467599.1" } ] } }, { "isoform_ac": "A0A0A0MR93-1", "url": "", "sequence": { "sequence": "MAMIELGFGRQNFHPLKRKSSLLLKLIAVVFAVLLFCEFLIYYLAIFQCNWPEVKTTASDGEQTTREPVLKAMFLADTHLLGEFLGHWLDKLRREWQMERAFQTALWLLQPEVVFILGDIFDEGKWSTPEAWADDVERFQKMFRHPSHVQLKVVAGNHDIGFHYEMNTYKVERFEKVFSSERLFSWKGINFVMVNSVALNGDGCGICSETEAELIEVSHRLNCSREHYPLYRRSDANCSGEDAAPAEERDIPFKENYDVLSREASQKLLWWLQPRLVLSGHTHSACEVHHGGRVPELSVPSFSWRNRNNPSFIMGSITPTDYTLSKCYLPREDVVLIIYCGVVGFLVVLTLTHFGLLASPFLSGLNLLGKRKTR", "length": 374, "header": "tr|A0A0A0MR93-1|MPPE1_HUMAN Computationally mapped isoform of Metallophosphoesterase 1 OS=Homo sapiens OX=9606 GN=MPPE1 PE=1 SV=1 CANONICAL=Q53F39-1" }, "locus": { "chromosome": "18", "start_pos": 11897264, "end_pos": 11884448, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000344987.11", "url": "https://www.ensembl.org/id/ENST00000344987.11" }, { "database": "Ensembl Peptide", "id": "ENSP00000339423.7", "url": "https://www.ensembl.org/id/ENSP00000339423.7" } ] } }, { "isoform_ac": "A0A0C4DH11-1", "url": "", "sequence": { "sequence": "MERAFQTALWLLQPEVVFILGDIFDEGKWSTPEAWADDVERFQKMFRHPSHVQLKVVAGNHDIGFHYEMNTYKVERFEKVFSSERLFSWKGINFVMVNSVALNGDGCGICSETEAELIEVSHRLNCSREARGSSRCGPGPLLPTSAPVLLQHYPLYRRSDANCSGEDAAPAEERDIPFKENYDVLSREASQKLLWWLQPRLVLSGHTHSACEVHHGGRVPELSVPSFSWRNRNNPSFIMGTDA", "length": 243, "header": "tr|A0A0C4DH11-1|MPPE1_HUMAN Computationally mapped isoform of Metallophosphoesterase 1 OS=Homo sapiens OX=9606 GN=MPPE1 PE=1 SV=1 CANONICAL=Q53F39-1" }, "locus": { "chromosome": "18", "start_pos": 11893566, "end_pos": 11885032, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000317251.8", "url": "https://www.ensembl.org/id/ENST00000317251.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000312935.4", "url": "https://www.ensembl.org/id/ENSP00000312935.4" } ] } }, { "isoform_ac": "K7EIQ0-1", "url": "", "sequence": { "sequence": "LTCTQQARGSSRCGPGPLLPTSAPVLLQHYPLYRRSDANCSGEDAAPAEERDIPFKENYDVLSREASQKERSDGQRPSAER", "length": 81, "header": "tr|K7EIQ0-1|MPPE1_HUMAN Computationally mapped isoform of Metallophosphoesterase 1 OS=Homo sapiens OX=9606 GN=MPPE1 PE=1 SV=1 CANONICAL=Q53F39-1" }, "locus": { "chromosome": "18", "start_pos": 11886796, "end_pos": 11885877, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000592306.5", "url": "https://www.ensembl.org/id/ENST00000592306.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000464842.1", "url": "https://www.ensembl.org/id/ENSP00000464842.1" } ] } }, { "isoform_ac": "K7EJU0-1", "url": "", "sequence": { "sequence": "MAMIELGFGRQNFHPLKRKSSLLLKLIAVVFAVLLFCEFLIYYLAIFQCNWPEVKTTASDGEQTTREPVLKAMFLADTHLLGEFLGHWLDKLRREWQMERAFQTALWLLQPEVVFILGDIFDEGKWSTPEAWADDVERFQK", "length": 141, "header": "tr|K7EJU0-1|MPPE1_HUMAN Computationally mapped isoform of Metallophosphoesterase 1 OS=Homo sapiens OX=9606 GN=MPPE1 PE=1 SV=1 CANONICAL=Q53F39-1" }, "locus": { "chromosome": "18", "start_pos": 11897264, "end_pos": 11889458, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000589267.5", "url": "https://www.ensembl.org/id/ENST00000589267.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000465318.1", "url": "https://www.ensembl.org/id/ENSP00000465318.1" } ] } }, { "isoform_ac": "K7ELZ7-1", "url": "", "sequence": { "sequence": "GNHDIGFHYDFVMVNSVALNGDGCGICSETEAELIEVSHRLNCSREQARGSSRCGPGPLLPTSAPVLLQHYPLYRRSDANCSGEDAAPAEERDIPFKENYDVLSREASQKLLWWLQPRLVLSGHTHSACEVHHGGRVPELSVPSFSWRNRNNPSFIMGTDA", "length": 161, "header": "tr|K7ELZ7-1|MPPE1_HUMAN Computationally mapped isoform of Metallophosphoesterase 1 OS=Homo sapiens OX=9606 GN=MPPE1 PE=1 SV=1 CANONICAL=Q53F39-1" }, "locus": { "chromosome": "18", "start_pos": 11889415, "end_pos": 11885032, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000587724.5", "url": "https://www.ensembl.org/id/ENST00000587724.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000466291.1", "url": "https://www.ensembl.org/id/ENSP00000466291.1" } ] } }, { "isoform_ac": "K7EM03-1", "url": "", "sequence": { "sequence": "MLVLNSWPQVILPPWPPKALKLQMERAFQTALWLLQPEVVFILGDIFDEGKWSTPEAWADDVERFQKMFRHPSHVQLKVVAGNHDIGFHYEMNTYKVERFEKVFSSERLFSWKGINFVMVNSVALNGDGCGICSETEAELIEVSHRLNCSREQARGSSRCGPGPLLPTSAPV", "length": 172, "header": "tr|K7EM03-1|MPPE1_HUMAN Computationally mapped isoform of Metallophosphoesterase 1 OS=Homo sapiens OX=9606 GN=MPPE1 PE=1 SV=1 CANONICAL=Q53F39-1" }, "locus": { "chromosome": "18", "start_pos": 11895253, "end_pos": 11886722, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000592331.5", "url": "https://www.ensembl.org/id/ENST00000592331.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000466303.1", "url": "https://www.ensembl.org/id/ENSP00000466303.1" } ] } }, { "isoform_ac": "K7EQ70-1", "url": "", "sequence": { "sequence": "MAMIELGFGRQNFHPLKRKSSLLLKLIAVVFAVLLFCEFLIYYLAIFQCNWPEVKTTASDGEQTTREPVLKAMFLADTHLLGEFLGHWLDKLRREWQMERAFQTALWLLQPEVVFILGDIFDEGKWSTPEAWADDVERFQKMFRHPSHVQLKVVAGNHDIGFHY", "length": 164, "header": "tr|K7EQ70-1|MPPE1_HUMAN Computationally mapped isoform of Metallophosphoesterase 1 OS=Homo sapiens OX=9606 GN=MPPE1 PE=1 SV=1 CANONICAL=Q53F39-1" }, "locus": { "chromosome": "18", "start_pos": 11897264, "end_pos": 11889389, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000588191.5", "url": "https://www.ensembl.org/id/ENST00000588191.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000467698.1", "url": "https://www.ensembl.org/id/ENSP00000467698.1" } ] } }, { "isoform_ac": "K7EQ74-1", "url": "", "sequence": { "sequence": "MAMIELGFGRQNFHPLKRKSSLLLKLIAVVFAVLLFCEFLIYYLAIFQCNWPEVKTTASDGEQTTREPV", "length": 69, "header": "tr|K7EQ74-1|MPPE1_HUMAN Computationally mapped isoform of Metallophosphoesterase 1 OS=Homo sapiens OX=9606 GN=MPPE1 PE=1 SV=8 CANONICAL=Q53F39-1" }, "locus": { "chromosome": "18", "start_pos": 11897264, "end_pos": 11897058, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000589859.1", "url": "https://www.ensembl.org/id/ENST00000589859.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000467703.1", "url": "https://www.ensembl.org/id/ENSP00000467703.1" } ] } }, { "isoform_ac": "K7EQV4-1", "url": "", "sequence": { "sequence": "MAMIELGFGRQNFHPLKRKSSLLLKLIAVVFAVLLFCEFLIYYLAIFQCNWPEVKTTASDGEQTTREPVLKAMFLADTHLLGEFLGHWLDKLRREWQMERAFQTALWLLQPEVVFILGDIFDEGKWSTPEAWADDVERFQKMFRHPSHVQLKVVAGNHDIGFHYEMNTYKVERFEKVF", "length": 178, "header": "tr|K7EQV4-1|MPPE1_HUMAN Computationally mapped isoform of Metallophosphoesterase 1 OS=Homo sapiens OX=9606 GN=MPPE1 PE=1 SV=1 CANONICAL=Q53F39-1" }, "locus": { "chromosome": "18", "start_pos": 11897264, "end_pos": 11888704, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000588186.5", "url": "https://www.ensembl.org/id/ENST00000588186.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000467993.1", "url": "https://www.ensembl.org/id/ENSP00000467993.1" } ] } }, { "isoform_ac": "K7ER13-1", "url": "", "sequence": { "sequence": "MAMIELGFGRQNFHPLKRKSSLLLKLIAVVFAVLLFCEFLIYYLAIFQCNWPEVKTTASDGEQTTREPVLKAMFLADTHLLGEFLGHWLDKL", "length": 92, "header": "tr|K7ER13-1|K7ER13_HUMAN Computationally mapped isoform of Metallophosphoesterase 1 OS=Homo sapiens OX=9606 GN=MPPE1 PE=1 SV=1 CANONICAL=Q53F39-1" }, "locus": { "chromosome": "18", "start_pos": 11897264, "end_pos": 11896989, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000588103.5", "url": "https://www.ensembl.org/id/ENST00000588103.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000468065.1", "url": "https://www.ensembl.org/id/ENSP00000468065.1" } ] } }, { "isoform_ac": "K7ERI3-1", "url": "", "sequence": { "sequence": "MAMIELGFGRQNFHPLKRKSSLLLKLIAVVFAVLLFCEFLIYYLAIFQCNWPEVKTTASDGEQTTREP", "length": 68, "header": "tr|K7ERI3-1|MPPE1_HUMAN Computationally mapped isoform of Metallophosphoesterase 1 OS=Homo sapiens OX=9606 GN=MPPE1 PE=1 SV=8 CANONICAL=Q53F39-1" }, "locus": { "chromosome": "18", "start_pos": 11897264, "end_pos": 11897061, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000586844.5", "url": "https://www.ensembl.org/id/ENST00000586844.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000468269.1", "url": "https://www.ensembl.org/id/ENSP00000468269.1" } ] } }, { "isoform_ac": "K7ES91-1", "url": "", "sequence": { "sequence": "MAMIELGFGRQNFHPLKRKSSLLLKLIAVVFAVLLFCEFLIYYLAIFQCNWPEVKTTASDGEQTTREPVLKAMFLADTHLLGEFLGHWLDKLRREWQMERAFQTALWLLQPEVVFILGDIFDEGKWSTPEAWADDVERFQKMFRHPSHVQLKVVAGNHDIGFHYEMNTYKVERFEKVFSSERLFSWKGINFVMVNSVALNGDGCGICSETEAELIEVSHRLNCSREARGSSRCGPGPLLPTSAPVLLQHYPLYRRSDANCSGEDAAPAEERDIPFKENYDVLSREASQKLLWWLQPRLVLSGHTHSAC", "length": 308, "header": "tr|K7ES91-1|K7ES91_HUMAN Computationally mapped isoform of Metallophosphoesterase 1 OS=Homo sapiens OX=9606 GN=MPPE1 PE=1 SV=1 CANONICAL=Q53F39-1" }, "locus": { "chromosome": "18", "start_pos": 11897264, "end_pos": 11885760, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000592977.5", "url": "https://www.ensembl.org/id/ENST00000592977.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000468606.1", "url": "https://www.ensembl.org/id/ENSP00000468606.1" } ] } }, { "isoform_ac": "K7ESB8-1", "url": "", "sequence": { "sequence": "MAMIELGFGRQNFHPLKRKSSLLLKLIAVVFAVLLFCEFLIYYLAIFQCNWPEVKTTASDGEQTTREPVLKAMFLADTHLLGEFLGHWLDKLRR", "length": 94, "header": "tr|K7ESB8-1|MPPE1_HUMAN Computationally mapped isoform of Metallophosphoesterase 1 OS=Homo sapiens OX=9606 GN=MPPE1 PE=1 SV=1 CANONICAL=Q53F39-1" }, "locus": { "chromosome": "18", "start_pos": 11897264, "end_pos": 11896983, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000590501.5", "url": "https://www.ensembl.org/id/ENST00000590501.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000468639.1", "url": "https://www.ensembl.org/id/ENSP00000468639.1" } ] } }, { "isoform_ac": "Q53F39-1", "url": "", "sequence": { "sequence": "MAMIELGFGRQNFHPLKRKSSLLLKLIAVVFAVLLFCEFLIYYLAIFQCNWPEVKTTASDGEQTTREPVLKAMFLADTHLLGEFLGHWLDKLRREWQMERAFQTALWLLQPEVVFILGDIFDEGKWSTPEAWADDVERFQKMFRHPSHVQLKVVAGNHDIGFHYEMNTYKVERFEKVFSSERLFSWKGINFVMVNSVALNGDGCGICSETEAELIEVSHRLNCSREARGSSRCGPGPLLPTSAPVLLQHYPLYRRSDANCSGEDAAPAEERDIPFKENYDVLSREASQKLLWWLQPRLVLSGHTHSACEVHHGGRVPELSVPSFSWRNRNNPSFIMGSITPTDYTLSKCYLPREDVVLIIYCGVVGFLVVLTLTHFGLLASPFLSGLNLLGKRKTR", "length": 396, "header": "sp|Q53F39-1|MPPE1_HUMAN Isoform 1 of Metallophosphoesterase 1 OS=Homo sapiens OX=9606 GN=MPPE1 PE=1 SV=2 CANONICAL=Q53F39-1" }, "locus": { "chromosome": "18", "start_pos": 11897264, "end_pos": 11884448, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000588072.6", "url": "https://www.ensembl.org/id/ENST00000588072.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000465894.1", "url": "https://www.ensembl.org/id/ENSP00000465894.1" } ] } }, { "isoform_ac": "Q53F39-2", "url": "", "sequence": { "sequence": "MAMIELGFGRQNFHPLKRKSSLLLKLIAVVFAVLLFCEFLIYYLAIFQCNWPEVKTTASDGEQTTREPVLKAMFLADTHLLGEFLGHWLDKLRREWQMERAFQTALWLLQPEVVFILGDIFDEGKWSTPEAWADDVERFQKMFRHPSHVQLKVVAGNHDIGFHYEMNTYKVERFEKVFSSERLFSWKGINFVMVNSVALNGDGCGICSETEAELIEVSHRLNCSREARGSSRCGPGPLLPTSAPVLLQHYPLYRRSDANCSGEDAAPAEERDIPFKENYDVLSREASQKLLWWLQPRLVLSGHTHSACEVHHGGRVPELSVPSFSWRNRNNPSFIMGTDA", "length": 340, "header": "sp|Q53F39-2|MPPE1_HUMAN Isoform 2 of Metallophosphoesterase 1 OS=Homo sapiens OX=9606 GN=MPPE1 PE=1 SV=2 CANONICAL=Q53F39-1" }, "locus": { "chromosome": "18", "start_pos": 11897264, "end_pos": 11885032, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000496196.5", "url": "https://www.ensembl.org/id/ENST00000496196.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000433950.1", "url": "https://www.ensembl.org/id/ENSP00000433950.1" } ] } }, { "isoform_ac": "Q53F39-3", "url": "", "sequence": { "sequence": "MAMIELGFGRQNFHPLKRKSSLLLKLIAVVFAVLLFCEFLIYYLAIFQCNWPEVKTTASDGEQTTREPVLKAMFLADTHLLGEFLGHWLDKLRREWQMERAFQTALWLLQPEVVFILGDIFDEGKWSTPEAWADDVERFQKMFRHPSHVQLKVVAGNHDIGFHYEMNTYKVERFEKVFSSERLFSWKGINFVMVNSVALNGDGCGICSETEAELIEVSHRLNCSREQARGSSRCGPGPLLPTSAPVLLQHYPLYRRSDANCSGEDAAPAEERDIPFKENYDVLSREASQKLLWWLQPRLVLSGHTHSACEVHHGGRVPELSVPSFSWRNRNNPSFIMGTDA", "length": 341, "header": "sp|Q53F39-3|MPPE1_HUMAN Isoform 3 of Metallophosphoesterase 1 OS=Homo sapiens OX=9606 GN=MPPE1 PE=1 SV=2 CANONICAL=Q53F39-1" }, "locus": {} }, { "isoform_ac": "Q53F39-4", "url": "", "sequence": { "sequence": "MAMIELGFGRQNFHPLKRKSSLLLKLIAVVFAVLLFCEFLIYYLAIFQCNWPEVKTTASDGEQTTREPVLKAMFLADTHLLGEFLGHWLDKLRREWQMERAFQTALWLLQPEVVFILGDIFDEGKWSTPEAWADDVERFQKMFRHPSHVQLKVVAGNHDIGFHYEMNTYKVERFEKVFSSERLFSWKGINFVMVNSVALNGDGCGICSETEAELIEVSHRLNCSRELLWWLQPRLVLSGHTHSACEVHHGGRVPELSVPSFSWRNRNNPSFIMGSITPTDYTLSKCYLPREDVVLIIYCGVVGFLVVLTLTHFGLLASPFLSGLNLLGKRKTR", "length": 333, "header": "sp|Q53F39-4|MPPE1_HUMAN Isoform 4 of Metallophosphoesterase 1 OS=Homo sapiens OX=9606 GN=MPPE1 PE=1 SV=2 CANONICAL=Q53F39-1" }, "locus": { "chromosome": "18", "start_pos": 11897264, "end_pos": 11884448, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000309976.13", "url": "https://www.ensembl.org/id/ENST00000309976.13" }, { "database": "Ensembl Peptide", "id": "ENSP00000311200.9", "url": "https://www.ensembl.org/id/ENSP00000311200.9" } ] } }, { "isoform_ac": "Q53F39-5", "url": "", "sequence": { "sequence": "MAMIELGFGRQNFHPLKRKSSLLLKLIAVVFAVLLFCEFLIYYLAIFQCNWPEVKTTASDGEQTTREPVLKAMFLADTHLLGEFLGHWLDKLRREWQMERAFQTALWLLQPEVVFILGDIFDEGKWSTPEAWADDVERFQKMFRHPSHVQLKVVAGNHDIGFHYEMNTYKVERFEKVFSSERLFSWKGINFVMVNSVALNGDGCGICSETEAELIEVSHRLNCSREVGEHLNATGAFCPVLLRFGCSLSPLALLAL", "length": 256, "header": "sp|Q53F39-5|MPPE1_HUMAN Isoform 5 of Metallophosphoesterase 1 OS=Homo sapiens OX=9606 GN=MPPE1 PE=1 SV=2 CANONICAL=Q53F39-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 259, "start_aa": "Asn", "end_pos": 259, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn259", "evidence": [ { "id": "24190977", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24190977" }, { "id": "GLY_000143", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000143" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported" ], "publication": [ { "title": "cDNA cloning, genomic organization and expression of the novel human metallophosphoesterase gene MPPE1 on chromosome 18p11.2.", "journal": "Cytogenet. Cell Genet.", "date": "2001", "authors": "Vuoristo JT, Ala-Kokko L", "evidence": [ { "database": "UniProtKB", "id": "Q53F39", "url": "https://www.uniprot.org/uniprot/Q53F39" }, { "database": "RefSeq", "id": "NP_001317492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317492" }, { "database": "RefSeq", "id": "NP_001229833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229833" } ], "reference": [ { "type": "PubMed", "id": "11978971", "url": "https://glygen.org/publication/PubMed/11978971" } ] }, { "title": "Large-scale cDNA transfection screening for genes related to cancer development and progression.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2004", "authors": "Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J", "evidence": [ { "database": "UniProtKB", "id": "Q53F39", "url": "https://www.uniprot.org/uniprot/Q53F39" } ], "reference": [ { "type": "PubMed", "id": "15498874", "url": "https://glygen.org/publication/PubMed/15498874" } ] }, { "title": "Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population.", "journal": "Journal of affective disorders", "date": "2009", "authors": "Yosifova A, Mushiroda T, Stoianov D, Vazharova R, Dimova I, Karachanak S, Zaharieva I, Milanova V, Madjirova N, Gerdjikov I, Tolev T, Velkova S, Kirov G, Owen MJ, O'Donovan MC, Toncheva D, Nakamura Y", "evidence": [ { "database": "RefSeq", "id": "NP_001317492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317492" }, { "database": "RefSeq", "id": "NP_001229833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229833" } ], "reference": [ { "type": "PubMed", "id": "19328558", "url": "https://glygen.org/publication/PubMed/19328558" } ] }, { "title": "GPI glycan remodeling by PGAP5 regulates transport of GPI-anchored proteins from the ER to the Golgi.", "journal": "Cell", "date": "2009", "authors": "Fujita M, Maeda Y, Ra M, Yamaguchi Y, Taguchi R, Kinoshita T", "evidence": [ { "database": "UniProtKB", "id": "Q53F39", "url": "https://www.uniprot.org/uniprot/Q53F39" }, { "database": "RefSeq", "id": "NP_001229833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229833" }, { "database": "RefSeq", "id": "NP_001317492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317492" } ], "reference": [ { "type": "PubMed", "id": "19837036", "url": "https://glygen.org/publication/PubMed/19837036" } ] }, { "title": "Association between polymorphisms in the metallophosphoesterase (MPPE1) gene and bipolar disorder.", "journal": "American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics", "date": "2010", "authors": "Lohoff FW, Ferraro TN, Brodkin ES, Weller AE, Bloch PJ", "evidence": [ { "database": "RefSeq", "id": "NP_001229833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229833" }, { "database": "RefSeq", "id": "NP_001317492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317492" } ], "reference": [ { "type": "PubMed", "id": "19859903", "url": "https://glygen.org/publication/PubMed/19859903" } ] }, { "title": "N-linked glycosylation enrichment for in-depth cell surface proteomics of diffuse large B-cell lymphoma subtypes.", "journal": "Molecular & cellular proteomics : MCP", "date": "2014", "authors": "Deeb SJ, Cox J, Schmidt-Supprian M, Mann M", "evidence": [ { "database": "GlyGen", "id": "GLY_000143", "url": "https://data.glygen.org/GLY_000143" } ], "reference": [ { "type": "PubMed", "id": "24190977", "url": "https://glygen.org/publication/PubMed/24190977" } ] }, { "title": "Identification of a Golgi GPI-N-acetylgalactosamine transferase with tandem transmembrane regions in the catalytic domain.", "journal": "Nat. Commun.", "date": "2018", "authors": "Hirata T, Mishra SK, Nakamura S, Saito K, Motooka D, Takada Y, Kanzawa N, Murakami Y, Maeda Y, Fujita M, Yamaguchi Y, Kinoshita T", "evidence": [ { "database": "UniProtKB", "id": "Q53F39", "url": "https://www.uniprot.org/uniprot/Q53F39" } ], "reference": [ { "type": "PubMed", "id": "29374258", "url": "https://glygen.org/publication/PubMed/29374258" } ] }, { "title": "Metallophosphoesterase 1, a novel candidate gene in hepatocellular carcinoma malignancy and recurrence.", "journal": "Cancer biology & therapy", "date": "2020", "authors": "Chen X, Xu J, Wang P, Shang L, Guo J, Huang L, Jiang YA, Chen J, Chen H, Shang Y, Zhang Q", "evidence": [ { "database": "RefSeq", "id": "NP_001317492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317492" }, { "database": "RefSeq", "id": "NP_001229833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229833" } ], "reference": [ { "type": "PubMed", "id": "33054568", "url": "https://glygen.org/publication/PubMed/33054568" } ] } ], "pathway": [ { "id": "hsa:65258", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:65258", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "B1WC86-1", "protein_name": "Metallophosphoesterase 1", "gene_name": "Mppe1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALVRWGLRRQNFHLLRRRRVLLLKLTVVVISVLLFCEYFIYYLVLFRCHWPEVKMPARGGRQEPVLKAMFLADTHLLGEIRGHWLDKLRREWQMERAFQTALWLLQPEVVFILGDVFDEGKWSSAQAWADDLHRFQRMFRHGSHVQLKVVIGNHDIGFHYQMSKYRINRFEKVFGSERLFSLKGVNFVMVNSVAMEGDGCTICSEAEAELREISRKLNCSQEQVQGSSQCDHEPRLPLSAPVLLQHYPLYRASDANCSGEDAAPPEERSVPFEEKYDVLSREASQKLLWWLRPRLILSGHTHSACEVLHPGGAPEVSVPSFSWRNRNNPSFIMGSLTSRDYALSKCYLPCEDTVLTTYCAAAAFLLVLILAHFERLPSSFLFGWKLCRSHLRR", "length": 394 }, "evidence": [ { "id": "45233559", "url": "http://www.informatics.jax.org/homology/45233559", "database": "MGI" }, { "id": "Q53F39", "url": 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