{
    "uniprot_canonical_ac": "Q4V882-1",
    "uniprot_ac": "Q4V882",
    "uniprot_id": "EPN3_RAT",
    "mass": {
        "chemical_mass": 65048.0,
        "monoisotopic_mass": 65048.0
    },
    "refseq": {
        "ac": "NP_001019962",
        "name": "epsin-3",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019962"
    },
    "gene_names": [
        {
            "name": "Epn3",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q4V882",
            "id": "Q4V882"
        },
        {
            "name": "Epn3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006247263",
            "id": "XP_006247263"
        }
    ],
    "protein_names": [
        {
            "name": "Epsin-3",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q4V882"
        },
        {
            "name": "EPS-15-interacting protein 3; epsin-3-like",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019962",
            "id": "NP_001019962"
        },
        {
            "name": "EPS-15-interacting protein 3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q4V882"
        },
        {
            "name": "epsin-3 isoform X1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006247263",
            "id": "XP_006247263"
        },
        {
            "name": "epsin-3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019962",
            "id": "NP_001019962"
        }
    ],
    "function": [],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q4V882",
                    "url": "https://www.uniprot.org/uniprot/Q4V882"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Epn3",
            "url": "https://www.uniprot.org/uniprot/Q4V882",
            "locus": {
                "chromosome": "10",
                "start_pos": 79438978,
                "end_pos": 79447356,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000003284",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000003284"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000003284",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000003284",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd16990",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16990",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "360605",
            "url": "https://www.ncbi.nlm.nih.gov/gene/360605",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR003903",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003903",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR008942",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008942",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR013809",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013809",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:360605",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:360605",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "SGTHESA",
            "url": "https://omabrowser.org/oma/group/SGTHESA/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "1532at2759",
            "url": "http://www.orthodb.org/?query=1532at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12276",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12276",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12276:SF16",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12276:SF16",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF01417",
            "url": "http://pfam.xfam.org/family/PF01417",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF02809",
            "url": "http://pfam.xfam.org/family/PF02809",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q4V882",
            "url": "http://purl.obolibrary.org/obo/PR_Q4V882",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_001019962",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019962",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1306416",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1306416",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A8I6A3U9",
            "url": "https://www.uniprot.org/uniprot/A0A8I6A3U9",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6A3U9-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6A3U9-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q4V882",
            "url": "https://www.uniprot.org/uniprot/Q4V882",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q4V882-1",
            "url": "https://www.uniprot.org/uniprot/Q4V882-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MTTSALRRQVKNIVHNYSEAEIKVREATSNDPWGPPSSLMSEIADLTFNTVAFAEVMGMVWRRLNDSGKNWRHVYKALTLLDYLLKTGSERVAHQCRENLYTIQTLKDFQYIDRDGKDQGVNVREKVKQVMALLKDEERLRQERTHALKTKERMALEGMGIGSGQLGFSRRSRGSPSSYTSASSSPRYASDLEQARPQTSGEEELQLQLALAMSREEAEKGGRSWKGDDFPVANGAEPAGQRRRDREPEREERKEEEKLKTSQSSILDLADVFAPAPALPSTHCSADPWDIPGLRPNTEPSGSSWGPSADPWSPVPSGNALSRSQPWDLLPTLSSSEPWGRTPVLPSGPPITDPWAPSSPTPKLPSTGVDPWGASVETSNTSALGGASPFDPFAKPLESTEPMESRDSAQALPKGKSPSPVELDPFGDSSPSCKQNGVKETEALDLGVLGEALTQQPGKEARPCRTPESFLGPSASSLVNLDSLVKAPLAARTRNPFLTGLSAPSPTNPFGAGEQGRPTLNQMRTGSPALGLPPGGPVGVPLGSMTYSASLPLPLSSVPVGATLPASVSVFPQAGAFAPPPASLPQPLLPTSDPVGPLPPQAGTNPFL",
        "length": 608,
        "header": "sp|Q4V882-1|EPN3_RAT Isoform 1 of Epsin-3  OS=Rattus norvegicus OX=10116 GN=Epn3 PE=1 SV=1 CANONICAL=Q4V882-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A8I6A3U9-1",
            "url": "",
            "sequence": {
                "sequence": "MTTSALRRQVKNIVHNYSEAEIKVREATSNDPWGPPSSLMSEIADLTFNTVAFAEVMGMVWRRLNDSGKNWRHVYKALTLLDYLLKTGSERVAHQCRENLYTIQTLKDFQYIDRDGKDQGVNVREKVKQVMALLKDEERLRQERTHALKTKERMALEGMGIGSGQLGFSRRSRGSPSSYTSASSSPRYASDLEQARPQTSGEEELQLQLALAMSREEAEKPVPPASHRDEDLQLQLALSLSRQEHEKGGRSWKGDDFPVANGAEPAGQRRRDREPEREERKEEEKLKTSQSSILDLADVFAPAPALPSTHCSADPWDIPGLRPNTEPSGSSWGPSADPWSPVPSGNALSRSQPWDLLPTLSSSEPWGRTPVLPSGPPITDPWAPSSPTPKLPSTGVDPWGASVETSNTSALGGASPFDPFAKPLESTEPMESRDSAQALPKGKSPSPVELDPFGDSSPSCKQNGVKETEALDLGVLGEALTQQPGKEARPCRTPESFLGPSASSLVNLDSLVKAPLAARTRNPFLTGLSAPSPTNPFGAGEQGRPTLNQMRTGSPALGLPPGGPVGVPLGSMTYSASLPLPLSSVPVGATLPASVSVFPQAGAFAPPPASLPQPLLPTSDPVGPLPPQAGTNPFL",
                "length": 635,
                "header": "tr|A0A8I6A3U9-1|EPN3_RAT Computationally mapped isoform of Epsin-3  OS=Rattus norvegicus OX=10116 GN=Epn3 PE=1 SV=1 CANONICAL=Q4V882-1"
            },
            "locus": {
                "chromosome": "10",
                "start_pos": 79445713,
                "end_pos": 79440491,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000117347.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000117347.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000087165.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000087165.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q4V882-1",
            "url": "",
            "sequence": {
                "sequence": "MTTSALRRQVKNIVHNYSEAEIKVREATSNDPWGPPSSLMSEIADLTFNTVAFAEVMGMVWRRLNDSGKNWRHVYKALTLLDYLLKTGSERVAHQCRENLYTIQTLKDFQYIDRDGKDQGVNVREKVKQVMALLKDEERLRQERTHALKTKERMALEGMGIGSGQLGFSRRSRGSPSSYTSASSSPRYASDLEQARPQTSGEEELQLQLALAMSREEAEKGGRSWKGDDFPVANGAEPAGQRRRDREPEREERKEEEKLKTSQSSILDLADVFAPAPALPSTHCSADPWDIPGLRPNTEPSGSSWGPSADPWSPVPSGNALSRSQPWDLLPTLSSSEPWGRTPVLPSGPPITDPWAPSSPTPKLPSTGVDPWGASVETSNTSALGGASPFDPFAKPLESTEPMESRDSAQALPKGKSPSPVELDPFGDSSPSCKQNGVKETEALDLGVLGEALTQQPGKEARPCRTPESFLGPSASSLVNLDSLVKAPLAARTRNPFLTGLSAPSPTNPFGAGEQGRPTLNQMRTGSPALGLPPGGPVGVPLGSMTYSASLPLPLSSVPVGATLPASVSVFPQAGAFAPPPASLPQPLLPTSDPVGPLPPQAGTNPFL",
                "length": 608,
                "header": "sp|Q4V882-1|EPN3_RAT Isoform 1 of Epsin-3  OS=Rattus norvegicus OX=10116 GN=Epn3 PE=1 SV=1 CANONICAL=Q4V882-1"
            },
            "locus": {
                "chromosome": "10",
                "start_pos": 79445713,
                "end_pos": 79440491,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000004400",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000004400"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000004400",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000004400"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 184,
            "end_pos": 184,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q4V882",
                    "url": "https://www.uniprot.org/uniprot/Q4V882"
                }
            ],
            "site_lbl": "Ser184"
        },
        {
            "start_pos": 185,
            "end_pos": 185,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q4V882",
                    "url": "https://www.uniprot.org/uniprot/Q4V882"
                }
            ],
            "site_lbl": "Ser185"
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.",
            "journal": "Nat. Commun.",
            "date": "2012",
            "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q4V882",
                    "url": "https://www.uniprot.org/uniprot/Q4V882"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "22673903",
                    "url": "https://glygen.org/publication/PubMed/22673903"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:360605",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:360605",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q91W69-1",
            "protein_name": "Epsin-3",
            "gene_name": "Epn3",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MTTSALRRQVKNIVHNYSEAEIKVREATSNDPWGPPSSLMSEIADLTFNTVAFAEVMGMVWRRLNDSGKNWRHVYKALTLLDYLLKTGSERVAHQCRENLYTIQTLKDFQYIDRDGKDQGVNVREKVKQVMALLKDEERLRQERTHALKTKERMALEGMGIGSGQLGYSRRSRGSPSSYTSASSSPRYASDLEQARPQTSGEEELQLQLALAMSREEAERPVPPASHRDEDLQLQLALSLSRQEHEKGVRSWKGDDSPVANGAEPAGQRRQRDREPEREERKEEEKLKTSQSSILDLADIFAPAPALPSTHCSADPWDIPGLRPNTEPSGSSWGPSADPWSPVPSGNALSRSQPWDLLPTLSSSEPWGRTPVLPSGPPIADPWAPSSPTRKLPSTGADPWGASMETSDTSALGGASPFDPFAKPLESTEPKESRDSAQALPTGKSPSTVELDPFGDSSPSCKQNGMKEPEALDLGVLGEALPQQPGKEARPCRTPESFLGPSASSLVNLDSLVKAPLAARTRNPFLTGLGVPSPTNPFGAGDQGRPTLNQMRTGSPALGLPPGGPVGAPVGSMTYSASLPLPLSSVPVGATLPASVSVFPQAGAFAPPPASLPQPLLPTSGPMGPLPPQAGTNPFL",
                "length": 636
            },
            "evidence": [
                {
                    "id": "45239238",
                    "url": "http://www.informatics.jax.org/homology/45239238",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q9H201-1",
            "protein_name": "Epsin-3",
            "gene_name": "EPN3",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MTTSALRRQVKNIVHNYSEAEIKVREATSNDPWGPPSSLMSEIADLTFNTVAFTEVMGMLWRRLNDSGKNWRHVYKALTLLDYLLKTGSERVAHQCRENLYTIQTLKDFQYIDRDGKDQGVNVREKVKQVMALLKDEERLRQERTHALKTKERMALEGIGIGSGQLGFSRRYGEDYSRSRGSPSSYNSSSSSPRYTSDLEQARPQTSGEEELQLQLALAMSREEAEKPVPPASHRDEDLQLQLALRLSRQEHEKEVRSWQGDGSPMANGAGAVVHHQRDREPEREERKEEEKLKTSQSSILDLADIFVPALAPPSTHCSADPWDIPGFRPNTEASGSSWGPSADPWSPIPSGTVLSRSQPWDLTPMLSSSEPWGRTPVLPAGPPTTDPWALNSPHHKLPSTGADPWGASLETSDTPGGASTFDPFAKPPESTETKEGLEQALPSGKPSSPVELDLFGDPSPSSKQNGTKEPDALDLGILGEALTQPSKEARACRTPESFLGPSASSLVNLDSLVKAPQVAKTRNPFLTGLSAPSPTNPFGAGEPGRPTLNQMRTGSPALGLAGGPVGAPLGSMTYSASLPLPLSSVPAGLTLPASVSVFPQAGAFAPQPLLPTPSSAGPRPPPPQTGTNPFL",
                "length": 632
            },
            "evidence": [
                {
                    "id": "45239238",
                    "url": "http://www.informatics.jax.org/homology/45239238",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 11,
                "go_terms": [
                    {
                        "name": "nucleoplasm",
                        "id": "GO:0005654",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q4V882",
                                "url": "https://www.uniprot.org/uniprot/Q4V882"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "clathrin-coated pit",
                        "id": "GO:0005905",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005905",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q4V882",
                                "url": "https://www.uniprot.org/uniprot/Q4V882"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "perinuclear region of cytoplasm",
                        "id": "GO:0048471",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q4V882",
                                "url": "https://www.uniprot.org/uniprot/Q4V882"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "clathrin-coated vesicle",
                        "id": "GO:0030136",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030136",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q4V882",
                                "url": "https://www.uniprot.org/uniprot/Q4V882"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasmic side of plasma membrane",
                        "id": "GO:0009898",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009898",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q4V882",
                                "url": "https://www.uniprot.org/uniprot/Q4V882"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "clathrin vesicle coat",
                        "id": "GO:0030125",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030125",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q4V882",
                                "url": "https://www.uniprot.org/uniprot/Q4V882"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q4V882",
                                "url": "https://www.uniprot.org/uniprot/Q4V882"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endosome",
                        "id": "GO:0005768",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q4V882",
                                "url": "https://www.uniprot.org/uniprot/Q4V882"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q4V882",
                                "url": "https://www.uniprot.org/uniprot/Q4V882"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cell cortex",
                        "id": "GO:0005938",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q4V882",
                                "url": "https://www.uniprot.org/uniprot/Q4V882"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "extrinsic component of plasma membrane",
                        "id": "GO:0019897",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019897",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q4V882",
                                "url": "https://www.uniprot.org/uniprot/Q4V882"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 4,
                "go_terms": [
                    {
                        "name": "lipid binding",
                        "id": "GO:0008289",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q4V882",
                                "url": "https://www.uniprot.org/uniprot/Q4V882"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "EH domain binding",
                        "id": "GO:1990175",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990175",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q4V882",
                                "url": "https://www.uniprot.org/uniprot/Q4V882"
                            }
                        ],
                        "pmid": ""
                    },
                    {
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