{ "uniprot_canonical_ac": "Q3V0G7-1", "uniprot_ac": "Q3V0G7", "uniprot_id": "GARL3_MOUSE", "mass": { "chemical_mass": 115437.0, "monoisotopic_mass": 115437.0 }, "refseq": { "ac": "NP_849219", "name": "GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849219" }, "gene_names": [ { "name": "Garnl3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q3V0G7", "id": "Q3V0G7" }, { "name": "Garnl3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849219", "id": "NP_849219" } ], "protein_names": [ { "name": "GTPase-activating Rap/Ran-GAP domain-like protein 3", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q3V0G7" }, { "name": "GTPase-activating Rap/Ran-GAP domain-like protein 3 isoform 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849219", "id": "NP_849219" }, { "name": "GTPase-activating Rap/Ran-GAP domain-like protein 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849219", "id": "NP_849219" } ], "function": [], "disease": [], "snv": [ { "evidence": [ { "id": "rs27171109", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs27171109" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1002, "end_pos": 1002, "sequence_org": "W", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NHW->NHS).", "chr_id": "2", "chr_pos": "32876780", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "W1002", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs3391457488", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3391457488" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 248, "end_pos": 248, "sequence_org": "I", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (IGS->NGS).", "chr_id": "2", "chr_pos": "32924138", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I248", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q3V0G7", "url": "https://www.uniprot.org/uniprot/Q3V0G7" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Garnl3", "url": "https://www.uniprot.org/uniprot/Q3V0G7", "locus": { "chromosome": "2", "start_pos": 32876236, "end_pos": 33021666, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000038860", "url": "https://www.ensembl.org/id/ENSMUSG00000038860" } ] } } ], "crossref": [ { "id": "ENSMUSG00000038860", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000038860", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "99326", "url": "https://www.ncbi.nlm.nih.gov/gene/99326", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000331", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001180", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001180", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035974", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035974", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:99326", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:99326", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2139309", "url": "http://www.informatics.jax.org/marker/MGI:2139309", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "Q3V0G7", "url": "https://oglcnac.org/atlas/detail/Q3V0G7", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "Q3V0G7", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q3V0G7", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "FEGYSER", "url": "https://omabrowser.org/oma/group/FEGYSER/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "25782at2759", "url": "http://www.orthodb.org/?query=25782at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15711", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15711", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15711:SF62", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15711:SF62", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00780", "url": "http://pfam.xfam.org/family/PF00780", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02145", "url": "http://pfam.xfam.org/family/PF02145", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q3V0G7", "url": "http://purl.obolibrary.org/obo/PR_Q3V0G7", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_849219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849219", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0A6YWF1", "url": "https://www.uniprot.org/uniprot/A0A0A6YWF1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0A6YWF1-1", "url": "https://www.uniprot.org/uniprot/A0A0A6YWF1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0A6YXP5", "url": "https://www.uniprot.org/uniprot/A0A0A6YXP5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0A6YXP5-1", "url": "https://www.uniprot.org/uniprot/A0A0A6YXP5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AHW8", "url": "https://www.uniprot.org/uniprot/A2AHW8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AHW8-1", "url": "https://www.uniprot.org/uniprot/A2AHW8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AUQ6", "url": "https://www.uniprot.org/uniprot/A2AUQ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AUQ6-1", "url": "https://www.uniprot.org/uniprot/A2AUQ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B1AW31", "url": "https://www.uniprot.org/uniprot/B1AW31", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B1AW31-1", "url": "https://www.uniprot.org/uniprot/B1AW31-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3V0G7", "url": "https://www.uniprot.org/uniprot/Q3V0G7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3V0G7-1", "url": "https://www.uniprot.org/uniprot/Q3V0G7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3V0G7-2", "url": "https://www.uniprot.org/uniprot/Q3V0G7-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPLTKGSCGSQLAQTLLWKAKSSLSFGIQPLQTWPTKDPELESQVNLSVSEDLGCRRGDFSRKHYGSVELLISSDADGAIQRAGRFRVENGSTDESAAALPGTWRRTDVHLENPEYHTRWYFKYFLGQVHQNYIGNDAEKSPFFLSVTLSDQNNQRVPQYRAILWRKTGTQKICLPYSPTKTLSVKSILSAMNLDKFEKGPREIFHPEIQKDLLVLEEQEGSVNFKFGVLFAKDGQLTDDEMFSNEIGSEAFQKFLNLLGDTITLKGWTGYRGGLDTKNNTTGINSVYTVYQGHEVMFHVSTMLPYSKENRQQVERKRHIGNDIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVRYDQQNDNYRLKIFSEESVPLFGPPLPSPPVFTDHQEFRDFLLVKLINGEKATLETPTFAQKRRRTLDMLIRSLYQDLMPDLHKNMLNRRSFSDVLPESPKSARKKEEARQAEFVRIGQALKLKSIVRGDAPSSLAASGMCKKEPWEPQCFCCNFPHEAVCADPWGQALLVSTDAGVLLVDDDLPSVPVFDRTLPVKQIHVLETLDLLVLRADKGKDARLFVFRLSAVQKGLDGRQTGRSRSDCRENKLEKTKGCHLYAINTHHSRELRIVVAIRNKLLLITRKPHNKPSGVPGVSLLSPLSESPVEEFQYIREICLCDSPAVMALVDGPTEESDNLICVAYRHQFDVVNESTGEAFRLHHVEANKVNFVAAIDVYEDGEAGLLLCYNYSCIYKKVCPFNGGSFLLQPSASDFQFCWNQAPYAIVCAFPYLLAFTTDSMEIRLVVNGNLVHTAVVPQLQLVASRSDIYFTAATTVHEGSSGGSSKGASAHTSPQTPPARDTPLFPSSLGEGEIQSKNLYKIPLRNLVGRSIERPLKSPLVSKVITPPTSIGLGVAAIPVTHSLSLSRMEIKEIASRTRRELLGLSDDGGTKTEGAPRAKSKTRKRLEESQGGPKPETVRSASSDRIPSGILESPASEANPEGHNHWASSEQDAGVDKEGSPGSGSSPFQLMASSEEDIIDLK", "length": 1038, "header": "sp|Q3V0G7-1|GARL3_MOUSE Isoform 1 of GTPase-activating Rap/Ran-GAP domain-like protein 3 OS=Mus musculus OX=10090 GN=Garnl3 PE=1 SV=1 CANONICAL=Q3V0G7-1" }, "isoforms": [ { "isoform_ac": "A0A0A6YWF1-1", "url": "", "sequence": { "sequence": "MDPLTKGSCGSQLAQTLLWKAKSSLSFGIQPLQTWPTKDPELESQVNL", "length": 48, "header": "tr|A0A0A6YWF1-1|GARL3_MOUSE Computationally mapped isoform of GTPase-activating Rap/Ran-GAP domain-like protein 3 OS=Mus musculus OX=10090 GN=Garnl3 PE=1 SV=1 CANONICAL=Q3V0G7-1" }, "locus": { "chromosome": "2", "start_pos": 32995007, "end_pos": 32994864, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000127509.2", "url": "https://www.ensembl.org/id/ENSMUST00000127509.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000141523.2", "url": "https://www.ensembl.org/id/ENSMUSP00000141523.2" } ] } }, { "isoform_ac": "A0A0A6YXP5-1", "url": "", "sequence": { "sequence": "XSVNFKFGVLFAKDGQLTDDEMFSNEIGSEAFQKFLNLLGDTITLKGWTGYRGGLDTKNNTTGINSVYTVYQGHEVMFHVSTMLPYSKENRQQVERKRHIGNDIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVRYDQQNDNYRLKIFSEESVPLFGPPLPSPPVFTDHQEFRDFLLVK", "length": 180, "header": "tr|A0A0A6YXP5-1|A0A0A6YXP5_MOUSE Computationally mapped isoform of GTPase activating RANGAP domain-like 3 OS=Mus musculus OX=10090 GN=Garnl3 PE=1 SV=1 CANONICAL=Q3V0G7-1" }, "locus": { "chromosome": "2", "start_pos": 32924796, "end_pos": 32912674, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000193171.2", "url": "https://www.ensembl.org/id/ENSMUST00000193171.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000142077.2", "url": "https://www.ensembl.org/id/ENSMUSP00000142077.2" } ] } }, { "isoform_ac": "A2AHW8-1", "url": "", "sequence": { "sequence": "MKHFCSSSVSEDLGCRRGDFSRKHYGSVELLISSDADGAIQRAGRFRVENGSTDESAAALPGTWRRTDVHLENPEYHTRWYFKYFLGQVHQNYIGNDAEKSPFFLSVTLSDQNNQRVPQYRAILWRKTGTQKICLPYSPTKTLSVKSILSAMNLDKFEKGPREIFHPEIQKDLLVLEEQEGSVNFKFGVLFAKDGQLTDDEMFSNEIGSEAFQKFLNLLGDTITLKGWTGYRGGLDTKNNTTGINSVYTVYQGHEVMFHVSTMLPYSKENRQQVERKRHIGNDIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVRYDQQNDNYRLKIFSEESVPLFGPPLPSPPVFTDHQEFRDFLLVKLINGEKATLETPTFAQKRRRTLDMLIRSLYQDLMPDLHKNMLNRRSFSDVLPESPKSARKKEEARQAEFVRIGQALKLKSIVRGDAPSSLAASGMCKKEPWEPQCFCCNFPHEAVCADPWGQALLVSTDAGVLLVDDDLPSVPVFDRTLPVKQIHVLETLDLLVLRADKGKDARLFVFRLSAVQKGLDGRQTGRSRSDCRENKLEKTKGCHLYAINTHHSRELRIVVAIRNKLLLITRKPHNKPSGVPGVSLLSPLSESPVEEFQYIREICLCDSPAVMALVDGPTEESDNLICVAYRHQFDVVNESTGEAFRLHHVEANKVNFVAAIDVYEDGEAGLLLCYNYSCIYKKVCPFNGGSFLLQPSASDFQFCWNQAPYAIVCAFPYLLAFTTDSMEIRLVVNGNLVHTAVVPQLQLVASRSDIYFTAATTVHEGSSGGSSKGASAHTSPQTPPARDTPLFPSSLGEGEIQSKNLYKIPLRNLVGRSIERPLKSPLVSKVITPPTSIGLGVAAIPVTHSLSLSRMEIKEIASRTRRELLGLSDDGGTKTEGAPRAKSKTRKRLEESQGGPKPETVRSASSDRIPSGILESPASEANPEGHNHWASSEQDAGVDKEGSPGSGSSPFQLMASSEEDIIDLK", "length": 997, "header": "tr|A2AHW8-1|A2AHW8_MOUSE Computationally mapped isoform of GTPase activating RANGAP domain-like 3 OS=Mus musculus OX=10090 GN=Garnl3 PE=1 SV=1 CANONICAL=Q3V0G7-1" }, "locus": { "chromosome": "2", "start_pos": 32975976, "end_pos": 32876671, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000049618.9", "url": "https://www.ensembl.org/id/ENSMUST00000049618.9" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000057582.3", "url": "https://www.ensembl.org/id/ENSMUSP00000057582.3" } ] } }, { "isoform_ac": "A2AUQ6-1", "url": "", "sequence": { "sequence": "MEQEPGGAAAALLRQKRAALRRRGCSFESPSTAPQPPGPLMDPLTKGSCGSQLAQTLLWKAKSSLSFGIQPLQTWPTKDPELESQVNLSVSEDLGCRRGDFSRKHYGSVELLISSDADGAIQRAGRFRVENGSTDESAAALPGTWRRTDV", "length": 150, "header": "tr|A2AUQ6-1|A2AUQ6_MOUSE Computationally mapped isoform of GTPase activating RANGAP domain-like 3 OS=Mus musculus OX=10090 GN=Garnl3 PE=1 SV=1 CANONICAL=Q3V0G7-1" }, "locus": { "chromosome": "2", "start_pos": 33020527, "end_pos": 32944228, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000124000.2", "url": "https://www.ensembl.org/id/ENSMUST00000124000.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000123601.2", "url": "https://www.ensembl.org/id/ENSMUSP00000123601.2" } ] } }, { "isoform_ac": "B1AW31-1", "url": "", "sequence": { "sequence": "MDPLTKGSCGSQLAQTLLWKAKSSLSFGIQPLQTWPTKDPELESQVNLSVSEDLGCRRGDFSRKHYGSVELLISSDADGAIQRAGRFRVENGSTDESAAALPGTWRRTDVHLENPEYHTRWYFKY", "length": 125, "header": "tr|B1AW31-1|GARL3_MOUSE Computationally mapped isoform of GTPase-activating Rap/Ran-GAP domain-like protein 3 OS=Mus musculus OX=10090 GN=Garnl3 PE=1 SV=1 CANONICAL=Q3V0G7-1" }, "locus": { "chromosome": "2", "start_pos": 32995007, "end_pos": 32944183, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000133135.8", "url": "https://www.ensembl.org/id/ENSMUST00000133135.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000119973.2", "url": "https://www.ensembl.org/id/ENSMUSP00000119973.2" } ] } }, { "isoform_ac": "Q3V0G7-1", "url": "", "sequence": { "sequence": "MDPLTKGSCGSQLAQTLLWKAKSSLSFGIQPLQTWPTKDPELESQVNLSVSEDLGCRRGDFSRKHYGSVELLISSDADGAIQRAGRFRVENGSTDESAAALPGTWRRTDVHLENPEYHTRWYFKYFLGQVHQNYIGNDAEKSPFFLSVTLSDQNNQRVPQYRAILWRKTGTQKICLPYSPTKTLSVKSILSAMNLDKFEKGPREIFHPEIQKDLLVLEEQEGSVNFKFGVLFAKDGQLTDDEMFSNEIGSEAFQKFLNLLGDTITLKGWTGYRGGLDTKNNTTGINSVYTVYQGHEVMFHVSTMLPYSKENRQQVERKRHIGNDIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVRYDQQNDNYRLKIFSEESVPLFGPPLPSPPVFTDHQEFRDFLLVKLINGEKATLETPTFAQKRRRTLDMLIRSLYQDLMPDLHKNMLNRRSFSDVLPESPKSARKKEEARQAEFVRIGQALKLKSIVRGDAPSSLAASGMCKKEPWEPQCFCCNFPHEAVCADPWGQALLVSTDAGVLLVDDDLPSVPVFDRTLPVKQIHVLETLDLLVLRADKGKDARLFVFRLSAVQKGLDGRQTGRSRSDCRENKLEKTKGCHLYAINTHHSRELRIVVAIRNKLLLITRKPHNKPSGVPGVSLLSPLSESPVEEFQYIREICLCDSPAVMALVDGPTEESDNLICVAYRHQFDVVNESTGEAFRLHHVEANKVNFVAAIDVYEDGEAGLLLCYNYSCIYKKVCPFNGGSFLLQPSASDFQFCWNQAPYAIVCAFPYLLAFTTDSMEIRLVVNGNLVHTAVVPQLQLVASRSDIYFTAATTVHEGSSGGSSKGASAHTSPQTPPARDTPLFPSSLGEGEIQSKNLYKIPLRNLVGRSIERPLKSPLVSKVITPPTSIGLGVAAIPVTHSLSLSRMEIKEIASRTRRELLGLSDDGGTKTEGAPRAKSKTRKRLEESQGGPKPETVRSASSDRIPSGILESPASEANPEGHNHWASSEQDAGVDKEGSPGSGSSPFQLMASSEEDIIDLK", "length": 1038, "header": "sp|Q3V0G7-1|GARL3_MOUSE Isoform 1 of GTPase-activating Rap/Ran-GAP domain-like protein 3 OS=Mus musculus OX=10090 GN=Garnl3 PE=1 SV=1 CANONICAL=Q3V0G7-1" }, "locus": { "chromosome": "2", "start_pos": 32995007, "end_pos": 32876671, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000137381", "url": "https://www.ensembl.org/id/ENSMUST00000137381" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000122576", "url": "https://www.ensembl.org/id/ENSMUSP00000122576" } ] } }, { "isoform_ac": "Q3V0G7-2", "url": "", "sequence": { "sequence": "MKSSVSEDLGCRRGDFSRKHYGSVELLISSDADGAIQRAGRFRVENGSTDESAAALPGTWRRTDVHLENPEYHTRWYFKYFLGQVHQNYIGNDAEKSPFFLSVTLSDQNNQRVPQYRAILWRKTGTQKICLPYSPTKTLSVKSILSAMNLDKFEKGPREIFHPEIQKDLLVLEEQEGSVNFKFGVLFAKDGQLTDDEMFSNEIGSEAFQKFLNLLGDTITLKGWTGYRGGLDTKNNTTGINSVYTVYQGHEVMFHVSTMLPYSKENRQQVERKRHIGNDIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVRYDQQNDNYRLKIFSEESVPLFGPPLPSPPVFTDHQEFRDFLLVKLINGEKATLETPTFAQKRRRTLDMLIRSLYQDLMPDLHKNMLNRRSFSDVLPESPKSARKKEEARQAEFVRIGQALKLKSIVRGDAPSSLAASGMCKKEPWEPQCFCCNFPHEAVCADPWGQALLVSTDAGVLLVDDDLPSVPVFDRTLPVKQIHVLETLDLLVLRADKGKDARLFVFRLSAVQKGLDGRQTGRSRSDCRENKLEKTKGCHLYAINTHHSRELRIVVAIRNKLLLITRKPHNKPSGVPGVSLLSPLSESPVEEFQYIREICLCDSPAVMALVDGPTEESDNLICVAYRHQFDVVNESTGEAFRLHHVEANKVNFVAAIDVYEDGEAGLLLCYNYSCIYKKVCPFNGGSFLLQPSASDFQFCWNQAPYAIVCAFPYLLAFTTDSMEIRLVVNGNLVHTAVVPQLQLVASRSDIYFTAATTVHEGSSGGSSKGASAHTSPQTPPARDTPLFPSSLGEGEIQSKNLYKIPLRNLVGRSIERPLKSPLVSKVITPPTSIGLGVAAIPVTHSLSLSRMEIKEIASRTRRELLGLSDDGGTKTEGAPRAKSKTRKRLEESQGGPKPETVRSASSDRIPSGILESPASEANPEGHNHWASSEQDAGVDKEGSPGSGSSPFQLMASSEEDIIDLK", "length": 993, "header": "sp|Q3V0G7-2|GARL3_MOUSE Isoform 2 of GTPase-activating Rap/Ran-GAP domain-like protein 3 OS=Mus musculus OX=10090 GN=Garnl3 PE=1 SV=1 CANONICAL=Q3V0G7-1" }, "locus": { "chromosome": "2", "start_pos": 32977101, "end_pos": 32876671, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000102810", "url": "https://www.ensembl.org/id/ENSMUST00000102810" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000099874", "url": "https://www.ensembl.org/id/ENSMUSP00000099874" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 901, "start_aa": "Thr", "end_pos": 901, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr901", "evidence": [ { "id": "Q3V0G7", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q3V0G7" }, { "id": "22517741", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22517741" }, { "id": "36852467", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36852467" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 905, "start_aa": "Ser", "end_pos": 905, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser905", "evidence": [ { "id": "Q3V0G7", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q3V0G7" }, { "id": "22517741", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22517741" }, { "id": "36852467", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36852467" }, { "id": "Q3V0G7", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q3V0G7" } ] } ], "phosphorylation": [ { "start_pos": 449, "end_pos": 449, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3V0G7", "url": "https://www.uniprot.org/uniprot/Q3V0G7" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q3V0G7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q3V0G7" } ], "site_lbl": "Ser449" }, { "start_pos": 455, "end_pos": 455, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3V0G7", "url": "https://www.uniprot.org/uniprot/Q3V0G7" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q3V0G7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q3V0G7" } ], "site_lbl": "Ser455" }, { "start_pos": 68, "end_pos": 68, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3V0G7", "url": "https://www.uniprot.org/uniprot/Q3V0G7" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q3V0G7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q3V0G7" } ], "site_lbl": "Ser68" }, { "start_pos": 851, "end_pos": 851, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3V0G7", "url": "https://www.uniprot.org/uniprot/Q3V0G7" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q3V0G7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q3V0G7" } ], "site_lbl": "Thr851" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q3V0G7", "url": "https://www.uniprot.org/uniprot/Q3V0G7" }, { "database": "iPTMnet", "id": "Q3V0G7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q3V0G7" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2012", "authors": "Alfaro JF, Gong CX, Monroe ME, Aldrich JT, Clauss TR, Purvine SO, Wang Z, Camp DG 2nd, Shabanowitz J, Stanley P, Hart GW, Hunt DF, Yang F, Smith RD", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q3V0G7", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q3V0G7" }, { "database": "O-GlcNAc Atlas", "id": "Q3V0G7", "url": "https://oglcnac.org/atlas/detail/Q3V0G7" } ], "reference": [ { "type": "PubMed", "id": "22517741", "url": "https://glygen.org/publication/PubMed/22517741" } ] }, { "title": "Chemoproteomic and Transcriptomic Analysis Reveals that O-GlcNAc Regulates Mouse Embryonic Stem Cell Fate through the Pluripotency Network.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2023-02-27", "authors": "Hao Yi, Li Xiang, Qin Ke, Shi Yujie, He Yanwen, Zhang Che, Cheng Bo, Zhang Xiwen, Hu Guangyu, Liang Shuyu, Tang Qi, Chen Xing", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q3V0G7", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q3V0G7" } ], "reference": [ { "type": "PubMed", "id": "36852467", "url": "https://glygen.org/publication/PubMed/36852467" } ] } ], "pathway": [ { "id": "mmu:99326", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:99326", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q5VVW2-1", "protein_name": "GTPase-activating Rap/Ran-GAP domain-like protein 3", "gene_name": "GARNL3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVVDFCRRFVARSLCIILMKHFCSSSVSEDLGCRRGDFSRKHYGSVELLISSDADGAIQRAGRFRVENGSSDENATALPGTWRRTDVHLENPEYHTRWYFKYFLGQVHQNYIGNDAEKSPFFLSVTLSDQNNQRVPQYRAILWRKTGTQKICLPYSPTKTLSVKSILSAMNLDKFEKGPREIFHPEIQKDLLVLEEQEGSVNFKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDTITLKGWTGYRGGLDTKNDTTGIHSVYTVYQGHEIMFHVSTMLPYSKENKQQVERKRHIGNDIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVRYNQQNDNYRLKIFSEESVPLFGPPLPTPPVFTDHQEFRDFLLVKLINGEKATLETPTFAQKRRRTLDMLIRSLHQDLMPDLHKNMLNRRSFSDVLPESPKSARKKEEARQAEFVRIGQALKLKSIVRGDAPSSLAASGICKKEPWEPQCFCSNFPHEAVCADPWGQALLVSTDAGVLLVDDDLPSVPVFDRTLPVKQMHVLETLDLLVLRADKGKDARLFVFRLSALQKGLEGKQAGKSRSDCRENKLEKTKGCHLYAINTHHSRELRIVVAIRNKLLLITRKHNKPSGVTSTSLLSPLSESPVEEFQYIREICLSDSPMVMTLVDGPAEESDNLICVAYRHQFDVVNESTGEAFRLHHVEANRVNFVAAIDVYEDGEAGLLLCYNYSCIYKKVCPFNGGSFLVQPSASDFQFCWNQAPYAIVCAFPYLLAFTTDSMEIRLVVNGNLVHTAVVPQLQLVASRSDIYFTATAAVNEVSSGGSSKGASARNSPQTPPGRDTPVFPSSLGEGEIQSKNLYKIPLRNLVGRSIERPLKSPLVSKVITPPTPISVGLAAIPVTHSLSLSRMEIKEIASRTRRELLGLSDEGGPKSEGAPKAKSKPRKRLEESQGGPKPGAVRSSSSDRIPSGSLESASTSEANPEGHSASSDQDPVADREGSPVSGSSPFQLTAFSDEDIIDLK", "length": 1013 }, "evidence": [ { "id": "45225751", "url": "http://www.informatics.jax.org/homology/45225751", "database": "MGI" }, { "id": "Q3V0G7", "url": "https://omabrowser.org/oma/group/Q3V0G7/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "Q3V0G7", "url": "https://www.uniprot.org/uniprot/Q3V0G7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3V0G7", "url": "https://www.uniprot.org/uniprot/Q3V0G7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of small GTPase mediated signal transduction", "id": "GO:0051056", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051056", "evidence": [ { "database": "UniProtKB", "id": "Q3V0G7", "url": "https://www.uniprot.org/uniprot/Q3V0G7" } ], "pmid": "" }, { "name": "activation of GTPase activity", "id": "GO:0090630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090630", "evidence": [ { "database": "UniProtKB", "id": "Q3V0G7", "url": "https://www.uniprot.org/uniprot/Q3V0G7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 280, "end_pos": 282, "annotation": "n_glycosylation_sequon" }, { "start_pos": 281, "end_pos": 283, "annotation": "n_glycosylation_sequon" }, { "start_pos": 47, "end_pos": 49, "annotation": "n_glycosylation_sequon" }, { "start_pos": 706, "end_pos": 708, "annotation": "n_glycosylation_sequon" }, { "start_pos": 744, "end_pos": 746, "annotation": "n_glycosylation_sequon" }, { "start_pos": 91, "end_pos": 93, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": 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"field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }