{ "uniprot_canonical_ac": "Q3UPR7-1", "uniprot_ac": "Q3UPR7", "uniprot_id": "TM102_MOUSE", "mass": { "chemical_mass": 54923.0, "monoisotopic_mass": 54923.0 }, "refseq": { "ac": "NP_001028605", "name": "transmembrane protein 102", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028605" }, "gene_names": [ { "name": "Tmem102", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q3UPR7", "id": "Q3UPR7" }, { "name": "4632403M07Rik; Cbap; Tmem102-ps", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028605", "id": "NP_001028605" }, { "name": "Tmem102", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028605", "id": "NP_001028605" } ], "protein_names": [ { "name": "Transmembrane protein 102", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q3UPR7" }, { "name": "transmembrane protein 102, pseudogene", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028605", "id": "NP_001028605" }, { "name": "transmembrane protein 102", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028605", "id": "NP_001028605" } ], "function": [ { "annotation": "CBAP indeed can function as a novel signaling component within the ZAP70/Vav1/talin complex and plays an important role in regulating chemokine-promoted T-cell trafficking. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001028605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028605" }, { "database": "PubMed", "id": "23620790", "url": "https://glygen.org/publication/PubMed/23620790" } ] }, { "annotation": "CBAP is a novel component in the TCR signaling pathway, and it modulates thymocyte apoptosis during negative selection. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001028605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028605" }, { "database": "PubMed", "id": "25393474", "url": "https://glygen.org/publication/PubMed/25393474" } ] }, { "annotation": "Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway.", "evidence": [ { "database": "UniProtKB", "id": "Q3UPR7", "url": "https://www.uniprot.org/uniprot/Q3UPR7#function" } ] }, { "annotation": "Shows functional evidence for the homologous human protein.", "evidence": [ { "database": "RefSeq", "id": "NP_001028605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028605" }, { "database": "PubMed", "id": "17828305", "url": "https://glygen.org/publication/PubMed/17828305" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q3UPR7", "url": "https://www.uniprot.org/uniprot/Q3UPR7" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Tmem102", "url": "https://www.uniprot.org/uniprot/Q3UPR7", "locus": { "chromosome": "11", "start_pos": 69694429, "end_pos": 69696450, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000089876", "url": "https://www.ensembl.org/id/ENSMUSG00000089876" } ] } } ], "crossref": [ { "id": "ENSMUSG00000089876", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000089876", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "380705", "url": "https://www.ncbi.nlm.nih.gov/gene/380705", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q3UPR7", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q3UPR7*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR024810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046906", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046906", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:380705", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:380705", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1921591", "url": "http://www.informatics.jax.org/marker/MGI:1921591", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "WPTLCPS", "url": "https://omabrowser.org/oma/group/WPTLCPS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5382069at2759", "url": "http://www.orthodb.org/?query=5382069at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10656", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10656", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10656:SF48", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10656:SF48", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF20266", "url": "http://pfam.xfam.org/family/PF20266", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q3UPR7", "url": "http://purl.obolibrary.org/obo/PR_Q3UPR7", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001028605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028605", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3UPR7", "url": "https://www.uniprot.org/uniprot/Q3UPR7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3UPR7-1", "url": "https://www.uniprot.org/uniprot/Q3UPR7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASTVWGGAPWWGPPPPAPARPLTDIDFCSGAQLQELTQLIQELRVQESWSEGPKPGADLLRAKDFVFALLGLVHRQDPRFPPQAELLLLRGGIREGSLDLGHAPLGPYSRGPHYDAGFTLLVPVFSLDGTGPELLLDLESCSAWLRLPELMRGILVREAWQDCLGPPVPEESDMTHQTHSKESPTDRENSVDPSHDYVPEPEPHMSLQKSSSDLSESQSSYKDITNPETPEPLETLSSDALDADESQVPKPSEAPKAWPTLCPTQVTSWFFVKLAEVAESLIPVPGAPRLVHAARHAGVTTVLLATPEPPRHLLLFDLIPVVTVTGWPDTARSHSWAGPLVSESASFYLVPGSLPEQPSTSGWQLCFARQELALKERIPTPLLQAHAAAQALLRPLVAGTRAAAPYLLRTLLYWACERLPALYLARPENAGACCLGLLDELSRVLEAGALPHYFLSGRKLRVGDGSAALRGALAQLRGDPAQALREAVEEAKVARKGGGLAGVGGGTH", "length": 509, "header": "sp|Q3UPR7-1|TM102_MOUSE Isoform 1 of Transmembrane protein 102 OS=Mus musculus OX=10090 GN=Tmem102 PE=1 SV=2 CANONICAL=Q3UPR7-1" }, "isoforms": [ { "isoform_ac": "Q3UPR7-1", "url": "", "sequence": { "sequence": "MASTVWGGAPWWGPPPPAPARPLTDIDFCSGAQLQELTQLIQELRVQESWSEGPKPGADLLRAKDFVFALLGLVHRQDPRFPPQAELLLLRGGIREGSLDLGHAPLGPYSRGPHYDAGFTLLVPVFSLDGTGPELLLDLESCSAWLRLPELMRGILVREAWQDCLGPPVPEESDMTHQTHSKESPTDRENSVDPSHDYVPEPEPHMSLQKSSSDLSESQSSYKDITNPETPEPLETLSSDALDADESQVPKPSEAPKAWPTLCPTQVTSWFFVKLAEVAESLIPVPGAPRLVHAARHAGVTTVLLATPEPPRHLLLFDLIPVVTVTGWPDTARSHSWAGPLVSESASFYLVPGSLPEQPSTSGWQLCFARQELALKERIPTPLLQAHAAAQALLRPLVAGTRAAAPYLLRTLLYWACERLPALYLARPENAGACCLGLLDELSRVLEAGALPHYFLSGRKLRVGDGSAALRGALAQLRGDPAQALREAVEEAKVARKGGGLAGVGGGTH", "length": 509, "header": "sp|Q3UPR7-1|TM102_MOUSE Isoform 1 of Transmembrane protein 102 OS=Mus musculus OX=10090 GN=Tmem102 PE=1 SV=2 CANONICAL=Q3UPR7-1" }, "locus": { "chromosome": "11", "start_pos": 69696059, "end_pos": 69694444, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000051025", "url": "https://www.ensembl.org/id/ENSMUST00000051025" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000132164", "url": "https://www.ensembl.org/id/ENSMUSP00000132164" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 211, "end_pos": 211, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "Q3UPR7", "url": "http://phospho.elm.eu.org/byAccession/Q3UPR7.html" }, { "database": "iPTMnet", "id": "Q3UPR7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q3UPR7" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" } ], "site_lbl": "Ser211" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2007", "authors": "Villen J, Beausoleil SA, Gerber SA, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q3UPR7", "url": "https://www.uniprot.org/uniprot/Q3UPR7" }, { "database": "iPTMnet", "id": "Q3UPR7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q3UPR7" } ], "reference": [ { "type": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" } ] }, { "title": "CBAP interacts with the un-liganded common beta-subunit of the GM-CSF/IL-3/IL-5 receptor and induces apoptosis via mitochondrial dysfunction.", "journal": "Oncogene", "date": "2008", "authors": "Kao CJ, Chiang YJ, Chen PH, Lin KR, Hwang PI, Yang-Yen HF, Yen JJ", "evidence": [ { "database": "RefSeq", "id": "NP_001028605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028605" } ], "reference": [ { "type": "PubMed", "id": "17828305", "url": "https://glygen.org/publication/PubMed/17828305" } ] }, { "title": "CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration.", "journal": "PloS one", "date": "2013", "authors": "Chiang YJ, Ho KC, Sun CT, Chiu JJ, Lee FJ, Liao F, Yang-Yen HF, Yen JJ", "evidence": [ { "database": "RefSeq", "id": "NP_001028605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028605" } ], "reference": [ { "type": "PubMed", "id": "23620790", "url": "https://glygen.org/publication/PubMed/23620790" } ] }, { "title": "CBAP promotes thymocyte negative selection by facilitating T-cell receptor proximal signaling.", "journal": "Cell death & disease", "date": "2014", "authors": "Ho KC, Chiang YJ, Lai AC, Liao NS, Chang YJ, Yang-Yen HF, Yen JJ", "evidence": [ { "database": "RefSeq", "id": "NP_001028605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028605" } ], "reference": [ { "type": "PubMed", "id": "25393474", "url": "https://glygen.org/publication/PubMed/25393474" } ] } ], "pathway": [ { "id": "mmu:380705", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:380705", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8N9M5-1", "protein_name": "Transmembrane protein 102", "gene_name": "TMEM102", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASAVWGSAPWWGPPPPAPARPLTDIDFCSGAQLQELTQLIQELGVQESWSDGPKPGADLLRAKDFVFSLLGLVHRRDPRFPPQAELLLLRGGIREGSLDLGHAPLGPYARGPHYDAGFTLLVPMFSLDGTELQLDLESCYAQVCLPEMVCGTPIREMWQDCLGPPVPGARDSIHRTESEESSKDWQSSVDQPHSYVTEHEAPVSLEKSPSDVSASESPQHDVVDLGSTAPLKTMSSDVTKAAVESPVPKPSEAREAWPTLCSAQVAAWFFATLAAVAESLIPVPGAPRLVHAARHAGFTTVLLATPEPPRRLLLFDLIPVVSVAGWPEGARSHSWAGPLASESASFYLVPGGGTERPCASAWQLCFARQELALKARIPAPLLQAHAAAQALLRPLVAGTRAAAPYLLRTLLYWACERLPALYLARPENAGACCLGLLDELGRVLEAGTLPHYFLNGRQLRTGDDSAALLGELARLRGDPARALRAAVEEAKVARKGGGLAGVGGGAH", "length": 508 }, "evidence": [ { "id": "45239829", "url": "http://www.informatics.jax.org/homology/45239829", "database": "MGI" }, { "id": "Q3UPR7", "url": "https://omabrowser.org/oma/group/Q3UPR7/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3UPR7", "url": "https://www.uniprot.org/uniprot/Q3UPR7" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q3UPR7", "url": "https://www.uniprot.org/uniprot/Q3UPR7" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "Q3UPR7", "url": "https://www.uniprot.org/uniprot/Q3UPR7" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "Q3UPR7", "url": "https://www.uniprot.org/uniprot/Q3UPR7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "Q3UPR7", "url": "https://www.uniprot.org/uniprot/Q3UPR7" } ], "pmid": "" }, { "name": "positive regulation of T cell chemotaxis", "id": "GO:0010820", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010820", "evidence": [ { "database": "UniProtKB", "id": "Q3UPR7", "url": "https://www.uniprot.org/uniprot/Q3UPR7" } ], "pmid": "" }, { "name": "positive regulation of cell adhesion", "id": "GO:0045785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045785", "evidence": [ { "database": "UniProtKB", "id": "Q3UPR7", "url": "https://www.uniprot.org/uniprot/Q3UPR7" } ], "pmid": "" }, { "name": "positive regulation of T cell migration", "id": "GO:2000406", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000406", "evidence": [ { "database": "UniProtKB", "id": "Q3UPR7", "url": "https://www.uniprot.org/uniprot/Q3UPR7" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "Q3UPR7", "url": "https://www.uniprot.org/uniprot/Q3UPR7" } ], "pmid": "" }, { "name": "regulation of peptidyl-tyrosine phosphorylation", "id": "GO:0050730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050730", "evidence": [ { "database": "UniProtKB", "id": "Q3UPR7", "url": "https://www.uniprot.org/uniprot/Q3UPR7" } ], "pmid": "" }, { "name": "response to cytokine", "id": "GO:0034097", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034097", "evidence": [ { "database": "UniProtKB", "id": "Q3UPR7", "url": "https://www.uniprot.org/uniprot/Q3UPR7" } ], "pmid": "" }, { "name": "regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "id": "GO:1901028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901028", "evidence": [ { "database": "UniProtKB", "id": "Q3UPR7", "url": "https://www.uniprot.org/uniprot/Q3UPR7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 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