{ "uniprot_canonical_ac": "Q3UMB9-1", "uniprot_ac": "Q3UMB9", "uniprot_id": "WASC4_MOUSE", "mass": { "chemical_mass": 136370.0, "monoisotopic_mass": 136370.0 }, "refseq": { "ac": "NP_001028547", "name": "WASH complex subunit 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028547" }, "gene_names": [ { "name": "Washc4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q3UMB9", "id": "Q3UMB9" }, { "name": "A230046K03Rik; Kiaa1033; mKIAA1033", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028547", "id": "NP_001028547" }, { "name": "Kiaa1033", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q3UMB9", "id": "Q3UMB9" }, { "name": "Washc4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028547", "id": "NP_001028547" } ], "protein_names": [ { "name": "WASH complex subunit 4", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q3UMB9" }, { "name": "WASH complex subunit 4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028547", "id": "NP_001028547" }, { "name": "WASH complex subunit 7; WASH complex subunit SWIP", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028547", "id": "NP_001028547" }, { "name": "WASH complex subunit SWIP", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q3UMB9" } ], "function": [ { "annotation": "Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.", "evidence": [ { "database": "UniProtKB", "id": "Q3UMB9", "url": "https://www.uniprot.org/uniprot/Q3UMB9#function" }, { "database": "PubMed", "id": "19922875", "url": "https://glygen.org/publication/PubMed/19922875" } ] } ], "disease": [ { "disease_id": "DOID:0081207", "recommended_name": { "id": "DOID:0081207", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0081207", "name": "autosomal recessive intellectual developmental disorder 43", "description": "An autosomal recessive intellectual developmental disorder that is characterized by impaired intellectual development, poor language skills, short stature, and dysmorphic features and that has_material_basis_in homozygous mutation in the KIAA1033 gene (WASHC4) on chromosome 12q23. Some patients may have significant motor delays." }, "synonyms": [ { "id": "MONDO:0014354", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014354", "name": "intellectual disability, autosomal recessive 43", "description": "Any autosomal recessive non-syndromic intellectual disability in which the cause of the disease is a mutation in the WASHC4 gene." }, { "id": "MONDO:0014354", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014354", "name": "WASHC4 autosomal recessive non-syndromic intellectual disability", "description": "" }, { "id": "MONDO:0014354", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014354", "name": "autosomal recessive non-syndromic intellectual disability caused by mutation in WASHC4", "description": "" }, { "id": "MONDO:0014354", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014354", "name": "intellectual developmental disorder, autosomal recessive 43", "description": "" }, { "id": "MONDO:0014354", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014354", "name": "intellectual disability, autosomal recessive 43", "description": "" }, { "id": "MONDO:0014354", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014354", "name": "intellectual disability, autosomal recessive type 43", "description": "" }, { "id": "MONDO:0014354", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014354", "name": "mental retardation, autosomal recessive type 43", "description": "" }, { "id": "MONDO:0014354", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014354", "name": "MRT43", "description": "" }, { "id": "MONDO:0014354", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014354", "name": "mental retardation, autosomal recessive 43", "description": "" }, { "id": "MIM:615817", "resource": "MIM", "url": "https://www.omim.org/entry/615817", "name": "Intellectual developmental disorder, autosomal recessive 43", "description": "Intellectual developmental disorder, autosomal recessive 43" } ], "evidence": [ { "id": "0081207", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0081207" } ] }, { "disease_id": "DOID:9169", "recommended_name": { "id": "DOID:9169", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9169", "name": "Wiskott-Aldrich syndrome", "description": "A syndrome that is characterized by abnormal immune system function and a reduced ability to form blood clots resulting from a decrease in the number and size of blood cell fragments involved in clotting (microthrombocytopenia)." }, "synonyms": [ { "id": "DOID:9169", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9169", "name": "Wiskott syndrome", "description": "" }, { "id": "MONDO:0010518", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010518", "name": "Wiskott-Aldrich syndrome", "description": "Wiskott-Aldrich syndrome (WAS) is a primary immunodeficiency disease characterized by microthrombocytopenia, eczema, infections and an increased risk for autoimmune manifestations and malignancies." }, { "id": "MONDO:0010518", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010518", "name": "WAS", "description": "" }, { "id": "MONDO:0010518", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010518", "name": "Wiskott Aldrich syndrome", "description": "" }, { "id": "MONDO:0010518", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010518", "name": "Wiskott syndrome", "description": "" }, { "id": "MONDO:0010518", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010518", "name": "Wiskott-Aldrich syndrome", "description": "" }, { "id": "MONDO:0010518", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010518", "name": "Wiskott-Aldrich syndrome 1", "description": "" }, { "id": "MONDO:0010518", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010518", "name": "Wiskott-Aldrich syndrome, X-linked recessive", "description": "" }, { "id": "MONDO:0010518", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010518", "name": "eczema-thrombocytopenia-immunodeficiency syndrome", "description": "" }, { "id": "MONDO:0010518", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010518", "name": "immunodeficiency 2", "description": "" }, { "id": "MONDO:0010518", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010518", "name": "Aldrich syndrome", "description": "" }, { "id": "MONDO:0010518", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010518", "name": "Imd 2", "description": "" }, { "id": "MONDO:0010518", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010518", "name": "eczema thrombocytopenia immunodeficiency syndrome", "description": "" }, { "id": "MIM:301000", "resource": "MIM", "url": "https://www.omim.org/entry/301000", "name": "Wiskott-Aldrich syndrome", "description": "Wiskott-Aldrich syndrome" } ], "evidence": [ { "id": "9169", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9169" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q3UMB9", "url": "https://www.uniprot.org/uniprot/Q3UMB9" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Washc4", "url": "https://www.uniprot.org/uniprot/Q3UMB9", "locus": { "chromosome": "10", "start_pos": 83432337, "end_pos": 83379616, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000034560", "url": "https://www.ensembl.org/id/ENSMUSG00000034560" } ] } } ], "crossref": [ { "id": "ENSMUSG00000034560", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000034560", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "319277", "url": "https://www.ncbi.nlm.nih.gov/gene/319277", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027307", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027307", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028191", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028191", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028282", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028282", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028283", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028283", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:319277", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:319277", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2441787", "url": "http://www.informatics.jax.org/marker/MGI:2441787", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "Q3UMB9", "url": "https://oglcnac.org/atlas/detail/Q3UMB9", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "Q3UMB9", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q3UMB9", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "QFLFDEH", "url": "https://omabrowser.org/oma/group/QFLFDEH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "121922at2759", "url": "http://www.orthodb.org/?query=121922at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31409", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31409", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31409:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31409:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14744", "url": "http://pfam.xfam.org/family/PF14744", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF14745", "url": "http://pfam.xfam.org/family/PF14745", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF14746", "url": "http://pfam.xfam.org/family/PF14746", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q3UMB9", "url": "http://purl.obolibrary.org/obo/PR_Q3UMB9", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001028547", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028547", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A1W2P6V9", "url": "https://www.uniprot.org/uniprot/A0A1W2P6V9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2P6V9-1", "url": "https://www.uniprot.org/uniprot/A0A1W2P6V9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3UMB9", "url": "https://www.uniprot.org/uniprot/Q3UMB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3UMB9-1", "url": "https://www.uniprot.org/uniprot/Q3UMB9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVDTLSPDWDFDRVDDGSQKIHAEVQLKNYGRFLEEYTSQLRRIEDALDDLIGDVWDFNLDPIALKLLPYEQSSLLELIKTENKVLNKVITVYAALCCEIKKLKYEAETKFYNGLLFYGEGATDSSMVEGDCQIQMGRFVSFLQELSCFVTRCYEVVMNVIHQLAALYISNKIGPKIIETTGVHFQTMYEHLGELLTVLLTLDEIVDNHVTLKDHWTMYKRLLKSVHHNPSKFGIQEEKLKPFEKFLLKLEGQLLDGMIFQACIEQQFDSLNGGISVSKNSTFAEEFAHSIRSIFANVEAKLGEPSEIDQRDKYVGICGLFVLHFQIFRTVDKKFYKSLLDICKKVPAITLTANIIWFPDNFLIHKMPAAAKLLDRKSLQAIKIHRDTFLQQKAQSLNKDVQSYYVFVSSWMMKMESMLSKEQRMDTFAEDLTNRCNVFIQGFLYAYSISTIIKTTMNLYMSMQKPMTKTSVKALCRLIELLKAIEHMFYRRSMVVADSVSHITQHLQHQALSSISVAKKRVISDKKYSEQRLDVLSALVLAENTLNGPSTKQRRLIVSLALSVGTQMKTFKDEELFPLQVVMKKLDLISELRERVQAQCDCCFLYWHRAVFPIYLDDVYENAVDAARLHYMFSALRDCVPAMMHSRHLESHELLLDCYDKEIMDILNEHLLDKLCKEIEKDLRLSVHTHLKLDDRNPFKVGRKDLALFFSLNPIRFFNRFIDIRAYVTHYLDKTFYNLTTVALHDWATYSEMRNLATQRYGLVMTEAHLPSQTLEQGLDVLEIMRNIHIFVSRYLYNLNNQIFIERTSNNKHLNTINIRHIANSIRTHGTGIMNTTVNFTYQFLKKKFYIFSQFMYDEHIKSRLIKDIRFFREIKDQNDHKYPFDRAEKFNRGIRKLGITPEGQSYLDQFRQLISQIGNAMGYIRMIRSGGLHCSSNAIRFVPDLEDIVSFEELVKEEGLAEETLRAARHLDSVLSDHTRNSAEGTEYFKMLVDVFAPEFRRPKNIHLRNFYIIVPPLTLNFVEHSISCKEKLNKKNKLGAAFTDDGFAMGVAYTLKLLDQYQEFDSLHWFQSVREKYIKEIRAVAKQQNVQSTSQDEKLLQTMNLTQKRLEVYLQEFELLYFSLSSARIFFRADKTAAEENQEKKEKEEETKTSNGDGPESTVSADPVVK", "length": 1173, "header": "sp|Q3UMB9-1|WASC4_MOUSE Isoform 1 of WASH complex subunit 4 OS=Mus musculus OX=10090 GN=Washc4 PE=1 SV=2 CANONICAL=Q3UMB9-1" }, "isoforms": [ { "isoform_ac": "A0A1W2P6V9-1", "url": "", "sequence": { "sequence": "MAVDTLSPDWDFDRVDDGSQKIHAEVQLKNYGRFLEEYTSQLRRIEDALDDLIGDVWDFNLDPIALKLLPYEQSSLLELIKTENKVLNKVITVYAALCCEIKKLKYEAETKFYNGLLFYGEGDSSMVEGDCQIQMGRFVSFLQELSCFVTRCYEVVMNVIHQLAALYISNKIGPKIIETTGVHFQVF", "length": 187, "header": "tr|A0A1W2P6V9-1|WASC4_MOUSE Computationally mapped isoform of WASH complex subunit 4 OS=Mus musculus OX=10090 GN=Washc4 PE=1 SV=1 CANONICAL=Q3UMB9-1" }, "locus": { "chromosome": "10", "start_pos": 83391870, "end_pos": 83379906, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000217842.2", "url": "https://www.ensembl.org/id/ENSMUST00000217842.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000151417.2", "url": "https://www.ensembl.org/id/ENSMUSP00000151417.2" } ] } }, { "isoform_ac": "Q3UMB9-1", "url": "", "sequence": { "sequence": "MAVDTLSPDWDFDRVDDGSQKIHAEVQLKNYGRFLEEYTSQLRRIEDALDDLIGDVWDFNLDPIALKLLPYEQSSLLELIKTENKVLNKVITVYAALCCEIKKLKYEAETKFYNGLLFYGEGATDSSMVEGDCQIQMGRFVSFLQELSCFVTRCYEVVMNVIHQLAALYISNKIGPKIIETTGVHFQTMYEHLGELLTVLLTLDEIVDNHVTLKDHWTMYKRLLKSVHHNPSKFGIQEEKLKPFEKFLLKLEGQLLDGMIFQACIEQQFDSLNGGISVSKNSTFAEEFAHSIRSIFANVEAKLGEPSEIDQRDKYVGICGLFVLHFQIFRTVDKKFYKSLLDICKKVPAITLTANIIWFPDNFLIHKMPAAAKLLDRKSLQAIKIHRDTFLQQKAQSLNKDVQSYYVFVSSWMMKMESMLSKEQRMDTFAEDLTNRCNVFIQGFLYAYSISTIIKTTMNLYMSMQKPMTKTSVKALCRLIELLKAIEHMFYRRSMVVADSVSHITQHLQHQALSSISVAKKRVISDKKYSEQRLDVLSALVLAENTLNGPSTKQRRLIVSLALSVGTQMKTFKDEELFPLQVVMKKLDLISELRERVQAQCDCCFLYWHRAVFPIYLDDVYENAVDAARLHYMFSALRDCVPAMMHSRHLESHELLLDCYDKEIMDILNEHLLDKLCKEIEKDLRLSVHTHLKLDDRNPFKVGRKDLALFFSLNPIRFFNRFIDIRAYVTHYLDKTFYNLTTVALHDWATYSEMRNLATQRYGLVMTEAHLPSQTLEQGLDVLEIMRNIHIFVSRYLYNLNNQIFIERTSNNKHLNTINIRHIANSIRTHGTGIMNTTVNFTYQFLKKKFYIFSQFMYDEHIKSRLIKDIRFFREIKDQNDHKYPFDRAEKFNRGIRKLGITPEGQSYLDQFRQLISQIGNAMGYIRMIRSGGLHCSSNAIRFVPDLEDIVSFEELVKEEGLAEETLRAARHLDSVLSDHTRNSAEGTEYFKMLVDVFAPEFRRPKNIHLRNFYIIVPPLTLNFVEHSISCKEKLNKKNKLGAAFTDDGFAMGVAYTLKLLDQYQEFDSLHWFQSVREKYIKEIRAVAKQQNVQSTSQDEKLLQTMNLTQKRLEVYLQEFELLYFSLSSARIFFRADKTAAEENQEKKEKEEETKTSNGDGPESTVSADPVVK", "length": 1173, "header": "sp|Q3UMB9-1|WASC4_MOUSE Isoform 1 of WASH complex subunit 4 OS=Mus musculus OX=10090 GN=Washc4 PE=1 SV=2 CANONICAL=Q3UMB9-1" }, "locus": { "chromosome": "10", "start_pos": 83430099, "end_pos": 83379906, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000038388", "url": "https://www.ensembl.org/id/ENSMUST00000038388" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000039322", "url": "https://www.ensembl.org/id/ENSMUSP00000039322" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 19, "start_aa": "Ser", "end_pos": 19, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser19", "evidence": [ { "id": "Q3UMB9", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q3UMB9" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "Q3UMB9", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q3UMB9" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" } ] } ], "phosphorylation": [ { "start_pos": 1154, "end_pos": 1154, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3UMB9", "url": "https://www.uniprot.org/uniprot/Q3UMB9" } ], "site_lbl": "Thr1154" }, { "start_pos": 7, "end_pos": 7, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3UMB9", "url": "https://www.uniprot.org/uniprot/Q3UMB9" } ], "site_lbl": "Ser7" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex.", "journal": "Dev. Cell", "date": "2009", "authors": "Derivery E, Sousa C, Gautier JJ, Lombard B, Loew D, Gautreau A", "evidence": [ { "database": "UniProtKB", "id": "Q3UMB9", "url": "https://www.uniprot.org/uniprot/Q3UMB9" } ], "reference": [ { "type": "PubMed", "id": "19922875", "url": "https://glygen.org/publication/PubMed/19922875" } ] }, { "title": "Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse.", "journal": "Molecular & cellular proteomics : MCP", "date": "2012", "authors": "Trinidad JC, Barkan DT, Gulledge BF, Thalhammer A, Sali A, Schoepfer R, Burlingame AL", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q3UMB9", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q3UMB9" }, { "database": "O-GlcNAc Atlas", "id": "Q3UMB9", "url": "https://oglcnac.org/atlas/detail/Q3UMB9" } ], "reference": [ { "type": "PubMed", "id": "22645316", "url": "https://glygen.org/publication/PubMed/22645316" } ] } ], "pathway": [ { "id": "mmu:319277", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:319277", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A7I6-1", "protein_name": "WASH complex subunit 4", "gene_name": "Washc4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAVDTLSPDWDFDRVDDGSQKIHAEVQLKNYGKFLEEYTSQLRRIEDALDDLVGDVWDFNLDPIALKLLPYEQSSLLELIKTENKVLNKVITVYAALCCEIKKLKHEAETKFYNGLLFYGEGAADSSMAEGDCQIQMGRFVSFLQELSCFVTRCYEVVMSVIHQLAALYISNKTGPKIIETTGVHFQTMYEHLGELLTVLLTLDEIIDNHVTLKDHWTMYKRLLKSVHHNPSKFGIQEERLKPFEKFLLKLEGQLLDGMIFQACIEQQFDSLNGGISVSKNSTFAEEFAHSIRSIFANVEAKLGEPSEIDQRDKYVGICGLFVLHFQIFRTVDKKFYKSLLDICKKVPAVTLTANIIWFPDNFLIHKMPAAAKLLDRKSLQAIKIHRDAFLQQKAQSLTKDVQSYYVFVSSWMMKMESMLSKEQRTDTFAEDLTNTCNVFIQGFLYAYSISTIIKTTMNLYMSMQKPMTRTSVKALCRLIELLKAVEHMFHRRSMVVADSVSHITQHLQHQALNSISVAKKRVISDKKYSEQRLDVLSALVLAENTLNGPSTKQRRLVVSLALSVGTQMKTFKDEELFPLQVVMKKLDLISELRERVQTQCDCCFLYWHRAVFPIYLDDVYENAVDAARLHYMFSALRDCVPAMMHSRHLESHELLLDCYDKEIMDILNERLLDKLCKETEKDLRLSVHTHLKLDDRNPFKVGRKDLALFFSLNPIRFFNRFIDIRAYVTHYLDKTFYNLTTVALHDWATYSEMRNLATQRYGLVMTEAHLPSQTLEQGLDVLEIMRNIHIFVSRYLYNLNNQIFIERTSNNKHLNTINIRHIANSIRTHGTGIMNTTVNFTYQFLKKKFYIFSQFMYDEHIKSRLIKDIRFFREIKDQNDHKYPFDRAEKFNRGIRKLGITPEGQSYLDQFRQLLSQIGNAMGYIRMIRSGGLHCSSNAIRFVPDLEDIVSFEELVKEEGLAEETLRAARHLDSVLSDHTRNSAEGTEYFKMLVDVFAPEFRRPKNIHLRNFYIIVPPLTLNFVEHSISCKEKLNKKNKIGAAFTDDGFAMGVAYTLKLLDQYQEFDSLHWFQSVREKYIKEIRAVAKQQSVQSTSQDEKLLQTMNLTQKRLEVYLQEFELLYFSLSSARIFFRADKTAAEENQEKKEKEETKMSNGDGSESTVSADPVVK", "length": 1172 }, "evidence": [ { "id": "45230376", "url": "http://www.informatics.jax.org/homology/45230376", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q2M389-1", "protein_name": "WASH complex subunit 4", "gene_name": "WASHC4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAVETLSPDWEFDRVDDGSQKIHAEVQLKNYGKFLEEYTSQLRRIEDALDDSIGDVWDFNLDPIALKLLPYEQSSLLELIKTENKVLNKVITVYAALCCEIKKLKYEAETKFYNGLLFYGEGATDASMVEGDCQIQMGRFISFLQELSCFVTRCYEVVMNVVHQLAALYISNKIAPKIIETTGVHFQTMYEHLGELLTVLLTLDEIIDNHITLKDHWTMYKRLLKSVHHNPSKFGIQEEKLKPFEKFLLKLEGQLLDGMIFQACIEQQFDSLNGGVSVSKNSTFAEEFAHSIRSIFANVEAKLGEPSEIDQRDKYVGICGLFVLHFQIFRTIDKKFYKSLLDICKKVPAITLTANIIWFPDNFLIQKIPAAAKLLDRKSLQAIKIHRDTFLQQKAQSLTKDVQSYYVFVSSWMMKMESILSKEQRMDKFAEDLTNRCNVFIQGFLYAYSISTIIKTTMNLYMSMQKPMTKTSVKALCRLVELLKAIEHMFYRRSMVVADSVSHITQHLQHQALHSISVAKKRVISDKKYSEQRLDVLSALVLAENTLNGPSTKQRRLIVSLALSVGTQMKTFKDEELFPLQVVMKKLDLISELRERVQTQCDCCFLYWHRAVFPIYLDDVYENAVDAARLHYMFSALRDCVPAMMHARHLESYEILLDCYDKEIMEILNEHLLDKLCKEIEKDLRLSVHTHLKLDDRNPFKVGMKDLALFFSLNPIRFFNRFIDIRAYVTHYLDKTFYNLTTVALHDWATYSEMRNLATQRYGLVMTEAHLPSQTLEQGLDVLEIMRNIHIFVSRYLYNLNNQIFIERTSNNKHLNTINIRHIANSIRTHGTGIMNTTVNFTYQFLKKKFYIFSQFMYDEHIKSRLIKDIRFFREIKDQNDHKYPFDRAEKFNRGIRKLGVTPEGQSYLDQFRQLISQIGNAMGYVRMIRSGGLHCSSNAIRFVPDLEDIVNFEELVKEEGLAEETLKAARHLDSVLSDHTRNSAEGTEYFKMLVDVFAPEFRRPKNIHLRNFYIIVPPLTLNFVEHSISCKEKLNKKNKIGAAFTDDGFAMGVAYILKLLDQYREFDSLHWFQSVREKYLKEIRAVAKQQNVQSASQDEKLLQTMNLTQKRLDVYLQEFELLYFSLSSARIFFRADKTAAEENQEKKEKEEETKTSNGDLSDSTVSADPVVK", "length": 1173 }, "evidence": [ { "id": "45230376", "url": "http://www.informatics.jax.org/homology/45230376", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "WASH complex", "id": "GO:0071203", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071203", "evidence": [ { "database": "UniProtKB", "id": "Q3UMB9", "url": "https://www.uniprot.org/uniprot/Q3UMB9" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q3UMB9", "url": "https://www.uniprot.org/uniprot/Q3UMB9" } ], "pmid": "" }, { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "Q3UMB9", "url": "https://www.uniprot.org/uniprot/Q3UMB9" } ], "pmid": "" }, { "name": "early endosome membrane", "id": "GO:0031901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "evidence": [ { "database": "UniProtKB", "id": "Q3UMB9", "url": "https://www.uniprot.org/uniprot/Q3UMB9" } ], "pmid": "" }, { "name": "BLOC-1 complex", "id": "GO:0031083", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031083", "evidence": [ { "database": "UniProtKB", "id": "Q3UMB9", "url": "https://www.uniprot.org/uniprot/Q3UMB9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q3UMB9", "url": "https://www.uniprot.org/uniprot/Q3UMB9" } ], "pmid": "" }, { "name": "endosome organization", "id": "GO:0007032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007032", "evidence": [ { "database": "UniProtKB", "id": "Q3UMB9", "url": "https://www.uniprot.org/uniprot/Q3UMB9" } ], "pmid": "" }, { "name": "endosomal transport", "id": "GO:0016197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016197", "evidence": [ { "database": "UniProtKB", "id": "Q3UMB9", "url": "https://www.uniprot.org/uniprot/Q3UMB9" } ], "pmid": "" }, { "name": "regulation of Arp2/3 complex-mediated actin nucleation", "id": "GO:0034315", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034315", "evidence": [ { "database": "UniProtKB", "id": "Q3UMB9", "url": "https://www.uniprot.org/uniprot/Q3UMB9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1107, "end_pos": 1109, "annotation": "n_glycosylation_sequon" }, { "start_pos": 281, "end_pos": 283, "annotation": "n_glycosylation_sequon" }, { "start_pos": 739, "end_pos": 741, "annotation": "n_glycosylation_sequon" }, { "start_pos": 836, "end_pos": 838, "annotation": "n_glycosylation_sequon" }, { "start_pos": 840, "end_pos": 842, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }