{ "uniprot_canonical_ac": "Q3UIZ8-1", "uniprot_ac": "Q3UIZ8", "uniprot_id": "MYLK3_MOUSE", "mass": { "chemical_mass": 86372.0, "monoisotopic_mass": 86372.0 }, "refseq": { "ac": "NP_001284541", "name": "myosin light chain kinase 3 isoform 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284541" }, "gene_names": [ { "name": "Mylk3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q3UIZ8", "id": "Q3UIZ8" }, { "name": "D830007F02Rik; MLCK", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284541", "id": "NP_001284541" }, { "name": "Mylk3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284541", "id": "NP_001284541" } ], "protein_names": [ { "name": "Myosin light chain kinase 3", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q3UIZ8" }, { "name": "2.7.11.18", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q3UIZ8" }, { "name": "Cardiac MLCK", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q3UIZ8" }, { "name": "Cardiac MyBP-C-associated Ca/CaM kinase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q3UIZ8" }, { "name": "myosin light chain kinase 3 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284541", "id": "NP_001284541" }, { "name": "putative myosin light chain kinase 3; cardiac MLCK; cardiac-specific myosin light chain kinase; cardiac-MyBP-C-associated Ca/CaM kinase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284541", "id": "NP_001284541" } ], "function": [ { "annotation": "A temporal Ca(2+) desensitization of myosin light chain kinase in phasic smooth muscles induced by CaMKKbeta/PP2A pathways.", "evidence": [ { "database": "RefSeq", "id": "NP_001284541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284541" }, { "database": "PubMed", "id": "34106787", "url": "https://glygen.org/publication/PubMed/34106787" } ] }, { "annotation": "Inhibiting MLCK increases the number of apoptotic cells and retards the growth of mammary cancer cells in mice.", "evidence": [ { "database": "RefSeq", "id": "NP_001284541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284541" }, { "database": "PubMed", "id": "15988034", "url": "https://glygen.org/publication/PubMed/15988034" } ] }, { "annotation": "Kinase that phosphorylates MYL2 in vitro (PubMed:18202317, PubMed:17885681). Has been proposed to be calmodulin-dependent (PubMed:17885681), although MYL2 phosphorylation has also been observed in the presence or absence of calmodulin (PubMed:18202317). Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3UIZ8", "url": "https://www.uniprot.org/uniprot/Q3UIZ8#function" }, { "database": "UniProtKB", "id": "E9PT87", "url": "https://www.uniprot.org/uniprot/E9PT87#function" }, { "database": "PubMed", "id": "18202317", "url": "https://glygen.org/publication/PubMed/18202317" }, { "database": "PubMed", "id": "17885681", "url": "https://glygen.org/publication/PubMed/17885681" } ] }, { "annotation": "MLCK is involved in egg polarity because inhibitors prevent sperm chromatin-induced cortical reorganization.", "evidence": [ { "database": "RefSeq", "id": "NP_001284541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284541" }, { "database": "PubMed", "id": "15680356", "url": "https://glygen.org/publication/PubMed/15680356" } ] }, { "annotation": "MLCK may be a regulatory target of Ca(2+)/calmodulin and may play an important role in insulin-stimulated glucose transport in adipocytes.", "evidence": [ { "database": "RefSeq", "id": "NP_001284541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284541" }, { "database": "PubMed", "id": "16672772", "url": "https://glygen.org/publication/PubMed/16672772" } ] }, { "annotation": "Mylk3 null C57BL/6N mice develop cardiomyopathy, whereas Nnt null C57BL/6J mice do not. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001284541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284541" }, { "database": "PubMed", "id": "32213617", "url": "https://glygen.org/publication/PubMed/32213617" } ] }, { "annotation": "Myosin light chain phosphorylation by the dedicated skeletal muscle Ca(2+)/calmodulin-dependent MLCK is a primary biochemical mechanism for tension potentiation due to repetitive stimulation in fast-twitch skeletal muscle.", "evidence": [ { "database": "RefSeq", "id": "NP_001284541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284541" }, { "database": "PubMed", "id": "16299103", "url": "https://glygen.org/publication/PubMed/16299103" } ] }, { "annotation": "Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin.", "evidence": [ { "database": "RefSeq", "id": "NP_001284541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284541" }, { "database": "PubMed", "id": "37128901", "url": "https://glygen.org/publication/PubMed/37128901" } ] }, { "annotation": "Ubiquitously expressed smooth muscle MLCK activity in MLCK null mice may be sufficient, but is not necessary for cytokinesis and early morphogenesis; other Ca2+-dependent kinases can phosphorylate myosin light-chain (20) and induce contraction in embryos.", "evidence": [ { "database": "RefSeq", "id": "NP_001284541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284541" }, { "database": "PubMed", "id": "15467390", "url": "https://glygen.org/publication/PubMed/15467390" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q3UIZ8", "url": "https://www.uniprot.org/uniprot/Q3UIZ8" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Mylk3", "url": "https://www.uniprot.org/uniprot/Q3UIZ8", "locus": { "chromosome": "8", "start_pos": 86050932, "end_pos": 86112974, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000031698", "url": "https://www.ensembl.org/id/ENSMUSG00000031698" } ] } } ], "crossref": [ { "id": "ENSMUSG00000031698", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000031698", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "2.7.11.18", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.11.18&UniProtAcc=Q3UIZ8", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd14192", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14192", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "213435", "url": "https://www.ncbi.nlm.nih.gov/gene/213435", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q3UIZ8", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q3UIZ8*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:213435", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:213435", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2443063", "url": "http://www.informatics.jax.org/marker/MGI:2443063", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "IHVQEMD", "url": "https://omabrowser.org/oma/group/IHVQEMD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5402680at2759", "url": "http://www.orthodb.org/?query=5402680at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24342", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24342", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24342:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24342:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "http://pfam.xfam.org/family/PF00069", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q3UIZ8", "url": "http://purl.obolibrary.org/obo/PR_Q3UIZ8", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001284541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284541", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "22004", "url": "https://www.rhea-db.org/rhea/22004", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "53900", "url": "https://www.rhea-db.org/rhea/53900", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "D3YZQ0", "url": "https://www.uniprot.org/uniprot/D3YZQ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3YZQ0-1", "url": "https://www.uniprot.org/uniprot/D3YZQ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3Z630", "url": "https://www.uniprot.org/uniprot/D3Z630", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3Z630-1", "url": "https://www.uniprot.org/uniprot/D3Z630-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3UIZ8", "url": "https://www.uniprot.org/uniprot/Q3UIZ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3UIZ8-1", "url": "https://www.uniprot.org/uniprot/Q3UIZ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3UIZ8-2", "url": "https://www.uniprot.org/uniprot/Q3UIZ8-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGVSEEDPEGLAPQGLPALGGACLATMDKKLNVLTEKVDRLLHFQEDVTEKLQCVCQGMDHLEQDLHRLEASRELSLAGSGSTPPTTAQAAWPEVLELVRAVRQEGAQHGARLEALFKMVVAVDRAITLVGSTFQNSKVADFIMQGTVPGRKGSLADGPEENKEQAEVAGVKPNHVLTTGGVQADASRTLWEESQKEDIPVRTVEGLPLIINTSLKGADLTQAGASLRQGVEVLGPGQVPLPTEAESRLPETASENTGATLELSVAIDRISEVLTSLKMSQGGGQETSSSKPDCWLSEEAMRLSSGPLPQPLGPLTPDSDIHSGDALPRIPINMQEMATPGELLETQSGSPIGSAEAPGLGTVLEDQIPKGARPFPPLPKRSSNNGGMSAEEEIGSGAEPMRGPSLATRDWRDETVGTTDLQQGIDPGAVSPEPGKDHAAQGPGRTEAGRLSSAAEAAIVVLDDSAAPPAPFEHRVVSIKDTLISAGYTVSQHEVLGGGRFGQVHRCTERSTGLALAAKIIKVKNVKDREDVKNEVNIMNQLSHVNLIQLYDAFESKSSFTLIMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVSQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFKGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWLSHLPAKASGSNVRLRSQQLLQKYMAQSKWKKHFHVVTAVNRLRKFPTCP", "length": 795, "header": "sp|Q3UIZ8-1|MYLK3_MOUSE Isoform 1 of Myosin light chain kinase 3 OS=Mus musculus OX=10090 GN=Mylk3 PE=1 SV=1 CANONICAL=Q3UIZ8-1" }, "isoforms": [ { "isoform_ac": "D3YZQ0-1", "url": "", "sequence": { "sequence": "MKNKEQAEVAGVKPNHVLTTGGVQADASRTLWEESQKEDIPVRTVEGLPLIINTSLKG", "length": 58, "header": "tr|D3YZQ0-1|D3YZQ0_MOUSE Computationally mapped isoform of Myosin light chain kinase 3 OS=Mus musculus OX=10090 GN=Mylk3 PE=1 SV=8 CANONICAL=Q3UIZ8-1" }, "locus": { "chromosome": "8", "start_pos": 86112742, "end_pos": 86085879, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000137290.2", "url": "https://www.ensembl.org/id/ENSMUST00000137290.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000123372.2", "url": "https://www.ensembl.org/id/ENSMUSP00000123372.2" } ] } }, { "isoform_ac": "D3Z630-1", "url": "", "sequence": { "sequence": "MGTLCPVPALCRPSTRGQQRASDYTQIFANKEQAEVAGVKPNHVLTTGGVQADASRTLWEESQKEDIPVRTVEGLPLIINTSLKGADLTQAGASLRQGVEVLGPGQVPLPTEAESRLPETASENTGATLELSVAIDRISEVLTSLKMSQGGGQETSSSKPDCWLSEEAMRLSSGPLPQPLGPLTPDSDIHSGDALPRIPINMQEMATPGELLETQSGSPIGSAEAPGLGTVLEDQIPKGARPFPPLPKRSSNNGGMSAEEEIGSGAEPMRGPSLATRDWRDETVGTTDLQQGIDPGAVSPEPGKDHAAQGPGRTEAGRLSSAAEAAIVVLDDSAAPPAPFEHRVVSIKDTLISAGYTVSQHEVLGGGRFGQVHRCTERSTGLALAAKIIKVKNVKDREDVKNEVNIMNQLSHVNLIQLYDAFESKSSFTLIMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVSQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFKGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWLSHLPAKASGSNVRLRSQQLLQKYMAQSKWKKHFHVVTAVNRLRKFPTCP", "length": 662, "header": "tr|D3Z630-1|MYLK3_MOUSE Computationally mapped isoform of Myosin light chain kinase 3 OS=Mus musculus OX=10090 GN=Mylk3 PE=1 SV=1 CANONICAL=Q3UIZ8-1" }, "locus": { "chromosome": "8", "start_pos": 86107574, "end_pos": 86052093, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000122452.8", "url": "https://www.ensembl.org/id/ENSMUST00000122452.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000113389.2", "url": "https://www.ensembl.org/id/ENSMUSP00000113389.2" } ] } }, { "isoform_ac": "Q3UIZ8-1", "url": "", "sequence": { "sequence": "MSGVSEEDPEGLAPQGLPALGGACLATMDKKLNVLTEKVDRLLHFQEDVTEKLQCVCQGMDHLEQDLHRLEASRELSLAGSGSTPPTTAQAAWPEVLELVRAVRQEGAQHGARLEALFKMVVAVDRAITLVGSTFQNSKVADFIMQGTVPGRKGSLADGPEENKEQAEVAGVKPNHVLTTGGVQADASRTLWEESQKEDIPVRTVEGLPLIINTSLKGADLTQAGASLRQGVEVLGPGQVPLPTEAESRLPETASENTGATLELSVAIDRISEVLTSLKMSQGGGQETSSSKPDCWLSEEAMRLSSGPLPQPLGPLTPDSDIHSGDALPRIPINMQEMATPGELLETQSGSPIGSAEAPGLGTVLEDQIPKGARPFPPLPKRSSNNGGMSAEEEIGSGAEPMRGPSLATRDWRDETVGTTDLQQGIDPGAVSPEPGKDHAAQGPGRTEAGRLSSAAEAAIVVLDDSAAPPAPFEHRVVSIKDTLISAGYTVSQHEVLGGGRFGQVHRCTERSTGLALAAKIIKVKNVKDREDVKNEVNIMNQLSHVNLIQLYDAFESKSSFTLIMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVSQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFKGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWLSHLPAKASGSNVRLRSQQLLQKYMAQSKWKKHFHVVTAVNRLRKFPTCP", "length": 795, "header": "sp|Q3UIZ8-1|MYLK3_MOUSE Isoform 1 of Myosin light chain kinase 3 OS=Mus musculus OX=10090 GN=Mylk3 PE=1 SV=1 CANONICAL=Q3UIZ8-1" }, "locus": { "chromosome": "8", "start_pos": 86091803, "end_pos": 86052093, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000034133", "url": "https://www.ensembl.org/id/ENSMUST00000034133" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000034133", "url": "https://www.ensembl.org/id/ENSMUSP00000034133" } ] } }, { "isoform_ac": "Q3UIZ8-2", "url": "", "sequence": { "sequence": "MSGVSEEDPEGLAPQGLPALGGACLATMDKKLNVLTEKVDRLLHFQEDVTEKLQCVCQGMDHLEQDLHRLEASRELSLAGSGSTPPTTAQAAWPEVLELNKEQAEVAGVKPNHVLTTGGVQADASRTLWEESQKEDIPVRTVEGLPLIINTSLKGADLTQAGASLRQGVEVLGPGQVPLPTEAESRLPETASENTGATLELSVAIDRISEVLTSLKMSQGGGQETSSSKPDCWLSEEAMRLSSGPLPQPLGPLTPDSDIHSGDALPRIPINMQEMATPGELLETQSGSPIGSAEAPGLGTVLEDQIPKGARPFPPLPKRSSNNGGMSAEEEIGSGAEPMRGPSLATRDWRDETVGTTDLQQGIDPGAVSPEPGKDHAAQGPGRTEAGRLSSAAEAAIVVLDDSAAPPAPFEHRVVSIKDTLISAGYTVSQHEVLGGGRFGQVHRCTERSTGLALAAKIIKVKNVKDREDVKNEVNIMNQLSHVNLIQLYDAFESKSSFTLIMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVSQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFKGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWLSHLPAKASGSNVRLRSQQLLQKYMAQSKWKVFWVFFSKSCI", "length": 724, "header": "sp|Q3UIZ8-2|MYLK3_MOUSE Isoform 2 of Myosin light chain kinase 3 OS=Mus musculus OX=10090 GN=Mylk3 PE=1 SV=1 CANONICAL=Q3UIZ8-1" }, "locus": { "chromosome": "8", "start_pos": 86091803, "end_pos": 86053744, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000121972", "url": "https://www.ensembl.org/id/ENSMUST00000121972" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000113960", "url": "https://www.ensembl.org/id/ENSMUSP00000113960" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 155, "end_pos": 155, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3UIZ8", "url": "https://www.uniprot.org/uniprot/Q3UIZ8" } ], "site_lbl": "Ser155" }, { "start_pos": 351, "end_pos": 351, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3UIZ8", "url": "https://www.uniprot.org/uniprot/Q3UIZ8" } ], "site_lbl": "Ser351" }, { "start_pos": 432, "end_pos": 432, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3UIZ8", "url": "https://www.uniprot.org/uniprot/Q3UIZ8" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q3UIZ8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q3UIZ8" } ], "site_lbl": "Ser432" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Myosin light chain kinase knockout.", "journal": "Journal of muscle research and cell motility", "date": "2004", "authors": "Somlyo AV, Wang H, Choudhury N, Khromov AS, Majesky M, Owens GK, Somlyo AP", "evidence": [ { "database": "RefSeq", "id": "NP_001284541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284541" } ], "reference": [ { "type": "PubMed", "id": "15467390", "url": "https://glygen.org/publication/PubMed/15467390" } ] }, { "title": "Role of MAP kinase and myosin light chain kinase in chromosome-induced development of mouse egg polarity.", "journal": "Developmental biology", "date": "2005", "authors": "Deng M, Williams CJ, Schultz RM", "evidence": [ { "database": "RefSeq", "id": "NP_001284541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284541" } ], "reference": [ { "type": "PubMed", "id": "15680356", "url": "https://glygen.org/publication/PubMed/15680356" } ] }, { "title": "Inhibiting myosin light chain kinase induces apoptosis in vitro and in vivo.", "journal": "Molecular and cellular biology", "date": "2005", "authors": "Fazal F, Gu L, Ihnatovych I, Han Y, Hu W, Antic N, Carreira F, Blomquist JF, Hope TJ, Ucker DS, de Lanerolle P", "evidence": [ { "database": "RefSeq", "id": "NP_001284541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284541" } ], "reference": [ { "type": "PubMed", "id": "15988034", "url": "https://glygen.org/publication/PubMed/15988034" } ] }, { "title": "Myosin light chain kinase and myosin phosphorylation effect frequency-dependent potentiation of skeletal muscle contraction.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2005", "authors": "Zhi G, Ryder JW, Huang J, Ding P, Chen Y, Zhao Y, Kamm KE, Stull JT", "evidence": [ { "database": "RefSeq", "id": "NP_001284541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284541" } ], "reference": [ { "type": "PubMed", "id": "16299103", "url": "https://glygen.org/publication/PubMed/16299103" } ] }, { "title": "Implication of phosphorylation of the myosin II regulatory light chain in insulin-stimulated GLUT4 translocation in 3T3-F442A adipocytes.", "journal": "Experimental & molecular medicine", "date": "2006", "authors": "Choi YO, Ryu HJ, Kim HR, Song YS, Kim C, Lee W, Choe H, Leem CH, Jang YJ", "evidence": [ { "database": "RefSeq", "id": "NP_001284541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284541" } ], "reference": [ { "type": "PubMed", "id": "16672772", "url": "https://glygen.org/publication/PubMed/16672772" } ] }, { "title": "A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart.", "journal": "J. Clin. Invest.", "date": "2007", "authors": "Seguchi O, Takashima S, Yamazaki S, Asakura M, Asano Y, Shintani Y, Wakeno M, Minamino T, Kondo H, Furukawa H, Nakamaru K, Naito A, Takahashi T, Ohtsuka T, Kawakami K, Isomura T, Kitamura S, Tomoike H, Mochizuki N, Kitakaze M", "evidence": [ { "database": "UniProtKB", "id": "Q3UIZ8", "url": "https://www.uniprot.org/uniprot/Q3UIZ8" } ], "reference": [ { "type": "PubMed", "id": "17885681", "url": "https://glygen.org/publication/PubMed/17885681" } ] }, { "title": "Identification of cardiac-specific myosin light chain kinase.", "journal": "Circ. Res.", "date": "2008", "authors": "Chan JY, Takeda M, Briggs LE, Graham ML, Lu JT, Horikoshi N, Weinberg EO, Aoki H, Sato N, Chien KR, Kasahara H", "evidence": [ { "database": "UniProtKB", "id": "Q3UIZ8", "url": "https://www.uniprot.org/uniprot/Q3UIZ8" } ], "reference": [ { "type": "PubMed", "id": "18202317", "url": "https://glygen.org/publication/PubMed/18202317" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q3UIZ8", "url": "https://www.uniprot.org/uniprot/Q3UIZ8" }, { "database": "iPTMnet", "id": "Q3UIZ8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q3UIZ8" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "Mylk3 null C57BL/6N mice develop cardiomyopathy, whereas Nnt null C57BL/6J mice do not.", "journal": "Life science alliance", "date": "2020", "authors": "Williams JL, Paudyal A, Awad S, Nicholson J, Grzesik D, Botta J, Meimaridou E, Maharaj AV, Stewart M, Tinker A, Cox RD, Metherell LA", "evidence": [ { "database": "RefSeq", "id": "NP_001284541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284541" } ], "reference": [ { "type": "PubMed", "id": "32213617", "url": "https://glygen.org/publication/PubMed/32213617" } ] }, { "title": "A temporal Ca(2+) desensitization of myosin light chain kinase in phasic smooth muscles induced by CaMKKbeta/PP2A pathways.", "journal": "American journal of physiology. Cell physiology", "date": "2021", "authors": "Kitazawa T, Matsui T, Katsuki S, Goto A, Akagi K, Hatano N, Tokumitsu H, Takeya K, Eto M", "evidence": [ { "database": "RefSeq", "id": "NP_001284541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284541" } ], "reference": [ { "type": "PubMed", "id": "34106787", "url": "https://glygen.org/publication/PubMed/34106787" } ] }, { "title": "Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin.", "journal": "Circulation", "date": "2023-05-02", "authors": "Hitsumoto Tatsuro, Tsukamoto Osamu, Matsuoka Ken, Li Junjun, Liu Li, Kuramoto Yuki, Higo Shuichiro, Ogawa Shou, Fujino Noboru, Yoshida Shohei, Kioka Hidetaka, Kato Hisakazu, Hakui Hideyuki, Saito Yuki, Okamoto Chisato, Inoue Hijiri, Hyejin Jo, Ueda Kyoko, Segawa Takatsugu, Nishimura Shunsuke, Asano Yoshihiro, Asanuma Hiroshi, Tani Akiyoshi, Imamura Riyo, Komagawa Shinsuke, Kanai Toshio, Takamura Masayuki, Sakata Yasushi, Kitakaze Masafumi, Haruta Jun-Ichi, Takashima Seiji", "evidence": [ { "database": "RefSeq", "id": "NP_001284541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284541" } ], "reference": [ { "type": "PubMed", "id": "37128901", "url": "https://glygen.org/publication/PubMed/37128901" } ] } ], "pathway": [ { "id": "mmu:213435", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:213435", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "E9PT87-1", "protein_name": "Myosin light chain kinase 3", "gene_name": "Mylk3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSGVSEEDPEGLGPQGLPALGGACLVTVDKKLNVLTEKVDRLLHFQEDVTEKLQCVCQGMDHLEQGLHRLEASQELGLAGPGSTSPAAAQAAWPEVLELVRAVRQEGAQHGARLEALFKMVVAVDRAITLVGSTIQNSKVDDFILQGTVPWRKGSLADGPEENKEQAEVAGVKPKHVLNTGSVQAATSRALWEESQKQDTPVGTVEGLPLIIDTSLKGADLTQAGASLRQGVEALDPGQEPPPTEAESRLPALASEDTGTTLELSVAIDRISEVLTSLRMSQSAGEGTSSSKPDCSEPGPQPLGPLTTDSDIHSDEGLPRISVRMREMTTPEELFETQGGSPIGSAEAPGPGTVLEDQIPKGARPFPPLPKRSCNNGGASAEEATGPGAEPIRGPSLVTRDWRDEPVGTTDLQQGRDPGAVSPEPGKDHAAQGPGRTEAGRRVSSAAEAAIVVLDDSAAPPAPFEHRVVSIKDTLISTSYTVSQHEVLGGGRFGQVHRCTERSTGLALAAKIIKVKNIKDREDVKNEINIMNQLSHVNLIQLYDAFESKNSFTLIMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVSQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFKGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWLNHLIAKASGSNVRLRSQLLLQKYMAQRKWKKHFHVVTAVNRLRKFPTCP", "length": 786 }, "evidence": [ { "id": "45226322", "url": "http://www.informatics.jax.org/homology/45226322", "database": "MGI" }, { "id": "Q3UIZ8", "url": "https://omabrowser.org/oma/group/Q3UIZ8/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q32MK0-3", "protein_name": "Myosin light chain kinase 3", "gene_name": "MYLK3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGTSKESLGHGGLPGLGKTCLTTMDTKLNMLNEKVDQLLHFQEDVTEKLQSMCRDMGHLERGLHRLEASRAPGPGGADGVPHIDTQAGWPEVLELVRAMQQDAAQHGARLEALFRMVAAVDRAIALVGATFQKSKVADFLMQGRVPWRRGSPGDSPEENKERVEEEGGKPKHVLSTSGVQSDAREPGEESQKADVLEGTAERLPPIRASGLGADPAQAVVSPGQGDGVPGPAQAFPGHLPLPTKVEAKAPETPSENLRTGLELAPAPGRVNVVSPSLEVAPGAGQGASSSRPDPEPLEEGTRLTPGPGPQCPGPPGLPAQARATHSGGETPPRISIHIQEMDTPGEMLMTGRGSLGPTLTTEAPAAAQPGKQGPPGTGRCLQAPGTEPGEQTPEGARELSPLQESSSPGGVKAEEEQRAGAEPGTRPSLARSDDNDHEVGALGLQQGKSPGAGNPEPEQDCAARAPVRAEAVRRMPPGAEAGSVVLDDSPAPPAPFEHRVVSVKETSISAGYEVCQHEVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVNQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKYIAQRKWKKHFYVVTAANRLRKFPTSP", "length": 819 }, "evidence": [ { "id": "45226322", "url": "http://www.informatics.jax.org/homology/45226322", "database": "MGI" }, { "id": "Q3UIZ8", "url": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0004687", "evidence": [ { "database": "UniProtKB", "id": "Q3UIZ8", "url": "https://www.uniprot.org/uniprot/Q3UIZ8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "protein phosphorylation", "id": "GO:0006468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006468", "evidence": [ { "database": "UniProtKB", "id": "Q3UIZ8", "url": "https://www.uniprot.org/uniprot/Q3UIZ8" } ], "pmid": "" }, { "name": "cardiac myofibril assembly", "id": "GO:0055003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055003", "evidence": [ { "database": "UniProtKB", "id": "Q3UIZ8", "url": "https://www.uniprot.org/uniprot/Q3UIZ8" } ], "pmid": "" }, { "name": "sarcomere organization", "id": "GO:0045214", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045214", "evidence": [ { "database": "UniProtKB", "id": "Q3UIZ8", "url": "https://www.uniprot.org/uniprot/Q3UIZ8" } ], "pmid": "" }, { "name": "cellular response to interleukin-1", "id": "GO:0071347", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071347", "evidence": [ { "database": "UniProtKB", "id": "Q3UIZ8", "url": "https://www.uniprot.org/uniprot/Q3UIZ8" } ], "pmid": "" }, { "name": "sarcomerogenesis", "id": "GO:0048769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048769", "evidence": [ { "database": "UniProtKB", "id": "Q3UIZ8", "url": "https://www.uniprot.org/uniprot/Q3UIZ8" } ], "pmid": "" }, { "name": "positive regulation of sarcomere organization", "id": "GO:0060298", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060298", "evidence": [ { "database": "UniProtKB", "id": "Q3UIZ8", "url": "https://www.uniprot.org/uniprot/Q3UIZ8" } ], "pmid": "" }, { "name": "regulation of vascular permeability involved in acute inflammatory response", "id": "GO:0002528", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002528", "evidence": [ { "database": "UniProtKB", "id": "Q3UIZ8", "url": "https://www.uniprot.org/uniprot/Q3UIZ8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3UIZ8", "url": "https://www.uniprot.org/uniprot/Q3UIZ8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3UIZ8", "url": "https://www.uniprot.org/uniprot/Q3UIZ8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 213, "end_pos": 215, "annotation": "n_glycosylation_sequon" }, { "start_pos": 702, "end_pos": 704, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Phosphorylated on serine residues.", "evidence": [ { "database": "UniProtKB", "id": "Q3UIZ8", "url": "https://www.uniprot.org/uniprot/Q3UIZ8" }, { "database": "PubMed", "id": "18202317", "url": "https://glygen.org/publication/PubMed/18202317" } ] } ], "interactions": [], "reactions": [ { "id": "22004", "name": "", "equation": "ATP + L-seryl-[myosin light chain] = ADP + H(+) + O-phospho-L-seryl-[myosin light chain]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E9PT87-1", "P20689-1", "Q9H1R3-1", "Q32MK0-3", "Q15746-1", "Q8VCR8-1", "Q3UIZ8-1", "Q6PDN3-1", "Q54PB4-1", "Q86AD7-1", "P25323-1", "Q54CY9-1", "Q54SJ5-1", "Q54W86-1", "Q869W6-1" ], "evidence": [ { "id": "22004", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/22004" } ] }, { "id": "53900", "name": "", "equation": "ATP + L-threonyl-[myosin light chain] = ADP + H(+) + O-phospho-L-threonyl-[myosin light chain]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E9PT87-1", "P20689-1", "Q9H1R3-1", "Q32MK0-3", "Q15746-1", "Q8VCR8-1", "Q3UIZ8-1", "Q6PDN3-1", "Q54PB4-1", "Q86AD7-1", "P25323-1", "Q54CY9-1", "Q54SJ5-1", "Q54W86-1", "Q869W6-1" ], "evidence": [ { "id": "53900", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53900" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "E9PT87", "gene_name": "Mylk3", "activity": [ { "ec_number": "2.7.11.18", "activity": "ATP + L-seryl-[myosin light chain] = ADP + H(+) + O-phospho-L-seryl-[myosin light chain].", "evidence": [ { "id": "E9PT87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PT87" } ] }, { "ec_number": "2.7.11.18", "activity": "", "evidence": [ { "id": "E9PT87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PT87" } ] } ] }, { "uniprot_ac": "P20689", "gene_name": "Mylk2", "activity": [ { "ec_number": "2.7.11.18", "activity": "ATP + L-seryl-[myosin light chain] = ADP + H(+) + O-phospho-L-seryl-[myosin light chain].", "evidence": [ { "id": "P20689", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20689" } ] }, { "ec_number": "2.7.11.18", "activity": "", "evidence": [ { "id": "P20689", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20689" } ] } ] }, { "uniprot_ac": "P25323", "gene_name": "mlkA", "activity": [ { "ec_number": "2.7.11.18", "activity": "ATP + L-seryl-[myosin light chain] = ADP + H(+) + O-phospho-L-seryl-[myosin light chain].", "evidence": [ { "id": "P25323", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25323" } ] }, { "ec_number": "2.7.11.18", "activity": "", "evidence": [ { "id": "P25323", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25323" } ] } ] }, { "uniprot_ac": "Q15746", "gene_name": "MYLK", "activity": [ { "ec_number": "2.7.11.18", "activity": "ATP + L-seryl-[myosin light chain] = ADP + H(+) + O-phospho-L-seryl-[myosin light chain].", "evidence": [ { "id": "Q15746", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15746" } ] }, { "ec_number": "2.7.11.18", "activity": "", "evidence": [ { "id": "Q15746", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15746" } ] } ] }, { "uniprot_ac": "Q32MK0", "gene_name": "MYLK3", "activity": [ { "ec_number": "2.7.11.18", "activity": "ATP + L-seryl-[myosin light chain] = ADP + H(+) + O-phospho-L-seryl-[myosin light chain].", "evidence": [ { "id": "Q32MK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q32MK0" } ] }, { "ec_number": "2.7.11.18", "activity": "", "evidence": [ { "id": "Q32MK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q32MK0" } ] } ] }, { "uniprot_ac": "Q3UIZ8", "gene_name": "Mylk3", "activity": [ { "ec_number": "2.7.11.18", "activity": "ATP + L-seryl-[myosin light chain] = ADP + H(+) + O-phospho-L-seryl-[myosin light chain].", "evidence": [ { "id": "Q3UIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UIZ8" } ] }, { "ec_number": "2.7.11.18", "activity": "", "evidence": [ { "id": "Q3UIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UIZ8" } ] } ] }, { 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 11 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }