{
    "uniprot_canonical_ac": "Q3U1Z5-1",
    "uniprot_ac": "Q3U1Z5",
    "uniprot_id": "GPSM3_MOUSE",
    "mass": {
        "chemical_mass": 17619.0,
        "monoisotopic_mass": 17619.0
    },
    "refseq": {
        "ac": "NP_598877",
        "name": "G-protein-signaling modulator 3",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598877"
    },
    "gene_names": [
        {
            "name": "Gpsm3",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q3U1Z5",
            "id": "Q3U1Z5"
        },
        {
            "name": "AGS4",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598877",
            "id": "NP_598877"
        },
        {
            "name": "Gpsm3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598877",
            "id": "NP_598877"
        }
    ],
    "protein_names": [
        {
            "name": "G-protein-signaling modulator 3",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q3U1Z5"
        },
        {
            "name": "G-protein-signaling modulator 3",
            "resource": "RefSeq",
            "type": "synonym",
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            "id": "NP_598877"
        }
    ],
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        {
            "annotation": "Findings suggest that GPSM3 acts as a direct negative regulator of NLRP3 function.",
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                {
                    "database": "RefSeq",
                    "id": "NP_598877",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598877"
                },
                {
                    "database": "PubMed",
                    "id": "25271165",
                    "url": "https://glygen.org/publication/PubMed/25271165"
                }
            ]
        },
        {
            "annotation": "GPSM3 is an important regulator of monocyte function involving mechanisms of differentiation, survival, and chemotaxis, and deficiency in GPSM3 expression is protective in acute inflammatory arthritis.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_598877",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598877"
                },
                {
                    "database": "PubMed",
                    "id": "23280397",
                    "url": "https://glygen.org/publication/PubMed/23280397"
                }
            ]
        },
        {
            "annotation": "Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins.",
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                {
                    "database": "UniProtKB",
                    "id": "Q3U1Z5",
                    "url": "https://www.uniprot.org/uniprot/Q3U1Z5#function"
                }
            ]
        },
        {
            "annotation": "The N-terminal region of G18 is a novel G protein-interacting domain that may have distinct regulatory effects within the G(i/o) subfamily",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_598877",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598877"
                },
                {
                    "database": "PubMed",
                    "id": "20097748",
                    "url": "https://glygen.org/publication/PubMed/20097748"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
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                    "url": "https://www.uniprot.org/uniprot/Q3U1Z5"
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            ],
            "common_name": "Mouse"
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        {
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        },
        {
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        },
        {
            "id": "IPR003109",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003109",
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            ]
        },
        {
            "id": "IPR011990",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR042888",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR042888",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:106512",
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            "database": "KEGG Pathway",
            "categories": [
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            ]
        },
        {
            "id": "2146785",
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            "database": "MGI",
            "categories": [
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            ]
        },
        {
            "id": "HQSQRME",
            "url": "https://omabrowser.org/oma/group/HQSQRME/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR47617",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47617",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR47617:SF1",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47617:SF1",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF02188",
            "url": "http://pfam.xfam.org/family/PF02188",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q3U1Z5",
            "url": "http://purl.obolibrary.org/obo/PR_Q3U1Z5",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-MMU-418594",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-418594",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_598877",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598877",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "G3UYL4",
            "url": "https://www.uniprot.org/uniprot/G3UYL4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "G3UYL4-1",
            "url": "https://www.uniprot.org/uniprot/G3UYL4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "G3UZQ1",
            "url": "https://www.uniprot.org/uniprot/G3UZQ1",
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            "categories": [
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            ]
        },
        {
            "id": "G3UZQ1-1",
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            "categories": [
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            ]
        },
        {
            "id": "Q3U1Z5",
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            "database": "UniProtKB",
            "categories": [
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            ]
        },
        {
            "id": "Q3U1Z5-1",
            "url": "https://www.uniprot.org/uniprot/Q3U1Z5-1",
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            ]
        },
        {
            "id": "Q3U1Z5-2",
            "url": "https://www.uniprot.org/uniprot/Q3U1Z5-2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
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        "sequence": "MEAERPQEEDGEQSLPQDDQGWPPVNATARPWRSAPPSPPPPGTRHTALGPRSGSLLSLQTELLLDLVAEAQSRRLEEQRATFHTPEAPPNLAPAPPRLLEDKEQLYSTILSHQCQRIEAQRSDPPLPPGGQELLELLLRVQGGGRMEEQRSRPPTHTC",
        "length": 159,
        "header": "sp|Q3U1Z5-1|GPSM3_MOUSE Isoform 1 of G-protein-signaling modulator 3  OS=Mus musculus OX=10090 GN=Gpsm3 PE=1 SV=2 CANONICAL=Q3U1Z5-1"
    },
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        {
            "isoform_ac": "G3UYL4-1",
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                "sequence": "ERPQEEDGEQCQRIEAQRSDPPLPPGGQELLELLLRVQGGGRMEEQRSRPPTHTC",
                "length": 55,
                "header": "tr|G3UYL4-1|GPSM3_MOUSE Computationally mapped isoform of G-protein-signaling modulator 3  OS=Mus musculus OX=10090 GN=Gpsm3 PE=1 SV=1 CANONICAL=Q3U1Z5-1"
            },
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                "end_pos": 34809205,
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                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000173772.2",
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                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000134130.2",
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        {
            "isoform_ac": "G3UZQ1-1",
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            },
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                    {
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                "sequence": "MEAERPQEEDGEQSLPQDDQGWPPVNATARPWRSAPPSPPPPGTRHTALGPRSGSLLSLQTELLLDLVAEAQSRRLEEQRATFHTPEAPPNLAPAPPRLLEDKEQLYSTILSHQCQRIEAQRSDPPLPPGGQELLELLLRVQGGGRMEEQRSRPPTHTC",
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                "header": "sp|Q3U1Z5-1|GPSM3_MOUSE Isoform 1 of G-protein-signaling modulator 3  OS=Mus musculus OX=10090 GN=Gpsm3 PE=1 SV=2 CANONICAL=Q3U1Z5-1"
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                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000045911",
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                ]
            }
        },
        {
            "isoform_ac": "Q3U1Z5-2",
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                "sequence": "MPPLGLGDLLLPPLLLLEPDTQTELLLDLVAEAQSRRLEEQRATFHTPEAPPNLAPAPPRLLEDKEQLYSTILSHQCQRIEAQRSDPPLPPGGQELLELLLRVQGGGRMEEQRSRPPTHTC",
                "length": 121,
                "header": "sp|Q3U1Z5-2|GPSM3_MOUSE Isoform 2 of G-protein-signaling modulator 3  OS=Mus musculus OX=10090 GN=Gpsm3 PE=1 SV=2 CANONICAL=Q3U1Z5-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 34,
            "end_pos": 34,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q3U1Z5",
                    "url": "https://www.uniprot.org/uniprot/Q3U1Z5"
                }
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            "site_lbl": "Ser34"
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        {
            "start_pos": 38,
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            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
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                    "database": "UniProtKB",
                    "id": "Q3U1Z5",
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                },
                {
                    "database": "PubMed",
                    "id": "19144319",
                    "url": "https://glygen.org/publication/PubMed/19144319"
                },
                {
                    "database": "phospho.ELM",
                    "id": "Q3U1Z5",
                    "url": "http://phospho.elm.eu.org/byAccession/Q3U1Z5.html"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q3U1Z5",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q3U1Z5"
                }
            ],
            "site_lbl": "Ser38"
        },
        {
            "start_pos": 55,
            "end_pos": 55,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q3U1Z5",
                    "url": "https://www.uniprot.org/uniprot/Q3U1Z5"
                },
                {
                    "database": "PubMed",
                    "id": "19144319",
                    "url": "https://glygen.org/publication/PubMed/19144319"
                },
                {
                    "database": "phospho.ELM",
                    "id": "Q3U1Z5",
                    "url": "http://phospho.elm.eu.org/byAccession/Q3U1Z5.html"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q3U1Z5",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q3U1Z5"
                }
            ],
            "site_lbl": "Ser55"
        },
        {
            "start_pos": 58,
            "end_pos": 58,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q3U1Z5",
                    "url": "https://www.uniprot.org/uniprot/Q3U1Z5"
                },
                {
                    "database": "PubMed",
                    "id": "19144319",
                    "url": "https://glygen.org/publication/PubMed/19144319"
                },
                {
                    "database": "phospho.ELM",
                    "id": "Q3U1Z5",
                    "url": "http://phospho.elm.eu.org/byAccession/Q3U1Z5.html"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q3U1Z5",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q3U1Z5"
                }
            ],
            "site_lbl": "Ser58"
        },
        {
            "start_pos": 61,
            "end_pos": 61,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "Phosphothreonine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q3U1Z5",
                    "url": "https://www.uniprot.org/uniprot/Q3U1Z5"
                }
            ],
            "site_lbl": "Thr61"
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "The phagosomal proteome in interferon-gamma-activated macrophages.",
            "journal": "Immunity",
            "date": "2009",
            "authors": "Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q3U1Z5",
                    "url": "https://www.uniprot.org/uniprot/Q3U1Z5"
                },
                {
                    "database": "UniProtKB",
                    "id": "G3UZQ1",
                    "url": "https://www.uniprot.org/uniprot/G3UZQ1"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q3U1Z5",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q3U1Z5"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "19144319",
                    "url": "https://glygen.org/publication/PubMed/19144319"
                }
            ]
        },
        {
            "title": "The proline-rich N-terminal domain of G18 exhibits a novel G protein regulatory function.",
            "journal": "The Journal of biological chemistry",
            "date": "2010",
            "authors": "Zhao P, Nguyen CH, Chidiac P",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_598877",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598877"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "20097748",
                    "url": "https://glygen.org/publication/PubMed/20097748"
                }
            ]
        },
        {
            "title": "G-protein signaling modulator-3, a gene linked to autoimmune diseases, regulates monocyte function and its deficiency protects from inflammatory arthritis.",
            "journal": "Molecular immunology",
            "date": "2013",
            "authors": "Giguere PM, Billard MJ, Laroche G, Buckley BK, Timoshchenko RG, McGinnis MW, Esserman D, Foreman O, Liu P, Siderovski DP, Tarrant TK",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_598877",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598877"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "23280397",
                    "url": "https://glygen.org/publication/PubMed/23280397"
                }
            ]
        },
        {
            "title": "G Protein signaling modulator-3 inhibits the inflammasome activity of NLRP3.",
            "journal": "The Journal of biological chemistry",
            "date": "2014",
            "authors": "Giguere PM, Gall BJ, Ezekwe EA Jr, Laroche G, Buckley BK, Kebaier C, Wilson JE, Ting JP, Siderovski DP, Duncan JA",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_598877",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598877"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "25271165",
                    "url": "https://glygen.org/publication/PubMed/25271165"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:106512",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:106512",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-418594",
            "name": "G alpha (i) signalling events",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-418594",
            "resource": "Reactome",
            "description": "G alpha (i) signalling events"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q6MG88-1",
            "protein_name": "G-protein-signaling modulator 3",
            "gene_name": "Gpsm3",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MEAERPQEDGEQSLPQDDQGWPPVNSTARPWRSAPPSPPPPGTRHTALGPRSGSLLSLQTELLLDLVAEAQSRRLEEQRAAFHTPKVPPSLAPTPPRLLEDKEQLYSTILSHQCQRIEAQRSDPPLPPGGQELLELLLRVQGGGRMEDQRSRPPTHTC",
                "length": 158
            },
            "evidence": [
                {
                    "id": "45241412",
                    "url": "http://www.informatics.jax.org/homology/45241412",
                    "database": "MGI"
                },
                {
                    "id": "Q3U1Z5",
                    "url": "https://omabrowser.org/oma/group/Q3U1Z5/",
                    "database": "OMA"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q9Y4H4-1",
            "protein_name": "G-protein-signaling modulator 3",
            "gene_name": "GPSM3",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MEAERPQEEEDGEQGPPQDEEGWPPPNSTTRPWRSAPPSPPPPGTRHTALGPRSASLLSLQTELLLDLVAEAQSRRLEEQRATFYTPQNPSSLAPAPLRPLEDREQLYSTILSHQCQRMEAQRSEPPLPPGGQELLELLLRVQGGGRMEEQRSRPPTHTC",
                "length": 160
            },
            "evidence": [
                {
                    "id": "45241412",
                    "url": "http://www.informatics.jax.org/homology/45241412",
                    "database": "MGI"
                },
                {
                    "id": "Q3U1Z5",
                    "url": "https://omabrowser.org/oma/group/Q3U1Z5/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 4,
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            "name": "homologset.mgi",
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