{ "uniprot_canonical_ac": "Q3TQQ9-1", "uniprot_ac": "Q3TQQ9", "uniprot_id": "FIRRM_MOUSE", "mass": { "chemical_mass": 101222.0, "monoisotopic_mass": 101222.0 }, "refseq": { "ac": "NP_958752", "name": "FIGNL1-interacting regulator of recombination and mitosis isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958752" }, "gene_names": [ { "name": "Firrm", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q3TQQ9", "id": "Q3TQQ9" }, { "name": "BC055324", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q3TQQ9", "id": "Q3TQQ9" }, { "name": "FLIP", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958752", "id": "NP_958752" }, { "name": "Firrm", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958752", "id": "NP_958752" } ], "protein_names": [ { "name": "FIGNL1-interacting regulator of recombination and mitosis", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q3TQQ9" }, { "name": "FIDGETIN-like-1 interacting protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q3TQQ9" }, { "name": "FIGNL1-interacting regulator of recombination and mitosis isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958752", "id": "NP_958752" }, { "name": "FLIP", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q3TQQ9" }, { "name": "POLO1-associating protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q3TQQ9" }, { "name": "uncharacterized protein C1orf112 homolog; POLO1-associating protein; FIDGETIN-like-1 interacting protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958752", "id": "NP_958752" } ], "function": [ { "annotation": "BC055324 gene is strongly co-expressed with known cancer-associated genes and with genes involved in the cell cycle. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_958752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958752" }, { "database": "PubMed", "id": "23039964", "url": "https://glygen.org/publication/PubMed/23039964" } ] }, { "annotation": "Regulates PLK1 kinase activity at kinetochores and promotes faithful chromosome segregation in prometaphase by bridging kinase and phosphatase activities. Phosphorylation of FIRRM by PLK1 negatively regulates its interaction with the phosphatase, PPP1CC, thus creating a negative feedback loop for maintaining proper PLK1 kinase activity during mitosis. In complex with FIGL1 may regulate homologous recombination.", "evidence": [ { "database": "UniProtKB", "id": "Q3TQQ9", "url": "https://www.uniprot.org/uniprot/Q3TQQ9#function" }, { "database": "UniProtKB", "id": "Q9NSG2", "url": "https://www.uniprot.org/uniprot/Q9NSG2#function" } ] }, { "annotation": "The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart.", "evidence": [ { "database": "RefSeq", "id": "NP_958752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958752" }, { "database": "PubMed", "id": "37439366", "url": "https://glygen.org/publication/PubMed/37439366" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q3TQQ9", "url": "https://www.uniprot.org/uniprot/Q3TQQ9" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Firrm", "url": "https://www.uniprot.org/uniprot/Q3TQQ9", "locus": { "chromosome": "1", "start_pos": 163773562, "end_pos": 163822365, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000041406", "url": "https://www.ensembl.org/id/ENSMUSG00000041406" } ] } } ], "crossref": [ { "id": "ENSMUSG00000041406", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000041406", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "381306", "url": "https://www.ncbi.nlm.nih.gov/gene/381306", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027902", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027902", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:381306", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:381306", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "3590554", "url": "http://www.informatics.jax.org/marker/MGI:3590554", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "PCVQQTF", "url": "https://omabrowser.org/oma/group/PCVQQTF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "3152308at2759", "url": "http://www.orthodb.org/?query=3152308at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16071", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16071", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16071:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16071:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14868", "url": "http://pfam.xfam.org/family/PF14868", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q3TQQ9", "url": "http://purl.obolibrary.org/obo/PR_Q3TQQ9", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_958752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958752", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E0CX91", "url": "https://www.uniprot.org/uniprot/E0CX91", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E0CX91-1", "url": "https://www.uniprot.org/uniprot/E0CX91-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F7DEW2", "url": "https://www.uniprot.org/uniprot/F7DEW2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F7DEW2-1", "url": "https://www.uniprot.org/uniprot/F7DEW2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3TQQ9", "url": "https://www.uniprot.org/uniprot/Q3TQQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3TQQ9-1", "url": "https://www.uniprot.org/uniprot/Q3TQQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3TQQ9-2", "url": "https://www.uniprot.org/uniprot/Q3TQQ9-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3TQQ9-3", "url": "https://www.uniprot.org/uniprot/Q3TQQ9-3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSQDDAEVASGVVLEELSSWSEEMCRRELPSVLPRLLSMYQCSESWIEHIRILKIIVEMFLPHMNHLTLEETLFSQVLPKSIKLFDGMICELTSEARELSSQNLEIQVTIRNILQAMVQVIGGFTGCVRHVCATQKSVFLGSIQSLPSFILHIIKSAFVHCKNSECVYSGRLHLVSDLLQVLFKEAYSLQKQLMGLLDTVCLDPSVDENNALIMVGVIHSLLDICSVISGMDQAFHANTWKFIIKQSLKHHSVIKSQLRHKEIISSLCEDILFSFHSCLQLAEQITQPAAQGNADYRLFQKTLKLCRFFANSLLHYTKECLPFLSDSCCTLHQLYLQIHSKFLSLCAAKTSKAQQEEIASTFLVLLDPLISQLLKSQPFVQAVLASKLALPCELQLPQVLLLVVAMDKLPSQPQDVQTLWSTEDMTRMSILKGIFYNFGQCSGELSLPTHLQGTKGKGQAEVPVTLYQHVCVHLCAFVASFHSSLFPRLDAALLNAVLSTNMSTSLLAMDVWCFLARYGTAKLGAHHVTLVAHLVKSCPGKCVQLTNLSILLKRLLFFMAAPHQVQFIQKFSPKEADNLHLWQYISLQAFDADLRKPVACELVRVCRAQCRKWLSSTRTLAELDSLNTALSVVLTVCNSAGEALDSRQLTAVTEVLGELWTFINVEQIISQPYVQQAFSLLLQLLAFFIQTVDLQLISQVVNVLTSVIKLEPPDHVSLAVLDFISSLGKLYISQTIRDKVLPSLSCILTSLIVNKNWLLEQHTLEAFTQFAEGTKHEEIVPQCLGSEEIKNKVVSFLEKTESVDEAEVATVDNVKQEKGTFWEPAAKVTVEEVKTSAFQPHTKRARRVLPFEEEYRSVFKAAARALETTEFLLKHSLAPAWLLPELEALQGRIEKLKRCVLTG", "length": 903, "header": "sp|Q3TQQ9-1|FIRRM_MOUSE Isoform 1 of FIGNL1-interacting regulator of recombination and mitosis OS=Mus musculus OX=10090 GN=Firrm PE=1 SV=2 CANONICAL=Q3TQQ9-1" }, "isoforms": [ { "isoform_ac": "E0CX91-1", "url": "", "sequence": { "sequence": "MSQDDAEVASGVVLEELSSWSEEMCRRELPSVLPRLLSMYQCSESWIEHIRKNFKNHC", "length": 58, "header": "tr|E0CX91-1|FIRRM_MOUSE Computationally mapped isoform of FIGNL1-interacting regulator of recombination and mitosis OS=Mus musculus OX=10090 GN=Firrm PE=1 SV=1 CANONICAL=Q3TQQ9-1" }, "locus": { "chromosome": "1", "start_pos": 163822289, "end_pos": 163817344, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000160926.2", "url": "https://www.ensembl.org/id/ENSMUST00000160926.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000124826.2", "url": "https://www.ensembl.org/id/ENSMUSP00000124826.2" } ] } }, { "isoform_ac": "F7DEW2-1", "url": "", "sequence": { "sequence": "QLTAVTEVLDYQSALCSTGI", "length": 20, "header": "tr|F7DEW2-1|FIRRM_MOUSE Computationally mapped isoform of FIGNL1-interacting regulator of recombination and mitosis OS=Mus musculus OX=10090 GN=Firrm PE=1 SV=1 CANONICAL=Q3TQQ9-1" }, "locus": { "chromosome": "1", "start_pos": 163789592, "end_pos": 163788210, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000159617.2", "url": "https://www.ensembl.org/id/ENSMUST00000159617.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000125075.2", "url": "https://www.ensembl.org/id/ENSMUSP00000125075.2" } ] } }, { "isoform_ac": "Q3TQQ9-1", "url": "", "sequence": { "sequence": "MSQDDAEVASGVVLEELSSWSEEMCRRELPSVLPRLLSMYQCSESWIEHIRILKIIVEMFLPHMNHLTLEETLFSQVLPKSIKLFDGMICELTSEARELSSQNLEIQVTIRNILQAMVQVIGGFTGCVRHVCATQKSVFLGSIQSLPSFILHIIKSAFVHCKNSECVYSGRLHLVSDLLQVLFKEAYSLQKQLMGLLDTVCLDPSVDENNALIMVGVIHSLLDICSVISGMDQAFHANTWKFIIKQSLKHHSVIKSQLRHKEIISSLCEDILFSFHSCLQLAEQITQPAAQGNADYRLFQKTLKLCRFFANSLLHYTKECLPFLSDSCCTLHQLYLQIHSKFLSLCAAKTSKAQQEEIASTFLVLLDPLISQLLKSQPFVQAVLASKLALPCELQLPQVLLLVVAMDKLPSQPQDVQTLWSTEDMTRMSILKGIFYNFGQCSGELSLPTHLQGTKGKGQAEVPVTLYQHVCVHLCAFVASFHSSLFPRLDAALLNAVLSTNMSTSLLAMDVWCFLARYGTAKLGAHHVTLVAHLVKSCPGKCVQLTNLSILLKRLLFFMAAPHQVQFIQKFSPKEADNLHLWQYISLQAFDADLRKPVACELVRVCRAQCRKWLSSTRTLAELDSLNTALSVVLTVCNSAGEALDSRQLTAVTEVLGELWTFINVEQIISQPYVQQAFSLLLQLLAFFIQTVDLQLISQVVNVLTSVIKLEPPDHVSLAVLDFISSLGKLYISQTIRDKVLPSLSCILTSLIVNKNWLLEQHTLEAFTQFAEGTKHEEIVPQCLGSEEIKNKVVSFLEKTESVDEAEVATVDNVKQEKGTFWEPAAKVTVEEVKTSAFQPHTKRARRVLPFEEEYRSVFKAAARALETTEFLLKHSLAPAWLLPELEALQGRIEKLKRCVLTG", "length": 903, "header": "sp|Q3TQQ9-1|FIRRM_MOUSE Isoform 1 of FIGNL1-interacting regulator of recombination and mitosis OS=Mus musculus OX=10090 GN=Firrm PE=1 SV=2 CANONICAL=Q3TQQ9-1" }, "locus": { "chromosome": "1", "start_pos": 163822289, "end_pos": 163781717, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000045876", "url": "https://www.ensembl.org/id/ENSMUST00000045876" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000043143", "url": "https://www.ensembl.org/id/ENSMUSP00000043143" } ] } }, { "isoform_ac": "Q3TQQ9-2", "url": "", "sequence": { "sequence": "MSQDDAEVASGVVLEELSSWSEEMCRRELPSVLPRLLSMYQCSESWIEHIRILKIIVEMFLPHMNHLTLEETLFSQVLPKSIKLFDGMICELTSEARELSSQNLEIQVTIRNILQAMVQVIGGFTGCVRHVCATQKSVFLGSIQSLPSFILHIIKSAFVHCKNSECVYSGRLHLVSDLLQVLFKEAYSLQKQLMGLLDTVCLDPSVDENNALIMVGVIHSLLDICSVISGMDQAFHANTWKFIIKQSLKHHSVIKSQLRHKEIISSLCEDILFSFHSCLQLAEQITQPAAQGNADYRLFQKTLKLCRFFANSLLHYTKECLPFLSDSCCTLHQLYLQIHSKFLSLCAAKTSKAQQEEIASTFLVLLDPLISQLLKSQPFVQAVLASKLALPCELQLPQVLLLVVAMDKLPSQPQDVQTLWSTEDMTRMSILKGIFYNFGQCSGELSLPTHLQGTKGKGQAEVPVTLYQHVCVHLCAFVASFHSSLFPRLDAALLNAVLSTNMSTSLLAMDVWCFLARYGTAKLGAHHVTLVAHLVKSCPGKCVQLTNLSILLKRLLFFMAAPHQVQFIQKFSPKEADNLHLWQYISLQAFDADLRKPVACELVRVCRAQCRKWLSSTRTLAELDSLNTALSVVLTVCNSAGEALDSRQLTAVTEVLGELWTFINVEQIISQPYVQQAFSLLLQLLAFFIQTVDLQLISQVVNVLTSVIKLEPPDHVSLAVLDFISSLGKLYISQTIRDKVLPSLSCILTSLIVNKNWLLEQHTLEAFTQFAEGTKHEEIVPQCLGSEEIKNKVVSFLEKTESVDEAEVATVDNVKQEKGTFWEPAAKVTVEEVKTSAFQPHTKRARRVLPFEEEYRSVFKAAARALETTEFLLKHSLAPAWLLPELEALQGRIEKLKRCVLTGGSTCAQSPRPALTRFDTLPLPTWL", "length": 927, "header": "sp|Q3TQQ9-2|FIRRM_MOUSE Isoform 2 of FIGNL1-interacting regulator of recombination and mitosis OS=Mus musculus OX=10090 GN=Firrm PE=1 SV=2 CANONICAL=Q3TQQ9-1" }, "locus": { "chromosome": "1", "start_pos": 163822289, "end_pos": 163773922, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000097493", "url": "https://www.ensembl.org/id/ENSMUST00000097493" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000095101", "url": "https://www.ensembl.org/id/ENSMUSP00000095101" } ] } }, { "isoform_ac": "Q3TQQ9-3", "url": "", "sequence": { "sequence": "MSQDDAEVASGVVLEELSSWSEEMCRRELPSVLPRLLSMYQCSESWIEHIRILKIIVEMVQVIGGFTGCVRHVCATQKSVFLGSIQSLPSFILHIIKSAFVHCKNSECVYSGRLHLVSDLLQVLFKEAYSLQKQLMGLLDTVCLDPSVDENNALIMVGVIHSLLDICSVISGMDQAFHANTWKFIIKQSLKHHSVIKSQLRHKEIISSLCEDILFSFHSCLQLAEQITQPAAQGNADYRLFQKTLKLCRFFANSLLHYTKECLPFLSDSCCTLHQLYLQIHSKFLSLCAAKTSKAQQEEIASTFLVLLDPLISQLLKSQPFVQAVLASKLALPCELQLPQVLLLVVAMDKLPSQPQDVQTLWSTEDMTRMSILKGIFYNFGQCSGELSLPTHLQGTKGKGQAEVPVTLYQHVCVHLCAFVASFHSSLFPRLDAALLNAVLSTNMSTSLLAMDVWCFLARYGTAKLGAHHVTLVAHLVKSCPGKCVQLTNLSILLKRLLFFMAAPHQVQFIQKFSPKEADNLHLWQYISLQAFDADLRKPVACELVRVCRAQCRKWLSSTRTLAELDSLNTALSVVLTVCNSAGEALDSRQLTAVTEVLGELWTFINVEQIISQPYVQQAFSLLLQLLAFFIQTVDLQLISQVVNVLTSVIKLEPPDHVSLAVLDFISSLGKLYISQTIRDKVLPSLSCILTSLIVNKNWLLEQHTLEAFTQFAEGTKHEEIVPQCLGSEEIKNKVVSFLEKTESVDEAEVATVDNVKQEKGTFWEPAAKVTVEEVKTSAFQPHTKRARRVLPFEEEYRSVFKAAARALETTEFLLKHSLAPAWLLPELEALQGRIEKLKRCVLTG", "length": 845, "header": "sp|Q3TQQ9-3|FIRRM_MOUSE Isoform 3 of FIGNL1-interacting regulator of recombination and mitosis OS=Mus musculus OX=10090 GN=Firrm PE=1 SV=2 CANONICAL=Q3TQQ9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 101, "end_pos": 101, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3TQQ9", "url": "https://www.uniprot.org/uniprot/Q3TQQ9" } ], "site_lbl": "Ser101" }, { "start_pos": 795, "end_pos": 795, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3TQQ9", "url": "https://www.uniprot.org/uniprot/Q3TQQ9" } ], "site_lbl": "Ser795" } ], "glycation": [], "keywords": [], "publication": [ { "title": "GeneFriends: an online co-expression analysis tool to identify novel gene targets for aging and complex diseases.", "journal": "BMC genomics", "date": "2012", "authors": "van Dam S, Cordeiro R, Craig T, van Dam J, Wood SH, de Magalhaes JP", "evidence": [ { "database": "RefSeq", "id": "NP_958752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958752" } ], "reference": [ { "type": "PubMed", "id": "23039964", "url": "https://glygen.org/publication/PubMed/23039964" } ] }, { "title": "The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart.", "journal": "Nucleic acids research", "date": "2023-09-08", "authors": "Zhang Qianting, Fan Jiayi, Xu Wei, Cao Huiwen, Qiu Cheng, Xiong Yi, Zhao Huacun, Wang Yong, Huang Jun, Yu Chao", "evidence": [ { "database": "RefSeq", "id": "NP_958752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958752" } ], "reference": [ { "type": "PubMed", "id": "37439366", "url": "https://glygen.org/publication/PubMed/37439366" } ] } ], "pathway": [ { "id": "mmu:381306", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:381306", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q5XI94-1", "protein_name": "FIGNL1-interacting regulator of recombination and mitosis", "gene_name": "Firrm", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSQNGAVATNGVMLEELSSWPEEICRRELPSVLPRLLSMYQCSESWIEHIRILKIIVEMFLPHMNHLTLEETLFSQILPKTIQLFDGMICELTSEARELSSQNLEIQITIRNILQTMVQIIGSLTGCVHHVCATQESIILGNIHSLPSFILHIIKSTFVHCKNSESVYSGRLHLVSDLLQTLFKEAYSLQKQLMELLDMVCLGPSEDENSILTMVEVIHSLMDICSVISSMDKAFHANTWKFIIKQSLKHQSVIRSQLKHKEIISSLCEDILFSFHSCLQLAEQTTEPAAQDNADYRLFQKTLKLCRFFANSLLHYTKEFLPFLPDSCRTLHQLYLQIYSKFPPCLYTAKISKVQQEEIAGTFLVVLDPLLSQLLKSQSFVQTVLASKLDLPHELQLPQVLLLVVVVDKLPSQPEDVQTLWCTEDMTRMSILKAIFYNFGQFSGELSLPAHLQGVKGKGQAEVPVTLYQRICVHLCTFVASLHPTLFPELDAALLNAVLSTNMSTSLLAMDVWCFLARYGTAELGAHHVTLVAHLIKSCPGRCVQLTNLSVLLRRLFFFMAPAHQVEFIQKFSPREADNLHLWQYISFQALPADLRKQVTCEVTGVCTAQCRKWLSGSHTLAELDSLNTALSVLLTVCNSAGEALDSRQLTAVTEVVGQLWAFINVEQIISQPHVQQAFSLLLQLLAFFIQTVDLQLISQVVNVLTLVIKLEPPDHVSLAVLDFLSSLGKLYISQTLRDKVLPSLSCIVASLMVNRNWLLEQHTLEAFTQFAEGTKHEEIVSQCLGSEEIKNKVVSFLEKTESVGETEAATADNSGEQKTDTFWEPVAKVTLEEAKGSAFQPCTKRARQELLLEEEYRSAFQTATRALETTEALLKHSRAPAWLLSELGALQERIEKLKCCVLRG", "length": 905 }, "evidence": [ { "id": "45240184", "url": "http://www.informatics.jax.org/homology/45240184", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9NSG2-1", "protein_name": "FIGNL1-interacting regulator of recombination and mitosis", "gene_name": "FIRRM", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFLPHMNHLTLEQTFFSQVLPKTVKLFDDMMYELTSQARGLSSQNLEIQTTLRNILQTMVQLLGALTGCVQHICATQESIILENIQSLPSSVLHIIKSTFVHCKNSESVYSGCLHLVSDLLQALFKEAYSLQKQLMELLDMVCMDPLVDDNDDILNMVIVIHSLLDICSVISSMDHAFHANTWKFIIKQSLKHQSIIKSQLKHKDIITSLCEDILFSFHSCLQLAEQMTQSDAQDNADYRLFQKTLKLCRFFANSLLHYAKEFLPFLSDSCCTLHQLYLQIHSKFPPSLYATRISKAHQEEIAGAFLVTLDPLISQLLTFQPFMQVVLDSKLDLPCELQFPQCLLLVVVMDKLPSQPKEVQTLWCTDSQVSETTTRISLLKAVFYSFEQCSGELSLPVHLQGLKSKGKAEVAVTLYQHVCVHLCTFITSFHPSLFAELDAALLNAVLSANMITSLLAMDAWCFLARYGTAELCAHHVTIVAHLIKSCPGECYQLINLSILLKRLFFFMAPPHQLEFIQKFSPKEAENLPLWQHISFQALPPELREQTVHEVTTVGTAECRKWLSRSRTLGELESLNTVLSALLAVCNSAGEALDTGKQTAIIEVVSQLWAFLNIKQVADQPYVQQTFSLLLPLLGFFIQTLDPKLILQAVTLQTSLLKLELPDYVRLAMLDFVSSLGKLFIPEAIQDRILPNLSCMFALLLADRSWLLEQHTLEAFTQFAEGTNHEEIVPQCLSSEETKNKVVSFLEKTGFVDETEAAKVERVKQEKGIFWEPFANVTVEEAKRSSLQPYAKRARQEFPWEEEYRSALHTIAGALEATESLLQKGPAPAWLSMEMEALQERMDKLKRYIHTLG", "length": 853 }, "evidence": [ { "id": "45240184", "url": "http://www.informatics.jax.org/homology/45240184", "database": "MGI" }, { "id": "Q3TQQ9", "url": "https://omabrowser.org/oma/group/Q3TQQ9/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "mitotic cell cycle", "id": "GO:0000278", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000278", "evidence": [ { "database": "UniProtKB", "id": "Q3TQQ9", "url": "https://www.uniprot.org/uniprot/Q3TQQ9" } ], "pmid": "" }, { "name": "chromosome segregation", "id": "GO:0007059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007059", "evidence": [ { "database": "UniProtKB", "id": "Q3TQQ9", "url": "https://www.uniprot.org/uniprot/Q3TQQ9" } ], "pmid": "" }, { "name": "regulation of protein kinase activity", "id": "GO:0045859", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045859", "evidence": [ { "database": "UniProtKB", "id": "Q3TQQ9", "url": "https://www.uniprot.org/uniprot/Q3TQQ9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": 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