{
    "uniprot_canonical_ac": "Q3TIV5-1",
    "uniprot_ac": "Q3TIV5",
    "uniprot_id": "ZC3HF_MOUSE",
    "mass": {
        "chemical_mass": 48327.0,
        "monoisotopic_mass": 48327.0
    },
    "refseq": {
        "ac": "NP_081210",
        "name": "zinc finger CCCH domain-containing protein 15",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081210"
    },
    "gene_names": [
        {
            "name": "Zc3h15",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q3TIV5",
            "id": "Q3TIV5"
        },
        {
            "name": "1700006A17Rik; 1810012H02Rik; 2610312B22Rik; FM22; Ierepo4",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081210",
            "id": "NP_081210"
        },
        {
            "name": "Dfrp1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q3TIV5",
            "id": "Q3TIV5"
        },
        {
            "name": "Zc3h15",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081210",
            "id": "NP_081210"
        }
    ],
    "protein_names": [
        {
            "name": "Zinc finger CCCH domain-containing protein 15",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q3TIV5"
        },
        {
            "name": "DRG family-regulatory protein 1; epo-immediate response gene protein FM22",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081210",
            "id": "NP_081210"
        },
        {
            "name": "DRG family-regulatory protein 1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q3TIV5"
        },
        {
            "name": "Epo-immediate response gene protein FM22",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q3TIV5"
        },
        {
            "name": "zinc finger CCCH domain-containing protein 15",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081210",
            "id": "NP_081210"
        }
    ],
    "function": [
        {
            "annotation": "Protects DRG1 from proteolytic degradation (PubMed:15676025). Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (By similarity).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q3TIV5",
                    "url": "https://www.uniprot.org/uniprot/Q3TIV5#function"
                },
                {
                    "database": "PubMed",
                    "id": "15676025",
                    "url": "https://glygen.org/publication/PubMed/15676025"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q8WU90",
                    "url": "https://www.uniprot.org/uniprot/Q8WU90#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q3TIV5",
                    "url": "https://www.uniprot.org/uniprot/Q3TIV5"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Zc3h15",
            "url": "https://www.uniprot.org/uniprot/Q3TIV5",
            "locus": {
                "chromosome": "2",
                "start_pos": 83494966,
                "end_pos": 83474779,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000027091",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000027091"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000027091",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000027091",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "69082",
            "url": "https://www.ncbi.nlm.nih.gov/gene/69082",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "Q3TIV5",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q3TIV5*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR000571",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000571",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR032378",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR032378",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036855",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036855",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:69082",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:69082",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1919747",
            "url": "http://www.informatics.jax.org/marker/MGI:1919747",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "KKDLYQD",
            "url": "https://omabrowser.org/oma/group/KKDLYQD/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5484722at2759",
            "url": "http://www.orthodb.org/?query=5484722at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12681",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12681",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12681:SF0",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12681:SF0",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00642",
            "url": "http://pfam.xfam.org/family/PF00642",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF14608",
            "url": "http://pfam.xfam.org/family/PF14608",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF16543",
            "url": "http://pfam.xfam.org/family/PF16543",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q3TIV5",
            "url": "http://purl.obolibrary.org/obo/PR_Q3TIV5",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-MMU-9629569",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9629569",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_081210",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081210",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q3TIV5",
            "url": "https://www.uniprot.org/uniprot/Q3TIV5",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q3TIV5-1",
            "url": "https://www.uniprot.org/uniprot/Q3TIV5-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q3TIV5-2",
            "url": "https://www.uniprot.org/uniprot/Q3TIV5-2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q3TIV5-3",
            "url": "https://www.uniprot.org/uniprot/Q3TIV5-3",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MPPKKQAQAGGSKKAEQKKKEKIIEDKTFGLKNKKGAKQQKFIKAVTHQVKFGQQNPRQVAQSEAEKKLKKDDKKKELQELNELFKPVVAAQKISKGADPKSVVCAFFKQGQCTKGDKCKFSHDLTLERKCEKRSVYIDARDEELEKDTMDNWDEKKLEEVVNKKHGEAEKKKPKTQIVCRHFLEAIENNKYGWFWVCPGGGDNCMYRHALPPGFVLKKDKKKEEKEDEISLEDLIERERSALGPNVTKITLESFLAWKKRKRQEKIDKLEQDMERRKADFKAGKALVISGREVFEFRPELVNDDDEEADDTRYIQGTGGDEVDDSMGVNDIDISLYVPRDVEETGITVASVERFSTYAPDKDENKLSEASGGLAENGERSDLDEDSGGGGQENGSIDAVPVDENLFTGEDLDELEEELNTLDLEE",
        "length": 426,
        "header": "sp|Q3TIV5-1|ZC3HF_MOUSE Isoform 1 of Zinc finger CCCH domain-containing protein 15  OS=Mus musculus OX=10090 GN=Zc3h15 PE=1 SV=2 CANONICAL=Q3TIV5-1"
    },
    "isoforms": [
        {
            "isoform_ac": "Q3TIV5-1",
            "url": "",
            "sequence": {
                "sequence": "MPPKKQAQAGGSKKAEQKKKEKIIEDKTFGLKNKKGAKQQKFIKAVTHQVKFGQQNPRQVAQSEAEKKLKKDDKKKELQELNELFKPVVAAQKISKGADPKSVVCAFFKQGQCTKGDKCKFSHDLTLERKCEKRSVYIDARDEELEKDTMDNWDEKKLEEVVNKKHGEAEKKKPKTQIVCRHFLEAIENNKYGWFWVCPGGGDNCMYRHALPPGFVLKKDKKKEEKEDEISLEDLIERERSALGPNVTKITLESFLAWKKRKRQEKIDKLEQDMERRKADFKAGKALVISGREVFEFRPELVNDDDEEADDTRYIQGTGGDEVDDSMGVNDIDISLYVPRDVEETGITVASVERFSTYAPDKDENKLSEASGGLAENGERSDLDEDSGGGGQENGSIDAVPVDENLFTGEDLDELEEELNTLDLEE",
                "length": 426,
                "header": "sp|Q3TIV5-1|ZC3HF_MOUSE Isoform 1 of Zinc finger CCCH domain-containing protein 15  OS=Mus musculus OX=10090 GN=Zc3h15 PE=1 SV=2 CANONICAL=Q3TIV5-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 83494351,
                "end_pos": 83474997,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000081591",
                        "url": "https://www.ensembl.org/id/ENSMUST00000081591"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000080301",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000080301"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q3TIV5-2",
            "url": "",
            "sequence": {
                "sequence": "MYRHALPPGFVLKKDKKKEEKEDEISLEDLIERERSALGPNVTKITLESFLAWKKRKRQEKIDKLEQDMERRKADFKAGKALVISGREVFEFRPELVNDDDEEADDTRYIQGTGGDEVDDSMGVNDIDISLYVPRDVEETGITVASVERFSTYAPDKDENKLSEASGGLAENGERSDLDEDSGGGGQENGSIDAVPVDENLFTGEDLDELEEELNTLDLEE",
                "length": 221,
                "header": "sp|Q3TIV5-2|ZC3HF_MOUSE Isoform 2 of Zinc finger CCCH domain-containing protein 15  OS=Mus musculus OX=10090 GN=Zc3h15 PE=1 SV=2 CANONICAL=Q3TIV5-1"
            },
            "locus": {}
        },
        {
            "isoform_ac": "Q3TIV5-3",
            "url": "",
            "sequence": {
                "sequence": "MPPKKQAQAGGSKKAEQKKKEKIIEDKTFGLKNKKGAKQQKFIKAVTHQVKFGQQNPRQVAQSEAEKKLKKDDKKKELQELNELFKPVVAAQKISKGADPKSVVCAFFKQGQCTKGDKCKFSHDLTLERKCEKRSVYIDARDEELEKGISS",
                "length": 151,
                "header": "sp|Q3TIV5-3|ZC3HF_MOUSE Isoform 3 of Zinc finger CCCH domain-containing protein 15  OS=Mus musculus OX=10090 GN=Zc3h15 PE=1 SV=2 CANONICAL=Q3TIV5-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 231,
            "end_pos": 231,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q3TIV5",
                    "url": "https://www.uniprot.org/uniprot/Q3TIV5"
                }
            ],
            "site_lbl": "Ser231"
        },
        {
            "start_pos": 351,
            "end_pos": 351,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q3TIV5",
                    "url": "https://www.uniprot.org/uniprot/Q3TIV5"
                }
            ],
            "site_lbl": "Ser351"
        },
        {
            "start_pos": 381,
            "end_pos": 381,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q3TIV5",
                    "url": "https://www.uniprot.org/uniprot/Q3TIV5"
                }
            ],
            "site_lbl": "Ser381"
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Subtraction cloning and initial characterization of novel EPO-immediate response genes.",
            "journal": "Cytokine",
            "date": "2000",
            "authors": "Lord K.A., Dillon S.B., Gaines P., Gregory R.C. Jr., Panek L.B., Wojchowski D.M.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q3TIV5",
                    "url": "https://www.uniprot.org/uniprot/Q3TIV5"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "10880228",
                    "url": "https://glygen.org/publication/PubMed/10880228"
                }
            ]
        },
        {
            "title": "Identification of DRG family regulatory proteins (DFRPs): specific regulation of DRG1 and DRG2.",
            "journal": "Genes Cells",
            "date": "2005",
            "authors": "Ishikawa K, Azuma S, Ikawa S, Semba K, Inoue J",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q3TIV5",
                    "url": "https://www.uniprot.org/uniprot/Q3TIV5"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15676025",
                    "url": "https://glygen.org/publication/PubMed/15676025"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:69082",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:69082",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-9629569",
            "name": "Protein hydroxylation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9629569",
            "resource": "Reactome",
            "description": "Protein hydroxylation"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q6U6G5-1",
            "protein_name": "Zinc finger CCCH domain-containing protein 15",
            "gene_name": "Zc3h15",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MPPKKQAQAGGSKKAEQKKKEKIIEDKTFGLKNKKGAKQQKFIKAVTHQVKFGQQNPRQVAQSEAEKKLKKDDKKKELQELNELFKPVVAAQKISKGADPKSVVCAFFKQGQCTKGDKCKFSHDLTLERKCEKRSVYIDARDEELEKDTMDNWDEKKLEEVVNKKHGEAEKKKPKTQIVCRHFLEAIENNKYGWFWVCPGGGDNCMYRHALPPGFVLKKDKKKEEKEDEISLEDLIERERSALGPNVTKITLESFLAWKKRKRQEKIDKLEQDMERRKADFKAGKALVISGREVFEFRPELVNDDDEEADDTRYIQGTGGDEVDDSVGVNDIDLSLYVPRDVEETGITVASLERFSTYASDKDENKLSEASGGLAENGERSDLDEDSGGGGQENGSIDAVPVDENLFTGEDLDELEEELNTLDLEE",
                "length": 426
            },
            "evidence": [
                {
                    "id": "45231642",
                    "url": "http://www.informatics.jax.org/homology/45231642",
                    "database": "MGI"
                },
                {
                    "id": "Q3TIV5",
                    "url": "https://omabrowser.org/oma/group/Q3TIV5/",
                    "database": "OMA"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q8WU90-1",
            "protein_name": "Zinc finger CCCH domain-containing protein 15",
            "gene_name": "ZC3H15",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MPPKKQAQAGGSKKAEQKKKEKIIEDKTFGLKNKKGAKQQKFIKAVTHQVKFGQQNPRQVAQSEAEKKLKKDDKKKELQELNELFKPVVAAQKISKGADPKSVVCAFFKQGQCTKGDKCKFSHDLTLERKCEKRSVYIDARDEELEKDTMDNWDEKKLEEVVNKKHGEAEKKKPKTQIVCKHFLEAIENNKYGWFWVCPGGGDICMYRHALPPGFVLKKDKKKEEKEDEISLEDLIERERSALGPNVTKITLESFLAWKKRKRQEKIDKLEQDMERRKADFKAGKALVISGREVFEFRPELVNDDDEEADDTRYTQGTGGDEVDDSVSVNDIDLSLYIPRDVDETGITVASLERFSTYTSDKDENKLSEASGGRAENGERSDLEEDNEREGTENGAIDAVPVDENLFTGEDLDELEEELNTLDLEE",
                "length": 426
            },
            "evidence": [
                {
                    "id": "45231642",
                    "url": "http://www.informatics.jax.org/homology/45231642",
                    "database": "MGI"
                },
                {
                    "id": "Q3TIV5",
                    "url": "https://omabrowser.org/oma/group/Q3TIV5/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q3TIV5",
                                "url": "https://www.uniprot.org/uniprot/Q3TIV5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q3TIV5",
                                "url": "https://www.uniprot.org/uniprot/Q3TIV5"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 3,
                "go_terms": [
                    {
                        "name": "positive regulation of GTPase activity",
                        "id": "GO:0043547",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043547",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q3TIV5",
                                "url": "https://www.uniprot.org/uniprot/Q3TIV5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytokine-mediated signaling pathway",
                        "id": "GO:0019221",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019221",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q3TIV5",
                                "url": "https://www.uniprot.org/uniprot/Q3TIV5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasmic translation",
                        "id": "GO:0002181",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002181",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q3TIV5",
                                "url": "https://www.uniprot.org/uniprot/Q3TIV5"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "metal ion binding",
                        "id": "GO:0046872",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q3TIV5",
                                "url": "https://www.uniprot.org/uniprot/Q3TIV5"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 246,
            "end_pos": 248,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 394,
            "end_pos": 396,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ],
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