{ "uniprot_canonical_ac": "Q3TBW2-1", "uniprot_ac": "Q3TBW2", "uniprot_id": "RM10_MOUSE", "mass": { "chemical_mass": 29396.0, "monoisotopic_mass": 29396.0 }, "refseq": { "ac": "NP_080430", "name": "large ribosomal subunit protein uL10m isoform 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080430" }, "gene_names": [ { "name": "Mrpl10", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q3TBW2", "id": "Q3TBW2" }, { "name": "0610040E02Rik; L10mt; MRP-L8; Rpml8", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080430", "id": "NP_080430" }, { "name": "Mrpl10", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080430", "id": "NP_080430" } ], "protein_names": [ { "name": "Large ribosomal subunit protein uL10m", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q3TBW2" }, { "name": "39S ribosomal protein L10, mitochondrial; large ribosomal subunit protein uL10m", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080430", "id": "NP_080430" }, { "name": "39S ribosomal protein L10, mitochondrial", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q3TBW2" }, { "name": "L10mt", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q3TBW2" }, { "name": "MRP-L10", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q3TBW2" }, { "name": "large ribosomal subunit protein uL10m isoform 1 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080430", "id": "NP_080430" } ], "function": [ { "annotation": "Data describe the regulation of mitochondrial protein synthesis by the reversible acetylation of the mitochondrial ribosome and characterize MRPL10 as a novel substrate of the NAD(+)-dependent deacetylase, SIRT3.", "evidence": [ { "database": "RefSeq", "id": "NP_080430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080430" }, { "database": "PubMed", "id": "20042612", "url": "https://glygen.org/publication/PubMed/20042612" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q3TBW2", "url": "https://www.uniprot.org/uniprot/Q3TBW2" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Mrpl10", "url": "https://www.uniprot.org/uniprot/Q3TBW2", "locus": { "chromosome": "11", "start_pos": 96940039, "end_pos": 96932386, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000001445", "url": "https://www.ensembl.org/id/ENSMUSG00000001445" } ] } } ], "crossref": [ { "id": "ENSMUSG00000001445", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000001445", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05797", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05797", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "107732", "url": "https://www.ncbi.nlm.nih.gov/gene/107732", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001790", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001790", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043141", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043141", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:107732", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:107732", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1333801", "url": "http://www.informatics.jax.org/marker/MGI:1333801", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "Q3TBW2", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q3TBW2", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "DSIYCNM", "url": "https://omabrowser.org/oma/group/DSIYCNM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4633216at2759", "url": "http://www.orthodb.org/?query=4633216at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11560", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11560", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11560:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11560:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PR_Q3TBW2", "url": "http://purl.obolibrary.org/obo/PR_Q3TBW2", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-5389840", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5389840", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5419276", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_080430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080430", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A2A715", "url": "https://www.uniprot.org/uniprot/A2A715", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2A715-1", "url": "https://www.uniprot.org/uniprot/A2A715-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3TBW2", "url": "https://www.uniprot.org/uniprot/Q3TBW2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3TBW2-1", "url": "https://www.uniprot.org/uniprot/Q3TBW2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAVAGILRGGLPPRAAWLPTLQTVRHGSKAVTRHWRVMHFQRQKLMAITEYIPPKPAINPRCLPPPPKPPKEESGLVRLLRQDIVAVFRDNRMIAVCQNVALSAEDKLLLRHQLRKHKIFIKVFPSQVLKPFLENSKYRNLLPLFVGHNLLLVSEEPKVKEMVRVLKSVPFLPLLGGCVDDTILSRQGLVDYAKLPSLDQLQGQLVGGLTHLMAQTRYLLQHQPVQLTSLLDQYVKEQNEGDCATSANEKLHPPDPAPDA", "length": 262, "header": "sp|Q3TBW2-1|RM10_MOUSE Isoform 1 of Large ribosomal subunit protein uL10m OS=Mus musculus OX=10090 GN=Mrpl10 PE=1 SV=2 CANONICAL=Q3TBW2-1" }, "isoforms": [ { "isoform_ac": "A2A715-1", "url": "", "sequence": { "sequence": "MAAAVAGILRGGLPPRAAWLPTLQTVRHGSKAVTRHWRVMHFQRQKLMAITEYIPPKPAINPRCLPPPPKPPKEESGLVRLLRQDIVAVFRDNRMIAVCQNVALSAEDKLLLRHQLRKHKIFIKVFPSQVLKPFLENSKYRNLLQHQPVQLTSLLDQYVKEQNEGDCATSANEKLHPPDPAPDA", "length": 184, "header": "tr|A2A715-1|RM10_MOUSE Computationally mapped isoform of Large ribosomal subunit protein uL10m OS=Mus musculus OX=10090 GN=Mrpl10 PE=1 SV=1 CANONICAL=Q3TBW2-1" }, "locus": { "chromosome": "11", "start_pos": 96939158, "end_pos": 96932427, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000054252.5", "url": "https://www.ensembl.org/id/ENSMUST00000054252.5" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000103244.2", "url": "https://www.ensembl.org/id/ENSMUSP00000103244.2" } ] } }, { "isoform_ac": "Q3TBW2-1", "url": "", "sequence": { "sequence": "MAAAVAGILRGGLPPRAAWLPTLQTVRHGSKAVTRHWRVMHFQRQKLMAITEYIPPKPAINPRCLPPPPKPPKEESGLVRLLRQDIVAVFRDNRMIAVCQNVALSAEDKLLLRHQLRKHKIFIKVFPSQVLKPFLENSKYRNLLPLFVGHNLLLVSEEPKVKEMVRVLKSVPFLPLLGGCVDDTILSRQGLVDYAKLPSLDQLQGQLVGGLTHLMAQTRYLLQHQPVQLTSLLDQYVKEQNEGDCATSANEKLHPPDPAPDA", "length": 262, "header": "sp|Q3TBW2-1|RM10_MOUSE Isoform 1 of Large ribosomal subunit protein uL10m OS=Mus musculus OX=10090 GN=Mrpl10 PE=1 SV=2 CANONICAL=Q3TBW2-1" }, "locus": { "chromosome": "11", "start_pos": 96939158, "end_pos": 96932427, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000001485", "url": "https://www.ensembl.org/id/ENSMUST00000001485" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000001485", "url": "https://www.ensembl.org/id/ENSMUSP00000001485" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "Q3TBW2", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q3TBW2" }, { "id": "28135057", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28135057" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "NAD+-dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10.", "journal": "The Journal of biological chemistry", "date": "2010", "authors": "Yang Y, Cimen H, Han MJ, Shi T, Deng JH, Koc H, Palacios OM, Montier L, Bai Y, Tong Q, Koc EC", "evidence": [ { "database": "RefSeq", "id": "NP_080430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080430" } ], "reference": [ { "type": "PubMed", "id": "20042612", "url": "https://glygen.org/publication/PubMed/20042612" } ] }, { "title": "The Small Molecule 2-Azido-2-deoxy-glucose Is a Metabolic Chemical Reporter of O-GlcNAc Modifications in Mammalian Cells, Revealing an Unexpected Promiscuity of O-GlcNAc Transferase.", "journal": "ACS chemical biology", "date": "2017", "authors": "Zaro BW, Batt AR, Chuh KN, Navarro MX, Pratt MR", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q3TBW2", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q3TBW2" } ], "reference": [ { "type": "PubMed", "id": "28135057", "url": "https://glygen.org/publication/PubMed/28135057" } ] } ], "pathway": [ { "id": "mmu:107732", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:107732", "resource": "KEGG Pathway" }, { "id": "R-MMU-5389840", "name": "Mitochondrial translation elongation", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5389840", "resource": "Reactome", "description": "Mitochondrial translation elongation" }, { "id": "R-MMU-5419276", "name": "Mitochondrial translation termination", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5419276", "resource": "Reactome", "description": "Mitochondrial translation termination" } ], "orthologs": [ { "uniprot_canonical_ac": "P0C2C4-1", "protein_name": "Large ribosomal subunit protein uL10m", "gene_name": "Mrpl10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPFSVEVEVFFLLVEDKLGWLPTLQPVRHGSKAVTRHRRVMHFQRQKLMAITEYIPPRPAVSPRCLPPPPKPPKEESGLIRLLRRDIAAVFRDNRMIAVCQNVALSAEDKLLLRHQLRKHKIFIKVFPSQVLKPFLEDSKYQNLLPLFVGHNLLLVSEEPKVKEMVRILKSVPFLPLLGGCIDDTILSRQGFVEYAKLPSLDRLQGELVGGLTHLTAQTRYLLQHQPVQLTSLLDQYVRQQHEGDCATSTEGKPHPPDPAPDS", "length": 263 }, "evidence": [ { "id": "45237958", "url": "http://www.informatics.jax.org/homology/45237958", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7Z7H8-1", "protein_name": "Large ribosomal subunit protein uL10m", "gene_name": "MRPL10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAVAGMLRGGLLPQAGRLPTLQTVRYGSKAVTRHRRVMHFQRQKLMAVTEYIPPKPAIHPSCLPSPPSPPQEEIGLIRLLRREIAAVFQDNRMIAVCQNVALSAEDKLLMRHQLRKHKILMKVFPNQVLKPFLEDSKYQNLLPLFVGHNMLLVSEEPKVKEMVRILRTVPFLPLLGGCIDDTILSRQGFINYSKLPSLPLVQGELVGGLTCLTAQTHSLLQHQPLQLTTLLDQYIREQREKDSVMSANGKPDPDTVPDS", "length": 261 }, "evidence": [ { "id": "45237958", "url": "http://www.informatics.jax.org/homology/45237958", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "mitochondrial large ribosomal subunit", "id": "GO:0005762", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005762", "evidence": [ { "database": "UniProtKB", "id": "Q3TBW2", "url": "https://www.uniprot.org/uniprot/Q3TBW2" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q3TBW2", "url": "https://www.uniprot.org/uniprot/Q3TBW2" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3TBW2", "url": "https://www.uniprot.org/uniprot/Q3TBW2" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q3TBW2", "url": "https://www.uniprot.org/uniprot/Q3TBW2" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "Q3TBW2", "url": "https://www.uniprot.org/uniprot/Q3TBW2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "Q3TBW2", "url": "https://www.uniprot.org/uniprot/Q3TBW2" } ], "pmid": "" }, { "name": "mitochondrial translation", "id": "GO:0032543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032543", "evidence": [ { "database": "UniProtKB", "id": "Q3TBW2", "url": "https://www.uniprot.org/uniprot/Q3TBW2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q3TBW2", "url": "https://www.uniprot.org/uniprot/Q3TBW2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }