{
    "uniprot_canonical_ac": "Q3T1J8-1",
    "uniprot_ac": "Q3T1J8",
    "uniprot_id": "RTF2_RAT",
    "mass": {
        "chemical_mass": 33812.0,
        "monoisotopic_mass": 33812.0
    },
    "refseq": {
        "ac": "NP_001029062",
        "name": "replication termination factor 2",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029062"
    },
    "gene_names": [
        {
            "name": "Rtf2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q3T1J8",
            "id": "Q3T1J8"
        },
        {
            "name": "Rtfdc1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q3T1J8",
            "id": "Q3T1J8"
        },
        {
            "name": "RGD1311072; RTF2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029062",
            "id": "NP_001029062"
        },
        {
            "name": "Rtfdc1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029062",
            "id": "NP_001029062"
        },
        {
            "name": "Rtfdc1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q3T1J8",
            "id": "Q3T1J8"
        }
    ],
    "protein_names": [
        {
            "name": "Replication termination factor 2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q3T1J8"
        },
        {
            "name": "RTF2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q3T1J8"
        },
        {
            "name": "Replication termination factor 2 domain-containing protein 1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q3T1J8"
        },
        {
            "name": "UPF0549 protein C20orf43 homolog; replication termination factor 2 domain-containing protein 1; protein RTF2 homolog",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029062",
            "id": "NP_001029062"
        },
        {
            "name": "replication termination factor 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029062",
            "id": "NP_001029062"
        }
    ],
    "function": [
        {
            "annotation": "Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q3T1J8",
                    "url": "https://www.uniprot.org/uniprot/Q3T1J8#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q9BY42",
                    "url": "https://www.uniprot.org/uniprot/Q9BY42#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q3T1J8",
                    "url": "https://www.uniprot.org/uniprot/Q3T1J8"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Rtf2",
            "url": "https://www.uniprot.org/uniprot/Q3T1J8",
            "locus": {}
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000005083",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000005083",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd16653",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16653",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "296410",
            "url": "https://www.ncbi.nlm.nih.gov/gene/296410",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR006735",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR006735",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR027799",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR027799",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:296410",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:296410",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "HKCGVPF",
            "url": "https://omabrowser.org/oma/group/HKCGVPF/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "463795at2759",
            "url": "http://www.orthodb.org/?query=463795at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12775",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12775",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12775:SF0",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12775:SF0",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF04641",
            "url": "http://pfam.xfam.org/family/PF04641",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q3T1J8",
            "url": "http://purl.obolibrary.org/obo/PR_Q3T1J8",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_001029062",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029062",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1311072",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311072",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A8L2Q2N4",
            "url": "https://www.uniprot.org/uniprot/A0A8L2Q2N4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8L2Q2N4-1",
            "url": "https://www.uniprot.org/uniprot/A0A8L2Q2N4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q3T1J8",
            "url": "https://www.uniprot.org/uniprot/Q3T1J8",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q3T1J8-1",
            "url": "https://www.uniprot.org/uniprot/Q3T1J8-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MGCDGGTIPKRHELVKGPKKVEKVDKDAELVAQWNYCTLSQEVLRRPIVACELGRLYNKDAVIEFLLDKSAEKALGKATSHIRSIKNVTELKLSDNPAWEGDKGNTKGDKHDDLQRARFICPVVGLEMNGRHRFCFLRCCGCVFSERALKEIKAEVCHTCGAAFQEEDIIVLNGTKEDVEMLKRRMEERRLRAKLEKKTKKPKTAESASKLGISQDSAGPSKAKAGKSEEADPDPREKKSSLAPRGTASNGSASGKVGKPPCGALKRSIADSEESETYKSIFTSHSSAKRSKEESAHWVTHTSYCF",
        "length": 306,
        "header": "sp|Q3T1J8-1|RTF2_RAT Isoform 1 of Replication termination factor 2  OS=Rattus norvegicus OX=10116 GN=Rtf2 PE=2 SV=1 CANONICAL=Q3T1J8-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A8L2Q2N4-1",
            "url": "",
            "sequence": {
                "sequence": "MGCDGGTIPKRHELVKGPKKVEKVDKDAELVAQWNYCTLSQEVLRRPIVACELGRLYNKDAVIEFLLDKSAEKALGKATSHIRSIKNVTELKLSDNPAWEGDKGNTKGDKHDDLQRARFICPVVGLEMNGRHRFCFLRCCGCVFSERALKEIKAEVCHTCGAAFQEEDIIVLNGTKEDVEMLKRRMEERRLRAKLEKAEGLFLLILSCTDSAGPSKAKAGKSEEADPDPREKKSSLAPRGTASNGSASGKVGKPPCGALKRSIADSEESETYKSIFTSHSSAKRSKEESAHWVTHTSYCF",
                "length": 300,
                "header": "tr|A0A8L2Q2N4-1|RTF2_RAT Computationally mapped isoform of Replication termination factor 2  OS=Rattus norvegicus OX=10116 GN=Rtf2 PE=2 SV=1 CANONICAL=Q3T1J8-1"
            },
            "locus": {
                "chromosome": "3",
                "start_pos": 161236552,
                "end_pos": 161208101,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000006884.6",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000006884.6"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000006884.4",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000006884.4"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q3T1J8-1",
            "url": "",
            "sequence": {
                "sequence": "MGCDGGTIPKRHELVKGPKKVEKVDKDAELVAQWNYCTLSQEVLRRPIVACELGRLYNKDAVIEFLLDKSAEKALGKATSHIRSIKNVTELKLSDNPAWEGDKGNTKGDKHDDLQRARFICPVVGLEMNGRHRFCFLRCCGCVFSERALKEIKAEVCHTCGAAFQEEDIIVLNGTKEDVEMLKRRMEERRLRAKLEKKTKKPKTAESASKLGISQDSAGPSKAKAGKSEEADPDPREKKSSLAPRGTASNGSASGKVGKPPCGALKRSIADSEESETYKSIFTSHSSAKRSKEESAHWVTHTSYCF",
                "length": 306,
                "header": "sp|Q3T1J8-1|RTF2_RAT Isoform 1 of Replication termination factor 2  OS=Rattus norvegicus OX=10116 GN=Rtf2 PE=2 SV=1 CANONICAL=Q3T1J8-1"
            },
            "locus": {
                "chromosome": "3",
                "start_pos": 161236552,
                "end_pos": 161208101,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000117578",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000117578"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000092936",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000092936"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 287,
            "end_pos": 287,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q3T1J8",
                    "url": "https://www.uniprot.org/uniprot/Q3T1J8"
                }
            ],
            "site_lbl": "Ser287"
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "rno:296410",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:296410",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q99K95-1",
            "protein_name": "Replication termination factor 2",
            "gene_name": "Rtf2",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MGCDGGTIPKRHELVKGPKKVEKVDKDAELVAQWNYCTLSQEILRRPIVACELGRLYNKDAVIEFLLDKSAEKALGKAASHIRSIKNVTELRLSDNPAWEGDKGNTKGDKHDDLQRARFICPVVGLEMNGRHRFCFLRCCGCVFSERALKEIKAEVCHTCGAAFQEEDIIVLNGTKEDVEMLKKRMEERRLRAKLEKKTKKPKTATECASKPGTTQDSAGPSKVKSGKPEEADPDPREKKSTPAPRGAATNGSASGKVGKPPCGALKRSIADSEESETYKSIFTSHSSAKRSKEESAHWVTHTSYCF",
                "length": 307
            },
            "evidence": [
                {
                    "id": "45238122",
                    "url": "http://www.informatics.jax.org/homology/45238122",
                    "database": "MGI"
                },
                {
                    "id": "Q3T1J8",
                    "url": "https://omabrowser.org/oma/group/Q3T1J8/",
                    "database": "OMA"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q9BY42-1",
            "protein_name": "Replication termination factor 2",
            "gene_name": "RTF2",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MGCDGGTIPKRHELVKGPKKVEKVDKDAELVAQWNYCTLSQEILRRPIVACELGRLYNKDAVIEFLLDKSAEKALGKAASHIKSIKNVTELKLSDNPAWEGDKGNTKGDKHDDLQRARFICPVVGLEMNGRHRFCFLRCCGCVFSERALKEIKAEVCHTCGAAFQEDDVIMLNGTKEDVDVLKTRMEERRLRAKLEKKTKKPKAAESVSKPDVSEEAPGPSKVKTGKPEEASLDSREKKTNLAPKSTAMNESSSGKAGKPPCGATKRSIADSEESEAYKSLFTTHSSAKRSKEESAHWVTHTSYCF",
                "length": 306
            },
            "evidence": [
                {
                    "id": "45238122",
                    "url": "http://www.informatics.jax.org/homology/45238122",
                    "database": "MGI"
                },
                {
                    "id": "Q3T1J8",
                    "url": "https://omabrowser.org/oma/group/Q3T1J8/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q3T1J8",
                                "url": "https://www.uniprot.org/uniprot/Q3T1J8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "replication fork",
                        "id": "GO:0005657",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005657",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q3T1J8",
                                "url": "https://www.uniprot.org/uniprot/Q3T1J8"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 3,
                "go_terms": [
                    {
                        "name": "mitotic DNA replication termination",
                        "id": "GO:1902979",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902979",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q3T1J8",
                                "url": "https://www.uniprot.org/uniprot/Q3T1J8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of DNA stability",
                        "id": "GO:0097752",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097752",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q3T1J8",
                                "url": "https://www.uniprot.org/uniprot/Q3T1J8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cellular response to hydroxyurea",
                        "id": "GO:0072711",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072711",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q3T1J8",
                                "url": "https://www.uniprot.org/uniprot/Q3T1J8"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "DNA binding",
                        "id": "GO:0003677",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q3T1J8",
                                "url": "https://www.uniprot.org/uniprot/Q3T1J8"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 173,
            "end_pos": 175,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 250,
            "end_pos": 252,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 87,
            "end_pos": 89,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [
        {
            "annotation": "Undergoes proteasomal degradation, via DDI1 and DDI2. Removal from stalled replisomes and degradation are required for genome stability.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q3T1J8",
                    "url": "https://www.uniprot.org/uniprot/Q3T1J8"
                },
                {
                    "database": "PubMed",
                    "id": "Q9BY42",
                    "url": "https://glygen.org/publication/PubMed/Q9BY42"
                }
            ]
        }
    ],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
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                    "field": "total",
                    "count": 0
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                {
                    "field": "total_sites",
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                {
                    "field": "n_linked_glycans",
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                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
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                {
                    "field": "n_linked_glycans",
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                {
                    "field": "n_linked_glycan_sites",
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                {
                    "field": "o_linked_glycans",
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                {
                    "field": "o_linked_glycan_sites",
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            ],
            "sort_fields": []
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        {
            "table_id": "glycosylation_predicted",
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                    "field": "total",
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                {
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                {
                    "field": "n_linked_glycan_sites",
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                {
                    "field": "o_linked_glycans",
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                {
                    "field": "o_linked_glycan_sites",
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            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
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                    "field": "total",
                    "count": 0
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                {
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                {
                    "field": "n_linked_glycan_sites",
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                {
                    "field": "o_linked_glycans",
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                {
                    "field": "o_linked_glycan_sites",
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                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                },
                {
                    "field": "total_sites",
                    "count": 1
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            ],
            "sort_fields": [
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                "kinase_uniprot_canonical_ac",
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        },
        {
            "table_id": "snv",
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