{ "uniprot_canonical_ac": "Q3MIB4-1", "uniprot_ac": "Q3MIB4", "uniprot_id": "LONP2_RAT", "mass": { "chemical_mass": 94393.0, "monoisotopic_mass": 94393.0 }, "refseq": {}, "gene_names": [ { "name": "Lonp2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q3MIB4", "id": "Q3MIB4" }, { "name": "LONP2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q3MIB4", "id": "Q3MIB4" } ], "protein_names": [ { "name": "Lon protease homolog 2, peroxisomal", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q3MIB4" }, { "name": "3.4.21.53", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q3MIB4" }, { "name": "Lon protease 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q3MIB4" }, { "name": "Lon protease-like protein 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q3MIB4" }, { "name": "Peroxisomal Lon protease", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q3MIB4" } ], "function": [ { "annotation": "ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.", "evidence": [ { "database": "UniProtKB", "id": "Q3MIB4", "url": "https://www.uniprot.org/uniprot/Q3MIB4#function" }, { "database": "UniProtKB", "id": "MF_03121", "url": "https://www.uniprot.org/uniprot/MF_03121#function" }, { "database": "UniProtKB", "id": "A0A8L2R0Z6", "url": "https://www.uniprot.org/uniprot/A0A8L2R0Z6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "Q3MIB4", "url": "https://www.uniprot.org/uniprot/Q3MIB4" } ], "common_name": "Rat" } ], "gene": [ { "name": "Lonp2", "url": "https://www.uniprot.org/uniprot/Q3MIB4", "locus": { "chromosome": "19", "start_pos": 20407477, "end_pos": 20499014, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000015162", "url": "https://www.ensembl.org/id/ENSRNOG00000015162" } ] } } ], "crossref": [ { "id": "ENSRNOG00000015162", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000015162", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "3.6.4.7", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.4.7&UniProtAcc=Q3MIB4", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd19500", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19500", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "291922", "url": "https://www.ncbi.nlm.nih.gov/gene/291922", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003111", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003111", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003959", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003959", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004815", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004815", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008268", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008268", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008269", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008269", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014721", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014721", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015947", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015947", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020568", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020568", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027065", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027065", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027501", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027501", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046336", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046336", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:291922", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:291922", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GAWQVVD", "url": "https://omabrowser.org/oma/group/GAWQVVD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "1103874at2759", "url": "http://www.orthodb.org/?query=1103874at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10046", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10046", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10046:SF24", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10046:SF24", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00004", "url": "http://pfam.xfam.org/family/PF00004", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02190", "url": "http://pfam.xfam.org/family/PF02190", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF05362", "url": "http://pfam.xfam.org/family/PF05362", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q3MIB4", "url": "http://purl.obolibrary.org/obo/PR_Q3MIB4", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-9033241", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9033241", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_006255300", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006255300", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1305466", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1305466", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A8I5ZUM4", "url": "https://www.uniprot.org/uniprot/A0A8I5ZUM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZUM4-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZUM4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8L2R0Z6", "url": "https://www.uniprot.org/uniprot/A0A8L2R0Z6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8L2R0Z6-1", "url": "https://www.uniprot.org/uniprot/A0A8L2R0Z6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MIB4", "url": "https://www.uniprot.org/uniprot/Q3MIB4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MIB4-1", "url": "https://www.uniprot.org/uniprot/Q3MIB4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6TXI3", "url": "https://www.uniprot.org/uniprot/Q6TXI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6TXI3-1", "url": "https://www.uniprot.org/uniprot/Q6TXI3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSVNPIQIPSRLPLLLTHESVLLPGSTMRTSVDTARNLQLVRSRLLKGTSLQSTILGVIPNTPDPASDSQDLPPLHRIGTAALAVQVVGSNWPKPHYTLLITGLCRFQIVQVLKEKPYPVAEVEQLDRLEEFPNTCKTREELGELSEQFYRYSVQLVEMLDMSVPAVAKLRRLLDSLPREALPDILTSIIRTSNKEKLQILDAVSLEDRFKMTIPLLVRQIEGLKLLQKTRKPKQDDDKRVIAIRPIRRITHIPGALEDEEEEEDNDDIVMLEKKIRTSSMPEQAHKVCVKEIKRLKKMPQSMPEYALTRNYLELMVELPWNKSTTDRLDIRAARILLDNDHYAMEKLKRRVLEYLAVRQLKNNLKGPILCFVGPPGVGKTSVGRSVAKTLGREFHRIALGGVCDQSDIRGHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKSLQGDPAAALLEVLDPEQNHNFTDHYLNVAFDLSQVLFIATANTTATIPPALLDRMEIIQVPGYTQEEKIEIAHRHLIPKQLEQHGLTPQQIQIPQLTTLAIITRYTREAGVRSLDRKFGAICRAVAVKVAEGQHKEAKLDRSDVADGEGCKEHVLEDAKPESIGDAADLALPPEMPILIDSHALKDILGPPLYELEVSERLSQPGVAIGLAWTPLGGKIMFVEASRMDGEGQLTLTGQLGDVMKESAHLAISWLRSNAKKYHLTNAFGSFDLLDNTDIHLHFPAGAVTKDGPSAGVTIVTCLASLFSGRLVRSDVAMTGEITLRGLVLPVGGIKDKVLAAHRAGLKHIIIPQRNEKDLEEIPSNVKQDLSFVTASCLDEVLNAAFDGGFTVKTRPGLTDSKL", "length": 852, "header": "sp|Q3MIB4-1|LONP2_RAT Isoform 1 of Lon protease homolog 2, peroxisomal OS=Rattus norvegicus OX=10116 GN=Lonp2 PE=1 SV=2 CANONICAL=Q3MIB4-1" }, "isoforms": [ { "isoform_ac": "A0A8I5ZUM4-1", "url": "", "sequence": { "sequence": "MSSVNPIQIPSRLPLLLTHESVLLPGSTMRTSVDTARNLQLVRSRLLKGTSLQSTILGVIPNTPDPASDSQDLPPLHRPICVDCFAPCSLGSRASLDCTVTVDIEHLKCVCSNTSFNTGMHVLLRAVQMMEAWLMEIQRRAKTQLGLLRVESGIWSAGNEELAATNKRTEPLRLKPLLCWDNGSGERAGESAVIKNKPASLRIGTAALAVQVVGSNWPKPHYTLLITGLCRFQIVQVLKEKPYPVAEVEQLDRLEEFPNTCKTREELGELSEQFYRYSVQLVEMLDMSVPAVAKLRRLLDSLPREALPDILTSIIRTSNKEKLQILDAVSLEDRFKMTIPLLVRQIEGLKLLQKTRKPKQDDDKRVIAIRPIRRITHIPGALEDEEEEEDNDDIVMLEKKIRTSSMPEQAHKVCVKEIKRLKKMPQSMPEYALTRNYLELMVELPWNKSTTDRLDIRAARILLDNDHYAMEKLKRRVLEYLAVRQLKNNLKGPILCFVGPPGVGKTSVGRSVAKTLGREFHRIALGGVCDQSDIRGHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKSLQGDPAAALLEVLDPEQNHNFTDHYLNVAFDLSQVLFIATANTTATIPPALLDRMEIIQVPGYTQEEKIEIAHRHLIPKQLEQHGLTPQQIQIPQLTTLAIITRYTREAGVRSLDRKFGAICRAVAVKVAEGQHKEAKLDRSDVADGEGLWFRSGMLSVAGKTSLFFTNSKELTLPQYSSVLLLQ", "length": 759, "header": "tr|A0A8I5ZUM4-1|LONP2_RAT Computationally mapped isoform of Lon protease homolog 2, peroxisomal OS=Rattus norvegicus OX=10116 GN=Lonp2 PE=1 SV=1 CANONICAL=Q3MIB4-1" }, "locus": { "chromosome": "19", "start_pos": 20498864, "end_pos": 20454539, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000103401.1", "url": "https://www.ensembl.org/id/ENSRNOT00000103401.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000082716.1", "url": "https://www.ensembl.org/id/ENSRNOP00000082716.1" } ] } }, { "isoform_ac": "A0A8L2R0Z6-1", "url": "", "sequence": { "sequence": "MSSVNPIQIPSRLPLLLTHESVLLPGSTMRTSVDTARNLQLVRSRLLKGTSLQSTILGVIPNTPDPASDSQDLPPLHRIGTAALAVQVVGSNWPKPHYTLLITGLCRFQIVQVLKEKPYPVAEVEQLDRLEEFPNTCKTREELGELSEQFYRYSVQLVEMLDMSVPAVAKLRRLLDSLPREALPDILTSIIRTSNKEKLQILDAVSLEDRFKMTIPLLVRQIEGLKLLQKTRKPKQDDDKRVIAIRPIRRITHIPGALEDEEEEEDNDDIVMLEKKIRTSSMPEQAHKVCVKEIKRLKKMPQSMPEYALTRNYLELMVELPWNKSTTDRLDIRAARILLDNDHYAMEKLKRRVLEYLAVRQLKNNLKGPILCFVGPPGVGKTSVGRSVAKTLGREFHRIALGGVCDQSDIRGHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKSLQGDPAAALLEVLDPEQNHNFTDHYLNVAFDLSQVLFIATANTTATIPPALLDRMEIIQVPGYTQEEKIEIAHRHLIPKQLEQHGLTPQQIQIPQLTTLAIITRYTREAGVRSLDRKFGAICRAVAVKVAEGQHKEAKLDRSDVADGEGCKEHVLEDAKPESIGDAADLALPPEMPILIDSHALKDILGPPLYELEVSERLSQPGVAIGLAWTPLGGKIMFVEASRMDGEGQLTLTGQLGDVMKESAHLAISWLRSNAKKYHLTNGTWPNCMGTQLGRRALDHDPGRISHGDKDITIQESRGLGLGSPAETLDIVRSAGWVPELDTKAKL", "length": 780, "header": "tr|A0A8L2R0Z6-1|LONP2_RAT Computationally mapped isoform of Lon protease homolog 2, peroxisomal OS=Rattus norvegicus OX=10116 GN=Lonp2 PE=1 SV=1 CANONICAL=Q3MIB4-1" }, "locus": { "chromosome": "19", "start_pos": 20498864, "end_pos": 20410733, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000087660.2", "url": "https://www.ensembl.org/id/ENSRNOT00000087660.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000069360.2", "url": "https://www.ensembl.org/id/ENSRNOP00000069360.2" } ] } }, { "isoform_ac": "Q3MIB4-1", "url": "", "sequence": { "sequence": "MSSVNPIQIPSRLPLLLTHESVLLPGSTMRTSVDTARNLQLVRSRLLKGTSLQSTILGVIPNTPDPASDSQDLPPLHRIGTAALAVQVVGSNWPKPHYTLLITGLCRFQIVQVLKEKPYPVAEVEQLDRLEEFPNTCKTREELGELSEQFYRYSVQLVEMLDMSVPAVAKLRRLLDSLPREALPDILTSIIRTSNKEKLQILDAVSLEDRFKMTIPLLVRQIEGLKLLQKTRKPKQDDDKRVIAIRPIRRITHIPGALEDEEEEEDNDDIVMLEKKIRTSSMPEQAHKVCVKEIKRLKKMPQSMPEYALTRNYLELMVELPWNKSTTDRLDIRAARILLDNDHYAMEKLKRRVLEYLAVRQLKNNLKGPILCFVGPPGVGKTSVGRSVAKTLGREFHRIALGGVCDQSDIRGHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKSLQGDPAAALLEVLDPEQNHNFTDHYLNVAFDLSQVLFIATANTTATIPPALLDRMEIIQVPGYTQEEKIEIAHRHLIPKQLEQHGLTPQQIQIPQLTTLAIITRYTREAGVRSLDRKFGAICRAVAVKVAEGQHKEAKLDRSDVADGEGCKEHVLEDAKPESIGDAADLALPPEMPILIDSHALKDILGPPLYELEVSERLSQPGVAIGLAWTPLGGKIMFVEASRMDGEGQLTLTGQLGDVMKESAHLAISWLRSNAKKYHLTNAFGSFDLLDNTDIHLHFPAGAVTKDGPSAGVTIVTCLASLFSGRLVRSDVAMTGEITLRGLVLPVGGIKDKVLAAHRAGLKHIIIPQRNEKDLEEIPSNVKQDLSFVTASCLDEVLNAAFDGGFTVKTRPGLTDSKL", "length": 852, "header": "sp|Q3MIB4-1|LONP2_RAT Isoform 1 of Lon protease homolog 2, peroxisomal OS=Rattus norvegicus OX=10116 GN=Lonp2 PE=1 SV=2 CANONICAL=Q3MIB4-1" }, "locus": { "chromosome": "19", "start_pos": 20498864, "end_pos": 20407629, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000020770", "url": "https://www.ensembl.org/id/ENSRNOT00000020770" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000020770", "url": "https://www.ensembl.org/id/ENSRNOP00000020770" } ] } }, { "isoform_ac": "Q6TXI3-1", "url": "", "sequence": { "sequence": "MSSVNPIQIPSRLPLLLTHESVLLPGSTMRTSVDTARNLQLVRSRLLKGTSLQSTILGVIPNTPDPASDSQDLPPLHRPICVDCFAPCSLGSRASLDCTVTVDIEHLKCVCSNTSFNTGMHVLLRAVQMMEAWLMEIQRRAKTQLGLLRVESGIWSAGNEELAATNKRTEPLRLKPLLCWDNGSGERAGESAVIKNKPASLRIGTAALAVQVVGSNWPKPHYTLLITGLCRFQIVQVLKEKPYPVAEVEQLDRLEEFPNTCKTREELGELSEQFYRYSVQLVEMLDMSVPAVAKLRRLLDSLPREALPDILTSIIRTSNKEKLQILDAVSLEDRFKMTIPLLVRQIEGLKLLQKTRKPKQDDDKRVIAIRPIRRITHIPGALEDEEEEEDNDDIVMLEKKIRTSSMPEQAHKVCVKEIKRLKKMPQSMPEYALTRNYLELMVELPWNKSTTDRLDIRAARILLDNDHYAMEKLKRRVLEYLAVRQLKNNLKGPILCFVGPPGVGKTSVGRSVAKTLGREFHRIALGGVCDQSDIRGHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKSLQGDPAAALLEVLDPEQNHNFTDHYLNVAFDLSQVLFIATANTTATIPPALLDRMEIIQVPGYTQEEKIEIAHRHLIPKQLEQHGLTPQQIQIPQLTTLAIITRYTREAGVRSLDRKFGAICRAVAVKVAEGQHKEAKLDRSDVADGEEPAASILGLRAALESRQTTLIPVHEEASDSRGSGCAPLVNLTTNGSVLAVPEMTIMSLFQKVLRTNLLCSAPLTLPIFPDKSPI", "length": 806, "header": "tr|Q6TXI3-1|LONP2_RAT Computationally mapped isoform of Lon protease homolog 2, peroxisomal OS=Rattus norvegicus OX=10116 GN=Lonp2 PE=1 SV=1 CANONICAL=Q3MIB4-1" }, "locus": { "chromosome": "19", "start_pos": 20498864, "end_pos": 20446769, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000048345.5", "url": "https://www.ensembl.org/id/ENSRNOT00000048345.5" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000040168.5", "url": "https://www.ensembl.org/id/ENSRNOP00000040168.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease.", "journal": "J. Biol. Chem.", "date": "2004", "authors": "Kikuchi M, Hatano N, Yokota S, Shimozawa N, Imanaka T, Taniguchi H", "evidence": [ { "database": "UniProtKB", "id": "Q3MIB4", "url": "https://www.uniprot.org/uniprot/Q3MIB4" } ], "reference": [ { "type": "PubMed", "id": "14561759", "url": "https://glygen.org/publication/PubMed/14561759" } ] } ], "pathway": [ { "id": "rno:291922", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:291922", "resource": "KEGG Pathway" }, { "id": "R-RNO-9033241", "name": "Peroxisomal protein import", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9033241", "resource": "Reactome", "description": "Peroxisomal protein import" } ], "orthologs": [ { "uniprot_canonical_ac": "Q86WA8-1", "protein_name": "Lon protease homolog 2, peroxisomal", "gene_name": "LONP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSVSPIQIPSRLPLLLTHEGVLLPGSTMRTSVDSARNLQLVRSRLLKGTSLQSTILGVIPNTPDPASDAQDLPPLHRIGTAALAVQVVGSNWPKPHYTLLITGLCRFQIVQVLKEKPYPIAEVEQLDRLEEFPNTCKMREELGELSEQFYKYAVQLVEMLDMSVPAVAKLRRLLDSLPREALPDILTSIIRTSNKEKLQILDAVSLEERFKMTIPLLVRQIEGLKLLQKTRKPKQDDDKRVIAIRPIRRITHISGTLEDEDEDEDNDDIVMLEKKIRTSSMPEQAHKVCVKEIKRLKKMPQSMPEYALTRNYLELMVELPWNKSTTDRLDIRAARILLDNDHYAMEKLKKRVLEYLAVRQLKNNLKGPILCFVGPPGVGKTSVGRSVAKTLGREFHRIALGGVCDQSDIRGHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKSLQGDPAAALLEVLDPEQNHNFTDHYLNVAFDLSQVLFIATANTTATIPAALLDRMEIIQVPGYTQEEKIEIAHRHLIPKQLEQHGLTPQQIQIPQVTTLDIITRYTREAGVRSLDRKLGAICRAVAVKVAEGQHKEAKLDRSDVTEREGCREHILEDEKPESISDTTDLALPPEMPILIDFHALKDILGPPMYEMEVSQRLSQPGVAIGLAWTPLGGEIMFVEASRMDGEGQLTLTGQLGDVMKESAHLAISWLRSNAKKYQLTNAFGSFDLLDNTDIHLHFPAGAVTKDGPSAGVTIVTCLASLFSGRLVRSDVAMTGEITLRGLVLPVGGIKDKVLAAHRAGLKQVIIPRRNEKDLEGIPGNVRQDLSFVTASCLDEVLNAAFDGGFTVKTRPGLLNSKL", "length": 852 }, "evidence": [ { "id": "45228819", "url": "http://www.informatics.jax.org/homology/45228819", "database": "MGI" }, { "id": "Q3MIB4", "url": "https://omabrowser.org/oma/group/Q3MIB4/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DBN5-1", "protein_name": "Lon protease homolog 2, peroxisomal", "gene_name": "Lonp2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSVSPIQIPSRLPLLLTHESVLLPGSTMRTSVDTARNLQLVRSRLLKGTSLQSTILGVIPNTPDPASDTQDLPPLHRIGTAALAVQVVGSNWPKPHYTLLITGLCRFQIVQVLKEKPYPVAEVEQLDRLEEFPNICKSREELGELSEQFYRYAVQLVEMLDMSVPAVAKLRRLLDNLPREALPDILTSIIRTSNKEKLQILDAVSLEDRFKMTIPLLVRQIEGLKLLQKTRKPKQDDDKRVIAIRPIRRIPHIPGTLEDEEEEEDNDDIVMLEKKIRTSSMPEQAHKVCVKEIKRLKKMPQSMPEYALTRNYLELMVELPWNKSTTDRLDIRAARILLDNDHYAMEKLKRRVLEYLAVRQLKNNLKGPILCFVGPPGVGKTSVGRSVAKTLGREFHRIALGGVCDQSDIRGHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKSLQGDPAAALLEVLDPEQNHNFTDHYLNVAFDLSQVLFIATANTTATIPPALLDRMEIIQVPGYTQEEKIEIAHRHLIPKQLEQHGLTPQQIQIPQHTTLAIITRYTREAGVRSLDRKFGAICRAVAVKVAEGQHKEAKLDRSDVADGEGCKEHVLEDAKPESISDTADLALPPEMPILIDSHALKDILGPPLYELEVSERLSQPGVAIGLAWTPLGGKIMFVEASRMDGEGQLTLTGQLGDVMKESAHLAISWLRSNAKKYHLTNAFGSFDLLDNTDIHLHFPAGAVTKDGPSAGVTIVTCLASLFSGRLVRSDVAMTGEITLRGLVLPVGGIKDKVLAAHRAGLKQIIIPQRNEKDLEEIPSNVRQDLSFVTASCLDEVLNAAFDGGFPVKTRPGLIDSKL", "length": 852 }, "evidence": [ { "id": "45228819", "url": "http://www.informatics.jax.org/homology/45228819", "database": "MGI" }, { "id": "Q3MIB4", "url": "https://omabrowser.org/oma/group/Q3MIB4/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "Q3MIB4", "url": "https://www.uniprot.org/uniprot/Q3MIB4" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q3MIB4", "url": "https://www.uniprot.org/uniprot/Q3MIB4" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "Q3MIB4", "url": "https://www.uniprot.org/uniprot/Q3MIB4" } ], "pmid": "" }, { "name": "ATP-dependent peptidase activity", "id": "GO:0004176", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004176", "evidence": [ { "database": "UniProtKB", "id": "Q3MIB4", "url": "https://www.uniprot.org/uniprot/Q3MIB4" } ], "pmid": "" }, { "name": "protease binding", "id": "GO:0002020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002020", "evidence": [ { "database": "UniProtKB", "id": "Q3MIB4", "url": "https://www.uniprot.org/uniprot/Q3MIB4" } ], "pmid": "" }, { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "Q3MIB4", "url": "https://www.uniprot.org/uniprot/Q3MIB4" } ], "pmid": "" }, { "name": "peptidase activity", "id": "GO:0008233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008233", "evidence": [ { "database": "UniProtKB", "id": "Q3MIB4", "url": "https://www.uniprot.org/uniprot/Q3MIB4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "peroxisomal matrix", "id": "GO:0005782", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005782", "evidence": [ { "database": "UniProtKB", "id": "Q3MIB4", "url": "https://www.uniprot.org/uniprot/Q3MIB4" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3MIB4", "url": "https://www.uniprot.org/uniprot/Q3MIB4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3MIB4", "url": "https://www.uniprot.org/uniprot/Q3MIB4" } ], "pmid": "" }, { "name": "peroxisome", "id": "GO:0005777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005777", "evidence": [ { "database": "UniProtKB", "id": "Q3MIB4", "url": "https://www.uniprot.org/uniprot/Q3MIB4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "protein processing", "id": "GO:0016485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016485", "evidence": [ { "database": "UniProtKB", "id": "Q3MIB4", "url": "https://www.uniprot.org/uniprot/Q3MIB4" } ], "pmid": "" }, { "name": "protein import into peroxisome matrix", "id": "GO:0016558", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016558", "evidence": [ { "database": "UniProtKB", "id": "Q3MIB4", "url": "https://www.uniprot.org/uniprot/Q3MIB4" } ], "pmid": "" }, { "name": "protein quality control for misfolded or incompletely synthesized proteins", "id": "GO:0006515", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006515", "evidence": [ { "database": "UniProtKB", "id": "Q3MIB4", "url": "https://www.uniprot.org/uniprot/Q3MIB4" } ], "pmid": "" }, { "name": "protein catabolic process", "id": "GO:0030163", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030163", "evidence": [ { "database": "UniProtKB", "id": "Q3MIB4", "url": "https://www.uniprot.org/uniprot/Q3MIB4" } ], "pmid": "" }, { "name": "response to organic cyclic compound", "id": "GO:0014070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014070", "evidence": [ { "database": "UniProtKB", "id": "Q3MIB4", "url": "https://www.uniprot.org/uniprot/Q3MIB4" } ], "pmid": "" }, { "name": "protein targeting to peroxisome", "id": "GO:0006625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006625", "evidence": [ { "database": "UniProtKB", "id": "Q3MIB4", "url": "https://www.uniprot.org/uniprot/Q3MIB4" } ], "pmid": "" }, { "name": "regulation of fatty acid beta-oxidation", "id": "GO:0031998", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031998", "evidence": [ { "database": "UniProtKB", "id": "Q3MIB4", "url": "https://www.uniprot.org/uniprot/Q3MIB4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 323, "end_pos": 325, "annotation": "n_glycosylation_sequon" }, { "start_pos": 470, "end_pos": 472, "annotation": "n_glycosylation_sequon" }, { "start_pos": 492, "end_pos": 494, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-RNO-9033235", "name": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "peroxisomal membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9ES71-1", "P07872-1", "P97562-1", "Q62651-1", "P11915-1", "Q06518-1", "Q8CHM7-1", "Q63276-1", "Q63448-1", "O88267-1", "Q5XIC0-1", "P09139-1", "Q3MIB4-1", "Q5I0K1-1", "P04762-1", "Q704S8-1", "Q920F5-1", "Q9Z2M4-1", "P24392-1", "P41562-1", "P97519-1", "B0BNF9-1", "B1H261-1", "O55171-1", "P70473-1", "Q8VHK0-1", "P97524-1", "Q6AYD9-1", "Q9WVK3-1", "O35078-1", "P11466-1", "P24473-1", "Q07523-1", "Q8VID1-1", "P35559-1", "D3ZDM7-1" ], "evidence": [ { "id": "R-RNO-9033235", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9033235" } ] }, { "id": "R-RNO-9033236", "name": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "peroxisomal membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9ES71-1", "P07872-1", "P97562-1", "Q62651-1", "P11915-1", "Q06518-1", "Q8CHM7-1", "Q63276-1", "Q63448-1", "O88267-1", "Q5XIC0-1", "P09139-1", "Q3MIB4-1", "Q5I0K1-1", "P04762-1", "Q704S8-1", "Q920F5-1", "Q9Z2M4-1", "P24392-1", "P41562-1", "P97519-1", "B0BNF9-1", "B1H261-1", "O55171-1", "P70473-1", "Q8VHK0-1", "P97524-1", "Q6AYD9-1", "Q9WVK3-1", "O35078-1", "P11466-1", "P24473-1", "Q07523-1", "Q8VID1-1", "P35559-1", "D3ZDM7-1" ], "evidence": [ { "id": "R-RNO-9033236", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9033236" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "B0BNF9", "gene_name": "Hao1", "activity": [ { "ec_number": "1.1.3.15", "activity": "glycolate + O2 = glyoxylate + H2O2.", "evidence": [ { "id": "B0BNF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0BNF9" } ] }, { "ec_number": "1.2.3.5", "activity": "glyoxylate + H2O + O2 = H(+) + H2O2 + oxalate.", "evidence": [ { "id": "B0BNF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0BNF9" } ] }, { "ec_number": "1.1.3.15", "activity": "", "evidence": [ { "id": "B0BNF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0BNF9" } ] } ] }, { "uniprot_ac": "B1H261", "gene_name": "Tysnd1", "activity": [ { "ec_number": "3.4.21.-", "activity": "", "evidence": [ { "id": "B1H261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1H261" } ] } ] }, { "uniprot_ac": "D3ZDM7", "gene_name": "Ddo", "activity": [ { "ec_number": "1.4.3.1", "activity": "D-aspartate + H2O + O2 = H2O2 + NH4(+) + oxaloacetate.", "evidence": [ { "id": "D3ZDM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDM7" } ] } ] }, { "uniprot_ac": "O35078", "gene_name": "Dao", "activity": [ { "ec_number": "1.4.3.3", "activity": "a D-alpha-amino acid + H2O + O2 = a 2-oxocarboxylate + H2O2 + NH4(+).", "evidence": [ { "id": "O35078", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35078" } ] }, { "ec_number": "1.4.3.3", "activity": "", "evidence": [ { "id": "O35078", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35078" } ] } ] }, { "uniprot_ac": "O55171", "gene_name": "Acot2", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O55171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55171" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "O55171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55171" } ] } ] }, { "uniprot_ac": "O88267", "gene_name": "Acot1", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "O88267", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88267" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O88267", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88267" } ] } ] }, { "uniprot_ac": "P04762", "gene_name": "Cat", "activity": [ { "ec_number": "1.11.1.6", "activity": "2 H2O2 = 2 H2O + O2.", "evidence": [ { "id": "P04762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04762" } ] }, { "ec_number": "1.11.1.6", "activity": "", "evidence": [ { "id": "P04762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04762" } ] } ] }, { "uniprot_ac": "P07872", "gene_name": "Acox1", "activity": [ { "ec_number": "1.3.3.6", "activity": "a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2.", "evidence": [ { "id": "P07872", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07872" } ] }, { "ec_number": "1.3.3.6", "activity": "", "evidence": [ { "id": "P07872", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07872" } ] } ] }, { "uniprot_ac": "P09139", "gene_name": "Agxt", "activity": [ { "ec_number": "2.6.1.51", "activity": "L-serine + pyruvate = 3-hydroxypyruvate + L-alanine.", "evidence": [ { "id": "P09139", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09139" } ] }, { "ec_number": "2.6.1.44", "activity": "glyoxylate + L-alanine = glycine + pyruvate.", "evidence": [ { "id": "P09139", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09139" } ] }, { "ec_number": "2.6.1.44", "activity": "", "evidence": [ { "id": "P09139", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09139" } ] } ] }, { "uniprot_ac": "P11466", "gene_name": "Crot", "activity": [ { "ec_number": "2.3.1.137", "activity": "(R)-carnitine + octanoyl-CoA = CoA + O-octanoyl-(R)-carnitine.", "evidence": [ { "id": "P11466", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11466" } ] }, { "ec_number": "2.3.1.137", "activity": "", "evidence": [ { "id": "P11466", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11466" } ] } ] }, { "uniprot_ac": "P11915", "gene_name": "Scp2", "activity": [ { "ec_number": "2.3.1.176", "activity": "4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA.", "evidence": [ { "id": "P11915", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11915" } ] }, { "ec_number": "2.3.1.16", "activity": "acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA.", "evidence": [ { "id": "P11915", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11915" } ] }, { "ec_number": "2.3.1.155", "activity": "acetyl-CoA + tetradecanoyl-CoA = 3-oxohexadecanoyl-CoA + CoA.", "evidence": [ { "id": "P11915", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11915" } ] }, { "ec_number": "2.3.1.155", "activity": "", "evidence": [ { "id": "P11915", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11915" } ] }, { "ec_number": "2.3.1.16", "activity": "", "evidence": [ { "id": "P11915", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11915" } ] }, { "ec_number": "2.3.1.176", "activity": "", "evidence": [ { "id": "P11915", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11915" } ] } ] }, { "uniprot_ac": "P24392", "gene_name": "Pex2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P24392", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24392" } ] }, { "ec_number": "2.3.2.36", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.", "evidence": [ { "id": "P24392", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24392" } ] }, { "ec_number": "2.3.2.36", "activity": "", "evidence": [ { "id": "P24392", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24392" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P24392", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24392" } ] } ] }, { "uniprot_ac": "P24473", "gene_name": "Gstk1", "activity": [ { "ec_number": "2.5.1.18", "activity": "glutathione + RX = a halide anion + an S-substituted glutathione + H(+).", "evidence": [ { "id": "P24473", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24473" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "P24473", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24473" } ] } ] }, { "uniprot_ac": "P35559", "gene_name": "Ide", "activity": [ { "ec_number": "3.4.24.56", "activity": "Degradation of insulin, glucagon and other polypeptides. No action on proteins.", "evidence": [ { "id": "P35559", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35559" } ] }, { "ec_number": "3.4.24.56", "activity": "", "evidence": [ { "id": "P35559", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35559" } ] } ] }, { "uniprot_ac": "P41562", "gene_name": "Idh1", "activity": [ { "ec_number": "1.1.1.42", "activity": "D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH.", "evidence": [ { "id": "P41562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41562" } ] }, { "ec_number": "1.1.1.42", "activity": "", "evidence": [ { "id": "P41562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41562" } ] } ] }, { "uniprot_ac": "P70473", "gene_name": "Amacr", "activity": [ { "ec_number": "5.1.99.4", "activity": "a (2S)-2-methylacyl-CoA = a (2R)-2-methylacyl-CoA.", "evidence": [ { "id": "P70473", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70473" } ] }, { "ec_number": "5.1.99.4", "activity": "", "evidence": [ { "id": "P70473", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70473" } ] } ] }, { "uniprot_ac": "P97519", "gene_name": "Hmgcl", "activity": [ { "ec_number": "4.1.3.4", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA.", "evidence": [ { "id": "P97519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97519" } ] }, { "ec_number": "4.1.3.4", "activity": "", "evidence": [ { "id": "P97519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97519" } ] } ] }, { "uniprot_ac": "P97524", "gene_name": "Slc27a2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] }, { "ec_number": "6.2.1.7", "activity": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] }, { "ec_number": "6.2.1.24", "activity": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA.", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] } ] }, { "uniprot_ac": "P97562", "gene_name": "Acox2", "activity": [ { "ec_number": "1.17.99.3", "activity": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2.", "evidence": [ { "id": "P97562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97562" } ] }, { "ec_number": "1.17.99.3", "activity": "", "evidence": [ { "id": "P97562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97562" } ] } ] }, { "uniprot_ac": "Q06518", "gene_name": "Nos2", "activity": [ { "ec_number": "1.14.13.39", "activity": "H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide.", "evidence": [ { "id": "Q06518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06518" } ] }, { "ec_number": "1.14.13.39", "activity": "", "evidence": [ { "id": "Q06518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06518" } ] } ] }, { "uniprot_ac": "Q07523", "gene_name": "Hao2", "activity": [ { "ec_number": "1.1.3.15", "activity": "glycolate + O2 = glyoxylate + H2O2.", "evidence": [ { "id": "Q07523", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07523" } ] }, { "ec_number": "1.1.3.15", "activity": "", "evidence": [ { "id": "Q07523", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07523" } ] } ] }, { "uniprot_ac": "Q3MIB4", "gene_name": "Lonp2", "activity": [ { "ec_number": "3.4.21.-", "activity": "", "evidence": [ { "id": "Q3MIB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3MIB4" } ] }, { "ec_number": "3.4.21.53", "activity": "Hydrolysis of proteins in presence of ATP.", "evidence": [ { "id": "Q3MIB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3MIB4" } ] }, { "ec_number": "3.4.21.53", "activity": "", "evidence": [ { "id": "Q3MIB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3MIB4" } ] } ] }, { "uniprot_ac": "Q5I0K1", "gene_name": "Pipox", "activity": [ { "ec_number": "1.5.3.1", "activity": "H2O + O2 + sarcosine = formaldehyde + glycine + H2O2.", "evidence": [ { "id": "Q5I0K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5I0K1" } ] }, { "ec_number": "1.5.3.1", "activity": "", "evidence": [ { "id": "Q5I0K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5I0K1" } ] } ] }, { "uniprot_ac": "Q5XIC0", "gene_name": "Eci2", "activity": [ { "ec_number": "5.3.3.8", "activity": "a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA.", "evidence": [ { "id": "Q5XIC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIC0" } ] }, { "ec_number": "5.3.3.8", "activity": "", "evidence": [ { "id": "Q5XIC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIC0" } ] } ] }, { "uniprot_ac": "Q62651", "gene_name": "Ech1", "activity": [ { "ec_number": "5.3.3.-", "activity": "", "evidence": [ { "id": "Q62651", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62651" } ] } ] }, { "uniprot_ac": "Q63276", "gene_name": "Baat", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q63276", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63276" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "Q63276", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63276" } ] }, { "ec_number": "2.3.1.65", "activity": "choloyl-CoA + glycine = CoA + glycocholate + H(+).", "evidence": [ { "id": "Q63276", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63276" } ] }, { "ec_number": "2.3.1.65", "activity": "", "evidence": [ { "id": "Q63276", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63276" } ] } ] }, { "uniprot_ac": "Q63448", "gene_name": "Acox3", "activity": [ { "ec_number": "1.3.3.6", "activity": "a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2.", "evidence": [ { "id": "Q63448", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63448" } ] }, { "ec_number": "1.3.3.6", "activity": "", "evidence": [ { "id": "Q63448", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63448" } ] } ] }, { "uniprot_ac": "Q6AYD9", "gene_name": "Nudt19", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q6AYD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYD9" } ] } ] }, { "uniprot_ac": "Q704S8", "gene_name": "Crat", "activity": [ { "ec_number": "2.3.1.137", "activity": "(R)-carnitine + octanoyl-CoA = CoA + O-octanoyl-(R)-carnitine.", "evidence": [ { "id": "Q704S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q704S8" } ] }, { "ec_number": "2.3.1.7", "activity": "(R)-carnitine + acetyl-CoA = CoA + O-acetyl-(R)-carnitine.", "evidence": [ { "id": "Q704S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q704S8" } ] }, { "ec_number": "2.3.1.137", "activity": "", "evidence": [ { "id": "Q704S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q704S8" } ] }, { "ec_number": "2.3.1.7", "activity": "", "evidence": [ { "id": "Q704S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q704S8" } ] } ] }, { "uniprot_ac": "Q8CHM7", "gene_name": "Hacl1", "activity": [ { "ec_number": "4.1.2.63", "activity": "2-hydroxy-3-methylhexadecanoyl-CoA = 2-methylpentadecanal + formyl-CoA.", "evidence": [ { "id": "Q8CHM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHM7" } ] }, { "ec_number": "4.1.2.63", "activity": "", "evidence": [ { "id": "Q8CHM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHM7" } ] } ] }, { "uniprot_ac": "Q8VHK0", "gene_name": "Acot8", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.11", "activity": "acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+).", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.3", "activity": "H2O + succinyl-CoA = CoA + H(+) + succinate.", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.5", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.11", "activity": "", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.5", "activity": "", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.3", "activity": "", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.1", "activity": "", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] } ] }, { "uniprot_ac": "Q8VID1", "gene_name": "Dhrs4", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "Q8VID1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VID1" } ] }, { "ec_number": "1.1.1.184", "activity": "a secondary alcohol + NADP(+) = a ketone + H(+) + NADPH.", "evidence": [ { "id": "Q8VID1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VID1" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "Q8VID1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VID1" } ] }, { "ec_number": "1.1.1.184", "activity": "", "evidence": [ { "id": "Q8VID1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VID1" } ] } ] }, { "uniprot_ac": "Q920F5", "gene_name": "Mlycd", "activity": [ { "ec_number": "4.1.1.9", "activity": "H(+) + malonyl-CoA = acetyl-CoA + CO2.", "evidence": [ { "id": "Q920F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q920F5" } ] }, { "ec_number": "4.1.1.9", "activity": 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"label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": 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