{ "uniprot_canonical_ac": "Q3KR37-1", "uniprot_ac": "Q3KR37", "uniprot_id": "ASTRB_HUMAN", "mass": { "chemical_mass": 85400.0, "monoisotopic_mass": 85400.0 }, "refseq": { "ac": "NP_001317325", "name": "protein Aster-B isoform 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317325" }, "gene_names": [ { "name": "GRAMD1B", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q3KR37", "id": "Q3KR37" }, { "name": "GRAMD1B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317325", "id": "NP_001317325" }, { "name": "KIAA1201", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q3KR37", "id": "Q3KR37" }, { "name": "LINC01059", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317325", "id": "NP_001317325" }, { "name": "PRO9834", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q3KR37", "id": "Q3KR37" }, { "name": "hCG_39893", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q3KR37", "id": "Q3KR37" } ], "protein_names": [ { "name": "Protein Aster-B", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q3KR37" }, { "name": "GRAM domain-containing protein 1B; long intergenic non-protein coding RNA 1059; protein Aster-B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273492", "id": "NP_001273492" }, { "name": "GRAM domain-containing protein 1B", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q3KR37" }, { "name": "protein Aster-B isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273492", "id": "NP_001273492" }, { "name": "protein Aster-B isoform 4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317325", "id": "NP_001317325" }, { "name": "protein Aster-B isoform X16", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011541235", "id": "XP_011541235" } ], "function": [ { "annotation": "Aster proteins mediate carotenoid transport in mammalian cells.", "evidence": [ { "database": "RefSeq", "id": "NP_001273492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273492" }, { "database": "PubMed", "id": "35394870", "url": "https://glygen.org/publication/PubMed/35394870" }, { "database": "RefSeq", "id": "NP_001317325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317325" } ] }, { "annotation": "Aster-B coordinates with Arf1 to regulate mitochondrial cholesterol transport.", "evidence": [ { "database": "RefSeq", "id": "NP_001273492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273492" }, { "database": "PubMed", "id": "32738348", "url": "https://glygen.org/publication/PubMed/32738348" }, { "database": "RefSeq", "id": "NP_001317325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317325" } ] }, { "annotation": "Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3KR37", "url": "https://www.uniprot.org/uniprot/Q3KR37#function" }, { "database": "UniProtKB", "id": "Q80TI0", "url": "https://www.uniprot.org/uniprot/Q80TI0#function" } ] }, { "annotation": "Circular RNA circGRAMD1B inhibits gastric cancer progression by sponging miR-130a-3p and regulating PTEN and p21 expression.", "evidence": [ { "database": "RefSeq", "id": "NP_001273492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273492" }, { "database": "PubMed", "id": "31719211", "url": "https://glygen.org/publication/PubMed/31719211" }, { "database": "RefSeq", "id": "NP_001317325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317325" } ] }, { "annotation": "GRAMD1B regulates cell migration in breast cancer cells through JAK/STAT and Akt signaling Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001273492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273492" }, { "database": "PubMed", "id": "29934528", "url": "https://glygen.org/publication/PubMed/29934528" }, { "database": "RefSeq", "id": "NP_001317325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317325" } ] }, { "annotation": "Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b.", "evidence": [ { "database": "RefSeq", "id": "NP_001273492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273492" }, { "database": "PubMed", "id": "33604931", "url": "https://glygen.org/publication/PubMed/33604931" }, { "database": "RefSeq", "id": "NP_001317325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317325" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "Q3KR37", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q3KR37" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 185, "end_pos": 185, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "L", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (4).", "chr_id": "11", "chr_pos": "123600481", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "S185", "disease": [ { "disease_id": "DOID:1319", "recommended_name": { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain cancer", "description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain." }, "synonyms": [ { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "BT - Brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "adult brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "adult malignant brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm, adult", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of Brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of adult brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary malignant neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "tumor of the Brain", "description": "" } ] }, { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] }, { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. 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"database": "Bgee", "id": "ENSG00000023171", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000023171" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "66.23", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000023171", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000023171" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "67.8", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000023171", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000023171" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "63.75", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000023171", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000023171" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "57.09", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000023171", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000023171" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "70.72", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000023171", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000023171" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "63.59", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000023171", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000023171" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "66.06", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000023171", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000023171" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "62.37", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000023171", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000023171" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "63.95", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000023171", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000023171" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "Q3KR37", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q3KR37" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": 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"" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": 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"https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": 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{ "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed 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cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "Q3KR37", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q3KR37" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q3KR37" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "Q3KR37", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q3KR37" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", 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"id": "Q3KR37-4", "url": "https://www.uniprot.org/uniprot/Q3KR37-4", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKGFKLSCTASNSNRSTPACSPILRKRSRSPTPQNQDGDTMVEKGSDHSSDKSPSTPEQGVQRSCSSQSGRSGGKNSKKSQSWYNVLSPTYKQRNEDFRKLFKQLPDTERLIVDYSCALQRDILLQGRLYLSENWICFYSNIFRWETLLTVRLKDICSMTKEKTARLIPNAIQVCTDSEKHFFTSFGARDRTYMMMFRLWQNALLEKPLCPKELWHFVHQCYGNELGLTSDDEDYVPPDDDFNTMGYCEEIPVEENEVNDSSSKSSIETKPDASPQLPKKSITNSTLTSTGSSEAPVSFDGLPLEEEALEGDGSLEKELAIDNIMGEKIEMIAPVNSPSLDFNDNEDIPTELSDSSDTHDEGEVQAFYEDLSGRQYVNEVFNFSVDKLYDLLFTNSPFQRDFMEQRRFSDIIFHPWKKEENGNQSRVILYTITLTNPLAPKTATVRETQTMYKASQESECYVIDAEVLTHDVPYHDYFYTINRYTLTRVARNKSRLRVSTELRYRKQPWGLVKTFIEKNFWSGLEDYFRHLESELAKTESTYLAEMHRQSPKEKASKTTTVRRRKRPHAHLRVPHLEEVMSPVTTPTDEDVGHRIKHVAGSTQTRHIPEDTPNGFHLQSVSKLLLVISCVICFSLVLLVILNMMLFYKLWMLEYTTQTLTAWQGLRLQERLPQSQTEWAQLLESQQKYHDTELQKWREIIKSSVMLLDQMKDSLINLQNGIRSRDYTSESEEKRNRYH", "length": 738, "header": "sp|Q3KR37-1|ASTRB_HUMAN Isoform 1 of Protein Aster-B OS=Homo sapiens OX=9606 GN=GRAMD1B PE=1 SV=1 CANONICAL=Q3KR37-1" }, "isoforms": [ { "isoform_ac": "A0A024R3M2-1", "url": "", "sequence": { "sequence": "MVEKGSDHSSDKSPSTPEQGVQRSCSSQSGRSGGKNSKKSQSWYNVLSPTYKQRNEDFRKLFKQLPDTERLIVDYSCALQRDILLQGRLYLSENWICFYSNIFRWETLLTVRLKDICSMTKEKTARLIPNAIQVCTDSEKHFFTSFGARDRTYMMMFRLWQNALLEKPLCPKELWHFVHQCYGNELGLTSDDEDYVPPDDDFNTMGYCEEIPVEENEVNDSSSKSSIETKPDASPQLPKKSITNSTLTSTGSSEAPVSFDGLPLEEEALEGDGSLEKELAIDNIMGEKIEMIAPVNSPSLDFNDNEDIPTELSDSSDTHDEGEVQAFYEDLSGRQYVNEVFNFSVDKLYDLLFTNSPFQRDFMEQRRFSDIIFHPWKKEENGNQSRVILYTITLTNPLAPKTATVRETQTMYKASQESECYVIDAEVLTHDVPYHDYFYTINRYTLTRVARNKSRLRVSTELRYRKQPWGLVKTFIEKNFWSGLEDYFRHLESELAKTESTYLAEMHRQSPKEKASKTTTVRRRKRPHAHLRVPHLEEVMSPVTTPTDEDVGHRIKHVAGSTQTRHIPEDTPNGFHLQSVSKLLLVISCVLVLLVILNMMLFYKLWMLEYTTQTLTAWQGLRLQERLPQSQTEWAQLLESQQKYHDTELQKWREIIKSSVMLLDQMKDSLINLQNGIRSRDYTSESEEKRNRYH", "length": 694, "header": "tr|A0A024R3M2-1|ASTRB_HUMAN Computationally mapped isoform of Protein Aster-B OS=Homo sapiens OX=9606 GN=GRAMD1B PE=1 SV=1 CANONICAL=Q3KR37-1" }, "locus": { "chromosome": "11", "start_pos": 123622592, "end_pos": 123577464, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000638157.1", "url": "https://www.ensembl.org/id/ENST00000638157.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000489896.1", "url": "https://www.ensembl.org/id/ENSP00000489896.1" } ] } }, { "isoform_ac": "A0A0J9YXF6-1", "url": "", "sequence": { "sequence": "MVEKGSDHSSDKSPSTPEQGVQRSCSSQSGRSGGKNSKKSQSWYNVLSPTYKQRNEDFRKLFKQLPDTERLIVDYSCALQRDILLQGRLYLSENWICFYSNIFRWETLLTVRLKDICSMTKEKTARLIPNAIQVCTDSEKHFFTSFGARDRTYMMMFRLWQNALLE", "length": 166, "header": "tr|A0A0J9YXF6-1|A0A0J9YXF6_HUMAN Computationally mapped isoform of GRAM domain containing 1B OS=Homo sapiens OX=9606 GN=GRAMD1B PE=1 SV=1 CANONICAL=Q3KR37-1" }, "locus": { "chromosome": "11", "start_pos": 123600545, "end_pos": 123577464, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000633646.1", "url": "https://www.ensembl.org/id/ENST00000633646.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000488382.1", "url": "https://www.ensembl.org/id/ENSP00000488382.1" } ] } }, { "isoform_ac": "A0A0J9YXZ1-1", "url": "", "sequence": { "sequence": "MSFLSSQQSSQQSSHDDDSSRFLSPRAREESTASNSNRSTPACSPILRKRSRSPTPQNQDGDTMVEKGSDHSSDKSPSTPEQGVQRSCSSQSGRSGGKNSKKSQSWYNVLSPTYKQRNEDFRKLFKQLPDTERLIVDYSCALQRDILLQGRLYLSENWICFYSNIFRWETL", "length": 171, "header": "tr|A0A0J9YXZ1-1|ASTRB_HUMAN Computationally mapped isoform of Protein Aster-B OS=Homo sapiens OX=9606 GN=GRAMD1B PE=1 SV=1 CANONICAL=Q3KR37-1" }, "locus": { "chromosome": "11", "start_pos": 123594838, "end_pos": 123480802, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000633087.1", "url": "https://www.ensembl.org/id/ENST00000633087.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000488613.1", "url": "https://www.ensembl.org/id/ENSP00000488613.1" } ] } }, { "isoform_ac": "A0A0J9YY71-1", "url": "", "sequence": { "sequence": "MVEKGSDHSSDKSPSTPEQGVQRSCSSQSGRSGGKNSKKSQSWYNVLSPTYKQRNEDFRKLFKQLPDTERLIVDYSCALQRDILLQGRLYLSENWICFYSNIFRWETL", "length": 108, "header": "tr|A0A0J9YY71-1|ASTRB_HUMAN Computationally mapped isoform of Protein Aster-B OS=Homo sapiens OX=9606 GN=GRAMD1B PE=1 SV=1 CANONICAL=Q3KR37-1" }, "locus": { "chromosome": "11", "start_pos": 123594838, "end_pos": 123577464, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000632815.1", "url": "https://www.ensembl.org/id/ENST00000632815.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000488714.1", "url": "https://www.ensembl.org/id/ENSP00000488714.1" } ] } }, { "isoform_ac": "A0A1B0GUD6-1", "url": "", "sequence": { "sequence": "MPAANMMENRPLPALQVPEPQGAPEGSPVWSSSSTPTLRRRRFKMRRMKNVQEQSLEAGLARDLPAVLAPGKEFLQLPSIEITPSSDEDTPWSNCSTPSASPRRKRFLLRKWLRVRERKECSESSSQQSSQQSSHDDDSSRFLSPRAREESTASNSNRSTPACSPILRKRSRSPTPQNQDGDTMVEKGSDHSSDKSPSTPEQGVQRSCSSQSGRSGGKNSKKSQSWYNVLSPTYKQRNEDFRKLFKQLPDTERLIVDYSCALQRDILLQGRLYLSENWICFYSNIFRWETLLTVRLKDICSMTKEKTARLIPNAIQVCTDSEKHFFTSFGARDRTYMMMFRLWQNALLEKPLCPKELWHFVHQCYGNELGLTSDDEDYVPPDDDFNTMGYCEEIPVEENEVNDSSSKSSIETKPDASPQLPKKSITNSTLTSTGSSEAPVSFDGLPLEEEALEGDGSLEKELAIDNIMGEKIEMIAPVNSPSLDFNDNEDIPTELSDSSDTHDEGEVQAFYEDLSGRQYVNEVFNFSVDKLYDLLFTNSPFQRDFMEQRRFSDIIFHPWKKEENGNQSRVILYTITLTNPLAPKTATVRETQTMYKASQESECYVIDAEVLTHDVPYHDYFYTINRYTLTRVARNKSRLRVSTELRYRKQPWGLVKTFIEKNFWSGLEDYFRHLESELAKTESTYLAEMHRQSPKEKASKTTTVRRRKRPHAHLRVPHLEEVMSPVTTPTDEDVGHRIKHVAGSTQTRHIPEDTPNGFHLQSVSKLLLVISCVLVLLVILNMMLFYKLWMLEYTTQTLTAWQGLRLQERLPQSQTEWAQLLESQQKYHDTELQKWREIIKSSVMLLDQMKDSLINLQNGIRSRDYTSESEEKRNRYH", "length": 877, "header": "tr|A0A1B0GUD6-1|ASTRB_HUMAN Computationally mapped isoform of Protein Aster-B OS=Homo sapiens OX=9606 GN=GRAMD1B PE=1 SV=1 CANONICAL=Q3KR37-1" }, "locus": { "chromosome": "11", "start_pos": 123622592, "end_pos": 123430793, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000635736.2", "url": "https://www.ensembl.org/id/ENST00000635736.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000490062.1", "url": "https://www.ensembl.org/id/ENSP00000490062.1" } ] } }, { "isoform_ac": "A0A1B0GVV0-1", "url": "", "sequence": { "sequence": "MPAANMMENRPLPALQVPEPQGAPEGSPVWSSSSTPTLRRRRFKMRRMKNVQEQSLEAGLARDLPAVLAPGKEFLQLPSIEITPSSDEDTPWSNCSTPSASPRRKRFLLRKWLRVRERKECSESSSSLRIFTAQS", "length": 135, "header": "tr|A0A1B0GVV0-1|ASTRB_HUMAN Computationally mapped isoform of Protein Aster-B OS=Homo sapiens OX=9606 GN=GRAMD1B PE=1 SV=1 CANONICAL=Q3KR37-1" }, "locus": { "chromosome": "11", "start_pos": 123435464, "end_pos": 123430793, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000533341.3", "url": "https://www.ensembl.org/id/ENST00000533341.3" }, { "database": "Ensembl Peptide", "id": "ENSP00000490665.1", "url": "https://www.ensembl.org/id/ENSP00000490665.1" } ] } }, { "isoform_ac": "A0A1B0GWG7-1", "url": "", "sequence": { "sequence": "MVQNLQPETVSCSTAVKQACHYHVSSLRKKLAFLRANTASNSNRSTPACSPILRKRSRSPTPQNQDGDTMVEKGSDHSSDKSPSTPEQGVQRSCSSQSGRSGGKNSKKSQSWYNVLSPTYKQRNEDFRKLFKQLPDTERLIVDYSCALQRDILLQGRLYLSENWICFYSNIFRWETLLTVRLKDICSMTKEKTARLIPNAIQVCTDSEKHFFTSFGARDRTYMMMFRLWQNALLEKPLCPKELWHFVHQCYGNELGLTSDDEDYVPPDDDFNTMGYCEEIPVEENEVNDSSSKSSIETKPDASPQLPKKSITNSTLTSTGSSEAPVSFDGLPLEEEALEGDGSLEKELAIDNIMGEKIEMIAPVNSPSLDFNDNEDIPTELSDSSDTHDEGEVQAFYEDLSGRQYVNEVFNFSVDKLYDLLFTNSPFQRDFMEQRRFSDIIFHPWKKEENGNQSRVILYTITLTNPLAPKTATVRETQTMYKASQESECYVIDAEVLTHDVPYHDYFYTINRYTLTRVARNKSRLRVSTELRYRKQPWGLVKTFIEKNFWSGLEDYFRHLESELAKTESTYLAEMHRQSPKEKASKTTTVRRRKRPHAHLRVPHLEEVMSPVTTPTDEDVGHRIKHVAGSTQTRHIPEDTPNGFHLQSVSKLLLVISCVICFSLVLLVILNMMLFYKLWMLEYTTQTLTAWQGLRLQERLPQSQTEWAQLLESQQKYHDTELQKWREIIKSSVMLLDQMKDSLINLQNGIRSRDYTSESEEKRNRYH", "length": 767, "header": "tr|A0A1B0GWG7-1|ASTRB_HUMAN Computationally mapped isoform of Protein Aster-B OS=Homo sapiens OX=9606 GN=GRAMD1B PE=1 SV=1 CANONICAL=Q3KR37-1" }, "locus": { "chromosome": "11", "start_pos": 123622592, "end_pos": 123491850, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000638086.1", "url": "https://www.ensembl.org/id/ENST00000638086.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000490920.1", "url": "https://www.ensembl.org/id/ENSP00000490920.1" } ] } }, { "isoform_ac": "A0A1W2PQ30-1", "url": "", "sequence": { "sequence": "MPAANMMENRPLPALQVPEPQGAPEGSPVWSSSSTPTLRRRRFKMRRMKNVQEQSLEAGLARDLPAVLAPGKEFLQLPSIEITPSSDEDTPWSNCSTPSASPRRKRFLLRKWLRVRERKECSESRVLSLNGFVFLCGATESLITFPGIPSPNLFNYIDFNSLKLADFHCTKLKI", "length": 174, "header": "tr|A0A1W2PQ30-1|ASTRB_HUMAN Computationally mapped isoform of Protein Aster-B OS=Homo sapiens OX=9606 GN=GRAMD1B PE=1 SV=1 CANONICAL=Q3KR37-1" }, "locus": { "chromosome": "11", "start_pos": 123435472, "end_pos": 123430793, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000640939.1", "url": "https://www.ensembl.org/id/ENST00000640939.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000491509.1", "url": "https://www.ensembl.org/id/ENSP00000491509.1" } ] } }, { "isoform_ac": "A0A2R8Y5X2-1", "url": "", "sequence": { "sequence": "MESLTESGVLWSLLLEQESQLLQWYLKQLGHAPAAAEHRCWHGSEEIPAVLSPTYKQRNEDFRKLFKQLPDTERLIVDYSCALQRDILLQGRLYLSENWICFYSNIFRWETLLTVRLKDICSMTKEKTARLIPNAIQVCTDSEKHFFTSFGARDRTYMMMFRLWQNALLEKPLCPKELWHFVHQCYGNELGLTSDDEDYVPPDDDFNTMGYCEEIPVEENEVNDSSSKSSIETKPDASPQLPKKSITNSTLTSTGSSEAPVSFDGLPLEEEALEGDGSLEKELAIDNIMGEKIEMIAPVNSPSLDFNDNEDIPTELSDSSDTHDEGEVQAFYEDLSGRQYVNEVFNFSVDKLYDLLFTNSPFQRDFMEQRRFSDIIFHPWKKEENGNQSRVILYTITLTNPLAPKTATVRETQTMYKASQESECYVIDAEVLTHDVPYHDYFYTINRYTLTRVARNKSRLRVSTELRYRKQPWGLVKTFIEKNFWSGLEDYFRHLESELAKTESTYLAEMHRQSPKEKASKTTTVRRRKRPHAHLRVPHLEEVMSPVTTPTDEDVGHRIKHVAGSTQTRHIPEDTPNGFHLQSVSKLLLVISCVICFSLVLLVILNMMLFYKLWMLEYTTQTLTAWQGLRLQERLPQSQTEWAQLLESQQKYHDTELQKWREIIKSSVMLLDQMKDSLINLQNGIRSRDYTSESEEKRNRYH", "length": 702, "header": "tr|A0A2R8Y5X2-1|ASTRB_HUMAN Computationally mapped isoform of Protein Aster-B OS=Homo sapiens OX=9606 GN=GRAMD1B PE=1 SV=1 CANONICAL=Q3KR37-1" }, "locus": { "chromosome": "11", "start_pos": 123622592, "end_pos": 123591395, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000646146.1", "url": "https://www.ensembl.org/id/ENST00000646146.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000494891.1", "url": "https://www.ensembl.org/id/ENSP00000494891.1" } ] } }, { "isoform_ac": "E9PRD6-1", "url": "", "sequence": { "sequence": "MASSTASNSNRSTPACSPILRKRSRSPTPQNQDGDTMVEKGSDHSSDKSPSTPEQGVQRSCSSQSGRSGGKNSKKSQSWYNVLSPTYKQRNEDFRKLFKQLPDTERLIVDYSCALQRDILLQGRLYLSENWICFYSNIFRWETLLTVRLKDICSMTKEKTARLIPNAIQVCTDSEKHFFTSFGARDRTYMMMFRLWQNALLEKPLCPKELWHFVHQCYGNELGLTSDDEDYVPPDDDFNTMGYCEEIPVEENEVNDSSSKSSIETKPDASPQLPKKSITNSTLTSTGSSEAPVSFDGLPLEEEALEGDGSLEKELAIDNIMGEKIEMIAPVNSPSLDFNDNEDIPTELSDSSDTHDEGEVQAFYEDLSGRQYVNEVFNFSVDKLYDLLFTNSPFQRDFMEQRRFSDIIFHPWKKEENGNQSRVILYTITLTNPLAPKTATV", "length": 441, "header": "tr|E9PRD6-1|ASTRB_HUMAN Computationally mapped isoform of Protein Aster-B OS=Homo sapiens OX=9606 GN=GRAMD1B PE=1 SV=1 CANONICAL=Q3KR37-1" }, "locus": { "chromosome": "11", "start_pos": 123609901, "end_pos": 123560642, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000534764.1", "url": "https://www.ensembl.org/id/ENST00000534764.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000434214.1", "url": "https://www.ensembl.org/id/ENSP00000434214.1" } ] } }, { "isoform_ac": "Q3KR37-1", "url": "", "sequence": { "sequence": "MKGFKLSCTASNSNRSTPACSPILRKRSRSPTPQNQDGDTMVEKGSDHSSDKSPSTPEQGVQRSCSSQSGRSGGKNSKKSQSWYNVLSPTYKQRNEDFRKLFKQLPDTERLIVDYSCALQRDILLQGRLYLSENWICFYSNIFRWETLLTVRLKDICSMTKEKTARLIPNAIQVCTDSEKHFFTSFGARDRTYMMMFRLWQNALLEKPLCPKELWHFVHQCYGNELGLTSDDEDYVPPDDDFNTMGYCEEIPVEENEVNDSSSKSSIETKPDASPQLPKKSITNSTLTSTGSSEAPVSFDGLPLEEEALEGDGSLEKELAIDNIMGEKIEMIAPVNSPSLDFNDNEDIPTELSDSSDTHDEGEVQAFYEDLSGRQYVNEVFNFSVDKLYDLLFTNSPFQRDFMEQRRFSDIIFHPWKKEENGNQSRVILYTITLTNPLAPKTATVRETQTMYKASQESECYVIDAEVLTHDVPYHDYFYTINRYTLTRVARNKSRLRVSTELRYRKQPWGLVKTFIEKNFWSGLEDYFRHLESELAKTESTYLAEMHRQSPKEKASKTTTVRRRKRPHAHLRVPHLEEVMSPVTTPTDEDVGHRIKHVAGSTQTRHIPEDTPNGFHLQSVSKLLLVISCVICFSLVLLVILNMMLFYKLWMLEYTTQTLTAWQGLRLQERLPQSQTEWAQLLESQQKYHDTELQKWREIIKSSVMLLDQMKDSLINLQNGIRSRDYTSESEEKRNRYH", "length": 738, "header": "sp|Q3KR37-1|ASTRB_HUMAN Isoform 1 of Protein Aster-B OS=Homo sapiens OX=9606 GN=GRAMD1B PE=1 SV=1 CANONICAL=Q3KR37-1" }, "locus": { "chromosome": "11", "start_pos": 123622592, "end_pos": 123526149, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000529750.5", "url": "https://www.ensembl.org/id/ENST00000529750.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000436500.1", "url": "https://www.ensembl.org/id/ENSP00000436500.1" } ] } }, { "isoform_ac": "Q3KR37-2", "url": "", "sequence": { "sequence": "MVEKGSDHSSDKSPSTPEQGVQRSCSSQSGRSGGKNSKKSQSWYNVLSPTYKQRNEDFRKLFKQLPDTERLIVDYSCALQRDILLQGRLYLSENWICFYSNIFRWETLLTVRLKDICSMTKEKTARLIPNAIQVCTDSEKHFFTSFGARDRTYMMMFRLWQNALLEKPLCPKELWHFVHQCYGNELGLTSDDEDYVPPDDDFNTMGYCEEIPVEENEVNDSSSKSSIETKPDASPQLPKKSITNSTLTSTGSSEAPVSFDGLPLEEEALEGDGSLEKELAIDNIMGEKIEMIAPVNSPSLDFNDNEDIPTELSDSSDTHDEGEVQAFYEDLSGRQYVNEVFNFSVDKLYDLLFTNSPFQRDFMEQRRFSDIIFHPWKKEENGNQSRVILYTITLTNPLAPKTATVRETQTMYKASQESECYVIDAEVLTHDVPYHDYFYTINRYTLTRVARNKSRLRVSTELRYRKQPWGLVKTFIEKNFWSGLEDYFRHLESELAKTESTYLAEMHRQSPKEKASKTTTVRRRKRPHAHLRVPHLEEVMSPVTTPTDEDVGHRIKHVAGSTQTRHIPEDTPNGFHLQSVSKLLLVISCVICFSLVLLVILNMMLFYKLWMLEYTTQTLTAWQGLRLQERLPQSQTEWAQLLESQQKYHDTELQKWREIIKSSVMLLDQMKDSLINLQNGIRSRDYTSESEEKRNRYH", "length": 698, "header": "sp|Q3KR37-2|ASTRB_HUMAN Isoform 2 of Protein Aster-B OS=Homo sapiens OX=9606 GN=GRAMD1B PE=1 SV=1 CANONICAL=Q3KR37-1" }, "locus": { "chromosome": "11", "start_pos": 123622592, "end_pos": 123577464, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000529432.5", "url": "https://www.ensembl.org/id/ENST00000529432.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000432987.1", "url": "https://www.ensembl.org/id/ENSP00000432987.1" } ] } }, { "isoform_ac": "Q3KR37-3", "url": "", "sequence": { "sequence": "MPTSSAVLLRVLSIPLLTVLILARDLSALGGCPWGPLPLRCHCLLPDPLFCAGEVQAFYEDLSGRQYVNEVFNFSVDKLYDLLFTNSPFQRDFMEQRRFSDIIFHPWKKEENGNQSRVILYTITLTNPLAPKTATVRETQTMYKASQESECYVIDAEVLTHDVPYHDYFYTINRYTLTRVARNKSRLRVSTELRYRKQPWGLVKTFIEKNFWSGLEDYFRHLESELAKTESTYLAEMHRQSPKEKASKTTTVRRRKRPHAHLRVPHLEEVMSPVTTPTDEDVGHRIKHVAGSTQTRHIPEDTPNGFHLQSVSKLLLVISCVLVLLVILNMMLFYKLWMLEYTTQTLTAWQGLRLQERLPQSQTEWAQLLESQQKYHDTELQKWREIIKSSVMLLDQMKDSLINLQNGIRSRDYTSESEEKRNRYH", "length": 425, "header": "sp|Q3KR37-3|ASTRB_HUMAN Isoform 3 of Protein Aster-B OS=Homo sapiens OX=9606 GN=GRAMD1B PE=1 SV=1 CANONICAL=Q3KR37-1" }, "locus": { "chromosome": "11", "start_pos": 123622592, "end_pos": 123608502, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000450171.2", "url": "https://www.ensembl.org/id/ENST00000450171.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000388458.2", "url": "https://www.ensembl.org/id/ENSP00000388458.2" } ] } }, { "isoform_ac": "Q3KR37-4", "url": "", "sequence": { "sequence": "MKGFKLSCTASNSNRSTPACSPILRKRSRSPTPQNQDGDTMVEKGSDHSSDKSPSTPEQGVQRSCSSQSGRSGGKNSKSHKRLSKKSQSWYNVLSPTYKQRNEDFRKLFKQLPDTERLIVDYSCALQRDILLQGRLYLSENWICFYSNIFRWETLLTVRLKDICSMTKEKTARLIPNAIQVCTDSEKHFFTSFGARDRTYMMMFRLWQNALLEKPLCPKELWHFVHQCYGNELGLTSDDEDYVPPDDDFNTMGYCEEIPVEENEVNDSSSKSSIETKPDASPQLPKKSITNSTLTSTGSSEAPVSFDGLPLEEEALEGDGSLEKELAIDNIMGEKIEMIAPVNSPSLDFNDNEDIPTELSDSSDTHDEGEVQAFYEDLSGRQYVNEVFNFSVDKLYDLLFTNSPFQRDFMEQRRFSDIIFHPWKKEENGNQSRVILYTITLTNPLAPKTATVRETQTMYKASQESECYVIDAEVLTHDVPYHDYFYTINRYTLTRVARNKSRLRVSTELRYRKQPWGLVKTFIEKNFWSGLEDYFRHLESELAKTESTYLAEMHRQSPKEKASKTTTVRRRKRPHAHLRVPHLEEVMSPVTTPTDEDVGHRIKHVAGSTQTRHIPEDTPNGFHLQSVSKLLLVISCVICFSLVLLVILNMMLFYKLWMLEYTTQTLTAWQGLRLQERLPQSQTEWAQLLESQQKYHDTELQKWREIIKSSVMLLDQMKDSLINLQNGIRSRDYTSESEEKRNRYH", "length": 745, "header": "sp|Q3KR37-4|ASTRB_HUMAN Isoform 4 of Protein Aster-B OS=Homo sapiens OX=9606 GN=GRAMD1B PE=1 SV=1 CANONICAL=Q3KR37-1" }, "locus": { "chromosome": "11", "start_pos": 123622592, "end_pos": 123526149, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000456860.6", "url": "https://www.ensembl.org/id/ENST00000456860.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000402457.2", "url": "https://www.ensembl.org/id/ENSP00000402457.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 269, "end_pos": 269, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q3KR37", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q3KR37" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "phospho.ELM", "id": "Q3KR37", "url": "http://phospho.elm.eu.org/byAccession/Q3KR37.html" } ], "site_lbl": "Thr269" }, { "start_pos": 274, "end_pos": 274, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3KR37", "url": "https://www.uniprot.org/uniprot/Q3KR37" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "Q3KR37", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q3KR37" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "phospho.ELM", "id": "Q3KR37", "url": "http://phospho.elm.eu.org/byAccession/Q3KR37.html" } ], "site_lbl": "Ser274" }, { "start_pos": 28, "end_pos": 28, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3KR37", "url": "https://www.uniprot.org/uniprot/Q3KR37" } ], "site_lbl": "Ser28" }, { "start_pos": 30, "end_pos": 30, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3KR37", "url": "https://www.uniprot.org/uniprot/Q3KR37" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "Q3KR37", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q3KR37" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "phospho.ELM", "id": "Q3KR37", "url": "http://phospho.elm.eu.org/byAccession/Q3KR37.html" } ], "site_lbl": "Ser30" }, { "start_pos": 389, "end_pos": 389, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q3KR37", "url": "https://www.uniprot.org/uniprot/Q3KR37" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "iPTMnet", "id": "Q3KR37", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q3KR37" }, { "database": "phospho.ELM", "id": "Q3KR37", "url": "http://phospho.elm.eu.org/byAccession/Q3KR37.html" } ], "site_lbl": "Tyr389" }, { "start_pos": 394, "end_pos": 394, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q3KR37", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q3KR37" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "phospho.ELM", "id": "Q3KR37", "url": "http://phospho.elm.eu.org/byAccession/Q3KR37.html" } ], "site_lbl": "Thr394" }, { "start_pos": 550, "end_pos": 550, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3KR37", "url": "https://www.uniprot.org/uniprot/Q3KR37" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "Q3KR37", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q3KR37" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ], "site_lbl": "Ser550" }, { "start_pos": 581, "end_pos": 581, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3KR37", "url": "https://www.uniprot.org/uniprot/Q3KR37" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "iPTMnet", "id": "Q3KR37", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q3KR37" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "phospho.ELM", "id": "Q3KR37", "url": "http://phospho.elm.eu.org/byAccession/Q3KR37.html" } ], "site_lbl": "Ser581" }, { "start_pos": 584, "end_pos": 584, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3KR37", "url": "https://www.uniprot.org/uniprot/Q3KR37" } ], "site_lbl": "Thr584" }, { "start_pos": 585, "end_pos": 585, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3KR37", "url": "https://www.uniprot.org/uniprot/Q3KR37" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "iPTMnet", "id": "Q3KR37", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q3KR37" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "phospho.ELM", "id": "Q3KR37", "url": "http://phospho.elm.eu.org/byAccession/Q3KR37.html" } ], "site_lbl": "Thr585" }, { "start_pos": 587, "end_pos": 587, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3KR37", "url": "https://www.uniprot.org/uniprot/Q3KR37" }, { "database": "phospho.ELM", "id": "Q3KR37", "url": "http://phospho.elm.eu.org/byAccession/Q3KR37.html" }, { "database": "iPTMnet", "id": "Q3KR37", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q3KR37" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" } ], "site_lbl": "Thr587" } ], "glycation": [], "keywords": [], "publication": [ { "title": "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.", "journal": "Genome Res.", "date": "2003", "authors": "Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A", "evidence": [ { "database": "UniProtKB", "id": "Q3KR37", "url": "https://www.uniprot.org/uniprot/Q3KR37" } ], "reference": [ { "type": "PubMed", "id": "12975309", "url": "https://glygen.org/publication/PubMed/12975309" } ] }, { "title": "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.", "journal": "Cell", "date": "2006", "authors": "Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M", "evidence": [ { "database": "iPTMnet", "id": "Q3KR37", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q3KR37" } ], "reference": [ { "type": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" } ] }, { "title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q3KR37", "url": "https://www.uniprot.org/uniprot/Q3KR37" }, { "database": "iPTMnet", "id": "Q3KR37-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q3KR37-1" } ], "reference": [ { "type": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ] }, { "title": "Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Pan C, Olsen JV, Daub H, Mann M", "evidence": [ { "database": "iPTMnet", "id": "Q3KR37-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q3KR37-1" } ], "reference": [ { "type": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "iPTMnet", "id": "Q3KR37-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q3KR37-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "Q3KR37", "url": "https://www.uniprot.org/uniprot/Q3KR37" }, { "database": "iPTMnet", "id": "Q3KR37", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q3KR37" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "GRAMD1B regulates cell migration in breast cancer cells through JAK/STAT and Akt signaling.", "journal": "Scientific reports", "date": "2018", "authors": "Khanna P, Lee JS, Sereemaspun A, Lee H, Baeg GH", "evidence": [ { "database": "RefSeq", "id": "NP_001273492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273492" }, { "database": "RefSeq", "id": "NP_001317325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317325" } ], "reference": [ { "type": "PubMed", "id": "29934528", "url": "https://glygen.org/publication/PubMed/29934528" } ] }, { "title": "Aster proteins facilitate nonvesicular plasma membrane to ER cholesterol transport in mammalian cells.", "journal": "Cell", "date": "2018", "authors": "Sandhu J, Li S, Fairall L, Pfisterer SG, Gurnett JE, Xiao X, Weston TA, Vashi D, Ferrari A, Orozco JL, Hartman CL, Strugatsky D, Lee SD, He C, Hong C, Jiang H, Bentolila LA, Gatta AT, Levine TP, Ferng A, Lee R, Ford DA, Young SG, Ikonen E, Schwabe JWR, Tontonoz P", "evidence": [ { "database": "UniProtKB", "id": "Q3KR37", "url": "https://www.uniprot.org/uniprot/Q3KR37" } ], "reference": [ { "type": "PubMed", "id": "30220461", "url": "https://glygen.org/publication/PubMed/30220461" } ] }, { "title": "Circular RNA circGRAMD1B inhibits gastric cancer progression by sponging miR-130a-3p and regulating PTEN and p21 expression.", "journal": "Aging", "date": "2019", "authors": "Dai X, Guo X, Liu J, Cheng A, Peng X, Zha L, Wang Z", "evidence": [ { "database": "RefSeq", "id": "NP_001317325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317325" }, { "database": "RefSeq", "id": "NP_001273492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273492" } ], "reference": [ { "type": "PubMed", "id": "31719211", "url": "https://glygen.org/publication/PubMed/31719211" } ] }, { "title": "Aster-B coordinates with Arf1 to regulate mitochondrial cholesterol transport.", "journal": "Molecular metabolism", "date": "2020", "authors": "Andersen JP, Zhang J, Sun H, Liu X, Liu J, Nie J, Shi Y", "evidence": [ { "database": "RefSeq", "id": "NP_001317325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317325" }, { "database": "RefSeq", "id": "NP_001273492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273492" } ], "reference": [ { "type": "PubMed", "id": "32738348", "url": "https://glygen.org/publication/PubMed/32738348" } ] }, { "title": "Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b.", "journal": "The EMBO journal", "date": "2021", "authors": "Ercan B, Naito T, Koh DHZ, Dharmawan D, Saheki Y", "evidence": [ { "database": "RefSeq", "id": "NP_001273492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273492" }, { "database": "RefSeq", "id": "NP_001317325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317325" } ], "reference": [ { "type": "PubMed", "id": "33604931", "url": "https://glygen.org/publication/PubMed/33604931" } ] }, { "title": "Aster proteins mediate carotenoid transport in mammalian cells.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2022", "authors": "Bandara S, Ramkumar S, Imanishi S, Thomas LD, Sawant OB, Imanishi Y, von Lintig J", "evidence": [ { "database": "RefSeq", "id": "NP_001273492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273492" }, { "database": "RefSeq", "id": "NP_001317325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317325" } ], "reference": [ { "type": "PubMed", "id": "35394870", "url": "https://glygen.org/publication/PubMed/35394870" } ] } ], "pathway": [ { "id": "hsa:57476", "name": "", "url": 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