{ "uniprot_canonical_ac": "Q2V057-1", "uniprot_ac": "Q2V057", "uniprot_id": "HYPDH_RAT", "mass": { "chemical_mass": 51002.0, "monoisotopic_mass": 51002.0 }, "refseq": { "ac": "NP_001033677", "name": "hydroxyproline dehydrogenase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033677" }, "gene_names": [ { "name": "Prodh2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q2V057", "id": "Q2V057" }, { "name": "HYPDH", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033677", "id": "NP_001033677" }, { "name": "Hypdh", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q2V057", "id": "Q2V057" }, { "name": "Prodh2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033677", "id": "NP_001033677" } ], "protein_names": [ { "name": "Hydroxyproline dehydrogenase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q2V057" }, { "name": "1.5.5.2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q2V057" }, { "name": "1.5.5.3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q2V057" }, { "name": "HYPDH", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q2V057" }, { "name": "Probable proline dehydrogenase 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q2V057" }, { "name": "Probable proline oxidase 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q2V057" }, { "name": "Proline oxidase-like protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q2V057" }, { "name": "hydroxyproline dehydrogenase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033677", "id": "NP_001033677" }, { "name": "probable proline dehydrogenase 2; proline oxidase-like protein; probable proline oxidase 2; proline dehydrogenase (oxidase) 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033677", "id": "NP_001033677" } ], "function": [ { "annotation": "Converts proline to delta-1-pyrroline-5-carboxylate.", "evidence": [ { "database": "UniProtKB", "id": "B0BNG1", "url": "https://www.uniprot.org/uniprot/B0BNG1#function" }, { "database": "UniProtKB", "id": "RU364054", "url": "https://www.uniprot.org/uniprot/RU364054#function" } ] }, { "annotation": "Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis.", "evidence": [ { "database": "UniProtKB", "id": "Q2V057", "url": "https://www.uniprot.org/uniprot/Q2V057#function" }, { "database": "UniProtKB", "id": "Q9UF12", "url": "https://www.uniprot.org/uniprot/Q9UF12#function" } ] } ], "disease": [ { "disease_id": "DOID:0060413", "recommended_name": { "id": "DOID:0060413", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060413", "name": "chromosome 22q11.2 deletion syndrome, distal", "description": "A chromosomal deletion syndrome that has_material_basis_in deletion of the chromosome 22q11.2 region, distinct from DiGeorge syndrome and velocardiofacial syndrome." }, "synonyms": [ { "id": "DOID:0060413", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060413", "name": "22q11.2 deletion syndrome", "description": "" }, { "id": "DOID:0060413", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060413", "name": "distal 22q11.2 microdeletion syndrome", "description": "" }, { "id": "MONDO:0012740", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012740", "name": "chromosome 22q11.2 deletion syndrome, distal", "description": "Distal 22q11.2 microdeletion syndrome is a rare chromosomal anomaly syndrome resulting from the partial deletion of the long arm of chromosome 22 with a highly variable phenotype characterized by prematurity, pre- and post-natal growth retardation, developmental delay (particularly speech), mild intellectual disability, variable cardiac defects, and minor skeletal anomalies (such as clinodactyly). Dysmorphic features include prominent forehead, arched eyebrows, deep set eyes, narrow upslanting palpebral fissures, ear abnormalities, hypoplastic alae nasi, smooth philtrum, down-turned mouth, thin upper lip, retro/micrognatia and pointed chin. For certain very distal deletions, there is a risk of developing malignant rhabdoid tumors." }, { "id": "MONDO:0012740", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012740", "name": "chromosome 22q11.2 deletion syndrome, distal", "description": "" }, { "id": "MONDO:0012740", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012740", "name": "distal 22q11.2 microdeletion syndrome", "description": "" }, { "id": "MONDO:0012740", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012740", "name": "distal del(22)(q11.2)", "description": "" }, { "id": "MONDO:0012740", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012740", "name": "distal monosomy 22q11.2", "description": "" }, { "id": "MONDO:0012740", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012740", "name": "distal chromosome 22Q11.2 deletion syndrome", "description": "" } ], "evidence": [ { "id": "0060413", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060413" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "Q2V057", "url": "https://www.uniprot.org/uniprot/Q2V057" } ], "common_name": "Rat" } ], "gene": [ { "name": "Prodh2", "url": "https://www.uniprot.org/uniprot/Q2V057", "locus": { "chromosome": "1", "start_pos": 85767162, "end_pos": 85753644, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000057578", "url": "https://www.ensembl.org/id/ENSRNOG00000057578" } ] } } ], "crossref": [ { "id": "ENSRNOG00000057578", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000057578", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "361538", "url": "https://www.ncbi.nlm.nih.gov/gene/361538", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015659", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015659", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029041", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029041", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:361538", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:361538", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WMQDAAD", "url": "https://omabrowser.org/oma/group/WMQDAAD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5473051at2759", "url": "http://www.orthodb.org/?query=5473051at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13914", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13914", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13914:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13914:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01619", "url": "http://pfam.xfam.org/family/PF01619", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q2V057", "url": "http://purl.obolibrary.org/obo/PR_Q2V057", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-389661", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-389661", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-70688", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-70688", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "1306761", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1306761", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "23784", "url": "https://www.rhea-db.org/rhea/23784", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "52512", "url": "https://www.rhea-db.org/rhea/52512", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "B0BNG1", "url": "https://www.uniprot.org/uniprot/B0BNG1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B0BNG1-1", "url": "https://www.uniprot.org/uniprot/B0BNG1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2V057", "url": "https://www.uniprot.org/uniprot/Q2V057", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2V057-1", "url": "https://www.uniprot.org/uniprot/Q2V057-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIWTRLPLYGHSKPSTGGWQPLRFDGGAFHLKRTAELARALLVLRLCAWPPLVTHGLAFQAWSQRLLGSRLSGALLRASIYGQFVAGETAEEVRGCVQQLQAIGLQPLLAVPTEEEPDSAAKTSEAWYEGNLSAMLHCVDLSRAVADAHGPARNSLMQLKVTALTSPRLCKELSAWIQRPRGSSELRPERLAEAMESGRNLQLSCLSTEQNQHLQASLSRLHRVAQHARAQDVRLLVDAEYTFINPALSLLVAALAMRLDSSEEEGPWVWNTYQAYLKDTHERLERDAKAAHEAGLAFGVKLVRGAYLDKERSVTQLHGKEDCTQPDYEATSRSYSRCLELMLRRVSNHGPRCHLMVASHNEESIRQATRRMWELGIPLDGPVCFGQLLGMCDHVSLALGQAGYMVYKSIPYGCLEEVIPYLIRRAQENRSVLQGARREQALLSQELWRRLLGRTA", "length": 456, "header": "sp|Q2V057-1|HYPDH_RAT Isoform 1 of Hydroxyproline dehydrogenase OS=Rattus norvegicus OX=10116 GN=Prodh2 PE=2 SV=1 CANONICAL=Q2V057-1" }, "isoforms": [ { "isoform_ac": "B0BNG1-1", "url": "", "sequence": { "sequence": "MVWTRLPLYGHSKPSTGGWQPLRFDGGAFHLKRTAELARALLVLRLCAWPPLVTHGLAFQAWSQRLLGSRLSGALLRASIYGQFVAGETAEEVRGCVQQLQAIGLQPLLAVPTEEEPDSAAKTSEAWYEGNLSAMLHCVDLSRAVADAHGPARNSLMQLKVTALTSPRLCKELSAWIQRPRGSSELRPERLAEAMESGRNLQLSCLSTEQNQHLQASLSRLHRVAQHARAQDVRLLVDAEYTFINPALSLLVAALAMRWNSSEEEGPWVWNTYQAYLKDTHERLERDAKAAHEAGLAFGVKLVRGAYLDKERSVTQLHGKEDCTQPDYEATSRSYSRCLELMLRRVSNHGPRCHLMVASHNEESIRQATRRMWELGIPLDGPVCFGQLLGMCDHVSLALGQAGYMVYKSIPYGCLEEVIPYLIRRAQENRSVLQGARREQALLSQELWRRLLGRKA", "length": 456, "header": "tr|B0BNG1-1|HYPDH_RAT Computationally mapped isoform of Hydroxyproline dehydrogenase OS=Rattus norvegicus OX=10116 GN=Prodh2 PE=2 SV=1 CANONICAL=Q2V057-1" }, "locus": { "chromosome": "1", "start_pos": 85767104, "end_pos": 85753654, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000083550.2", "url": "https://www.ensembl.org/id/ENSRNOT00000083550.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000073423.2", "url": "https://www.ensembl.org/id/ENSRNOP00000073423.2" } ] } }, { "isoform_ac": "Q2V057-1", "url": "", "sequence": { "sequence": "MIWTRLPLYGHSKPSTGGWQPLRFDGGAFHLKRTAELARALLVLRLCAWPPLVTHGLAFQAWSQRLLGSRLSGALLRASIYGQFVAGETAEEVRGCVQQLQAIGLQPLLAVPTEEEPDSAAKTSEAWYEGNLSAMLHCVDLSRAVADAHGPARNSLMQLKVTALTSPRLCKELSAWIQRPRGSSELRPERLAEAMESGRNLQLSCLSTEQNQHLQASLSRLHRVAQHARAQDVRLLVDAEYTFINPALSLLVAALAMRLDSSEEEGPWVWNTYQAYLKDTHERLERDAKAAHEAGLAFGVKLVRGAYLDKERSVTQLHGKEDCTQPDYEATSRSYSRCLELMLRRVSNHGPRCHLMVASHNEESIRQATRRMWELGIPLDGPVCFGQLLGMCDHVSLALGQAGYMVYKSIPYGCLEEVIPYLIRRAQENRSVLQGARREQALLSQELWRRLLGRTA", "length": 456, "header": "sp|Q2V057-1|HYPDH_RAT Isoform 1 of Hydroxyproline dehydrogenase OS=Rattus norvegicus OX=10116 GN=Prodh2 PE=2 SV=1 CANONICAL=Q2V057-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "rno:361538", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:361538", "resource": "KEGG Pathway" }, { "id": "R-RNO-389661", "name": "Glyoxylate metabolism and glycine degradation", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-389661", "resource": "Reactome", "description": "Glyoxylate metabolism and glycine degradation" }, { "id": "R-RNO-70688", "name": "Proline catabolism", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-70688", "resource": "Reactome", "description": "Proline catabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8VCZ9-1", "protein_name": "Hydroxyproline dehydrogenase", "gene_name": "Prodh2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIWTRLPLYGPSKPSTGGWQPLRFDGGAFHVKGTAELARALLVLRLCAWPPLVTHGLAFQAWSQRLLGSRLSGALLRASIYGQFVAGETAEEVRNCVGQLQALGLQPLLAVPTEEEPDSTAKTSEVWYEENLSAMLRCVDLSRALVDAHGPARNSLMQLKVTALASTRLCKELSAWIQRPRGSSELSPERLAEAMDSGRNLQLSCLSTEQNQHLQASLSRLHRVAQHARAKCVRLLVDAEYTFINPALSLLVAALAVRWNSPEEGGPWVWNTYQAYLKDTHQRLEQDAEAAHKAGLAFGVKLVRGAYLDKERSMTQLQGKEDCTQPDYEATSRSYSRCLELMLRCVSNHGPPCHLMVASHNEESVRQATKRMWELGIPLDGPVCFGQLLGMCDHVSLALGQAGYMVYKSIPYGCLEEVIPYLIRRAQENRSVLQGARREQALLSQELWRRLLGRTA", "length": 456 }, "evidence": [ { "id": "45239624", "url": "http://www.informatics.jax.org/homology/45239624", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proline catabolic process", "id": "GO:0006562", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006562", "evidence": [ { "database": "UniProtKB", "id": "Q2V057", "url": "https://www.uniprot.org/uniprot/Q2V057" } ], "pmid": "" }, { "name": "proline catabolic process to glutamate", "id": "GO:0010133", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010133", "evidence": [ { "database": "UniProtKB", "id": "Q2V057", "url": "https://www.uniprot.org/uniprot/Q2V057" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "proline dehydrogenase activity", "id": "GO:0004657", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004657", "evidence": [ { "database": "UniProtKB", "id": "Q2V057", "url": "https://www.uniprot.org/uniprot/Q2V057" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on the CH-NH group of donors", "id": "GO:0016645", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016645", "evidence": [ { "database": "UniProtKB", "id": "Q2V057", "url": "https://www.uniprot.org/uniprot/Q2V057" } ], "pmid": "" }, { "name": "FAD binding", "id": "GO:0071949", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071949", "evidence": [ { "database": "UniProtKB", "id": "Q2V057", "url": "https://www.uniprot.org/uniprot/Q2V057" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q2V057", "url": "https://www.uniprot.org/uniprot/Q2V057" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 131, "end_pos": 133, "annotation": "n_glycosylation_sequon" }, { "start_pos": 429, "end_pos": 431, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "23784", "name": "", "equation": "a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2V057-1", "F1MAR6-1", "Q9UF12-1", "O43272-4", "Q8VCZ9-1", "Q9WU79-1", "P09368-1", "Q86H28-1", "Q04499-1" ], "evidence": [ { "id": "23784", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/23784" } ] }, { "id": "52512", "name": "", "equation": "a quinone + trans-4-hydroxy-L-proline = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2V057-1", "Q9UF12-1", "Q8VCZ9-1" ], "evidence": [ { "id": "52512", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52512" } ] }, { "id": "R-RNO-6784224", "name": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane, mitochondrial matrix", "input_participant_list": [ "R-ALL-6784215" ], "output_participant_list": [ "R-ALL-6784241" ], "enzyme_list": [ "Q2V057-1" ], "evidence": [ { "id": "R-RNO-6784224", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6784224" } ] }, { "id": "R-RNO-8955817", "name": "PRODH2 oxidises HPRO to 1PYR-5COOH", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane, mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2V057-1" ], "evidence": [ { "id": "R-RNO-8955817", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8955817" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-6784215", "participant_name": "HPRO [mitochondrial matrix]", "crossref": [ { "id": "000000901791", "database": "ZINC", "url": "" }, { "id": "58419", "database": "ChEBI", "url": "" }, { "id": "000000901736", "database": "ZINC", "url": "" }, { "id": "000000901736", "database": "ZINC", "url": "" }, { "id": "58419", "database": "ChEBI", "url": "" }, { "id": "000000901791", "database": "ZINC", "url": "" }, { "id": "000000901736", "database": "ZINC", "url": "" }, { "id": "58419", "database": "ChEBI", "url": "" }, { "id": "000000901791", "database": "ZINC", "url": "" }, { 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