{ "uniprot_canonical_ac": "Q2MHN3-1", "uniprot_ac": "Q2MHN3", "uniprot_id": "ZFHX2_MOUSE", "mass": { "chemical_mass": 273485.0, "monoisotopic_mass": 273485.0 }, "refseq": { "ac": "NP_001034287", "name": "zinc finger homeobox protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034287" }, "gene_names": [ { "name": "Zfhx2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q2MHN3", "id": "Q2MHN3" }, { "name": "Kiaa1056", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q2MHN3", "id": "Q2MHN3" }, { "name": "ZFH-5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034287", "id": "NP_001034287" }, { "name": "Zfhx2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034287", "id": "NP_001034287" }, { "name": "zfh-5", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q2MHN3", "id": "Q2MHN3" } ], "protein_names": [ { "name": "Zinc finger homeobox protein 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q2MHN3" }, { "name": "Zinc finger homeodomain protein 5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q2MHN3" }, { "name": "zinc finger homeobox protein 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034287", "id": "NP_001034287" }, { "name": "zinc finger homeodomain protein 5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034287", "id": "NP_001034287" } ], "function": [ { "annotation": "Homozygous Zfhx2-deficient mice showed several behavioral abnormalities, namely, hyperactivity, enhanced depression-like behaviors, and an aberrantly altered anxiety-like phenotype", "evidence": [ { "database": "RefSeq", "id": "NP_001034287", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034287" }, { "database": "PubMed", "id": "23300874", "url": "https://glygen.org/publication/PubMed/23300874" } ] }, { "annotation": "Results report features of zfh-5 isolated from the mouse brain; in addition to the mRNA, the antisense strand of zfh-5 is also expressed in the developing brain, in a manner complementary to the expression of zfh-5 mRNA.", "evidence": [ { "database": "RefSeq", "id": "NP_001034287", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034287" }, { "database": "PubMed", "id": "16257534", "url": "https://glygen.org/publication/PubMed/16257534" } ] }, { "annotation": "Transcriptional regulator that is critical for the regulation of pain perception and processing of noxious stimuli.", "evidence": [ { "database": "UniProtKB", "id": "Q2MHN3", "url": "https://www.uniprot.org/uniprot/Q2MHN3#function" }, { "database": "PubMed", "id": "29253101", "url": "https://glygen.org/publication/PubMed/29253101" } ] } ], "disease": [ { "disease_id": "DOID:0081075", "recommended_name": { "id": "DOID:0081075", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0081075", "name": "Marsili syndrome", "description": "A syndrome that is characterized by a lowered ability to sense pain, to experience temperature, and to sweat and that has_material_basis_in heterozygous mutation in the ZFHX2 gene on chromosome 14q11." }, "synonyms": [ { "id": "DOID:0081075", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0081075", "name": "congenital analgesia", "description": "" }, { "id": "DOID:0081075", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0081075", "name": "congenital insensitivity to pain", "description": "" }, { "id": "MONDO:0007828", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007828", "name": "indifference to pain, congenital, autosomal dominant", "description": "" }, { "id": "MONDO:0007828", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007828", "name": "indifference to pain, congenital, autosomal dominant", "description": "" }, { "id": "MONDO:0007828", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007828", "name": "MARSILI syndrome", "description": "" }, { "id": "MONDO:0007828", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007828", "name": "MARSIS", "description": "" }, { "id": "MONDO:0007828", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007828", "name": "Marsili syndrome", "description": "" }, { "id": "MONDO:0007828", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007828", "name": "congenital analgesia, autosomal dominant", "description": "" }, { "id": "MONDO:0007828", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007828", "name": "insensitivity to pain, congenital, autosomal dominant", "description": "" }, { "id": "MIM:147430", "resource": "MIM", "url": "https://www.omim.org/entry/147430", "name": "Marsili syndrome", "description": "Marsili syndrome" } ], "evidence": [ { "id": "0081075", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0081075" } ] }, { "disease_id": "DOID:9970", "recommended_name": { "id": "DOID:9970", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9970", "name": "obesity", "description": "An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness." }, "synonyms": [ { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "inherited obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "genetic obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "genetic obesity (disease)", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "leanness, inherited, autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "monogenic obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, association with, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, early-onset, susceptibility to, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, late-onset, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, mild, early-onset, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, severe, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, severe, and type II diabetes, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, susceptibility to, Autosomal recessive", "description": "" }, { "id": "MIM:601665", "resource": "MIM", "url": "https://www.omim.org/entry/601665", "name": "Obesity", "description": "Obesity" } ], "evidence": [ { "id": "9970", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9970" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 1907, "end_pos": 1907, "sequence_org": "R", "sequence_mut": "K", "comment": "Results in hyposensitivity to noxious heat.", "evidence": [ { "database": "UniProtKB", "id": "Q2MHN3", "url": "https://www.uniprot.org/uniprot/Q2MHN3" }, { "database": "PubMed", "id": "29253101", "url": "https://glygen.org/publication/PubMed/29253101" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q2MHN3", "url": "https://www.uniprot.org/uniprot/Q2MHN3" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Zfhx2", "url": "https://www.uniprot.org/uniprot/Q2MHN3", "locus": { "chromosome": "14", "start_pos": 55297719, "end_pos": 55329781, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000040721", "url": "https://www.ensembl.org/id/ENSMUSG00000040721" } ] } } ], "crossref": [ { "id": "ENSMUSG00000040721", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000040721", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "239102", "url": "https://www.ncbi.nlm.nih.gov/gene/239102", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003604", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003604", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:239102", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:239102", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2686934", "url": "http://www.informatics.jax.org/marker/MGI:2686934", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "Q2MHN3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q2MHN3", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "PDTHLPQ", "url": "https://omabrowser.org/oma/group/PDTHLPQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4180951at2759", "url": "http://www.orthodb.org/?query=4180951at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45891", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45891", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45891:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45891:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "http://pfam.xfam.org/family/PF00046", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q2MHN3", "url": "http://purl.obolibrary.org/obo/PR_Q2MHN3", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001034287", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034287", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2MHN3", "url": "https://www.uniprot.org/uniprot/Q2MHN3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2MHN3-1", "url": "https://www.uniprot.org/uniprot/Q2MHN3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATLNSASPSGTVPSPGHNVRSPPPETSSSSTSDPVTKDPPDAPSTSESIRSSEPGGERLESGSDLDPPKEIGEPQEEPGCGHIPPKDLGVAKEEEEILPLDLSSHLFFAAGGQAYLLANLPLPRGSELSLPKGFPWDEASAKEEPSLPLLTHFPSSHLTTLHIQHGFDPIQGFSSSDQMLSHDTSAPSLAACERRDGSFWSYQLVPNPTEDPKDGPLGSRREDHRAMFWICLLCRLGFGRLQTFIGHTLSHGVKLSPAHHQGLLGSPAVLQEGHDGGMALLSFLEPKFLTRPSPEVPDTSTVTVKTNGAQAEDGPPEADGQALVLPAEEVIALSPPSPPTALATWDPSPTQAKDSPVPRGEAGPDWFPEGQEEDGGLCLPLNQSSPTSKEVAVLPAPAGSPEDTSDPPPSCRLADDYTPAPAAFQGLSLSSHMSLLHSRNSCKTLKCPKCNWHYKYQQTLDVHMREKHPESNSHCSYCSAGGAHPRLARGESYNCGYKPYRCDVCNYSTTTKGNLSIHMQSDKHLANLQGFQAGPGGQASPPEASLPPTSVGDKEPKTKSSWQCKVCSYETNISRNLRIHMTSEKHMQNVLMLHQGLPLGLPPGLVGPGPPPPPGAAPTNPPELFQYFGPQALGQPQTPMPGPGLRPDKPLEAQLLLNGFHHLGAPARKFPTAAPGSLSPETHLPPSQLLGSSSDGLPTSPSPDDSPALKVFRCLVCQAFSTDSLELLLYHCSIGRSLPEAEWKEVAGDTHRCKLCCYGTQLKANFQLHLKTDKHTQKYQLAAHLREGGGAMGTPSLLALGDGASYGSISPLHLRCNICDFESNSKEKMQLHTRGSAHEENSQIYKFLLEMEGAEAGPEPGLYHCLLCAWDTPSRLALLQHLRTPAHRDAQAQRRLQLLQNGPAAEEGLSALQSILSFSHGRLQTPGKASDTPLAQPPTSEKDAQNKTEQQASEVTEDRSGPPRDSANQITVFCCPYCSFLSPECDQVRVHTLSQHAVQPKYRCPLCQEQLVGRPALHFHLSHLHNVVPECVEKLLLVATTVEMTFATKMLPGPTLNPVEDGLDHPAPGAEPTPNRDQVAESSNLAPEVSPDPPLEPPLAPVEGSREPSESPDQPPSPAPSPAPRLDAQVEELAPLPTMSEEEEGAMGEPRSAEPTPADSRHPLTYRKTTNFALDKFLDPARPYKCTVCKESFTQKNILLVHYNSVSHLHKMKKAAIDPSGPARGEAGIPPPAATASDKPFKCTVCRVSYNQSSTLEIHMRSVLHQTRSRGAKIDARAEGAERGQEEFKEGETEGEAGTEKKGPDPGGFMSGLPFLSPPPPPLDLHRFSAPLFTPPVLPPFPLVPESLLKLQQQQLLLPFYLHDLKVGPKLALASPTPMLSLPAANPPPLPAPPKAELAEQEWERPLMAEEGTEAGPSSPTHTSPNEAARTAAKALLENFGFELVIQYNEGKQAVPPPPTPPPPESLGGGDKLACGACGKLFSNMLILKTHEEHVHRRFLPFEALSRYAAQFRKSYDSLYPPPVEPPKPPDGCLESPPQLGPPFVVPEPEVGGIHTSEERSLSGGGPWPSEEEEGSRGSLPPAVPVGRRFSRTKFTEFQTQALQSFFETSAYPKDGEVERLASLLGLASRVVVVWFQNARQKARKNACEGGPVTAGGASGGASGCRRCHATFACVFELVRHLKKCYDDQPPEEEEEAERGEEEEEVEEEEAEERNLEPAAARPGGPSPEHADGEDLSQTEPTRPESKESEGKAPPSPPVYACDQCAASFPSQDLLTTHHRLHLLPSVQPSAPPPSQLLDLPLLVFGERNPVVSGTSSVTGTPLKRKHDDGSLSPTGSEAGGGGEGEPPKDKRLRTTILPEQLEILYRWYMQDSNPTRKMLDCISEEVGLKKRVVQVWFQNTRARERKGQFRSTPGGVAGPAVKPTVPPSPAPFPKFNLLLSKIEDETGKEAPKRDAPAFPYPTVTPAVGPLPFLPPGKEAAVPTPEPPPPLPPPALSEDEGPEEPSKASPESEACSPSAGDLSDSSASSLAEPESPGAGGTSGGPGGGTGVPDSMGQRRYRTQMSSLQLKIMKACYEAYRTPTMQECEVLGEEIGLPKRVIQVWFQNARAKEKKAKLQGTAPPGSGGSSEGTSAAQRTDCPYCDVKYDFYVSCRGHLFSRQHLAKLKEAVRAQLKSESKCYDLAPAPETPLAPKGPPATTPASSVPLGASPTLPRLAPVLLPGPTLAQPPLGSIASFNSGPAASSGLLGLATSVLPATTVVQTAGPGRPLPQRPVSNQTNSSTDPTPGPATEPSGDKVSGERKPVATLPNSSTDALKNLKALKATVPALLGGQFLPFPLPPAGGAAPPAVFGPQLQGAYFQQLYGMKKGLFPMNPVIPQTLIGLLPNALLQQPPQAPEPTATAPPKPPELPASGEGESSEADELLTGSTGISTVDVTHRYLCRQCKMAFDGEAPATAHQRSFCFFGRGSGASMPAPLRVPICTYHCLACEVLLSGREALASHLRSSAHRRKAAPPPGGPPITVTNSATAVPAAVAFAKEEARLPHTDPNPKTTTTSTLLAL", "length": 2562, "header": "sp|Q2MHN3-1|ZFHX2_MOUSE Isoform 1 of Zinc finger homeobox protein 2 OS=Mus musculus OX=10090 GN=Zfhx2 PE=1 SV=1 CANONICAL=Q2MHN3-1" }, "isoforms": [ { "isoform_ac": "Q2MHN3-1", "url": "", "sequence": { "sequence": "MATLNSASPSGTVPSPGHNVRSPPPETSSSSTSDPVTKDPPDAPSTSESIRSSEPGGERLESGSDLDPPKEIGEPQEEPGCGHIPPKDLGVAKEEEEILPLDLSSHLFFAAGGQAYLLANLPLPRGSELSLPKGFPWDEASAKEEPSLPLLTHFPSSHLTTLHIQHGFDPIQGFSSSDQMLSHDTSAPSLAACERRDGSFWSYQLVPNPTEDPKDGPLGSRREDHRAMFWICLLCRLGFGRLQTFIGHTLSHGVKLSPAHHQGLLGSPAVLQEGHDGGMALLSFLEPKFLTRPSPEVPDTSTVTVKTNGAQAEDGPPEADGQALVLPAEEVIALSPPSPPTALATWDPSPTQAKDSPVPRGEAGPDWFPEGQEEDGGLCLPLNQSSPTSKEVAVLPAPAGSPEDTSDPPPSCRLADDYTPAPAAFQGLSLSSHMSLLHSRNSCKTLKCPKCNWHYKYQQTLDVHMREKHPESNSHCSYCSAGGAHPRLARGESYNCGYKPYRCDVCNYSTTTKGNLSIHMQSDKHLANLQGFQAGPGGQASPPEASLPPTSVGDKEPKTKSSWQCKVCSYETNISRNLRIHMTSEKHMQNVLMLHQGLPLGLPPGLVGPGPPPPPGAAPTNPPELFQYFGPQALGQPQTPMPGPGLRPDKPLEAQLLLNGFHHLGAPARKFPTAAPGSLSPETHLPPSQLLGSSSDGLPTSPSPDDSPALKVFRCLVCQAFSTDSLELLLYHCSIGRSLPEAEWKEVAGDTHRCKLCCYGTQLKANFQLHLKTDKHTQKYQLAAHLREGGGAMGTPSLLALGDGASYGSISPLHLRCNICDFESNSKEKMQLHTRGSAHEENSQIYKFLLEMEGAEAGPEPGLYHCLLCAWDTPSRLALLQHLRTPAHRDAQAQRRLQLLQNGPAAEEGLSALQSILSFSHGRLQTPGKASDTPLAQPPTSEKDAQNKTEQQASEVTEDRSGPPRDSANQITVFCCPYCSFLSPECDQVRVHTLSQHAVQPKYRCPLCQEQLVGRPALHFHLSHLHNVVPECVEKLLLVATTVEMTFATKMLPGPTLNPVEDGLDHPAPGAEPTPNRDQVAESSNLAPEVSPDPPLEPPLAPVEGSREPSESPDQPPSPAPSPAPRLDAQVEELAPLPTMSEEEEGAMGEPRSAEPTPADSRHPLTYRKTTNFALDKFLDPARPYKCTVCKESFTQKNILLVHYNSVSHLHKMKKAAIDPSGPARGEAGIPPPAATASDKPFKCTVCRVSYNQSSTLEIHMRSVLHQTRSRGAKIDARAEGAERGQEEFKEGETEGEAGTEKKGPDPGGFMSGLPFLSPPPPPLDLHRFSAPLFTPPVLPPFPLVPESLLKLQQQQLLLPFYLHDLKVGPKLALASPTPMLSLPAANPPPLPAPPKAELAEQEWERPLMAEEGTEAGPSSPTHTSPNEAARTAAKALLENFGFELVIQYNEGKQAVPPPPTPPPPESLGGGDKLACGACGKLFSNMLILKTHEEHVHRRFLPFEALSRYAAQFRKSYDSLYPPPVEPPKPPDGCLESPPQLGPPFVVPEPEVGGIHTSEERSLSGGGPWPSEEEEGSRGSLPPAVPVGRRFSRTKFTEFQTQALQSFFETSAYPKDGEVERLASLLGLASRVVVVWFQNARQKARKNACEGGPVTAGGASGGASGCRRCHATFACVFELVRHLKKCYDDQPPEEEEEAERGEEEEEVEEEEAEERNLEPAAARPGGPSPEHADGEDLSQTEPTRPESKESEGKAPPSPPVYACDQCAASFPSQDLLTTHHRLHLLPSVQPSAPPPSQLLDLPLLVFGERNPVVSGTSSVTGTPLKRKHDDGSLSPTGSEAGGGGEGEPPKDKRLRTTILPEQLEILYRWYMQDSNPTRKMLDCISEEVGLKKRVVQVWFQNTRARERKGQFRSTPGGVAGPAVKPTVPPSPAPFPKFNLLLSKIEDETGKEAPKRDAPAFPYPTVTPAVGPLPFLPPGKEAAVPTPEPPPPLPPPALSEDEGPEEPSKASPESEACSPSAGDLSDSSASSLAEPESPGAGGTSGGPGGGTGVPDSMGQRRYRTQMSSLQLKIMKACYEAYRTPTMQECEVLGEEIGLPKRVIQVWFQNARAKEKKAKLQGTAPPGSGGSSEGTSAAQRTDCPYCDVKYDFYVSCRGHLFSRQHLAKLKEAVRAQLKSESKCYDLAPAPETPLAPKGPPATTPASSVPLGASPTLPRLAPVLLPGPTLAQPPLGSIASFNSGPAASSGLLGLATSVLPATTVVQTAGPGRPLPQRPVSNQTNSSTDPTPGPATEPSGDKVSGERKPVATLPNSSTDALKNLKALKATVPALLGGQFLPFPLPPAGGAAPPAVFGPQLQGAYFQQLYGMKKGLFPMNPVIPQTLIGLLPNALLQQPPQAPEPTATAPPKPPELPASGEGESSEADELLTGSTGISTVDVTHRYLCRQCKMAFDGEAPATAHQRSFCFFGRGSGASMPAPLRVPICTYHCLACEVLLSGREALASHLRSSAHRRKAAPPPGGPPITVTNSATAVPAAVAFAKEEARLPHTDPNPKTTTTSTLLAL", "length": 2562, "header": "sp|Q2MHN3-1|ZFHX2_MOUSE Isoform 1 of Zinc finger homeobox protein 2 OS=Mus musculus OX=10090 GN=Zfhx2 PE=1 SV=1 CANONICAL=Q2MHN3-1" }, "locus": { "chromosome": "14", "start_pos": 55312692, "end_pos": 55300064, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000036328", "url": "https://www.ensembl.org/id/ENSMUST00000036328" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000045156", "url": "https://www.ensembl.org/id/ENSMUSP00000045156" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "Q2MHN3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q2MHN3" }, { "id": "34678516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34678516" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Novel transcription factor zfh-5 is negatively regulated by its own antisense RNA in mouse brain.", "journal": "Mol. Cell. Neurosci.", "date": "2006", "authors": "Komine Y, Nakamura K, Katsuki M, Yamamori T", "evidence": [ { "database": "UniProtKB", "id": "Q2MHN3", "url": "https://www.uniprot.org/uniprot/Q2MHN3" }, { "database": "RefSeq", "id": "NP_001034287", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034287" } ], "reference": [ { "type": "PubMed", "id": "16257534", "url": "https://glygen.org/publication/PubMed/16257534" } ] }, { "title": "Behavioral abnormalities observed in Zfhx2-deficient mice.", "journal": "PLoS ONE", "date": "2012", "authors": "Komine Y, Takao K, Miyakawa T, Yamamori T", "evidence": [ { "database": "UniProtKB", "id": "Q2MHN3", "url": "https://www.uniprot.org/uniprot/Q2MHN3" }, { "database": "RefSeq", "id": "NP_001034287", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034287" } ], "reference": [ { "type": "PubMed", "id": "23300874", "url": "https://glygen.org/publication/PubMed/23300874" } ] }, { "title": "A novel human pain insensitivity disorder caused by a point mutation in ZFHX2.", "journal": "Brain", "date": "2018", "authors": "Habib AM, Matsuyama A, Okorokov AL, Santana-Varela S, Bras JT, Aloisi AM, Emery EC, Bogdanov YD, Follenfant M, Gossage SJ, Gras M, Humphrey J, Kolesnikov A, Le Cann K, Li S, Minett MS, Pereira V, Ponsolles C, Sikandar S, Torres JM, Yamaoka K, Zhao J, Komine Y, Yamamori T, Maniatis N, Panov KI, Houlden H, Ramirez JD, Bennett DLH, Marsili L, Bachiocco V, Wood JN, Cox JJ", "evidence": [ { "database": "UniProtKB", "id": "Q2MHN3", "url": "https://www.uniprot.org/uniprot/Q2MHN3" } ], "reference": [ { "type": "PubMed", "id": "29253101", "url": "https://glygen.org/publication/PubMed/29253101" } ] }, { "title": "Novel Antibodies for the Simple and Efficient Enrichment of Native O-GlcNAc Modified Peptides.", "journal": "Molecular & cellular proteomics : MCP", "date": "2021", "authors": "Burt RA, Dejanovic B, Peckham HJ, Lee KA, Li X, Ounadjela JR, Rao A, Malaker SA, Carr SA, Myers SA", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q2MHN3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q2MHN3" } ], "reference": [ { "type": "PubMed", "id": "34678516", "url": "https://glygen.org/publication/PubMed/34678516" } ] } ], "pathway": [ { "id": "mmu:239102", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:239102", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q9C0A1-1", "protein_name": "Zinc finger homeobox protein 2", "gene_name": "ZFHX2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATLNSASTTGTTPSPGHNAPSLPSDTFSSSTPSDPVTKDPPAASSTSENMRSSEPGGQLLESGCGLVPPKEIGEPQEGPDCGHFPPNDPGVEKDKEQEEEEEGLPPMDLSNHLFFTAGGEAYLVAKLSLPGGSELLLPKGFPWGEAGIKEEPSLPFLAYPPPSHLTALHIQHGFDPIQGFSSSDQILSHDTSAPSPAACEERHGAFWSYQLAPNPPGDPKDGPMGNSGGNHVAVFWLCLLCRLGFSKPQAFMDHTQSHGVKLTPAQYQGLSGSPAVLQEGDEGCKALISFLEPKLPARPSSDIPLDNSSTVNMEANVAQTEDGPPEAEVQALILLDEEVMALSPPSPPTATWDPSPTQAKESPVAAGEAGPDWFPEGQEEDGGLCPPLNQSSPTSKEGGTLPAPVGSPEDPSDPPQPYRLADDYTPAPAAFQGLSLSSHMSLLHSRNSCKTLKCPKCNWHYKYQQTLDVHMREKHPESNSHCSYCSAGGAHPRLARGESYNCGYKPYRCDVCNYSTTTKGNLSIHMQSDKHLANLQGFQAGPGGQGSPPEASLPPSAGDKEPKTKSSWQCKVCSYETNISRNLRIHMTSEKHMQNVLMLHQGLPLGLPPGLMGPGPPPPPGATPTSPPELFQYFGPQALGQPQTPLAGPGLRPDKPLEAQLLLNGFHHVGAPARKFPTSAPGSLSPDAHLPPSQLLGSSSDSLPTSPPPDDSLSLKVFRCLVCQAFSTDSLELLLYHCSIGRSLPEAEWKEVAGDTHRCKLCCYGTQLKANFQLHLKTDKHAQKYQLAAHLREGGGAMGTPSPASLGDGAPYGSVSPLHLRCNICDFESNSKEKMQLHARGAAHEENSQIYKFLLDMEGAEAGAELGLYHCLLCAWETPSRLAVLQHLRTPAHRDAQAQRRLQLLQNGPTTEEGLAALQSILSFSHGQLRTPGKAPVTPLAEPPTPEKDAQNKTEQLASEETENKTGPSRDSANQTTVYCCPYCSFLSPESSQVRAHTLSQHAVQPKYRCPLCQEQLVGRPALHFHLSHLHNVVPECVEKLLLVATTVEMTFTTKVLSAPTLSPLDNGQEPPTHGPEPTPSRDQAAEGPNLTPEASPDPLPEPPLASVEVPDKPSGSPGQPPSPAPSPVPEPDAQAEDVAPPPTMAEEEEGTTGELRSAEPAPADSRHPLTYRKTTNFALDKFLDPARPYKCTVCKESFTQKNILLVHYNSVSHLHKMKKAAIDPSAPARGEAGAPPTTTAATDKPFKCTVCRVSYNQSSTLEIHMRSVLHQTRSRGTKTDSKIEGPERSQEEPKEGETEGEVGTEKKGPDTSGFISGLPFLSPPPPPLDLHRFPAPLFTPPVLPPFPLVPESLLKLQQQQLLLPFYLHDLKVGPKLTLAGPAPVLSLPAATPPPPPQPPKAELAEREWERPPMAKEGNEAGPSSPPDPLPNEAARTAAKALLENFGFELVIQYNEGKQAVPPPPTPPPPEALGGGDKLACGACGKLFSNMLILKTHEEHVHRRFLPFEALSRYAAQFRKSYDSLYPPLAEPPKPPDGSLDSPVPHLGPPFLVPEPEAGGTRAPEERSRAGGHWPIEEEESSRGNLPPLVPAGRRFSRTKFTEFQTQALQSFFETSAYPKDGEVERLASLLGLASRVVVVWFQNARQKARKNACEGGSMPTGGGTGGASGCRRCHATFSCVFELVRHLKKCYDDQTLEEEEEEAERGEEEEEVEEEEVEEEQGLEPPAGPEGPLPEPPDGEELSQAEATKAGGKEPEEKATPSPSPAHTCDQCAISFSSQDLLTSHRRLHFLPSLQPSAPPQLLDLPLLVFGERNPLVAATSPMPGPPLKRKHEDGSLSPTGSEAGGGGEGEPPRDKRLRTTILPEQLEILYRWYMQDSNPTRKMLDCISEEVGLKKRVVQVWFQNTRARERKGQFRSTPGGVPSPAVKPPATATPASLPKFNLLLGKVDDGTGREAPKREAPAFPYPTATLASGPQPFLPPGKEATTPTPEPPLPLLPPPPPSEEEGPEEPPKASPESEACSLSAGDLSDSSASSLAEPESPGAGGTSGGPGGGTGVPDGMGQRRYRTQMSSLQLKIMKACYEAYRTPTMQECEVLGEEIGLPKRVIQVWFQNARAKEKKAKLQGTAAGSTGGSSEGLLAAQRTDCPYCDVKYDFYVSCRGHLFSRQHLAKLKEAVRAQLKSESKCYDLAPAPEAPPALKAPPATTPASMPLGAAPTLPRLAPVLLSGPALAQPPLGNLAPFNSGPAASSGLLGLATSVLPTTTVVQTAGPGRPLPQRPMPDQTNTSTAGTTDPVPGPPTEPLGDKVSSERKPVAGPTSSSNDALKNLKALKTTVPALLGGQFLPFPLPPAGGTAPPAVFGPQLQGAYFQQLYGMKKGLFPMNPMIPQTLIGLLPNALLQPPPQPPEPTATAPPKPPELPAPGEGEAGEVDELLTGSTGISTVDVTHRYLCRQCKMAFDGEAPATAHQRSFCFFGRGSGGSMPPPLRVPICTYHCLACEVLLSGREALASHLRSSAHRRKAAPPQGGPPISITNAATAASAAVAFAKEEARLPHTDSNPKTTTTSTLLAL", "length": 2572 }, "evidence": [ { "id": "45239576", "url": "http://www.informatics.jax.org/homology/45239576", "database": "MGI" }, { "id": "Q2MHN3", "url": "https://omabrowser.org/oma/group/Q2MHN3/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2MHN3", "url": "https://www.uniprot.org/uniprot/Q2MHN3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q2MHN3", "url": "https://www.uniprot.org/uniprot/Q2MHN3" } ], "pmid": "" }, { "name": "adult behavior", "id": "GO:0030534", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030534", 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