{ "uniprot_canonical_ac": "Q24352-1", "uniprot_ac": "Q24352", "uniprot_id": "GBRAL_DROME", "mass": { "chemical_mass": 76558.0, "monoisotopic_mass": 76558.0 }, "refseq": { "ac": "NP_524131", "name": "glycine receptor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524131" }, "gene_names": [ { "name": "Grd", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q24352", "id": "Q24352" }, { "name": "CG7446; CT22917; Dmel\\CG7446; DmGABA(GRD); GRD", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524131", "id": "NP_524131" }, { "name": "CG7446", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q24352", "id": "Q24352" }, { "name": "Grd", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524131", "id": "NP_524131" } ], "protein_names": [ { "name": "Gamma-aminobutyric acid receptor alpha-like", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q24352" }, { "name": "CG7446-PA; Grd-PA; GABA-and-glycine-receptor-like-subunit-of-Drosophila; GABA and glycine-like receptor of drosophila; GABA/Glycine-gated chloride channel-like", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524131", "id": "NP_524131" }, { "name": "GABA(A) receptor alpha-like and glycine receptor-like subunit of Drosophila", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q24352" }, { "name": "GRD", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q24352" }, { "name": "glycine receptor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524131", "id": "NP_524131" } ], "function": [ { "annotation": "GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. May combine with the ligand-gated ion channel subunit Lcch3 to form cation-selective GABA-gated ion channels.", "evidence": [ { "database": "UniProtKB", "id": "Q24352", "url": "https://www.uniprot.org/uniprot/Q24352#function" }, { "database": "PubMed", "id": "15148245", "url": "https://glygen.org/publication/PubMed/15148245" } ] } ], "disease": [ { "disease_id": "DOID:0080431", "recommended_name": { "id": "DOID:0080431", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080431", "name": "developmental and epileptic encephalopathy 19", "description": "A developmental and epileptic encephalopathy characterized by onset of seizures in the first year of life and mild to moderate impaired intellectual development that has_material_basis_in heterozygous mutation in the GABRA1 gene on chromosome 5q34." }, "synonyms": [ { "id": "DOID:0080431", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080431", "name": "early infantile epileptic encephalopathy 19", "description": "" }, { "id": "DOID:0080431", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080431", "name": "DEE19", "description": "" }, { "id": "MONDO:0014328", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014328", "name": "developmental and epileptic encephalopathy, 19", "description": "Any early infantile epileptic encephalopathy in which the cause of the disease is a mutation in the GABRA1 gene." }, { "id": "MONDO:0014328", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014328", "name": "DEE19", "description": "" }, { "id": "MONDO:0014328", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014328", "name": "EIEE19", "description": "" }, { "id": "MONDO:0014328", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014328", "name": "Early Infantile epileptic encephalopathy 19", "description": "" }, { "id": "MONDO:0014328", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014328", "name": "GABRA1 early infantile epileptic encephalopathy", "description": "" }, { "id": "MONDO:0014328", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014328", "name": "developmental and epileptic encephalopathy 19", "description": "" }, { "id": "MONDO:0014328", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014328", "name": "early infantile epileptic encephalopathy caused by mutation in GABRA1", "description": "" }, { "id": "MONDO:0014328", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014328", "name": "epileptic encephalopathy, early infantile, 19", "description": "" }, { "id": "MONDO:0014328", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014328", "name": "epileptic encephalopathy, early infantile, type 19", "description": "" }, { "id": "MIM:615744", "resource": "MIM", "url": "https://www.omim.org/entry/615744", "name": "Developmental and epileptic encephalopathy 19", "description": "Developmental and epileptic encephalopathy 19" } ], "evidence": [ { "id": "0080431", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0080431" } ] }, { "disease_id": "DOID:0111314", "recommended_name": { "id": "DOID:0111314", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111314", "name": "idiopathic generalized epilepsy 13", "description": "An idiopathic generalized epilepsy that has_material_basis_in heterozygous mutation in the GABRA1 on chromosome 5q34." }, "synonyms": [ { "id": "DOID:0111314", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111314", "name": "EIG13", "description": "" }, { "id": "MONDO:0012627", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012627", "name": "epilepsy, idiopathic generalized, susceptibility to, 13", "description": "An inherited susceptibility or predisposition to developing juvenile myclonic epilepsy, idiopathic generalized epilepsy, or childhood absence epilepsy in which the cause of the disease is a mutation in the GABRA1 gene." }, { "id": "MONDO:0012627", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012627", "name": "EIG13", "description": "" }, { "id": "MONDO:0012627", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012627", "name": "epilepsy, idiopathic generalized, susceptibility to, 13", "description": "" }, { "id": "MONDO:0012627", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012627", "name": "epilepsy, idiopathic generalized, susceptibility to, type 13", "description": "" }, { "id": "MONDO:0012627", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012627", "name": "susceptibility to idiopathic generalised epilepsy 13", "description": "" }, { "id": "MONDO:0012627", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012627", "name": "susceptibility to idiopathic generalized epilepsy 13", "description": "" }, { "id": "MONDO:0012627", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012627", "name": "GABRA1 juvenile myoclonic epilepsy", "description": "" }, { "id": "MONDO:0012627", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012627", "name": "epilepsy, childhood absence, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012627", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012627", "name": "epilepsy, juvenile myoclonic, susceptibility to, 5", "description": "" }, { "id": "MONDO:0012627", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012627", "name": "juvenile myoclonic epilepsy caused by mutation in GABRA1", "description": "" }, { "id": "MIM:611136", "resource": "MIM", "url": "https://www.omim.org/entry/611136", "name": "Epilepsy, childhood absence 4", "description": "Epilepsy, childhood absence 4" } ], "evidence": [ { "id": "0111314", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0111314" } ] }, { "disease_id": "DOID:0112215", "recommended_name": { "id": "DOID:0112215", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112215", "name": "developmental and epileptic encephalopathy 79", "description": "A developmental and epileptic encephalopathy characterized by onset in the first months of life of refractory seizures, severely impaired psychomotor development, hypomyelination, cerebral atrophy, and thinning of the corpus callosum that has_material_basis_in heterozygous mutation in the GABRA5 gene on chromosome 15q12." }, "synonyms": [ { "id": "DOID:0112215", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112215", "name": "DEE79", "description": "" }, { "id": "DOID:0112215", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112215", "name": "early infantile epileptic encephalopathy 79", "description": "" }, { "id": "MONDO:0032813", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032813", "name": "developmental and epileptic encephalopathy, 79", "description": "" }, { "id": "MONDO:0032813", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032813", "name": "DEE79", "description": "" }, { "id": "MONDO:0032813", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032813", "name": "EIEE79", "description": "" }, { "id": "MONDO:0032813", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032813", "name": "EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 79", "description": "" }, { "id": "MONDO:0032813", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032813", "name": "developmental and epileptic encephalopathy 79", "description": "" }, { "id": "MONDO:0032813", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032813", "name": "epileptic encephalopathy, early infantile, 79", "description": "" }, { "id": "MIM:618559", "resource": "MIM", "url": "https://www.omim.org/entry/618559", "name": "Developmental and epileptic encephalopathy 79", "description": "Developmental and epileptic encephalopathy 79" } ], "evidence": [ { "id": "0112215", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0112215" } ] }, { "disease_id": "DOID:12849", "recommended_name": { "id": "DOID:12849", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12849", "name": "autistic disorder", "description": "An autism spectrum disorder that is characterized by symptoms across all three symptom domains (communication, social, restricted repetitive interests and behaviors), delayed language development, and symptom onset prior to age 3 years." }, "synonyms": [ { "id": "DOID:12849", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12849", "name": "Kanner's syndrome", "description": "" }, { "id": "DOID:12849", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12849", "name": "autism", "description": "" }, { "id": "DOID:12849", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12849", "name": "autistic disorder of childhood onset", "description": "" }, { "id": "DOID:12849", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12849", "name": "childhood autism", "description": "" }, { "id": "DOID:12849", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12849", "name": "infantile autism", "description": "" }, { "id": "MONDO:0005260", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005260", "name": "autism", "description": "Persistent deficits in social interaction and communication and interaction as well as a markedly restricted repertoire of activity and interest as well as repetitive patterns of behavior." }, { "id": "MONDO:0005260", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005260", "name": "autism spectrum disorder", "description": "" }, { "id": "MONDO:0005260", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005260", "name": "Kanner's syndrome", "description": "" }, { "id": "MONDO:0005260", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005260", "name": "autism", "description": "" }, { "id": "MONDO:0005260", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005260", "name": "autism (disease)", "description": "" }, { "id": "MONDO:0005260", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005260", "name": "autistic disorder of childhood onset", "description": "" }, { "id": "MONDO:0005260", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005260", "name": "childhood autism", "description": "" }, { "id": "MONDO:0005260", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005260", "name": "infantile autism", "description": "" }, { "id": "MONDO:0005260", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005260", "name": "autism, susceptiblity to", "description": "" }, { "id": "MONDO:0005260", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005260", "name": "autistic disorder", "description": "" } ], "evidence": [ { "id": "12849", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:12849" } ] }, { "disease_id": "DOID:1596", "recommended_name": { "id": "DOID:1596", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1596", "name": "depressive disorder", "description": "A mood disorder characterized by persistent sadness, emptiness, or irritability and decreased ability to function." }, "synonyms": [ { "id": "DOID:1596", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1596", "name": "mental depression", "description": "" } ], "evidence": [ { "id": "1596", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1596" } ] }, { "disease_id": "DOID:1826", "recommended_name": { "id": "DOID:1826", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1826", "name": "epilepsy", "description": "A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions." }, "synonyms": [ { "id": "DOID:1826", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1826", "name": "epilepsy syndrome", "description": "" }, { "id": "DOID:1826", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1826", "name": "epileptic syndrome", "description": "" } ], "evidence": [ { "id": "1826", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1826" } ] }, { "disease_id": "DOID:1827", "recommended_name": { "id": "DOID:1827", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1827", "name": "idiopathic generalized epilepsy", "description": "An epilepsy syndrome that is characterised by generalised seizures with no apparent cause which arise from many independent foci (multifocal epilepsies) or from epileptic circuits that involve the whole brain." }, "synonyms": [ { "id": "DOID:1827", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1827", "name": "Generalised epilepsy", "description": "" }, { "id": "MONDO:0005579", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005579", "name": "epilepsy, idiopathic generalized", "description": "A chronic condition characterized by recurrent generalized seizures." }, { "id": "MONDO:0005579", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005579", "name": "EIG", "description": "" }, { "id": "MONDO:0005579", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005579", "name": "epilepsy, idiopathic generalized", "description": "" }, { "id": "MONDO:0005579", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005579", "name": "generalised epilepsy", "description": "" }, { "id": "MONDO:0005579", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005579", "name": "generalized epilepsy", "description": "" }, { "id": "MONDO:0005579", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005579", "name": "idiopathic generalised epilepsy", "description": "" }, { "id": "MONDO:0005579", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005579", "name": "idiopathic generalized epilepsy", "description": "" } ], "evidence": [ { "id": "1827", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1827" } ] }, { "disease_id": "DOID:2377", "recommended_name": { "id": "DOID:2377", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2377", "name": "multiple sclerosis", "description": "A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring." }, "synonyms": [ { "id": "DOID:2377", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2377", "name": "Generalized multiple sclerosis", "description": "" }, { "id": "DOID:2377", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2377", "name": "insular sclerosis", "description": "" }, { "id": "MONDO:0012957", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012957", "name": "multiple sclerosis, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012957", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012957", "name": "MS3", "description": "" }, { "id": "MONDO:0012957", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012957", "name": "multiple sclerosis, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012956", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012956", "name": "multiple sclerosis, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012956", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012956", "name": "MS2", "description": "" }, { "id": "MONDO:0012956", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012956", "name": "multiple sclerosis, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012958", "name": "multiple sclerosis, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012958", "name": "MS4", "description": "" }, { "id": "MONDO:0012958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012958", "name": "multiple sclerosis, susceptibility to, 4", "description": "" }, { "id": "MIM:612595", "resource": "MIM", "url": "https://www.omim.org/entry/612595", "name": "Multiple sclerosis 3", "description": "Multiple sclerosis 3" } ], "evidence": [ { "id": "2377", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2377" } ] }, { "disease_id": "DOID:3312", "recommended_name": { "id": "DOID:3312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3312", "name": "bipolar disorder", "description": "A mood disorder that involves alternating periods of mania and depression." }, "synonyms": [ { "id": "DOID:3312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3312", "name": "Manic Bipolar Affective disorder", "description": "" }, { "id": "DOID:3312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3312", "name": "Manic Depressive disorder", "description": "" }, { "id": "DOID:3312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3312", "name": "Manic bipolar I disorder", "description": "" }, { "id": "DOID:3312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3312", "name": "bipolar depression", "description": "" }, { "id": "DOID:3312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3312", "name": "bipolar disorder manic phase", "description": "" }, { "id": "DOID:3312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3312", "name": "manic depression", "description": "" }, { "id": "DOID:3312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3312", "name": "manic disorder", "description": "" }, { "id": "DOID:3312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3312", "name": "mixed bipolar disorder", "description": "" } ], "evidence": [ { "id": "3312", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3312" } ] }, { "disease_id": "DOID:7725", "recommended_name": { "id": "DOID:7725", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:7725", "name": "epilepsy with generalized tonic-clonic seizures", "description": "An adolescence-adult electroclinical syndrome 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"https://www.uniprot.org/uniprot/Q24352-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCTMPATRDASGSGDASTDLIAARSLSSHQGQRSNLRIFKLLISCCLLMLCIYPNAWPWSIGPGSGPFSVSADSIKGRGDTHRLGEMGTSLSSSLPSSWLTQSNNHANISELLDNLLRGYDNSIRPDFGGPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVDKRLAFEGAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLTIKAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMKLSQFDLVDCPAGNLTDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGSGSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATADRVSLGITTVLTMTFLGLEARTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHYYTKYGSGECYFIIEELDSESGESETEPLTSDFRGSTESKIYEVIPLSMCAISMPPPPTRLGMLTSRNRRPRNRRHGLWSMKLLGLFDWRRRRKPPRADSDEDEDDEQTQLRANEAPTTSAAAAAAQAAAQAARISPPTGGRRRMSYYRREEMEARRKGKRTPQYNSVSKIDRASRIVFPLLFILINVFYWYGYLSRSSRILANTPDAST", "length": 686, "header": "sp|Q24352-1|GBRAL_DROME Isoform 1 of Gamma-aminobutyric acid receptor alpha-like OS=Drosophila melanogaster OX=7227 GN=Grd PE=1 SV=1 CANONICAL=Q24352-1" }, 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17838674, "end_pos": 17829314, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0075139", "url": "https://www.ensembl.org/id/FBtr0075139" }, { "database": "Ensembl Peptide", "id": "FBpp0074905", "url": "https://www.ensembl.org/id/FBpp0074905" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 108, "start_aa": "Asn", "end_pos": 108, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn108", "evidence": [ { "id": "Q24352", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24352#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 292, "start_aa": "Asn", "end_pos": 292, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn292", "evidence": [ { "id": "Q24352", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24352#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "The genome sequence of Drosophila melanogaster.", "journal": "Science", "date": "2000", "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC", "evidence": [ { "database": "UniProtKB", "id": "Q24352", "url": "https://www.uniprot.org/uniprot/Q24352" } ], "reference": [ { "type": "PubMed", "id": "10731132", "url": "https://glygen.org/publication/PubMed/10731132" } ] }, { "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.", "journal": "Genome Biol.", "date": "2002", "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE", "evidence": [ { "database": "UniProtKB", "id": "Q24352", "url": "https://www.uniprot.org/uniprot/Q24352" } ], "reference": [ { "type": "PubMed", "id": "12537572", "url": "https://glygen.org/publication/PubMed/12537572" } ] }, { "title": "Drosophila melanogaster GRD and LCCH3 subunits form heteromultimeric GABA-gated cation channels.", "journal": "Br. J. Pharmacol.", "date": "2004", "authors": "Hatt H., Gisselmann G., Pusch H., Plonka J.", "evidence": [ { "database": "UniProtKB", "id": "Q24352", "url": "https://www.uniprot.org/uniprot/Q24352" } ], "reference": [ { "type": "PubMed", "id": "15148245", "url": "https://glygen.org/publication/PubMed/15148245" } ] }, { "title": "Sequence of a Drosophila ligand-gated ion-channel polypeptide with an unusual amino-terminal extracellular domain.", "journal": "J. Neurochem.", "date": "1994", "authors": "Schmitt B., Harvey R.J., Gundelfinger E.D., Hermans-Borgmeyer I., Betz H., Darlison M.G.", "evidence": [ { "database": "UniProtKB", "id": "Q24352", "url": "https://www.uniprot.org/uniprot/Q24352" } ], "reference": [ { "type": "PubMed", "id": "8189252", "url": "https://glygen.org/publication/PubMed/8189252" } ] } ], "pathway": [ { "id": "dme:Dmel_CG7446", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG7446", "resource": "KEGG Pathway" }, { "id": "R-DME-977443", "name": "GABA receptor activation", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-977443", "resource": "Reactome", "description": "GABA receptor activation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "extracellularly glycine-gated ion channel activity", "id": "GO:0016933", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016933", "evidence": [ { "database": 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