{ "uniprot_canonical_ac": "Q24087-1", "uniprot_ac": "Q24087", "uniprot_id": "XPF_DROME", "mass": { "chemical_mass": 109519.0, "monoisotopic_mass": 109519.0 }, "refseq": { "ac": "NP_001284859", "name": "meiotic 9, isoform B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284859" }, "gene_names": [ { "name": "mei-9", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q24087", "id": "Q24087" }, { "name": "CG3697; DhR1; Dmel\\CG3697; DmXPF; Mei-9; MEI-9; mei9; mus(1)110; mus110; Rad1p; xpf/mei-9", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284859", "id": "NP_001284859" }, { "name": "CG3697", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q24087", "id": "Q24087" }, { "name": "DhR1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q24087", "id": "Q24087" }, { "name": "DmXPF", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q24087", "id": "Q24087" }, { "name": "Dmel\\CG3697", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q24087", "id": "Q24087" }, { "name": "Dmel_CG3697", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q24087", "id": "Q24087" }, { "name": "MEI-9", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q24087", "id": "Q24087" }, { "name": "Mei-9", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q24087", "id": "Q24087" }, { "name": "Rad1p", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q24087", "id": "Q24087" }, { "name": "mei-9-RA", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q24087", "id": "Q24087" }, { "name": "mei-9", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284859", "id": "NP_001284859" }, { "name": "mei-9", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q24087", "id": "Q24087" }, { "name": "mei9", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q24087", "id": "Q24087" }, { "name": "mus(1)110", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q24087", "id": "Q24087" }, { "name": "mus110", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q24087", "id": "Q24087" } ], "protein_names": [ { "name": "DNA repair endonuclease XPF", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q24087" }, { "name": "3.1.-.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q24087" }, { "name": "CG3697-PB; mei-9-PB; meiotic-9", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284859", "id": "NP_001284859" }, { "name": "Protein meiotic 9", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q24087" }, { "name": "meiotic 9, isoform B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284859", "id": "NP_001284859" } ], "function": [ { "annotation": "Implicated in recombination events during meiosis, mostly in meiotic exchange. May directly resolve Holliday junctions within recombination intermediates leading to DNA exchange. Also required for the repair of mismatches within meiotic heteroduplex DNA and for nucleotide excision repair.", "evidence": [ { "database": "UniProtKB", "id": "Q24087", "url": "https://www.uniprot.org/uniprot/Q24087#function" } ] } ], "disease": [ { "disease_id": "DOID:0050427", "recommended_name": { "id": "DOID:0050427", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050427", "name": "xeroderma pigmentosum", "description": "A syndrome that is characterized by a deficiency in the ability to repair ultraviolet damage that has_material_basis_in autosomal recessive inheritance of DNA repair." }, "synonyms": [], "evidence": [ { "id": "0050427", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050427" } ] }, { "disease_id": "DOID:0060590", "recommended_name": { "id": "DOID:0060590", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060590", "name": "XFE progeroid syndrome", "description": "A progeroid syndrome that is characterized by aged bird-like facies, lack of subcutaneous fat, dwarfism, cachexia and microcephaly and that has_material_basis_in homozygous mutation in the ERCC4 gene on chromosome 16p13." }, "synonyms": [ { "id": "DOID:0060590", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060590", "name": "XFEPS", "description": "" }, { "id": "DOID:0060590", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060590", "name": "XPF-ERCC1 progeroid syndrome", "description": "" }, { "id": "MONDO:0012590", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012590", "name": "XFE progeroid syndrome", "description": "A syndrome characterized by aged bird-like facies, lack of subcutaneous fat, dwarfism, cachexia and microcephaly. Additional features include sun-sensitivity from birth, learning disabilities, hearing loss, and visual impairment. It has material basis in homozygous mutation in the ERCC4 gene on chromosome 16p13." }, { "id": "MONDO:0012590", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012590", "name": "XFE progeroid syndrome", "description": "" }, { "id": "MONDO:0012590", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012590", "name": "XFEPS", "description": "" }, { "id": "MONDO:0012590", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012590", "name": "XPF-ERCC1 progeroid syndrome", "description": "" }, { "id": "MIM:610965", "resource": "MIM", "url": "https://www.omim.org/entry/610965", "name": "XFE progeroid syndrome", "description": "XFE progeroid syndrome" } ], "evidence": [ { "id": "0060590", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060590" } ] }, { "disease_id": "DOID:0110848", "recommended_name": { "id": "DOID:0110848", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110848", "name": "xeroderma pigmentosum group F", "description": "A xeroderma pigmentosum characterized by milder symptoms and later onset of skin cancer that has_material_basis_in homozygous or compound heterozygous mutation in the ERCC4 gene on chromosome 16p13." }, "synonyms": [ { "id": "DOID:0110848", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110848", "name": "XP group F", "description": "" }, { "id": "DOID:0110848", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110848", "name": "XP6", "description": "" }, { "id": "DOID:0110848", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110848", "name": "XPF", "description": "" }, { "id": "DOID:0110848", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110848", "name": "xeroderma pigmentosum VI", "description": "" }, { "id": "MONDO:0010215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010215", "name": "xeroderma pigmentosum group F", "description": "Any xeroderma pigmentosum in which the cause of the disease is a mutation in the ERCC4 gene." }, { "id": "MONDO:0010215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010215", "name": "ERCC4 xeroderma pigmentosum", "description": "" }, { "id": "MONDO:0010215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010215", "name": "XP group F", "description": "" }, { "id": "MONDO:0010215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010215", "name": "XP, group F", "description": "" }, { "id": "MONDO:0010215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010215", "name": "XP-F", "description": "" }, { "id": "MONDO:0010215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010215", "name": "XP6", "description": "" }, { "id": "MONDO:0010215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010215", "name": "XPF", "description": "" }, { "id": "MONDO:0010215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010215", "name": "xeroderma pigmentosum VI", "description": "" }, { "id": "MONDO:0010215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010215", "name": "xeroderma pigmentosum caused by mutation in ERCC4", "description": "" }, { "id": "MONDO:0010215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010215", "name": "xeroderma pigmentosum group F", "description": "" }, { "id": "MONDO:0010215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010215", "name": "xeroderma pigmentosum group type F", "description": "" }, { "id": "MONDO:0010215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010215", "name": "xeroderma pigmentosum, complementation group type F", "description": "" }, { "id": "MONDO:0010215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010215", "name": "xeroderma pigmentosum, group F", "description": "" }, { "id": "MONDO:0010215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010215", "name": "xeroderma pigmentosum 6", "description": "" }, { "id": "MONDO:0010215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010215", "name": "xeroderma pigmentosum, complementation group F", "description": "" }, { "id": "MONDO:0010215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010215", "name": "xeroderma pigmentosum, type 6", "description": "" }, { "id": "MONDO:0010215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010215", "name": "xeroderma pigmentosum, type F/Cockayne syndrome", "description": "" }, { "id": "MIM:278760", "resource": "MIM", "url": "https://www.omim.org/entry/278760", "name": "Xeroderma pigmentosum complementation group F", "description": "Xeroderma pigmentosum complementation group F" } ], "evidence": [ { "id": "0110848", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0110848" } ] }, { "disease_id": "DOID:0111093", "recommended_name": { "id": "DOID:0111093", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111093", "name": "Fanconi anemia complementation group Q", "description": "A Fanconi anemia that has_material_basis_in compound heterozygous mutation in the ERCC4 gene on chromosome 16p13." }, "synonyms": [ { "id": "DOID:0111093", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111093", "name": "FANCQ", "description": "" }, { "id": "MONDO:0014108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014108", "name": "Fanconi anemia complementation group Q", "description": "Any Fanconi anemia in which the cause of the disease is a mutation in the ERCC4 gene." }, { "id": "MONDO:0014108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014108", "name": "ERCC4 Fanconi anaemia", "description": "" }, { "id": "MONDO:0014108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014108", "name": "ERCC4 Fanconi anemia", "description": "" }, { "id": "MONDO:0014108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014108", "name": "FANCQ", "description": "" }, { "id": "MONDO:0014108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014108", "name": "Fanconi Anemia, complementation group type Q", "description": "" }, { "id": "MONDO:0014108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014108", "name": "Fanconi anaemia caused by mutation in ERCC4", "description": "" }, { "id": "MONDO:0014108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014108", "name": "Fanconi anaemia complementation group type Q", "description": "" }, { "id": "MONDO:0014108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014108", "name": "Fanconi anemia caused by mutation in ERCC4", "description": "" }, { "id": "MONDO:0014108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014108", "name": "Fanconi anemia complementation group type Q", "description": "" }, { "id": "MONDO:0014108", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014108", "name": "Fanconi anemia, complementation group Q", "description": "" }, { "id": "MIM:615272", "resource": "MIM", "url": "https://www.omim.org/entry/615272", "name": "Fanconi anemia complementation group Q", "description": "Fanconi anemia complementation group Q" } ], "evidence": [ { "id": "0111093", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0111093" } ] }, { "disease_id": "DOID:13636", "recommended_name": { "id": "DOID:13636", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13636", "name": "Fanconi anemia", "description": "A congenital hypoplastic anemia characterized by progressive pancytopenia with bone marrow failure, variable congenital malformations and predisposition to develop hematological or solid tumors. It is a result of a genetic defect in a cluster of proteins responsible for DNA repair." }, "synonyms": [ { "id": "DOID:13636", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13636", "name": "Fanconi anaemia", "description": "" }, { "id": "DOID:13636", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13636", "name": "Fanconi pancytopenia", "description": "" }, { "id": "DOID:13636", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13636", "name": "Fanconi panmyelopathy", "description": "" }, { "id": "DOID:13636", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13636", "name": "Fanconi's anaemia", "description": "" }, { "id": "DOID:13636", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13636", "name": "Fanconi's anemia", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi anemia complementation group A", "description": "Fanconi anemia caused by mutations of the FANCA gene. FANCA gene mutations are the most common cause of Fanconi anemia. This gene provides instructions for making a protein that is involved in the Fanconi anemia (FA) pathway." }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "FANCA", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "FANCA Fanconi anaemia", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "FANCA Fanconi anemia", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi Anemia, complementation group type a", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi anaemia caused by mutation in FANCA", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi anaemia complementation group type A", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi anemia caused by mutation in FANCA", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi anemia complementation group A", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi anemia complementation group type A", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Estren-Dameshek variant of Fanconi Anaemia", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Estren-Dameshek variant of Fanconi Anemia", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Estren-Dameshek variant of Fanconi pancytopenia", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi Anaemia", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi Anemia", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi Anemia, Estren-Dameshek variant", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi anemia, complementation group A", "description": "" }, { "id": "MIM:227650", "resource": "MIM", "url": "https://www.omim.org/entry/227650", "name": "Fanconi anemia, complementation group A", "description": "Fanconi anemia, complementation group A" } ], "evidence": [ { "id": "13636", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:13636" } ] }, { "disease_id": "DOID:14184", "recommended_name": { "id": "DOID:14184", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:14184", "name": "polyneuropathy due to drug", "description": "" }, "synonyms": [], "evidence": [ { "id": "14184", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:14184" } ] }, { "disease_id": "DOID:162", "recommended_name": { "id": "DOID:162", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:162", "name": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis." }, "synonyms": [ { "id": "DOID:162", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:162", "name": "malignant neoplasm", "description": "" }, { "id": "DOID:162", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:162", "name": "malignant tumor", "description": "" }, { "id": "DOID:162", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:162", "name": "primary cancer", "description": "" } ], "evidence": [ { "id": "162", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:162" } ] }, { "disease_id": "DOID:1793", "recommended_name": { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas." }, "synonyms": [ { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreas neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic tumor", "description": "" } ], "evidence": [ { "id": "1793", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1793" } ] }, { "disease_id": "DOID:2962", "recommended_name": { "id": "DOID:2962", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2962", "name": "Cockayne syndrome", "description": "A syndrome that is characterized by an abnormally small head size (microcephaly), a failure to gain weight and grow at the expected rate (failure to thrive) leading to very short stature, and delayed development." }, "synonyms": [ { "id": "DOID:2962", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2962", "name": "Neill-Dingwall syndrome", "description": "" } ], "evidence": [ { "id": "2962", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2962" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ], "evidence": [ { "id": "9256", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q24087", "url": "https://www.uniprot.org/uniprot/Q24087" } ], "common_name": "Fruit fly" } ], "gene": [ { "name": "mei-9", "url": "https://www.uniprot.org/uniprot/Q24087", "locus": { "chromosome": "X", "start_pos": 4314230, "end_pos": 4318801, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0002707", "url": "https://www.ensembl.org/id/FBgn0002707" } ] } } ], "crossref": [ { "id": "FBgn0002707", "url": "https://bgee.org/?page=gene&gene_id=FBgn0002707", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20078", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20078", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "FBgn0002707", "url": "https://flybase.org/reports/FBgn0002707", "database": "FlyBase", "categories": [ "Organism-specific" ] }, { "id": "31373", "url": "https://www.ncbi.nlm.nih.gov/gene/31373", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q24087", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q24087*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR006166", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006166", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006167", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006167", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010994", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010994", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011335", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011335", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047520", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047520", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG3697", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG3697", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CVTKKFH", "url": "https://omabrowser.org/oma/group/CVTKKFH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "277005at2759", "url": "http://www.orthodb.org/?query=277005at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10150", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10150", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10150:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10150:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02732", "url": "http://pfam.xfam.org/family/PF02732", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q24087", "url": "http://purl.obolibrary.org/obo/PR_Q24087", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DME-5696395", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5696395", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-5696400", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5696400", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-6782135", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-6782135", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001284859", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284859", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q24087", "url": "https://www.uniprot.org/uniprot/Q24087", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q24087-1", "url": "https://www.uniprot.org/uniprot/Q24087-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "T2FFI3", "url": "https://www.uniprot.org/uniprot/T2FFI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "T2FFI3-1", "url": "https://www.uniprot.org/uniprot/T2FFI3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADSCAENAAKGTENERPKEVEASADTVPQVEEGVEEYLKRKNMVLLDYEKQMFLDLVEADGLLVCAKGLSYDRVVISILKAYSDSGNLVLVINSSDWEEQYYKSKIEPKYVHEVASTATERERVYLEGGLQFISTRILVVDLLKQRIPIELISGIIVLRAHTIIESCQEAFALRLFRQKNKTGFVKAFSSSPEAFTIGYSHVERTMRNLFVKHLYIWPRFHESVRTVLQPWKIQSIEMHVPISQNITSIQSHILEIMNFLVQEIKRINRTVDMEAVTVENCVTKSFHKILQAQLDCIWHQLNSQTKLIVADLKILRSLMISTMYHDAVSAYAFMKRYRSTEYALSNSGWTLLDAAEQIFKLSRQRVFNGQQEFEPEPCPKWQTLTDLLTKEIPGDMRRSRRSEQQPKVLILCQDARTCHQLKQYLTQGGPRFLLQQALQHEVPVGKLSDNYAKESQTRSAPPKNVSSNKELRREEVSGSQPPLAGMDELAQLLSESETEGQHFEESYMLTMTQPVEVGPAAIDIKPDPDVSIFETIPELEQFDVTAALASVPHQPYICLQTFKTEREGSMALEHMLEQLQPHYVVMYNMNVTAIRQLEVFEARRRLPPADRMKVYFLIHARTVEEQAYLTSLRREKAAFEFIIDTKSKMVIPKYQDGKTDEAFLLLKTYDDEPTDENAKSRQAGGQAPQATKETPKVIVDMREFRSDLPCLIHKRGLEVLPLTITIGDYILTPDICVERKSISDLIGSLNSGRLYNQCVQMQRHYAKPILLIEFDQNKPFHLQGKFMLSQQTSMANADIVQKLQLLTLHFPKLRLIWSPSPYATAQLFEELKLGKPEPDPQTAAALGSDEPTAGEQLHFNSGIYDFLLRLPGVHTRNIHGLLRKGGSLRQLLLRSQKELEELLQSQESAKLLYDILHVAHLPEKDEVTGSTALLAASKQFGAGSHNRFRMAAAASRRGRR", "length": 961, "header": "sp|Q24087-1|XPF_DROME Isoform 1 of DNA repair endonuclease XPF OS=Drosophila melanogaster OX=7227 GN=mei-9 PE=1 SV=2 CANONICAL=Q24087-1" }, "isoforms": [ { "isoform_ac": "Q24087-1", "url": "", "sequence": { "sequence": "MADSCAENAAKGTENERPKEVEASADTVPQVEEGVEEYLKRKNMVLLDYEKQMFLDLVEADGLLVCAKGLSYDRVVISILKAYSDSGNLVLVINSSDWEEQYYKSKIEPKYVHEVASTATERERVYLEGGLQFISTRILVVDLLKQRIPIELISGIIVLRAHTIIESCQEAFALRLFRQKNKTGFVKAFSSSPEAFTIGYSHVERTMRNLFVKHLYIWPRFHESVRTVLQPWKIQSIEMHVPISQNITSIQSHILEIMNFLVQEIKRINRTVDMEAVTVENCVTKSFHKILQAQLDCIWHQLNSQTKLIVADLKILRSLMISTMYHDAVSAYAFMKRYRSTEYALSNSGWTLLDAAEQIFKLSRQRVFNGQQEFEPEPCPKWQTLTDLLTKEIPGDMRRSRRSEQQPKVLILCQDARTCHQLKQYLTQGGPRFLLQQALQHEVPVGKLSDNYAKESQTRSAPPKNVSSNKELRREEVSGSQPPLAGMDELAQLLSESETEGQHFEESYMLTMTQPVEVGPAAIDIKPDPDVSIFETIPELEQFDVTAALASVPHQPYICLQTFKTEREGSMALEHMLEQLQPHYVVMYNMNVTAIRQLEVFEARRRLPPADRMKVYFLIHARTVEEQAYLTSLRREKAAFEFIIDTKSKMVIPKYQDGKTDEAFLLLKTYDDEPTDENAKSRQAGGQAPQATKETPKVIVDMREFRSDLPCLIHKRGLEVLPLTITIGDYILTPDICVERKSISDLIGSLNSGRLYNQCVQMQRHYAKPILLIEFDQNKPFHLQGKFMLSQQTSMANADIVQKLQLLTLHFPKLRLIWSPSPYATAQLFEELKLGKPEPDPQTAAALGSDEPTAGEQLHFNSGIYDFLLRLPGVHTRNIHGLLRKGGSLRQLLLRSQKELEELLQSQESAKLLYDILHVAHLPEKDEVTGSTALLAASKQFGAGSHNRFRMAAAASRRGRR", "length": 961, "header": "sp|Q24087-1|XPF_DROME Isoform 1 of DNA repair endonuclease XPF OS=Drosophila melanogaster OX=7227 GN=mei-9 PE=1 SV=2 CANONICAL=Q24087-1" }, "locus": { "chromosome": "X", "start_pos": 4318055, "end_pos": 4314855, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0343574", "url": "https://www.ensembl.org/id/FBtr0343574" }, { "database": "Ensembl Peptide", "id": "FBpp0310174", "url": "https://www.ensembl.org/id/FBpp0310174" } ] } }, { "isoform_ac": "T2FFI3-1", "url": "", "sequence": { "sequence": "MADSCAENAAKGTENERPKEVEASADTVPQVEEGVEEYLKRKNMVLLDYEKQMFLDLVEADGLLVCAKGLSYDRVVISILKAYSDSGNLVLVINSSDWEEQYYKSKIEPKYVHEVASTATERERVYLEGGLQFISTRILVVDLLKQRIPIELISGIIVLRAHTIIESCQEAFALRLFRQKNKTGFVKAFSSSPEAFTIGYSHVERTMRNLFVKHLYIWPRFHESVRTVLQPWKIQSIEMHVPISQNITSIQSHILEIMNFLVQEIKRINRTVDMEAVTVENCVTKSFHKILQAQLDCIWHQLNSQTKLIVADLKILRSLMISTMYHDAVSAYAFMKRYRSTEYALSNSGWTLLDAAEQIFKLSRQRVFNGQQEFEPEPCPKWQTLTDLLTKEIPGDMRRSRRSEQQPKVLILCQDARTCHQLKQYLTQGGPRFLLQQALQHEVPVGKLSDNYAKESQTRSAPPKNVSSNKELRREEVSGSQPPLAGMDELAQLLSESETEGQHFEESYMLTMTQPVEVGPAAIDIKPDPDVSIFETIPELEQFDVTAALASVPHQPYICLQTFKTEREGSMALEHMLEQLQPHYVVMYNMNVTAIRQLEVFEARRRLPPADRMKVYFLIHARTVEEQAYLTSLRREKAAFEFIIDTKSKMVIPKYQDGKTDEAFLLLKTYDDEPTDENAKSRQAGGQAPQATKETPKVIVDMREFRSDLPCLIHKRGLEVLPLTITIGDYILTPDICVERKSISDLIGSLNSGRLYNQCVQMQRHYAKPILLIEFDQNKPFHLQGKFMLSQQTSMANADIVQKLQLLTLHFPKLRLIWSPSPYATAQLFEELKLGKPEPDPQTAAALGSDEPTAGEQLHFNSGIYDFLLRLPGVHTRNIHGLLRKGGSLRQLLLRSQKELEELLQSQESAKLLYDILHVAHLPEKDEVTGSTALLAASKQFGAGSHNRFRMAAAASRRGRR", "length": 961, "header": "tr|T2FFI3-1|XPF_DROME Computationally mapped isoform of DNA repair endonuclease XPF OS=Drosophila melanogaster OX=7227 GN=mei-9 PE=1 SV=1 CANONICAL=Q24087-1" }, "locus": { "chromosome": "X", "start_pos": 4318055, "end_pos": 4314855, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0343574", "url": "https://www.ensembl.org/id/FBtr0343574" }, { "database": "Ensembl Peptide", "id": "FBpp0310174", "url": "https://www.ensembl.org/id/FBpp0310174" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "The genome sequence of Drosophila melanogaster.", "journal": "Science", "date": "2000", "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC", "evidence": [ { "database": "UniProtKB", "id": "T2FFI3", "url": "https://www.uniprot.org/uniprot/T2FFI3" }, { "database": "UniProtKB", "id": "Q24087", "url": "https://www.uniprot.org/uniprot/Q24087" } ], "reference": [ { "type": "PubMed", "id": "10731132", "url": "https://glygen.org/publication/PubMed/10731132" } ] }, { "title": "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.", "journal": "Genome Biol.", "date": "2002", "authors": "Celniker SE, Wheeler DA, Kronmiller B, Carlson JW, Halpern A, Patel S, Adams M, Champe M, Dugan SP, Frise E, Hodgson A, George RA, Hoskins RA, Laverty T, Muzny DM, Nelson CR, Pacleb JM, Park S, Pfeiffer BD, Richards S, Sodergren EJ, Svirskas R, Tabor PE, Wan K, Stapleton M, Sutton GG, Venter C, Weinstock G, Scherer SE, Myers EW, Gibbs RA, Rubin GM", "evidence": [ { "database": "UniProtKB", "id": "T2FFI3", "url": "https://www.uniprot.org/uniprot/T2FFI3" } ], "reference": [ { "type": "PubMed", "id": "12537568", "url": "https://glygen.org/publication/PubMed/12537568" } ] }, { "title": "A Drosophila full-length cDNA resource.", "journal": "Genome Biol.", "date": "2002", "authors": "Stapleton M, Carlson J, Brokstein P, Yu C, Champe M, George R, Guarin H, Kronmiller B, Pacleb J, Park S, Wan K, Rubin GM, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "Q24087", "url": "https://www.uniprot.org/uniprot/Q24087" } ], "reference": [ { "type": "PubMed", "id": "12537569", "url": "https://glygen.org/publication/PubMed/12537569" } ] }, { "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.", "journal": "Genome Biol.", "date": "2002", "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE", "evidence": [ { "database": "UniProtKB", "id": "T2FFI3", "url": "https://www.uniprot.org/uniprot/T2FFI3" }, { "database": "UniProtKB", "id": "Q24087", "url": "https://www.uniprot.org/uniprot/Q24087" } ], "reference": [ { "type": "PubMed", "id": "12537572", "url": "https://glygen.org/publication/PubMed/12537572" } ] }, { "title": "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.", "journal": "Genome Biol.", "date": "2002", "authors": "Kaminker JS, Bergman CM, Kronmiller B, Carlson J, Svirskas R, Patel S, Frise E, Wheeler DA, Lewis SE, Rubin GM, Ashburner M, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "T2FFI3", "url": "https://www.uniprot.org/uniprot/T2FFI3" } ], "reference": [ { "type": "PubMed", "id": "12537573", "url": "https://glygen.org/publication/PubMed/12537573" } ] }, { "title": "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.", "journal": "Genome Biol.", "date": "2002", "authors": "Hoskins RA, Smith CD, Carlson JW, Carvalho AB, Halpern A, Kaminker JS, Kennedy C, Mungall CJ, Sullivan BA, Sutton GG, Yasuhara JC, Wakimoto BT, Myers EW, Celniker SE, Rubin GM, Karpen GH", "evidence": [ { "database": "UniProtKB", "id": "T2FFI3", "url": "https://www.uniprot.org/uniprot/T2FFI3" } ], "reference": [ { "type": "PubMed", "id": "12537574", "url": "https://glygen.org/publication/PubMed/12537574" } ] }, { "title": "Combined evidence annotation of transposable elements in genome sequences.", "journal": "PLoS Comput. Biol.", "date": "2005", "authors": "Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D", "evidence": [ { "database": "UniProtKB", "id": "T2FFI3", "url": "https://www.uniprot.org/uniprot/T2FFI3" } ], "reference": [ { "type": "PubMed", "id": "16110336", "url": "https://glygen.org/publication/PubMed/16110336" } ] }, { "title": "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.", "journal": "Science", "date": "2007", "authors": "Smith CD, Shu S, Mungall CJ, Karpen GH", "evidence": [ { "database": "UniProtKB", "id": "T2FFI3", "url": "https://www.uniprot.org/uniprot/T2FFI3" } ], "reference": [ { "type": "PubMed", "id": "17569856", "url": "https://glygen.org/publication/PubMed/17569856" } ] }, { "title": "Sequence finishing and mapping of Drosophila melanogaster heterochromatin.", "journal": "Science", "date": "2007", "authors": "Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "T2FFI3", "url": "https://www.uniprot.org/uniprot/T2FFI3" } ], "reference": [ { "type": "PubMed", "id": "17569867", "url": "https://glygen.org/publication/PubMed/17569867" } ] }, { "title": "Drosophila hold'em is required for a subset of meiotic crossovers and interacts with the dna repair endonuclease complex subunits MEI-9 and ERCC1.", "journal": "Genetics", "date": "2009", "authors": "McKim K.S., Joyce E.F., Tanneti S.N.", "evidence": [ { "database": "UniProtKB", "id": "Q24087", "url": "https://www.uniprot.org/uniprot/Q24087" } ], "reference": [ { "type": "PubMed", "id": "18957705", "url": "https://glygen.org/publication/PubMed/18957705" } ] }, { "title": "The Release 6 reference sequence of the Drosophila melanogaster genome.", "journal": "Genome Res.", "date": "2015", "authors": "Hoskins RA, Carlson JW, Wan KH, Park S, Mendez I, Galle SE, Booth BW, Pfeiffer BD, George RA, Svirskas R, Krzywinski M, Schein J, Accardo MC, Damia E, Messina G, Mendez-Lago M, de Pablos B, Demakova OV, Andreyeva EN, Boldyreva LV, Marra M, Carvalho AB, Dimitri P, Villasante A, Zhimulev IF, Rubin GM, Karpen GH, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "T2FFI3", "url": "https://www.uniprot.org/uniprot/T2FFI3" } ], "reference": [ { "type": "PubMed", "id": "25589440", "url": "https://glygen.org/publication/PubMed/25589440" } ] }, { "title": "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.", "journal": "G3 (Bethesda)", "date": "2015", "authors": "Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM", "evidence": [ { "database": "UniProtKB", "id": "T2FFI3", "url": "https://www.uniprot.org/uniprot/T2FFI3" } ], "reference": [ { "type": "PubMed", "id": "26109356", "url": "https://glygen.org/publication/PubMed/26109356" } ] }, { "title": "Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.", "journal": "G3 (Bethesda)", "date": "2015", "authors": "Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM", "evidence": [ { "database": "UniProtKB", "id": "T2FFI3", "url": "https://www.uniprot.org/uniprot/T2FFI3" } ], "reference": [ { "type": "PubMed", "id": "26109357", "url": "https://glygen.org/publication/PubMed/26109357" } ] }, { "title": "The Drosophila meiotic recombination gene mei-9 encodes a homologue of the yeast excision repair protein Rad1.", "journal": "Genetics", "date": "1995", "authors": "Hawley R.S., Sekelsky J.J., McKim K.S., Chin G.M.", "evidence": [ { "database": "UniProtKB", "id": "Q24087", "url": "https://www.uniprot.org/uniprot/Q24087" } ], "reference": [ { "type": "PubMed", "id": "8647398", "url": "https://glygen.org/publication/PubMed/8647398" } ] } ], "pathway": [ { "id": "dme:Dmel_CG3697", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG3697", "resource": "KEGG Pathway" }, { "id": "R-DME-5696395", "name": "Formation of Incision Complex in GG-NER", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5696395", "resource": "Reactome", "description": "Formation of Incision Complex in GG-NER" }, { "id": "R-DME-5696400", "name": "Dual Incision in GG-NER", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5696400", "resource": "Reactome", "description": "Dual Incision in GG-NER" }, { "id": "R-DME-6782135", "name": "Dual incision in TC-NER", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-6782135", "resource": "Reactome", "description": "Dual incision in TC-NER" } ], "orthologs": [ { "uniprot_canonical_ac": "P06777-1", "protein_name": "DNA repair protein RAD1", "gene_name": "RAD1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSQLFYQGDSDDELQEELTRQTTQASQSSKIKNEDEPDDSNHLNEVENEDSKVLDDDAVLYPLIPNEPDDIETSKPNINDIRPVDIQLTLPLPFQQKVVENSLITEDALIIMGKGLGLLDIVANLLHVLATPTSINGQLKRALVLVLNAKPIDNVRIKEALEELSWFSNTGKDDDDTAVESDDELFERPFNVVTADSLSIEKRRKLYISGGILSITSRILIVDLLSGIVHPNRVTGMLVLNADSLRHNSNESFILEIYRSKNTWGFIKAFSEAPETFVMEFSPLRTKMKELRLKNVLLWPRFRVEVSSCLNATNKTSHNKVIEVKVSLTNSMSQIQFGLMECLKKCIAELSRKNPELALDWWNMENVLDINFIRSIDSVMVPNWHRISYESKQLVKDIRFLRHLLKMLVTSDAVDFFGEIQLSLDANKPSVSRKYSESPWLLVDEAQLVISYAKKRIFYKNEYTLEENPKWEQLIHILHDISHERMTNHLQGPTLVACSDNLTCLELAKVLNASNKKRGVRQVLLNKLKWYRKQREETKKLVKEVQSQDTFPENATLNVSSTFSKEQVTTKRRRTRGASQVAAVEKLRNAGTNVDMEVVFEDHKLSEEIKKGSGDDLDDGQEENAANDSKIFEIQEQENEILIDDGDAEFDNGELEYVGDLPQHITTHFNKDLWAEHCNEYEYVDRQDEILISTFKSLNDNCSLQEMMPSYIIMFEPDISFIRQIEVYKAIVKDLQPKVYFMYYGESIEEQSHLTAIKREKDAFTKLIRENANLSHHFETNEDLSHYKNLAERKLKLSKLRKSNTRNAGGQQGFHNLTQDVVIVDTREFNASLPGLLYRYGIRVIPCMLTVGDYVITPDICLERKSISDLIGSLQNNRLANQCKKMLKYYAYPTLLIEFDEGQSFSLEPFSERRNYKNKDISTVHPISSKLSQDEIQLKLAKLVLRFPTLKIIWSSSPLQTVNIILELKLGREQPDPSNAVILGTNKVRSDFNSTAKGLKDGDNESKFKRLLNVPGVSKIDYFNLRKKIKSFNKLQKLSWNEINELINDEDLTDRIYYFLRTEKEEQEQESTDENLESPGKTTDDNALHDHHNDVPEAPV", "length": 1100 }, "evidence": [ { "id": "Q24087", "url": "https://omabrowser.org/oma/group/Q24087/", "database": "OMA" } ], "common_name": "Yeast" }, { "uniprot_canonical_ac": "Q92889-1", "protein_name": "DNA repair endonuclease XPF", "gene_name": "ERCC4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MESGQPARRIAMAPLLEYERQLVLELLDTDGLVVCARGLGADRLLYHFLQLHCHPACLVLVLNTQPAEEEYFINQLKIEGVEHLPRRVTNEITSNSRYEVYTQGGVIFATSRILVVDFLTDRIPSDLITGILVYRAHRIIESCQEAFILRLFRQKNKRGFIKAFTDNAVAFDTGFCHVERVMRNLFVRKLYLWPRFHVAVNSFLEQHKPEVVEIHVSMTPTMLAIQTAILDILNACLKELKCHNPSLEVEDLSLENAIGKPFDKTIRHYLDPLWHQLGAKTKSLVQDLKILRTLLQYLSQYDCVTFLNLLESLRATEKAFGQNSGWLFLDSSTSMFINARARVYHLPDAKMSKKEKISEKMEIKEGEETKKELVLESNPKWEALTEVLKEIEAENKESEALGGPGQVLICASDDRTCSQLRDYITLGAEAFLLRLYRKTFEKDSKAEEVWMKFRKEDSSKRIRKSHKRPKDPQNKERASTKERTLKKKKRKLTLTQMVGKPEELEEEGDVEEGYRREISSSPESCPEEIKHEEFDVNLSSDAAFGILKEPLTIIHPLLGCSDPYALTRVLHEVEPRYVVLYDAELTFVRQLEIYRASRPGKPLRVYFLIYGGSTEEQRYLTALRKEKEAFEKLIREKASMVVPEEREGRDETNLDLVRGTASADVSTDTRKAGGQEQNGTQQSIVVDMREFRSELPSLIHRRGIDIEPVTLEVGDYILTPEMCVERKSISDLIGSLNNGRLYSQCISMSRYYKRPVLLIEFDPSKPFSLTSRGALFQEISSNDISSKLTLLTLHFPRLRILWCPSPHATAELFEELKQSKPQPDAATALAITADSETLPESEKYNPGPQDFLLKMPGVNAKNCRSLMHHVKNIAELAALSQDELTSILGNAANAKQLYDFIHTSFAEVVSKGKGKK", "length": 916 }, "evidence": [ { "id": "Q24087", "url": "https://omabrowser.org/oma/group/Q24087/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QZD4-1", "protein_name": "DNA repair endonuclease XPF", "gene_name": "Ercc4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEPGLSGERRSMAPLLEYERQQVLELLDSDGLVVCARGLGTDRLLYHFLRLHCHPACLVLVLNTQPAEEEYFINQLKIEGVEHLPRRVTNEIASNSRYEVYTQGGIIFATSRILVVDFLTGRIPSDLITGILVYRAHRIIESCQEAFILRLFRQKNKRGFIKAFTDNAVAFDTGFCHVERVMRNLFVRKLYLWPRFHVAVNSFLEQHKPEVVEIHVSMTPAMLAIQTAILDILNACLKELKCHNPSLEVEDLSLENALGKPFDKTIRHYLDPLWHQLGAKTKSLVQDLKILRTLLQYLSQYDCVTFLNLLESLRATEKVFGQNSGWLFLDASTSMFVNARARVYRVPDVKLNKKAKTSEKTSSPEVQETKKELVLESNPKWEALTDVLKEIEAENKESEALGGPGRVLICASDDRTCCQLRDYLSAGAETFLLRLYRKTFEKDGKAEEVWVNVRKGDGPKRTTKSDKRPKAAPNKERASAKRGAPLKRKKQELTLTQVLGSAEEPPEDKALEEDLCRQTSSSPEGCGVEIKRESFDLNVSSDAAYGILKEPLTIIHPLLGCSDPYALTRVLHEVEPRYVVLYDAELTFVRQLEIYRASRPGKPLRVYFLIYGGSTEEQRYLTALRKEKEAFEKLIREKASMVVPEEREGRDETNLDLARGSAALDAPTDTRKAGGQEQNGTQSSIVVDMREFRSELPSLIHRRGIDIEPVTLEVGDYILTPELCVERKSVSDLIGSLHSGRLYSQCLAMSRYYRRPVLLIEFDPSKPFSLAPRGAFFQEMSSSDVSSKLTLLTLHFPRLRLLWCPSPHATAELFEELKQNKPQPDAATAMAITADSETLPESDRYNPGPQDFVLKMPGVNAKNCRSLMNQVKNIAELATLSLERLTTILGHSGNAKQLHDFLHTAYADLVSKGRVRK", "length": 917 }, "evidence": [ { "id": "Q24087", "url": "https://omabrowser.org/oma/group/Q24087/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q24087", "url": "https://www.uniprot.org/uniprot/Q24087" } ], "pmid": "" }, { "name": "nucleotide-excision repair factor 1 complex", "id": "GO:0000110", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000110", "evidence": [ { "database": "UniProtKB", "id": "Q24087", "url": "https://www.uniprot.org/uniprot/Q24087" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "Q24087", "url": "https://www.uniprot.org/uniprot/Q24087" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 14, "go_terms": [ { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "Q24087", "url": "https://www.uniprot.org/uniprot/Q24087" } ], "pmid": "" }, { "name": "resolution of meiotic recombination intermediates", "id": "GO:0000712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000712", "evidence": [ { "database": "UniProtKB", "id": "Q24087", "url": "https://www.uniprot.org/uniprot/Q24087" } ], "pmid": "" }, { "name": "female meiosis chromosome segregation", "id": "GO:0016321", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016321", "evidence": [ { "database": "UniProtKB", "id": "Q24087", "url": "https://www.uniprot.org/uniprot/Q24087" } ], "pmid": "" }, { "name": "DNA recombination", "id": "GO:0006310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006310", "evidence": [ { "database": "UniProtKB", "id": "Q24087", "url": "https://www.uniprot.org/uniprot/Q24087" } ], "pmid": "" }, { "name": "DNA damage response", "id": "GO:0006974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "database": "UniProtKB", "id": "Q24087", "url": "https://www.uniprot.org/uniprot/Q24087" } ], "pmid": "" }, { "name": "mismatch repair", "id": "GO:0006298", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006298", "evidence": [ { "database": "UniProtKB", "id": "Q24087", "url": "https://www.uniprot.org/uniprot/Q24087" } ], "pmid": "" }, { "name": "double-strand break repair", "id": "GO:0006302", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006302", "evidence": [ { "database": "UniProtKB", "id": "Q24087", "url": "https://www.uniprot.org/uniprot/Q24087" } ], "pmid": "" }, { "name": "female meiotic nuclear division", "id": "GO:0007143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007143", "evidence": [ { "database": "UniProtKB", "id": "Q24087", "url": "https://www.uniprot.org/uniprot/Q24087" } ], "pmid": "" }, { "name": "double-strand break repair via homologous recombination", "id": "GO:0000724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000724", "evidence": [ { "database": "UniProtKB", "id": "Q24087", "url": "https://www.uniprot.org/uniprot/Q24087" } ], "pmid": "" }, { "name": "meiotic chromosome segregation", "id": "GO:0045132", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045132", "evidence": [ { "database": "UniProtKB", "id": "Q24087", "url": "https://www.uniprot.org/uniprot/Q24087" } ], "pmid": "" }, { "name": "nucleotide-excision repair", "id": "GO:0006289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006289", "evidence": [ { "database": "UniProtKB", "id": "Q24087", "url": "https://www.uniprot.org/uniprot/Q24087" } ], "pmid": "" }, { "name": "reciprocal meiotic recombination", "id": "GO:0007131", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007131", "evidence": [ { "database": "UniProtKB", "id": "Q24087", "url": "https://www.uniprot.org/uniprot/Q24087" } ], "pmid": "" }, { "name": "nucleotide-excision repair involved in interstrand cross-link repair", "id": "GO:1901255", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901255", "evidence": [ { "database": "UniProtKB", "id": "Q24087", "url": "https://www.uniprot.org/uniprot/Q24087" } ], "pmid": "" }, { "name": "oocyte fate determination", "id": "GO:0030716", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030716", "evidence": [ { "database": "UniProtKB", "id": "Q24087", "url": "https://www.uniprot.org/uniprot/Q24087" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA endonuclease activity", "id": "GO:0004520", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004520", "evidence": [ { "database": "UniProtKB", "id": "Q24087", "url": "https://www.uniprot.org/uniprot/Q24087" } ], "pmid": "" }, { "name": "single-stranded DNA binding", "id": "GO:0003697", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003697", "evidence": [ { "database": "UniProtKB", "id": "Q24087", "url": "https://www.uniprot.org/uniprot/Q24087" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "Q24087", "url": "https://www.uniprot.org/uniprot/Q24087" } ], "pmid": "" }, { "name": "damaged DNA binding", "id": "GO:0003684", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003684", "evidence": [ { "database": "UniProtKB", "id": "Q24087", "url": "https://www.uniprot.org/uniprot/Q24087" } ], "pmid": "" }, { "name": "single-stranded DNA endodeoxyribonuclease activity", "id": "GO:0000014", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000014", "evidence": [ { "database": "UniProtKB", "id": "Q24087", "url": "https://www.uniprot.org/uniprot/Q24087" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 181, "end_pos": 183, "annotation": "n_glycosylation_sequon" }, { "start_pos": 246, "end_pos": 248, "annotation": "n_glycosylation_sequon" }, { "start_pos": 269, "end_pos": 271, "annotation": "n_glycosylation_sequon" }, { "start_pos": 465, "end_pos": 467, "annotation": "n_glycosylation_sequon" }, { "start_pos": 591, "end_pos": 593, "annotation": "n_glycosylation_sequon" }, { "start_pos": 94, "end_pos": 96, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-DME-109955", "name": "Formation of ERCC1:XPF heterodimeric complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q24087-1" ], "evidence": [ { "id": "R-DME-109955", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-109955" } ] }, { "id": "R-DME-5690213", "name": "DNA polymerases delta, epsilon or kappa bind the GG-NER site", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q24087-1", "Q9VCN1-1", "P35875-1", "Q02870-1", "Q7KVP9-1" ], "evidence": [ { "id": "R-DME-5690213", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5690213" } ] }, { "id": "R-DME-5690990", "name": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q24087-1", "P35875-1", "Q02870-1", "Q7KVP9-1" ], "evidence": [ { "id": "R-DME-5690990", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5690990" } ] }, { "id": "R-DME-5690991", "name": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q24087-1", "P35875-1", "Q02870-1", "Q7KVP9-1" ], "evidence": [ { "id": "R-DME-5690991", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5690991" } ] }, { "id": "R-DME-6782141", "name": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q24087-1", "O97183-1", "P04052-1", "P08266-1", "Q9V3G3-1", "Q7KLW9-1", "Q02870-1", "Q7KVP9-1", "M9MS40-1", "Q9VYQ8-1", "Q24216-1" ], "evidence": [ { "id": "R-DME-6782141", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-6782141" } ] }, { "id": "R-DME-6782204", "name": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q24087-1", "O97183-1", "P04052-1", "P08266-1", "Q9V3G3-1", "Q7KLW9-1", "Q02870-1", "Q7KVP9-1", "M9MS40-1", "Q9VYQ8-1", "Q24216-1" ], "evidence": [ { "id": "R-DME-6782204", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-6782204" } ] }, { "id": "R-DME-6782211", "name": "DNA polymerases delta, epsilon or kappa bind the TC-NER site", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. 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"ec_number": "2.7.7.6", "activity": "", "evidence": [ { "id": "P08266", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08266" } ] } ] }, { "uniprot_ac": "P35875", "gene_name": "Parp", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "P35875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35875" } ] }, { "ec_number": "2.4.2.30", "activity": "NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).", "evidence": [ { "id": "P35875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35875" } ] }, { "ec_number": "2.4.2.30", "activity": "", "evidence": [ { "id": "P35875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35875" } ] } ] }, { "uniprot_ac": "Q02870", "gene_name": "hay", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q02870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02870" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q02870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02870" } ] } ] }, { "uniprot_ac": "Q24087", "gene_name": "mei-9", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q24087", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24087" } ] } ] }, { "uniprot_ac": "Q24216", "gene_name": "Cdk7", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q24216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24216" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "Q24216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24216" } ] }, { "ec_number": "2.7.11.23", "activity": "", 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