{ "uniprot_canonical_ac": "Q23983-1", "uniprot_ac": "Q23983", "uniprot_id": "SNAP_DROME", "mass": { "chemical_mass": 33000.0, "monoisotopic_mass": 33000.0 }, "refseq": { "ac": "NP_524180", "name": "alpha soluble NSF attachment protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524180" }, "gene_names": [ { "name": "alphaSnap", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q23983", "id": "Q23983" }, { "name": "CG6625", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q23983", "id": "Q23983" }, { "name": "Snap", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q23983", "id": "Q23983" }, { "name": "a-Snap; alpha-snap; alpha-Snap; alpha-SNAP; alphaSNAP; aSnap; CG6625; dalpha-SNAP; dalphaSNAP; Dmel\\CG6625; dsnap; dSNAP; l(3)77ABa; l(3)77ABc; snap; Snap; SNAP; SnapII", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524180", "id": "NP_524180" }, { "name": "alphaSnap", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524180", "id": "NP_524180" } ], "protein_names": [ { "name": "Alpha-soluble NSF attachment protein", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q23983" }, { "name": "CG6625-PA; alphaSnap-PA; lethal (3) 77ABa; soluble NSF-attachment protein; soluble N-ethylmaleimide-sensitive factor attachment protein; lethal (3) 77ABc; soluble NSF attachment protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524180", "id": "NP_524180" }, { "name": "N-ethylmaleimide-sensitive factor attachment protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q23983" }, { "name": "SNAP-alpha", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q23983" }, { "name": "alpha soluble NSF attachment protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524180", "id": "NP_524180" } ], "function": [ { "annotation": "Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. 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"DOID:0070393", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070393", "name": "early infantile epileptic encephalopathy 107", "description": "" }, { "id": "MONDO:0031055", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031055", "name": "developmental and epileptic encephalopathy 107", "description": "" }, { "id": "MONDO:0031055", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031055", "name": "DEE107", "description": "" }, { "id": "MONDO:0031055", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031055", "name": "developmental and epileptic encephalopathy 107", "description": "" }, { "id": "MIM:620033", "resource": "MIM", "url": "https://www.omim.org/entry/620033", "name": "Developmental and epileptic encephalopathy 107", "description": "Developmental and epileptic encephalopathy 107" } ], "evidence": [ { "id": "0070393", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0070393" } ] }, { "disease_id": "DOID:10652", "recommended_name": { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer's disease", "description": "A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid." }, "synonyms": [ { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer disease", "description": "" }, { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimers dementia", "description": "" } ], "evidence": [ { "id": "10652", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10652" } ] }, { "disease_id": "DOID:14250", "recommended_name": { "id": "DOID:14250", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:14250", "name": "Down syndrome", "description": "A chromosomal disease that is characterized by flat-looking facial features and weak muscle tone (hypotonia) in infancy and is caused by trisomy of all or a critical portion of chromosome 21 and is associated with intellectual disability." }, "synonyms": [ { "id": "DOID:14250", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:14250", "name": "Complete trisomy 21 syndrome", "description": "" }, { "id": "DOID:14250", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:14250", "name": "Down's syndrome", "description": "" }, { "id": "DOID:14250", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:14250", "name": "Down's syndrome - trisomy 21", "description": "" }, { "id": "DOID:14250", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:14250", "name": "Downs syndrome", "description": "" }, { "id": "DOID:14250", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:14250", "name": "G Trisomy", "description": "" }, { "id": "DOID:14250", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:14250", "name": "trisomy 21 syndrome", "description": "" }, { "id": "MONDO:0008608", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008608", "name": "Down syndrome", "description": "Down syndrome is a chromosomal abnormality caused by the presence of a third (partial or total) copy of the chromosome 21 genetic material and that is characterized by variable intellectual disability, muscular hypotonia, and joint laxity, often associated with a characteristic facial dysmorphism and various anomalies such as cardiac, gastrointestinal, or endocrine defects." }, { "id": "MONDO:0008608", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008608", "name": "Down syndrome", "description": "" }, { "id": "MONDO:0008608", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008608", "name": "Down syndrome, Isolated cases", "description": "" }, { "id": "MONDO:0008608", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008608", "name": "Down's syndrome", "description": "" }, { "id": "MONDO:0008608", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008608", "name": "Down's syndrome - trisomy 21", "description": "" }, { "id": "MONDO:0008608", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008608", "name": "Downs syndrome", "description": "" }, { "id": "MONDO:0008608", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008608", "name": "G trisomy", "description": "" }, { "id": "MONDO:0008608", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008608", "name": "leukemia, megakaryoblastic, with or without Down syndrome, somatic", "description": "" }, { "id": "MONDO:0008608", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008608", "name": "trisomy 21 (Down syndrome)", "description": "" }, { "id": "MONDO:0008608", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008608", "name": "complete trisomy 21 syndrome", "description": "" }, { "id": "MONDO:0008608", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008608", "name": "trisomy 21", "description": "" }, { "id": "MONDO:0008608", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008608", "name": "trisomy 21 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"https://www.ncbi.nlm.nih.gov/gene/40233", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q23983", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q23983*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000744", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000744", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG6625", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG6625", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WSVKEYL", "url": "https://omabrowser.org/oma/group/WSVKEYL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4487902at2759", "url": "http://www.orthodb.org/?query=4487902at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13768", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13768", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13768:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13768:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14938", "url": "http://pfam.xfam.org/family/PF14938", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q23983", "url": "http://purl.obolibrary.org/obo/PR_Q23983", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DME-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-204005", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-6807878", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-6807878", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-6811434", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-6811434", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-6811438", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-6811438", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-6811440", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-6811440", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_524180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524180", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q23983", "url": "https://www.uniprot.org/uniprot/Q23983", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q23983-1", "url": "https://www.uniprot.org/uniprot/Q23983-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGDNEQKALQLMAEAEKKLTQQKGFLGSLFGGSNKVEDAIECYQRAGNMFKMSKNWTKAGECFCEAATLHARAGSRHDAGTCYVDASNCYKKVDVESAVNCLMKSIDIYTDMGRFTMAAKHHQSIAEMYESDPNNLAKSIQHYEQAADYFKGEESVSSANKCMLKVAQYAAQLEDYEKAISIYEQVAASSLESSLLKYSAKEYFFRAALCHLSVDLLNAQHAIEKYAQQYPAFQDSREFKLIKVLCENLEEQNIEGFTEAVKDYDSISRLDQWYTTILLRIKKAADEDPDLR", "length": 292, "header": "sp|Q23983-1|SNAP_DROME Isoform 1 of Alpha-soluble NSF attachment protein OS=Drosophila melanogaster OX=7227 GN=alphaSnap PE=1 SV=1 CANONICAL=Q23983-1" }, "isoforms": [ { "isoform_ac": "Q23983-1", "url": "", "sequence": { "sequence": "MGDNEQKALQLMAEAEKKLTQQKGFLGSLFGGSNKVEDAIECYQRAGNMFKMSKNWTKAGECFCEAATLHARAGSRHDAGTCYVDASNCYKKVDVESAVNCLMKSIDIYTDMGRFTMAAKHHQSIAEMYESDPNNLAKSIQHYEQAADYFKGEESVSSANKCMLKVAQYAAQLEDYEKAISIYEQVAASSLESSLLKYSAKEYFFRAALCHLSVDLLNAQHAIEKYAQQYPAFQDSREFKLIKVLCENLEEQNIEGFTEAVKDYDSISRLDQWYTTILLRIKKAADEDPDLR", "length": 292, "header": "sp|Q23983-1|SNAP_DROME Isoform 1 of Alpha-soluble NSF attachment protein OS=Drosophila melanogaster OX=7227 GN=alphaSnap PE=1 SV=1 CANONICAL=Q23983-1" }, "locus": { "chromosome": "3L", "start_pos": 20315544, "end_pos": 20313793, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0074840", "url": "https://www.ensembl.org/id/FBtr0074840" }, { "database": "Ensembl Peptide", "id": "FBpp0074609", "url": "https://www.ensembl.org/id/FBpp0074609" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The genome sequence of Drosophila melanogaster.", "journal": "Science", "date": "2000", "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC", "evidence": [ { "database": "UniProtKB", "id": "Q23983", "url": "https://www.uniprot.org/uniprot/Q23983" } ], "reference": [ { "type": "PubMed", "id": "10731132", "url": "https://glygen.org/publication/PubMed/10731132" } ] }, { "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.", "journal": "Genome Biol.", "date": "2002", "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE", "evidence": [ { "database": "UniProtKB", "id": "Q23983", "url": "https://www.uniprot.org/uniprot/Q23983" } ], "reference": [ { "type": "PubMed", "id": "12537572", "url": "https://glygen.org/publication/PubMed/12537572" } ] }, { "title": "A systems biology analysis of the Drosophila phagosome.", "journal": "Nature", "date": "2007", "authors": "Huang H., Rondeau C., Stuart L.M., Morales F., Ezekowitz R.A.B., Desjardins M., Brunet S., Ye P., Boulais J., Hennessy E.J., Bader J.S., Charriere G.M., Goyette G., Jutras I., Kocks C., Letarte S.", "evidence": [ { "database": "UniProtKB", "id": "Q23983", "url": "https://www.uniprot.org/uniprot/Q23983" } ], "reference": [ { "type": "PubMed", "id": "17151602", "url": "https://glygen.org/publication/PubMed/17151602" } ] }, { "title": "Neurally expressed Drosophila genes encoding homologs of the NSF and SNAP secretory proteins.", "journal": "Proc. Natl. Acad. Sci. 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