{ "uniprot_canonical_ac": "Q16819-1", "uniprot_ac": "Q16819", "uniprot_id": "MEP1A_HUMAN", "mass": { "chemical_mass": 84419.0, "monoisotopic_mass": 84419.0 }, "refseq": { "ac": "XP_011512930", "name": "meprin A subunit alpha isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011512930" }, "gene_names": [ { "name": "MEP1A", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q16819", "id": "Q16819" }, { "name": "MEP1A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011512930", "id": "XP_011512930" }, { "name": "PPHA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011512930", "id": "XP_011512930" } ], "protein_names": [ { "name": "Meprin A subunit alpha", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q16819" }, { "name": "3.4.24.18", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q16819" }, { "name": "Endopeptidase-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q16819" }, { "name": "N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q16819" }, { "name": "PABA peptide hydrolase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q16819" }, { "name": "PPH alpha", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q16819" }, { "name": "bA268F1.1 (meprin A alpha (PABA peptide hydrolase)); PPH alpha; endopeptidase-2; N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha; meprin A, alpha (PABA peptide hydrolase)", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005579", "id": "NP_005579" }, { "name": "meprin A subunit alpha isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011512930", "id": "XP_011512930" }, { "name": "meprin A subunit alpha precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005579", "id": "NP_005579" } ], "function": [ { "annotation": "In this review we report on recent findings that summarize the complex molecular regulation of meprins, particular folding, activation and shedding. Dysregulation of meprin alpha and meprin beta is often associated with pathological conditions such as neurodegeneration, inflammatory bowel disease and fibrosis Review article", "evidence": [ { "database": "RefSeq", "id": "NP_005579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005579" }, { "database": "PubMed", "id": "28502593", "url": "https://glygen.org/publication/PubMed/28502593" } ] }, { "annotation": "Mep1A is overexpressed in most hepatocellular carcinomas and induces tumor cell migration and invasion. Mep1A expression is regulated by Reptin, and Mep1A mediates Reptin-induced migration.", "evidence": [ { "database": "RefSeq", "id": "NP_005579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005579" }, { "database": "PubMed", "id": "27999200", "url": "https://glygen.org/publication/PubMed/27999200" } ] }, { "annotation": "Meprin metalloproteases A and B inactivate interleukin 6", "evidence": [ { "database": "RefSeq", "id": "NP_005579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005579" }, { "database": "PubMed", "id": "24474695", "url": "https://glygen.org/publication/PubMed/24474695" } ] }, { "annotation": "Results showed that MEP1A expression was elevated in colorectal cancer (CRC) tissues at both the mRNA and protein levels, and provided evidence for its functionally crucial role in CRC carcinogenesis as tumor proliferation and invasion. Erratum:[BMC Cancer. 2018 Jan 11;18(1):70. PMID: 29325540] Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_005579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005579" }, { "database": "PubMed", "id": "27378469", "url": "https://glygen.org/publication/PubMed/27378469" } ] }, { "annotation": "Variants rs17468190 (G/T) in the MEP1A gene are associated with glucose and insulin metabolism in overweight/obese central European women with polycystic ovary syndrome.", "evidence": [ { "database": "RefSeq", "id": "NP_005579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005579" }, { "database": "PubMed", "id": "24388959", "url": "https://glygen.org/publication/PubMed/24388959" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "Q16819", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q16819" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 140, "end_pos": 140, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "N", "sequence_mut": "T", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-loss (NIS->TIS).", "chr_id": "6", "chr_pos": "46819567", "ref_nt": "A", "alt_nt": "C", "minor_allelic_frequency": "", "site_lbl": "N140", "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "Q16819", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q16819" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 142, "end_pos": 142, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "F", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-loss (NIS->NIF).", "chr_id": "6", "chr_pos": "46819573", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "S142", "disease": [ { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs781068330", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs781068330" }, { "id": "rs781068330", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs781068330" }, { "id": "rs781068330", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs781068330#frequency_tab" }, { "id": "rs781068330", "database": 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}, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "Q16819", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q16819" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", 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"description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "Q16819", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q16819" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder 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"MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q16819" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": 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"Protein Classification" ] }, { "id": "PF01400", "url": "http://pfam.xfam.org/family/PF01400", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "Q16819", "url": "https://pharos.nih.gov/targets/Q16819", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_Q16819", "url": "http://purl.obolibrary.org/obo/PR_Q16819", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_005579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005579", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A7P0Z478", "url": "https://www.uniprot.org/uniprot/A0A7P0Z478", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0Z478-1", "url": "https://www.uniprot.org/uniprot/A0A7P0Z478-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B7ZL91", "url": "https://www.uniprot.org/uniprot/B7ZL91", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B7ZL91-1", "url": "https://www.uniprot.org/uniprot/B7ZL91-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q16819", "url": "https://www.uniprot.org/uniprot/Q16819", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q16819-1", "url": "https://www.uniprot.org/uniprot/Q16819-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAWIRSTCILFFTLLFAHIAAVPIKYLPEENVHDADFGEQKDISEINLAAGLDLFQGDILLQKSRNGLRDPNTRWTFPIPYILADNLGLNAKGAILYAFEMFRLKSCVDFKPYEGESSYIIFQQFDGCWSEVGDQHVGQNISIGQGCAYKAIIEHEILHALGFYHEQSRTDRDDYVNIWWDQILSGYQHNFDTYDDSLITDLNTPYDYESLMHYQPFSFNKNASVPTITAKIPEFNSIIGQRLDFSAIDLERLNRMYNCTTTHTLLDHCTFEKANICGMIQGTRDDTDWAHQDSAQAGEVDHTLLGQCTGAGYFMQFSTSSGSAEEAALLESRILYPKRKQQCLQFFYKMTGSPSDRLVVWVRRDDSTGNVRKLVKVQTFQGDDDHNWKIAHVVLKEEQKFRYLFQGTKGDPQNSTGGIYLDDITLTETPCPTGVWTVRNFSQVLENTSKGDKLQSPRFYNSEGYGFGVTLYPNSRESSGYLRLAFHVCSGENDAILEWPVENRQVIITILDQEPDVRNRMSSSMVFTTSKSHTSPAINDTVIWDRPSRVGTYHTDCNCFRSIDLGWSGFISHQMLKRRSFLKNDDLIIFVDFEDITHLSQTEVPTKGKRLSPQGLILQGQEQQVSEEGSGKAMLEEALPVSLSQGQPSRQKRSVENTGPLEDHNWPQYFRDPCDPNPCQNDGICVNVKGMASCRCISGHAFFYTGERCQAVQVHGSVLGMVIGGTAGVIFLTFSIIAILSQRPRK", "length": 746, "header": "sp|Q16819-1|MEP1A_HUMAN Isoform 1 of Meprin A subunit alpha OS=Homo sapiens OX=9606 GN=MEP1A PE=1 SV=2 CANONICAL=Q16819-1" }, "isoforms": [ { "isoform_ac": "A0A7P0Z478-1", "url": "", "sequence": { "sequence": "MAWIRSTCILFFTLLFAHIAAVPIKYLPEENVHDADFGEQKDISEINLAAGLDLFQGDILLQKSRNGLRDPNTRWTFPIPYILADNLGLNAKGAILYAFEMFRLKSCVDFKPYEGESSYIIFQQFDGCWSEVGDQHVGQNISIGQGCAYKAIIEHEILHALGFYHEQSRTDRDDYVNIWWDQILSGYQHNFDTYDDSLITDLNTPYDYESLMHYQPFSFNKNASVPTITAKIPEFNSIIGQRLDFSAIDLERLNRMYNCNDKNIICSHNSHSFGPLYF", "length": 278, "header": "tr|A0A7P0Z478-1|A0A7P0Z478_HUMAN Computationally mapped isoform of Metalloendopeptidase OS=Homo sapiens OX=9606 GN=MEP1A PE=1 SV=1 CANONICAL=Q16819-1" }, "locus": { "chromosome": "6", "start_pos": 46826387, "end_pos": 46793399, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000680229.1", "url": "https://www.ensembl.org/id/ENST00000680229.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000505289.1", "url": "https://www.ensembl.org/id/ENSP00000505289.1" } ] } }, { "isoform_ac": "B7ZL91-1", "url": "", "sequence": { "sequence": "MAWIRSTCILFFTLLFAHIAAVPVSRVLLFGYLEILILVYIIHFLYIYFFQIKYLPEENVHDADFGEQKDISEINLAAGLDLFQGDILLQKSRNGLRDPNTRWTFPIPYILADNLGLNAKGAILYAFEMFRLKSCVDFKPYEGESSYIIFQQFDGCWSEVGDQHVGQNISIGQGCAYKAIIEHEILHALGFYHEQSRTDRDDYVNIWWDQILSGYQHNFDTYDDSLITDLNTPYDYESLMHYQPFSFNKNASVPTITAKIPEFNSIIGQRLDFSAIDLERLNRMYNCTTTHTLLDHCTFEKANICGMIQGTRDDTDWAHQDSAQAGEVDHTLLGQCTGAGYFMQFSTSSGSAEEAALLESRILYPKRKQQCLQFFYKMTGSPSDRLVVWVRRDDSTGNVRKLVKVQTFQGDDDHNWKIAHVVLKEEQKFRYLFQGTKGDPQNSTGGIYLDDITLTETPCPTGVWTVRNFSQVLENTSKGDKLQSPRFYNSEGYGFGVTLYPNSRESSGYLRLAFHVCSGENDAILEWPVENRQVIITILDQEPDVRNRMSSSMVFTTSKSHTSPAINDTVIWDRPSRVGTYHTDCNCFRSIDLGWSGFISHQMLKRRSFLKNDDLIIFVDFEDITHLSQTEVPTKGKRLSPQGLILQGQEQQVSEEGSGKAMLEEALPVSLSQGQPSRQKRSVENTGPLEDHNWPQYFRDPCDPNPCQNDGICVNVKGMASCRCISGHAFFYTGERCQAVQVHGSVLGMVIGGTAGVIFLTFSIIAILSQRPRK", "length": 774, "header": "tr|B7ZL91-1|MEP1A_HUMAN Computationally mapped isoform of Meprin A subunit alpha OS=Homo sapiens OX=9606 GN=MEP1A PE=1 SV=1 CANONICAL=Q16819-1" }, "locus": { "chromosome": "6", "start_pos": 46839133, "end_pos": 46793399, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000611727.2", "url": "https://www.ensembl.org/id/ENST00000611727.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000480465.1", "url": "https://www.ensembl.org/id/ENSP00000480465.1" } ] } }, { "isoform_ac": "Q16819-1", "url": "", "sequence": { "sequence": "MAWIRSTCILFFTLLFAHIAAVPIKYLPEENVHDADFGEQKDISEINLAAGLDLFQGDILLQKSRNGLRDPNTRWTFPIPYILADNLGLNAKGAILYAFEMFRLKSCVDFKPYEGESSYIIFQQFDGCWSEVGDQHVGQNISIGQGCAYKAIIEHEILHALGFYHEQSRTDRDDYVNIWWDQILSGYQHNFDTYDDSLITDLNTPYDYESLMHYQPFSFNKNASVPTITAKIPEFNSIIGQRLDFSAIDLERLNRMYNCTTTHTLLDHCTFEKANICGMIQGTRDDTDWAHQDSAQAGEVDHTLLGQCTGAGYFMQFSTSSGSAEEAALLESRILYPKRKQQCLQFFYKMTGSPSDRLVVWVRRDDSTGNVRKLVKVQTFQGDDDHNWKIAHVVLKEEQKFRYLFQGTKGDPQNSTGGIYLDDITLTETPCPTGVWTVRNFSQVLENTSKGDKLQSPRFYNSEGYGFGVTLYPNSRESSGYLRLAFHVCSGENDAILEWPVENRQVIITILDQEPDVRNRMSSSMVFTTSKSHTSPAINDTVIWDRPSRVGTYHTDCNCFRSIDLGWSGFISHQMLKRRSFLKNDDLIIFVDFEDITHLSQTEVPTKGKRLSPQGLILQGQEQQVSEEGSGKAMLEEALPVSLSQGQPSRQKRSVENTGPLEDHNWPQYFRDPCDPNPCQNDGICVNVKGMASCRCISGHAFFYTGERCQAVQVHGSVLGMVIGGTAGVIFLTFSIIAILSQRPRK", "length": 746, "header": "sp|Q16819-1|MEP1A_HUMAN Isoform 1 of Meprin A subunit alpha OS=Homo sapiens OX=9606 GN=MEP1A PE=1 SV=2 CANONICAL=Q16819-1" }, "locus": { "chromosome": "6", "start_pos": 46839133, "end_pos": 46793399, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000230588.9", "url": "https://www.ensembl.org/id/ENST00000230588.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000230588.4", "url": "https://www.ensembl.org/id/ENSP00000230588.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 140, "start_aa": "Asn", "end_pos": 140, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn140", "evidence": [ { "id": "Q16819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16819#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 222, "start_aa": "Asn", "end_pos": 222, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn222", "evidence": [ { "id": "Q16819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16819#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 258, "start_aa": "Asn", "end_pos": 258, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn258", "evidence": [ { "id": "Q16819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16819#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 414, "start_aa": "Asn", "end_pos": 414, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn414", "evidence": [ { "id": "Q16819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16819#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 440, "start_aa": "Asn", "end_pos": 440, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn440", "evidence": [ { "id": "Q16819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16819#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 447, "start_aa": "Asn", "end_pos": 447, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn447", "evidence": [ { "id": "Q16819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16819#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 539, "start_aa": "Asn", "end_pos": 539, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn539", "evidence": [ { "id": "Q16819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16819#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "site_category": "reported", "site_seq": "S", "relation": "attached", "comment": "O-linked (Xyl...) (chondroitin sulfate) serine", "start_pos": 630, "start_aa": "Ser", "end_pos": 630, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser630", "evidence": [ { "id": "Q16819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16819#ptm_processing" }, { "id": "27399812", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27399812" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "Q16819", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q16819" }, { "id": "30444036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30444036" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted", "glycoprotein_reported", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Human and mouse homo-oligomeric meprin A metalloendopeptidase: substrate and inhibitor specificities.", "journal": "Biol. Chem.", "date": "2007", "authors": "Bertenshaw G.P., Bond J.S., Bylander J.E., Hubbard S.J., Matters G.L.", "evidence": [ { "database": "UniProtKB", "id": "Q16819", "url": "https://www.uniprot.org/uniprot/Q16819" } ], "reference": [ { "type": "PubMed", "id": "17976009", "url": "https://glygen.org/publication/PubMed/17976009" } ] }, { "title": "Melanoma genome sequencing reveals frequent PREX2 mutations.", "journal": "Nature", "date": "2012", "authors": "Berger MF, Hodis E, Heffernan TP, Deribe YL, Lawrence MS, Protopopov A, Ivanova E, Watson IR, Nickerson E, Ghosh P, Zhang H, Zeid R, Ren X, Cibulskis K, Sivachenko AY, Wagle N, Sucker A, Sougnez C, Onofrio R, Ambrogio L, Auclair D, Fennell T, Carter SL, Drier Y, Stojanov P, Singer MA, Voet D, Jing R, Saksena G, Barretina J, Ramos AH, Pugh TJ, Stransky N, Parkin M, Winckler W, Mahan S, Ardlie K, Baldwin J, Wargo J, Schadendorf D, Meyerson M, Gabriel SB, Golub TR, Wagner SN, Lander ES, Getz G, Chin L, Garraway LA", "evidence": [ { "database": "dbSNP", "id": "rs746944566", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs746944566" } ], "reference": [ { "type": "PubMed", "id": "22622578", "url": "https://glygen.org/publication/PubMed/22622578" } ] }, { "title": "Recurrent R-spondin fusions in colon cancer.", "journal": "Nature", "date": "2012", "authors": "Seshagiri S, Stawiski EW, Durinck S, Modrusan Z, Storm EE, Conboy CB, Chaudhuri S, Guan Y, Janakiraman V, Jaiswal BS, Guillory J, Ha C, Dijkgraaf GJ, Stinson J, Gnad F, Huntley MA, Degenhardt JD, Haverty PM, Bourgon R, Wang W, Koeppen H, Gentleman R, Starr TK, Zhang Z, Largaespada DA, Wu TD, de Sauvage FJ", "evidence": [ { "database": "dbSNP", "id": "rs746944566", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs746944566" } ], "reference": [ { "type": "PubMed", "id": "22895193", "url": "https://glygen.org/publication/PubMed/22895193" } ] }, { "title": "Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation.", "journal": "Nature genetics", "date": "2013", "authors": "Guo G, Sun X, Chen C, Wu S, Huang P, Li Z, Dean M, Huang Y, Jia W, Zhou Q, Tang A, Yang Z, Li X, Song P, Zhao X, Ye R, Zhang S, Lin Z, Qi M, Wan S, Xie L, Fan F, Nickerson ML, Zou X, Hu X, Xing L, Lv Z, Mei H, Gao S, Liang C, Gao Z, Lu J, Yu Y, Liu C, Li L, Fang X, Jiang Z, Yang J, Li C, Zhao X, Chen J, Zhang F, Lai Y, Lin Z, Zhou F, Chen H, Chan HC, Tsang S, Theodorescu D, Li Y, Zhang X, Wang J, Yang H, Gui Y, Wang J, Cai Z", "evidence": [ { "database": "dbSNP", "id": "rs1382744089", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1382744089" } ], "reference": [ { "type": "PubMed", "id": "24121792", "url": "https://glygen.org/publication/PubMed/24121792" } ] }, { "title": "Association of MEP1A gene variants with insulin metabolism in central European women with polycystic ovary syndrome.", "journal": "Gene", "date": "2014", "authors": "Lam UD, Lerchbaum E, Schweighofer N, Trummer O, Eberhard K, Genser B, Pieber TR, Obermayer-Pietsch B", "evidence": [ { "database": "RefSeq", "id": "NP_005579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005579" } ], "reference": [ { "type": "PubMed", "id": "24388959", "url": "https://glygen.org/publication/PubMed/24388959" } ] }, { "title": "Meprin metalloproteases inactivate interleukin 6.", "journal": "The Journal of biological chemistry", "date": "2014", "authors": "Keiffer TR, Bond JS", "evidence": [ { "database": "RefSeq", "id": "NP_005579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005579" } ], "reference": [ { "type": "PubMed", "id": "24474695", "url": "https://glygen.org/publication/PubMed/24474695" } ] }, { "title": "Metalloproteases meprin-a (MEP1A) is a prognostic biomarker and promotes proliferation and invasion of colorectal cancer.", "journal": "BMC cancer", "date": "2016", "authors": "Wang X, Chen J, Wang J, Yu F, Zhao S, Zhang Y, Tang H, Peng Z", "evidence": [ { "database": "RefSeq", "id": "NP_005579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005579" } ], "reference": [ { "type": "PubMed", "id": "27378469", "url": "https://glygen.org/publication/PubMed/27378469" } ] }, { "title": "SweetNET: A Bioinformatics Workflow for Glycopeptide MS/MS Spectral Analysis.", "journal": "Journal of proteome research", "date": "2016-08-05", "authors": "Nasir Waqas, Toledo Alejandro Gomez, Noborn Fredrik, Nilsson Jonas, Wang Mingxun, Bandeira Nuno, Larson G\u00f6ran", "evidence": [ { "database": "UniProtKB", "id": "Q16819", "url": "https://www.uniprot.org/uniprot/Q16819#ptm_processing" }, { "database": "UniProtKB", "id": "Q16819", "url": "https://www.uniprot.org/uniprot/Q16819" } ], "reference": [ { "type": "PubMed", "id": "27399812", "url": "https://glygen.org/publication/PubMed/27399812" } ] }, { "title": "Metalloproteinase meprin alpha regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein Reptin.", "journal": "Oncotarget", "date": "2017", "authors": "Breig O, Yates M, Neaud V, Couchy G, Grigoletto A, Lucchesi C, Prox J, Zucman-Rossi J, Becker-Pauly C, Rosenbaum J", "evidence": [ { "database": "RefSeq", "id": "NP_005579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005579" } ], "reference": [ { "type": "PubMed", "id": "27999200", "url": "https://glygen.org/publication/PubMed/27999200" } ] }, { "title": "Meprin metalloproteases: Molecular regulation and function in inflammation and fibrosis.", "journal": "Biochimica et biophysica acta. Molecular cell research", "date": "2017", "authors": "Arnold P, Otte A, Becker-Pauly C", "evidence": [ { "database": "RefSeq", "id": "NP_005579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005579" } ], "reference": [ { "type": "PubMed", "id": "28502593", "url": "https://glygen.org/publication/PubMed/28502593" } ] }, { "title": "O-GlcNAc-induced nuclear translocation of hnRNP-K is associated with progression and metastasis of cholangiocarcinoma.", "journal": "Molecular oncology", "date": "2019", "authors": "Phoomak C, Park D, Silsirivanit A, Sawanyawisuth K, Vaeteewoottacharn K, Detarya M, Wongkham C, Lebrilla CB, Wongkham S", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q16819", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q16819" } ], "reference": [ { "type": "PubMed", "id": "30444036", "url": "https://glygen.org/publication/PubMed/30444036" } ] }, { "title": "Cloning of the PABA peptide hydrolase alpha subunit (PPH alpha) from human small intestine and its expression in COS-1 cells.", "journal": "FEBS Lett.", "date": "1993", "authors": "Dumermuth E, Eldering JA, Grunberg J, Jiang W, Sterchi EE", "evidence": [ { "database": "UniProtKB", "id": "Q16819", "url": "https://www.uniprot.org/uniprot/Q16819" } ], "reference": [ { "type": "PubMed", "id": "8262185", "url": "https://glygen.org/publication/PubMed/8262185" } ] } ], "pathway": [ { "id": "hsa:4224", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:4224", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P28825-1", "protein_name": "Meprin A subunit alpha", "gene_name": "Mep1a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLWIQPACLLSLIFSAHIAAVSIKHLLNGSDHDTDVGEQKDIFEINLAAGLNLFQGDILLPRTRNAMRDPSSRWKLPIPYILADNLELNAKGAILHAFEMFRLKSCVDFKPYEGESSYIIFQKLSGCWSMIGDQQVGQNISIGEGCDFKATIEHEILHALGFFHEQSRTDRDDYVNIWWDQIITDYEHNFNTYDDNTITDLNTPYDYESLMHYGPFSFNKNESIPTITTKIPEFNTIIGQLPDFSAIDLIRLNRMYNCTATHTLLDHCDFEKTNVCGMIQGTRDDADWAHGDSSQPEQVDHTLVGQCKGAGYFMFFNTSLGARGEAALLESRILYPKRKQQCLQFFYKMTGSPADRFEVWVRRDDNAGKVRQLAKIQTFQGDSDHNWKIAHVTLNEEKKFRYVFLGTKGDPGNSSGGIYLDDITLTETPCPAGVWTIRNISQILENTVKGDKLVSPRFYNSEGYGVGVTLYPNGRITSNSGFLGLTFHLYSGDNDAILEWPVENRQAIMTILDQEADTRNRMSLTLMFTTSKNQTSSAINGSVIWDRPSKVGVYDKDCDCFRSLDWGWGQAISHQLLKRRNFLKGDSLIIFVDFKDLTHLNRTEVPASARSTMPRGLLLQGQESPALGESSRKAMLEESLPSSLGQRHPSRQKRSVENTGPMEDHNWPQYFRDPCDPNPCQNEGTCVNVKGMASCRCVSGHAFFYAGERCQAMHVHGSLLGLLIGCIAGLIFLTFVTFSTTNGKLRQ", "length": 747 }, "evidence": [ { "id": "45227274", "url": "http://www.informatics.jax.org/homology/45227274", "database": "MGI" }, { "id": "Q16819", "url": "https://omabrowser.org/oma/group/Q16819/", "database": "OMA" } ], "common_name": "Mouse" }, 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