{ "uniprot_canonical_ac": "Q16799-1", "uniprot_ac": "Q16799", "uniprot_id": "RTN1_HUMAN", "mass": { "chemical_mass": 83618.0, "monoisotopic_mass": 83618.0 }, "refseq": { "ac": "NP_066959", "name": "reticulon-1 isoform A", "summary": "This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and cancer, and is a potential molecular target for therapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066959" }, "gene_names": [ { "name": "RTN1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q16799", "id": "Q16799" }, { "name": "NSP", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q16799", "id": "Q16799" } ], "protein_names": [ { "name": "Reticulon-1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q16799" }, { "name": "Neuroendocrine-specific protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q16799" }, { "name": "neuroendocrine-specific protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066959", "id": "NP_066959" }, { "name": "reticulon-1 isoform A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066959", "id": "NP_066959" } ], "function": [ { "annotation": "CircRTN1 acts as a miR-431-5p sponge to promote thyroid cancer progression by upregulating TGFA.", "evidence": [ { "database": "RefSeq", "id": "NP_066959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066959" }, { "database": "PubMed", "id": "35804263", "url": "https://glygen.org/publication/PubMed/35804263" } ] }, { "annotation": "Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity.", "evidence": [ { "database": "UniProtKB", "id": "Q16799", "url": "https://www.uniprot.org/uniprot/Q16799#function" }, { "database": "PubMed", "id": "15286784", "url": "https://glygen.org/publication/PubMed/15286784" } ] }, { "annotation": "Interoperability of RTN1A in dendrite dynamics and immune functions in human Langerhans cells. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_066959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066959" }, { "database": "PubMed", "id": "36223176", "url": "https://glygen.org/publication/PubMed/36223176" } ] }, { "annotation": "Reticulon-1A mediates diabetic kidney disease progression through endoplasmic reticulum-mitochondrial contacts in tubular epithelial cells.", "evidence": [ { "database": "RefSeq", "id": "NP_066959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066959" }, { "database": "PubMed", "id": "35469894", "url": "https://glygen.org/publication/PubMed/35469894" } ] }, { "annotation": "This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and cancer, and is a potential molecular target for therapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011].", "evidence": [ { "database": "RefSeq", "id": "NP_066959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066959" } ] }, { "annotation": "[The Expression of RTN1 in Lung Adenocarcinoma and Its Effect on Immune Microenvironment].", "evidence": [ { "database": "RefSeq", "id": "NP_066959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066959" }, { "database": "PubMed", "id": "35747917", "url": "https://glygen.org/publication/PubMed/35747917" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs759395932", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs759395932" }, { "id": "rs759395932", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs759395932" }, { "id": "rs759395932", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs759395932" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 200, "end_pos": 200, "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->I).", "chr_id": "14", "chr_pos": "59746124", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T200", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs767482992", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs767482992" }, { "id": "rs767482992", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs767482992" }, { "id": "rs767482992", "database": "NCI-TCGA", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs767482992" }, { "id": "rs767482992", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs767482992" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 200, "end_pos": 200, "sequence_org": "T", "sequence_mut": "P", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->P).", "chr_id": "14", "chr_pos": "59746125", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T200", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1233538059", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1233538059" }, { "id": "rs1233538059", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1233538059" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 228, "end_pos": 228, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DIS->NIS).", "chr_id": "14", "chr_pos": "59746041", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D228", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "Q16799", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q16799" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 266, "end_pos": 266, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "D", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (DLS->NLS).", "chr_id": "14", "chr_pos": "59745927", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "D266", "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, 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"MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs1181115379", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1181115379" }, { "id": "rs1181115379", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1181115379#frequency_tab" }, { "id": "rs1181115379", "database": "gnomAD", "url": 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"minor_allelic_frequency": "", "site_lbl": "A32", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1286483045", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1286483045" }, { "id": "rs1286483045", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1286483045" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 350, "end_pos": 350, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SIS->NIS).", "chr_id": "14", "chr_pos": "59727635", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S350", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs771898598", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs771898598" }, { "id": "rs771898598", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs771898598" }, { "id": "rs771898598", "database": "NCI-TCGA", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs771898598" }, { "id": "rs771898598", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs771898598" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 472, "end_pos": 472, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DAS->NAS).", "chr_id": "14", "chr_pos": "59727270", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D472", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "65.56", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000139970", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139970" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "59.93", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000139970", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139970" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "64.14", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000139970", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139970" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "68.3", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000139970", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139970" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "79.31", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000139970", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139970" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "82.09", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000139970", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139970" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "62.77", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000139970", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139970" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "65.03", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000139970", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139970" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "74.26", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000139970", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139970" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "66.99", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000139970", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139970" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "63.61", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000139970", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139970" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "80.63", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000139970", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139970" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "85.51", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000139970", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139970" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "Q16799", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q16799" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease 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"resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", 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"https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, 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"malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16799", "url": "https://www.uniprot.org/uniprot/Q16799" } ], "common_name": "Human" } ], "gene": [ { "name": "RTN1", "url": "https://www.uniprot.org/uniprot/Q16799", "locus": { "chromosome": "14", "start_pos": 59595976, "end_pos": 59870776, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000139970", "url": "https://www.ensembl.org/id/ENSG00000139970" } ] } } ], "crossref": [ { "id": "ENSG00000139970", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000139970", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "Q16799", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q16799", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "RTN1", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=RTN1", "database": "GeneCards", "categories": [ "Organism-specific", "Gene Annotation" ] }, { "id": "6252", "url": "https://www.ncbi.nlm.nih.gov/gene/6252", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "10467", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=10467", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "Q16799", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q16799*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR003388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046964", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046964", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:6252", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:6252", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "600865", "url": "http://www.omim.org/entry/600865", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_Q16799", "url": "https://www.nextprot.org/entry/NX_Q16799", "database": "neXtProt", "categories": [ "Organism-specific", "Protein" ] }, { "id": "Q16799", "url": "https://oglcnac.org/atlas/detail/Q16799", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "Q16799", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q16799", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "CLWSCWK", "url": "https://omabrowser.org/oma/group/CLWSCWK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "7284at2759", "url": "http://www.orthodb.org/?query=7284at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45799", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45799", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45799:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45799:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02453", "url": "http://pfam.xfam.org/family/PF02453", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "Q16799", "url": "https://pharos.nih.gov/targets/Q16799", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_Q16799", "url": "http://purl.obolibrary.org/obo/PR_Q16799", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_066959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066959", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A8MT72", "url": "https://www.uniprot.org/uniprot/A8MT72", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A8MT72-1", "url": "https://www.uniprot.org/uniprot/A8MT72-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q16799", "url": "https://www.uniprot.org/uniprot/Q16799", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q16799-1", "url": "https://www.uniprot.org/uniprot/Q16799-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q16799-2", "url": "https://www.uniprot.org/uniprot/Q16799-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q16799-3", "url": "https://www.uniprot.org/uniprot/Q16799-3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPGDPQDELLPLAGPGSQWLRHRGEGENEAVTPKGATPAPQAGEPSPGLGARAREAASREAGSGPARQSPVAMETASTGVAGVSSAMDHTFSTTSKDGEGSCYTSLISDICYPPQEDSTYFTGILQKENGHVTISESPEELGTPGPSLPDVPGIESRGLFSSDSGIEMTPAESTEVNKILADPLDQMKAEAYKYIDITRPEEVKHQEQHHPELEDKDLDFKNKDTDISIKPEGVREPDKPAPVEGKIIKDHLLEESTFAPYIDDLSEEQRRAPQITTPVKITLTEIEPSVETTTQEKTPEKQDICLKPSPDTVPTVTVSEPEDDSPGSITPPSSGTEPSAAESQGKGSISEDELITAIKEAKGLSYETAENPRPVGQLADRPEVKARSGPPTIPSPLDHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE", "length": 776, "header": "sp|Q16799-1|RTN1_HUMAN Isoform 1 of Reticulon-1 OS=Homo sapiens OX=9606 GN=RTN1 PE=1 SV=1 CANONICAL=Q16799-1" }, "isoforms": [ { "isoform_ac": "A8MT72-1", "url": "", "sequence": { "sequence": "MPFLPAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE", "length": 193, "header": "tr|A8MT72-1|A8MT72_HUMAN Computationally mapped isoform of Reticulon OS=Homo sapiens OX=9606 GN=RTN1 PE=1 SV=1 CANONICAL=Q16799-1" }, "locus": { "chromosome": "14", "start_pos": 59610137, "end_pos": 59596748, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000395090.5", "url": "https://www.ensembl.org/id/ENST00000395090.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000378525.1", "url": "https://www.ensembl.org/id/ENSP00000378525.1" } ] } }, { "isoform_ac": "Q16799-1", "url": "", "sequence": { "sequence": "MAAPGDPQDELLPLAGPGSQWLRHRGEGENEAVTPKGATPAPQAGEPSPGLGARAREAASREAGSGPARQSPVAMETASTGVAGVSSAMDHTFSTTSKDGEGSCYTSLISDICYPPQEDSTYFTGILQKENGHVTISESPEELGTPGPSLPDVPGIESRGLFSSDSGIEMTPAESTEVNKILADPLDQMKAEAYKYIDITRPEEVKHQEQHHPELEDKDLDFKNKDTDISIKPEGVREPDKPAPVEGKIIKDHLLEESTFAPYIDDLSEEQRRAPQITTPVKITLTEIEPSVETTTQEKTPEKQDICLKPSPDTVPTVTVSEPEDDSPGSITPPSSGTEPSAAESQGKGSISEDELITAIKEAKGLSYETAENPRPVGQLADRPEVKARSGPPTIPSPLDHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE", "length": 776, "header": "sp|Q16799-1|RTN1_HUMAN Isoform 1 of Reticulon-1 OS=Homo sapiens OX=9606 GN=RTN1 PE=1 SV=1 CANONICAL=Q16799-1" }, "locus": { "chromosome": "14", "start_pos": 59870630, "end_pos": 59596748, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000267484.10", "url": "https://www.ensembl.org/id/ENST00000267484.10" }, { "database": "Ensembl Peptide", "id": "ENSP00000267484.5", "url": "https://www.ensembl.org/id/ENSP00000267484.5" } ] } }, { "isoform_ac": "Q16799-2", "url": "", "sequence": { "sequence": "MAAEDALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE", "length": 356, "header": "sp|Q16799-2|RTN1_HUMAN Isoform 2 of Reticulon-1 OS=Homo sapiens OX=9606 GN=RTN1 PE=1 SV=1 CANONICAL=Q16799-1" }, "locus": {} }, { "isoform_ac": "Q16799-3", "url": "", "sequence": { "sequence": "MQATADSTKMDCVWSNWKSQAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE", "length": 208, "header": "sp|Q16799-3|RTN1_HUMAN Isoform 3 of Reticulon-1 OS=Homo sapiens OX=9606 GN=RTN1 PE=1 SV=1 CANONICAL=Q16799-1" }, "locus": { "chromosome": "14", "start_pos": 59630506, "end_pos": 59596748, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000342503.8", "url": "https://www.ensembl.org/id/ENST00000342503.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000340716.4", "url": "https://www.ensembl.org/id/ENSP00000340716.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 200, "start_aa": "Thr", "end_pos": 200, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr200", "evidence": [ { "id": "Q16799", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q16799" }, { "id": "28657654", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28657654" }, { "id": "Q16799", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q16799" } ] } ], "phosphorylation": [ { "start_pos": 327, "end_pos": 327, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q16799", "url": "https://www.uniprot.org/uniprot/Q16799" } ], "site_lbl": "Ser327" }, { "start_pos": 350, "end_pos": 350, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q16799", "url": "https://www.uniprot.org/uniprot/Q16799" } ], "site_lbl": "Ser350" }, { "start_pos": 352, "end_pos": 352, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q16799", "url": "https://www.uniprot.org/uniprot/Q16799" }, { "database": "iPTMnet", "id": "Q16799", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q16799" }, { "database": "PubMed", "id": "18088087", "url": "https://glygen.org/publication/PubMed/18088087" }, { "database": "PubMed", "id": "18707149", "url": "https://glygen.org/publication/PubMed/18707149" }, { "database": "PubMed", "id": "19415658", "url": "https://glygen.org/publication/PubMed/19415658" }, { "database": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" }, { "database": "PubMed", "id": "20058876", "url": "https://glygen.org/publication/PubMed/20058876" }, { "database": "phospho.ELM", "id": "Q16799", "url": "http://phospho.elm.eu.org/byAccession/Q16799.html" } ], "site_lbl": "Ser352" }, { "start_pos": 487, "end_pos": 487, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q16799", "url": "https://www.uniprot.org/uniprot/Q16799" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "PubMed", "id": "18088087", "url": "https://glygen.org/publication/PubMed/18088087" }, { "database": "iPTMnet", "id": "Q16799", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q16799" }, { "database": "phospho.ELM", "id": "Q16799", "url": "http://phospho.elm.eu.org/byAccession/Q16799.html" } ], "site_lbl": "Ser487" }, { "start_pos": 48, "end_pos": 48, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q16799", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q16799" }, { "database": "PubMed", "id": "19415658", "url": "https://glygen.org/publication/PubMed/19415658" } ], "site_lbl": "Ser48" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells.", "journal": "Cancer Res.", "date": "2003", "authors": "Di Sano F, Fazi B, Citro G, Lovat PE, Cesareni G, Piacentini M", "evidence": [ { "database": "UniProtKB", "id": "Q16799", "url": "https://www.uniprot.org/uniprot/Q16799" } ], "reference": [ { "type": "PubMed", "id": "12873973", "url": "https://glygen.org/publication/PubMed/12873973" } ] }, { "title": "Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation.", "journal": "Nat. Med.", "date": "2004", "authors": "Lu Y., He W., Chang A., Hu X.-Y., Qahwash I., Yan R.", "evidence": [ { "database": "UniProtKB", "id": "Q16799", "url": "https://www.uniprot.org/uniprot/Q16799" } ], "reference": [ { "type": "PubMed", "id": "15286784", "url": "https://glygen.org/publication/PubMed/15286784" } ] }, { "title": "NDRG1 interacts with APO A-I and A-II and is a functional candidate for the HDL-C QTL on 8q24.", "journal": "Biochem. Biophys. Res. Commun.", "date": "2005", "authors": "Angelicheva D., Chan D.C., Hunter M., Ingley E., Kalaydjieva L., Kremensky I., Tournev I., Watts G.F.", "evidence": [ { "database": "UniProtKB", "id": "Q16799", "url": "https://www.uniprot.org/uniprot/Q16799" } ], "reference": [ { "type": "PubMed", "id": "15922294", "url": "https://glygen.org/publication/PubMed/15922294" } ] }, { "title": "Phosphoproteome of resting human platelets.", "journal": "Journal of proteome research", "date": "2008", "authors": "Zahedi RP, Lewandrowski U, Wiesner J, Wortelkamp S, Moebius J, Schutz C, Walter U, Gambaryan S, Sickmann A", "evidence": [ { "database": "UniProtKB", "id": "Q16799", "url": "https://www.uniprot.org/uniprot/Q16799" }, { "database": "iPTMnet", "id": "Q16799-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q16799-1" } ], "reference": [ { "type": "PubMed", "id": "18088087", "url": "https://glygen.org/publication/PubMed/18088087" } ] }, { "title": "Immobilized metal affinity chromatography revisited: pH/acid control toward high selectivity in phosphoproteomics.", "journal": "Journal of proteome research", "date": "2008", "authors": "Tsai CF, Wang YT, Chen YR, Lai CY, Lin PY, Pan KT, Chen JY, Khoo KH, Chen YJ", "evidence": [ { "database": "iPTMnet", "id": "Q16799-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q16799-1" } ], "reference": [ { "type": "PubMed", "id": "18707149", "url": "https://glygen.org/publication/PubMed/18707149" } ] }, { "title": "Phosphoproteomic analysis of distinct tumor cell lines in response to nocodazole treatment.", "journal": "Proteomics", "date": "2009", "authors": "Nagano K, Shinkawa T, Mutoh H, Kondoh O, Morimoto S, Inomata N, Ashihara M, Ishii N, Aoki Y, Haramura M", "evidence": [ { "database": "iPTMnet", "id": "Q16799-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q16799-1" } ], "reference": [ { "type": "PubMed", "id": "19415658", "url": "https://glygen.org/publication/PubMed/19415658" } ] }, { "title": "Phosphoproteomic analysis of human embryonic stem cells.", "journal": "Cell stem cell", "date": "2009", "authors": "Brill LM, Xiong W, Lee KB, Ficarro SB, Crain A, Xu Y, Terskikh A, Snyder EY, Ding S", "evidence": [ { "database": "iPTMnet", "id": "Q16799-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q16799-1" } ], "reference": [ { "type": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" } ] }, { "title": "Exploring the human leukocyte phosphoproteome using a microfluidic reversed-phase-TiO2-reversed-phase high-performance liquid chromatography phosphochip coupled to a quadrupole time-of-flight mass spectrometer.", "journal": "Analytical chemistry", "date": "2010", "authors": "Raijmakers R, Kraiczek K, de Jong AP, Mohammed S, Heck AJ", "evidence": [ { "database": "iPTMnet", "id": "Q16799-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q16799-1" } ], "reference": [ { "type": "PubMed", "id": "20058876", "url": "https://glygen.org/publication/PubMed/20058876" } ] }, { "title": "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.", "journal": "Journal of proteomics", "date": "2014", "authors": "Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H", "evidence": [ { "database": "UniProtKB", "id": "Q16799", "url": "https://www.uniprot.org/uniprot/Q16799" }, { "database": "iPTMnet", "id": "Q16799", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q16799" } ], "reference": [ { "type": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" } ] }, { "title": "Identification and characterization of TMEM33 as a reticulon-binding protein.", "journal": "Kobe J. 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Sci.", "date": "2014", "authors": "Zhang X., Yamamoto Y., Ku Y., Sakisaka T., Urade T.", "evidence": [ { "database": "UniProtKB", "id": "Q16799", "url": "https://www.uniprot.org/uniprot/Q16799" } ], "reference": [ { "type": "PubMed", "id": "25612671", "url": "https://glygen.org/publication/PubMed/25612671" } ] }, { "title": "Quantitative proteomics identifies altered O-GlcNAcylation of structural, synaptic and memory-associated proteins in Alzheimer's disease.", "journal": "The Journal of pathology", "date": "2017", "authors": "Wang S, Yang F, Petyuk VA, Shukla AK, Monroe ME, Gritsenko MA, Rodland KD, Smith RD, Qian WJ, Gong CX, Liu T", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q16799", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q16799" }, { "database": "O-GlcNAc Atlas", "id": "Q16799", "url": "https://oglcnac.org/atlas/detail/Q16799" } ], "reference": [ { "type": "PubMed", "id": "28657654", "url": "https://glygen.org/publication/PubMed/28657654" } ] }, { "title": "Reticulon-1A mediates diabetic kidney disease progression through endoplasmic reticulum-mitochondrial contacts in tubular epithelial cells.", "journal": "Kidney international", "date": "2022", "authors": "Xie Y, E J, Cai H, Zhong F, Xiao W, Gordon RE, Wang L, Zheng YL, Zhang A, Lee K, He JC", "evidence": [ { "database": "RefSeq", "id": "NP_066959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066959" } ], "reference": [ { "type": "PubMed", "id": "35469894", "url": "https://glygen.org/publication/PubMed/35469894" } ] }, { "title": "[The Expression of RTN1 in Lung Adenocarcinoma and \u2029Its Effect on Immune Microenvironment].", "journal": "Zhongguo fei ai za zhi = Chinese journal of lung cancer", "date": "2022", "authors": "Zhu S, Zu L, Xu S", "evidence": [ { "database": "RefSeq", "id": "NP_066959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066959" } ], "reference": [ { "type": "PubMed", "id": "35747917", "url": "https://glygen.org/publication/PubMed/35747917" } ] }, { "title": "CircRTN1 acts as a miR-431-5p sponge to promote thyroid cancer progression by upregulating TGFA.", "journal": "Hormones (Athens, Greece)", "date": "2022-12", "authors": "Gao Yu, Wang Yichun, Xu Lei, Xie Xiaoque, Zhu Liyang, Wang Fan", "evidence": [ { "database": "RefSeq", "id": "NP_066959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066959" } ], "reference": [ { "type": "PubMed", "id": "35804263", "url": "https://glygen.org/publication/PubMed/35804263" } ] }, { "title": "Interoperability of RTN1A in dendrite dynamics and immune functions in human Langerhans cells.", "journal": "eLife", "date": "2022-10-12", "authors": "Cicho\u0144 Ma\u0142gorzata Anna, Pfisterer Karin, Leitner Judith, Wagner Lena, Staud Clement, Steinberger Peter, Elbe-B\u00fcrger Adelheid", "evidence": [ { "database": "RefSeq", "id": "NP_066959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066959" } ], "reference": [ { "type": "PubMed", "id": "36223176", "url": "https://glygen.org/publication/PubMed/36223176" } ] }, { "title": "Cloning and expression of alternative transcripts of a novel neuroendocrine-specific gene and identification of its 135-kDa translational product.", "journal": "J. 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Chem.", "date": "1993", "authors": "Van Bokhoven A., Van de Ven W.J.M., Broers J.L.V., Ramaekers F.C.S., Roebroek A.J.M., Van de Velde H.J.K.", "evidence": [ { "database": "UniProtKB", "id": "Q16799", "url": "https://www.uniprot.org/uniprot/Q16799" } ], "reference": [ { "type": "PubMed", "id": "7685762", "url": "https://glygen.org/publication/PubMed/7685762" } ] }, { "title": "Genomic organization of the human NSP gene, prototype of a novel gene family encoding reticulons.", "journal": "Genomics", "date": "1996", "authors": "Van de Ven W.J.M., Schoenmakers E.F.P.M., Roebroek A.J.M., Ayoubi T.A.Y., Pauli I.G.L., Van de Velde H.J.K.", "evidence": [ { "database": "UniProtKB", "id": "Q16799", "url": "https://www.uniprot.org/uniprot/Q16799" } ], "reference": [ { "type": "PubMed", "id": "8833145", "url": "https://glygen.org/publication/PubMed/8833145" } ] }, { "title": "Neuronal differentiation is accompanied by NSP-C expression.", "journal": "Cell Tissue Res.", "date": "1998", "authors": 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