{ "uniprot_canonical_ac": "Q14U74-1", "uniprot_ac": "Q14U74", "uniprot_id": "Q14U74_RAT", "mass": { "chemical_mass": 92729.0, "monoisotopic_mass": 92729.0 }, "refseq": { "ac": "NP_001040579", "name": "protein O-mannosyl-transferase 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040579" }, "gene_names": [ { "name": "Pomt2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q14U74", "id": "Q14U74" }, { "name": "Pomt2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040579", "id": "NP_001040579" } ], "protein_names": [ { "name": "Dolichyl-phosphate-mannose--protein mannosyltransferase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q14U74" }, { "name": "2.4.1.109", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q14U74" }, { "name": "protein O-mannosyl-transferase 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040579", "id": "NP_001040579" } ], "function": [ { "annotation": "Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.", "evidence": [ { "database": "UniProtKB", "id": "Q14U74", "url": "https://www.uniprot.org/uniprot/Q14U74#function" }, { "database": "UniProtKB", "id": "RU367007", "url": "https://www.uniprot.org/uniprot/RU367007#function" } ] } ], "disease": [ { "disease_id": "DOID:0050453", "recommended_name": { "id": "DOID:0050453", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050453", "name": "lissencephaly", "description": "A congenital nervous system abnormality characterized by the absence of folds in the cerebral cortex and caused_by defective neuronal migration during the 12th to 24th weeks of gestation." }, "synonyms": [ { "id": "MONDO:0011830", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011830", "name": "lissencephaly due to LIS1 mutation", "description": "Lissencephaly due to LIS1 mutation is a cerebral malformation with epilepsy characterized predominantly by posterior isolated lissencephaly with developmental delay, intellectual disability and epilepsy that usually evolves from West syndrome to Lennox-Gastaut syndrome. Additional features include muscular hypotonia, acquired microcephaly, failure to thrive and poor control of airways leading to aspiration pneumonia." }, { "id": "MONDO:0011830", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011830", "name": "PAFAH1B1-related lissencephaly", "description": "" }, { "id": "MONDO:0011830", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011830", "name": "LIS1", "description": "" }, { "id": "MONDO:0011830", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011830", "name": "lissencephaly 1", "description": "" }, { "id": "MONDO:0011830", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011830", "name": "lissencephaly sequence, isolated", "description": "" }, { "id": "MONDO:0011830", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011830", "name": "lissencephaly, classic", "description": "" }, { "id": "MONDO:0011830", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011830", "name": "subcortical band heterotopia", "description": "" }, { "id": "MONDO:0011830", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011830", "name": "subcortical laminar heterotopia", "description": "" }, { "id": "MIM:607432", "resource": "MIM", "url": "https://www.omim.org/entry/607432", "name": "Subcortical band heterotopia", "description": "Subcortical band heterotopia" } ], "evidence": [ { "id": "0050453", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050453" } ] }, { "disease_id": "DOID:0050560", "recommended_name": { "id": "DOID:0050560", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050560", "name": "Walker-Warburg syndrome", "description": "A congenital muscular dystrophy that is characterized by hypotonia, seizures, severe intellectual and developmental disability, eye abnormalities and early death and has_material_basis_in mutations in multiple genes including POMT1, POMT2, ISPD, FKTN, FKRP, and LARGE1." }, "synonyms": [ { "id": "DOID:0050560", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050560", "name": "HARD syndrome", "description": "" }, { "id": "DOID:0050560", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050560", "name": "cerebroocular dysplasia-muscular dystrophy syndrome", "description": "" } ], "evidence": [ { "id": "0050560", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050560" } ] }, { "disease_id": "DOID:0110274", "recommended_name": { "id": "DOID:0110274", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110274", "name": "autosomal recessive limb-girdle muscular dystrophy", "description": "A limb-girdle muscular dystrophy has_material_basis_in autosomal recessive inheritance." }, "synonyms": [ { "id": "MONDO:0009675", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009675", "name": "autosomal recessive limb-girdle muscular dystrophy type 2A", "description": "Autosomal recessive limb-girdle muscular dystrophy type 2A (LGMD2A) is a subtype of autosomal recessive limb girdle muscular dystrophy characterized by a variable age of onset of progressive, typically symmetrical and selective weakness and atrophy of proximal shoulder- and pelvic-girdle muscles (gluteus maximus, thigh adductors, and muscles of the posterior compartment of the limbs are most commonly affected) without cardiac or facial involvement. Clinical manifestations include exercise intolerance, a waddling gait, scapular winging and calf pseudo-hypertrophy." }, { "id": "MONDO:0009675", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009675", "name": "CAPN3 autosomal recessive limb-girdle muscular dystrophy", "description": "" }, { "id": "MONDO:0009675", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009675", "name": "LGMD2A", "description": "" }, { "id": "MONDO:0009675", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009675", "name": "Leyden-Moebius muscular dystrophy", "description": "" }, { "id": "MONDO:0009675", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009675", "name": "autosomal recessive limb-girdle muscular dystrophy caused by mutation in CAPN3", "description": "" }, { "id": "MONDO:0009675", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009675", "name": "autosomal recessive limb-girdle muscular dystrophy type 2A", "description": "" }, { "id": "MONDO:0009675", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009675", "name": "calpainopathy", "description": "" }, { "id": "MONDO:0009675", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009675", "name": "limb-girdle muscular dystrophy due to calpain deficiency", "description": "" }, { "id": "MONDO:0009675", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009675", "name": "limb-girdle muscular dystrophy type 2A", "description": "" }, { "id": "MONDO:0009675", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009675", "name": "muscular dystrophy, limb-girdle, autosomal recessive 1", "description": "" }, { "id": "MONDO:0009675", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009675", "name": "muscular dystrophy, limb-girdle, type 2A", "description": "" }, { "id": "MONDO:0009675", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009675", "name": "pelvofemoral muscular dystrophy", "description": "" }, { "id": "MONDO:0009675", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009675", "name": "primary calpainopathy", "description": "" }, { "id": "MONDO:0009675", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009675", "name": "LGMD2", "description": "" }, { "id": "MONDO:0009675", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009675", "name": "limb-girdle muscular dystrophy type 2", "description": "" }, { "id": "MONDO:0009675", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009675", "name": "muscular dystrophy limb girdle type 2A, erb type", "description": "" }, { "id": "MONDO:0009675", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009675", "name": "muscular dystrophy, Pelvofemoral", "description": "" }, { "id": "MONDO:0009675", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009675", "name": "muscular dystrophy, limb-girdle, type 2", "description": "" }, { "id": "MONDO:0009675", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009675", "name": "myositis, eosinophilic", "description": "" }, { "id": "MIM:253600", "resource": "MIM", "url": "https://www.omim.org/entry/253600", "name": "Muscular dystrophy, limb-girdle, autosomal recessive 1", "description": "Muscular dystrophy, limb-girdle, autosomal recessive 1" } ], "evidence": [ { "id": "0110274", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0110274" } ] }, { "disease_id": "DOID:0110298", "recommended_name": { "id": "DOID:0110298", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110298", "name": "autosomal recessive limb-girdle muscular dystrophy type 2N", "description": "An autosomal recessive limb-girdle muscular dystrophy that has_material_basis_in homozygous or compound heterozygous mutation in the POMT2 gene on chromosome 14q24.3." }, "synonyms": [ { "id": "DOID:0110298", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110298", "name": "muscular dystrophy-dystroglycanopathy (limb-girdle) type C 2", "description": "" }, { "id": "DOID:0110298", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110298", "name": "LGMD2N", "description": "" }, { "id": "DOID:0110298", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110298", "name": "MDDGC2", "description": "" }, { "id": "DOID:0110298", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110298", "name": "muscular dystrophy-dystroglycanopathy limb-girdle POMT2-related", "description": "" }, { "id": "MONDO:0013162", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013162", "name": "autosomal recessive limb-girdle muscular dystrophy type 2N", "description": "Autosomal recessive limb-girdle muscular dystrophy type 2N (LGMD2N) is a form of limb-girdle muscular dystrophy characterized by proximal weakness (manifesting as slowness in running) presenting in infancy, along with calf hypertrophy, mild lordosis, scapular winging and normal intelligence or mild intellectual disability." }, { "id": "MONDO:0013162", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013162", "name": "LGMD-POMT2 related", "description": "" }, { "id": "MONDO:0013162", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013162", "name": "LGMD2N", "description": "" }, { "id": "MONDO:0013162", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013162", "name": "MDDGC2", "description": "" }, { "id": "MONDO:0013162", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013162", "name": "POMT2 autosomal recessive limb-girdle muscular dystrophy", "description": "" }, { "id": "MONDO:0013162", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013162", "name": "autosomal recessive limb-girdle muscular dystrophy caused by mutation in POMT2", "description": "" }, { "id": "MONDO:0013162", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013162", "name": "muscular dystrophy-dystroglycanopathy (limb-girdle) type C 2", "description": "" }, { "id": "MONDO:0013162", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013162", "name": "muscular dystrophy-dystroglycanopathy limb-girdle POMT2-related", "description": "" }, { "id": "MONDO:0013162", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013162", "name": "limb-girdle muscular dystrophy type 2N", "description": "" }, { "id": "MONDO:0013162", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013162", "name": "muscular dystrophy, limb-girdle, type 2N", "description": "" }, { "id": "MONDO:0013162", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013162", "name": "muscular dystrophy-dystroglycanopathy (limb-girdle), type C, 2", "description": "" }, { "id": "MONDO:0013162", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013162", "name": "muscular dystrophy-dystroglycanopathy, limb-girdle, Pomt2-related", "description": "" }, { "id": "MIM:613158", "resource": "MIM", "url": "https://www.omim.org/entry/613158", "name": "Muscular dystrophy-dystroglycanopathy limb-girdle C2", "description": "Muscular dystrophy-dystroglycanopathy limb-girdle C2" } ], "evidence": [ { "id": "0110298", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0110298" } ] }, { "disease_id": "DOID:0111240", "recommended_name": { "id": "DOID:0111240", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111240", "name": "congenital muscular dystrophy-dystroglycanopathy type A2", "description": "A congenital muscular dystrophy-dystroglycanopathy type A that has_material_basis_in homozygous or compound heterozygous mutation in POMT2 on 14q24.3." }, "synonyms": [ { "id": "DOID:0111240", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111240", "name": "congenital muscular dystrophy-dystroglycanopathy with brain and eye anomalies type A2", "description": "" }, { "id": "DOID:0111240", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111240", "name": "MDDGA2", "description": "" }, { "id": "DOID:0111240", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111240", "name": "Walker-Warburg syndrome or muscle-eye-brain disease, POMT2-related", "description": "" }, { "id": "MONDO:0013154", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013154", "name": "muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A2", "description": "An autosomal recessive muscular dystrophy caused by mutations in the POMT2 gene. It is associated with characteristic brain and eye malformations and profound mental retardation." }, { "id": "MONDO:0013154", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013154", "name": "MDDGA2", "description": "" }, { "id": "MONDO:0013154", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013154", "name": "Walker-Warburg syndrome or muscle-eye-brain disease, Pomt2-related", "description": "" }, { "id": "MONDO:0013154", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013154", "name": "muscle-eye-brain-POMT2 related", "description": "" }, { "id": "MONDO:0013154", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013154", "name": "muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies) type A, 2", "description": "" }, { "id": "MONDO:0013154", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013154", "name": "muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 2", "description": "" }, { "id": "MIM:613150", "resource": "MIM", "url": "https://www.omim.org/entry/613150", "name": "Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A2", "description": "Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A2" } ], "evidence": [ { "id": "0111240", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0111240" } ] }, { "disease_id": "DOID:0112380", "recommended_name": { "id": "DOID:0112380", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112380", "name": "muscular dystrophy-dystroglycanopathy type B2", "description": "A muscular dystrophy-dystroglycanopathy type B that has_material_basis_in homozygous or compound heterozygous mutation in the POMT2 gene on chromosome 14q24.3." }, "synonyms": [ { "id": "DOID:0112380", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112380", "name": "MDDGB2", "description": "" }, { "id": "DOID:0112380", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112380", "name": "congenital muscular dystrophy POMT2-related", "description": "" }, { "id": "MONDO:0013160", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013160", "name": "muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B2", "description": "An autosomal recessive inherited congenital muscular dystrophy caused by mutations in the POMT2 gene. It is characterized by mental retardation and mild structural brain abnormalities resulting from defective glycosylation of alpha-dystroglycan." }, { "id": "MONDO:0013160", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013160", "name": "congenital muscular dystrophy-POMT2 related", "description": "" }, { "id": "MONDO:0013160", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013160", "name": "congenital muscular dystrophy-dystroglycanopathy with intellectual disability type B2", "description": "" }, { "id": "MONDO:0013160", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013160", "name": "congenital muscular dystrophy-dystroglycanopathy with mental retardation type B2", "description": "" }, { "id": "MONDO:0013160", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013160", "name": "MDDGB2", "description": "" }, { "id": "MONDO:0013160", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013160", "name": "muscular dystrophy, congenital, Pomt2-related", "description": "" }, { "id": "MONDO:0013160", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013160", "name": "muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B, 2", "description": "" }, { "id": "MONDO:0013160", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013160", "name": "muscular dystrophy-dystroglycanopathy (congenital with mental retardation), type B, 2", "description": "" }, { "id": "MIM:613156", "resource": "MIM", "url": "https://www.omim.org/entry/613156", "name": "Muscular dystrophy-dystroglycanopathy congenital with impaired intellectual development B2", "description": "Muscular dystrophy-dystroglycanopathy congenital with impaired intellectual development B2" } ], "evidence": [ { "id": "0112380", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0112380" } ] }, { "disease_id": "DOID:9884", "recommended_name": { "id": "DOID:9884", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9884", "name": "muscular dystrophy", "description": "A myopathy is characterized by progressive skeletal muscle weakness degeneration." }, "synonyms": [ { "id": "MONDO:0010678", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010678", "name": "muscular dystrophy, progressive Pectorodorsal", "description": "" }, { "id": "MONDO:0010678", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010678", "name": "muscular dystrophy, progressive Pectorodorsal", "description": "" }, { "id": "MONDO:0010678", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010678", "name": "muscular dystrophy, progressive, involving shoulder girdle and back", "description": "" }, { "id": "MONDO:0010884", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010884", "name": "muscular dystrophy, scapulohumeral", "description": "" }, { "id": "MONDO:0010884", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010884", "name": "muscular dystrophy, scapulohumeral", "description": "" }, { "id": "MONDO:0010676", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010676", "name": "muscular dystrophy, Hemizygous lethal type", "description": "" }, { "id": "MONDO:0010676", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010676", "name": "muscular dystrophy, Hemizygous lethal type", "description": "" }, { "id": "MONDO:0010675", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010675", "name": "muscular dystrophy, cardiac type", "description": "" }, { "id": "MONDO:0010675", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010675", "name": "muscular dystrophy, cardiac type", "description": "" }, { "id": "MONDO:0010677", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010677", "name": "muscular dystrophy, Mabry type", "description": "" }, { "id": "MONDO:0010677", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010677", "name": "muscular dystrophy, Mabry type", "description": "" }, { "id": "MONDO:0008028", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008028", "name": "muscular dystrophy, Barnes type", "description": "" }, { "id": "MONDO:0008028", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008028", "name": "muscular dystrophy, Barnes type", "description": "" }, { "id": "MONDO:0008034", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008034", "name": "muscular dystrophy, pseudohypertrophic, with Internalized capillaries", "description": "" }, { "id": "MONDO:0008034", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008034", "name": "muscular dystrophy, pseudohypertrophic, with Internalized capillaries", "description": "" } ], "evidence": [ { "id": "9884", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9884" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "Q14U74", "url": "https://www.uniprot.org/uniprot/Q14U74" } ], "common_name": "Rat" } ], "gene": [ { "name": "Pomt2", "url": "https://www.uniprot.org/uniprot/Q14U74", "locus": { "chromosome": "6", "start_pos": 106755462, "end_pos": 106794849, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000012146", "url": "https://www.ensembl.org/id/ENSRNOG00000012146" } ] } } ], "crossref": [ { "id": "ENSRNOG00000012146", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000012146", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "2.4.1.109", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.4.1.109&UniProtAcc=Q14U74", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "GT39", "url": "http://www.cazy.org/GT39.html", "database": "CAZy", "categories": [ "Protein Classification" ] }, { "id": "688673", "url": "https://www.ncbi.nlm.nih.gov/gene/688673", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003342", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003342", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016093", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016093", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027005", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027005", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036300", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036300", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:688673", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:688673", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HYAGIYP", "url": "https://omabrowser.org/oma/group/HYAGIYP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5489060at2759", "url": "http://www.orthodb.org/?query=5489060at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10050", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10050", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10050:SF46", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10050:SF46", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02366", "url": "http://pfam.xfam.org/family/PF02366", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02815", "url": "http://pfam.xfam.org/family/PF02815", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16192", "url": "http://pfam.xfam.org/family/PF16192", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-5173105", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5173105", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001040579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040579", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1586427", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1586427", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "17377", "url": "https://www.rhea-db.org/rhea/17377", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "53396", "url": "https://www.rhea-db.org/rhea/53396", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q14U74", "url": "https://www.uniprot.org/uniprot/Q14U74", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q14U74-1", "url": "https://www.uniprot.org/uniprot/Q14U74-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFYASGRLLAAREATTLYAPPRARGPALRGKRRELQIPWHLETPSYDSLTGQRTRPGVPPARRVILRKGRMPPAIGGGLAGSELRPRRGRSVQQAARAVSRDVVPEAATRKLKRPAWSSRRFQAAGWWATLAVVTLLSFATRFHRLDQPAHICWDETHFGKMGSYYINRTFFFDVHPPLGKMLIGLAGYLSGYDGTFLFQKPGDRYEHHSYMGMRGFCAFLGSWLIPFAYLTVLDLSKSFPAALLTAALLTCDTGCLTLSQYILLDPILMFFIMAAMLSMVKYNSFANRPFSAPWWFWLSLTGISLAGALGVKFVGLFIIVQVGLNTISDLWHLFGDLSLSLVTVGKHLTARILCLIVLPLVLYVTIFAVHVMVLNKSGPGDGFFSSAFQARLSGNSLHNASIPEHLAYGSVITVKNLRMAIGYLHSHRHLYPEGIGARQQQVTTYLHKDYNNLWIIKKYNTNTDPLDPSFPVEFVRHGDIIRLEHKETTRNLHSHYHEAPLTRKHYQVTGYGINGTGDSNDFWRIEVVNRKFGNRIKVLRSRIRFIHLVTGCVLGSSGKILPKWGWEQLEVTCNPYLKETSNSIWNIEEHINPKLPNISLDVLQPSFPEILLESHMVMIRGNNGLKPKDNEFTSKPWHWPINYQGLRFSGANDTDFRVYLLGNPVVWWLNLVSLVLYLLTGSTIAIAMQRGIQLPAELQGLTKLLLRGGGQLLLGWTLHYFPFFLMGRVLYFHHYFPAMLFSSMLTGLLWDTLLRFCAWALAPSPLGRRIHMVGILSLLLATAYSFYLFHPLAYGMVGPLAQEPESPMAGLRWLESWDF", "length": 820, "header": "tr|Q14U74-1|Q14U74_RAT Isoform 1 of Dolichyl-phosphate-mannose--protein mannosyltransferase OS=Rattus norvegicus OX=10116 GN=Pomt2 PE=3 SV=1 CANONICAL=Q14U74-1" }, "isoforms": [ { "isoform_ac": "Q14U74-1", "url": "", "sequence": { "sequence": "MFYASGRLLAAREATTLYAPPRARGPALRGKRRELQIPWHLETPSYDSLTGQRTRPGVPPARRVILRKGRMPPAIGGGLAGSELRPRRGRSVQQAARAVSRDVVPEAATRKLKRPAWSSRRFQAAGWWATLAVVTLLSFATRFHRLDQPAHICWDETHFGKMGSYYINRTFFFDVHPPLGKMLIGLAGYLSGYDGTFLFQKPGDRYEHHSYMGMRGFCAFLGSWLIPFAYLTVLDLSKSFPAALLTAALLTCDTGCLTLSQYILLDPILMFFIMAAMLSMVKYNSFANRPFSAPWWFWLSLTGISLAGALGVKFVGLFIIVQVGLNTISDLWHLFGDLSLSLVTVGKHLTARILCLIVLPLVLYVTIFAVHVMVLNKSGPGDGFFSSAFQARLSGNSLHNASIPEHLAYGSVITVKNLRMAIGYLHSHRHLYPEGIGARQQQVTTYLHKDYNNLWIIKKYNTNTDPLDPSFPVEFVRHGDIIRLEHKETTRNLHSHYHEAPLTRKHYQVTGYGINGTGDSNDFWRIEVVNRKFGNRIKVLRSRIRFIHLVTGCVLGSSGKILPKWGWEQLEVTCNPYLKETSNSIWNIEEHINPKLPNISLDVLQPSFPEILLESHMVMIRGNNGLKPKDNEFTSKPWHWPINYQGLRFSGANDTDFRVYLLGNPVVWWLNLVSLVLYLLTGSTIAIAMQRGIQLPAELQGLTKLLLRGGGQLLLGWTLHYFPFFLMGRVLYFHHYFPAMLFSSMLTGLLWDTLLRFCAWALAPSPLGRRIHMVGILSLLLATAYSFYLFHPLAYGMVGPLAQEPESPMAGLRWLESWDF", "length": 820, "header": "tr|Q14U74-1|Q14U74_RAT Isoform 1 of Dolichyl-phosphate-mannose--protein mannosyltransferase OS=Rattus norvegicus OX=10116 GN=Pomt2 PE=3 SV=1 CANONICAL=Q14U74-1" }, "locus": { "chromosome": "6", "start_pos": 106794578, "end_pos": 106755828, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000016242.8", "url": "https://www.ensembl.org/id/ENSRNOT00000016242.8" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000016242.5", "url": "https://www.ensembl.org/id/ENSRNOP00000016242.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "rno:688673", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:688673", "resource": "KEGG Pathway" }, { "id": "R-RNO-5173105", "name": "O-linked glycosylation", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5173105", "resource": "Reactome", "description": "O-linked glycosylation" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8BGQ4-1", "protein_name": "Protein O-mannosyl-transferase 2", "gene_name": "Pomt2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLYASGRLLAARAATTLSAPPRARGPALRGKRRELQIPWHLETPSYDPLTGQRTRPGVPPARRVILRKGRMPPAIGGGLAGSELRPRRGRCVPQAARAVSRDVVPQAAARKLKRPAWSSRRFQAAGWWATLAVVTLLSFATRFHRLDQPAHICWDETHFGKMGSYYINRTFFFDVHPPLGKMLIGLAGYLSGYDGTFLFQKPGDRYEHHSYMGMRGFCAFLGSWLIPFAYLTVLDLSKSFPAALLTAALLTFDTGCLTLSQYILLDPILMFFIMAAMLSMVKYNSCANRPFSAPWWFWLSLTGISLAGALGVKFVGLFIIVQVGLNTISDLWHLFGDLSLSLVTVGKHLTARILCLIVLPLVLYVTIFAVHVMVLNKSGPGDGFFSSAFQARLSGNSLHNASIPEHLAYGSVITVKNLRMAIGYLHSHRHLYPEGIGARQQQVTTYLHKDYNNLWIIKKYNANTDPLDPSFPVEFVRHGDIIRLEHKETTRNLHSHYHEAPLTRKHYQVTGYGINGTGDSNDFWRIEVVNRKFGNRIKVLRSRIRLIHLVTGCVLGSSGKILPKWGWEQLEVTCTPYLKETTNSIWNIEEHINPKLPNISLDVLQPSFPEILLESHMVMIRGNNGLKPKDNEFTSKPWHWPINYQGLRFSGANDTDFRVYLLGNPVVWWLNLVSIVLYLLSGSTIAVAMQRGIQLPAELQGLTKVLLRGGGQLLLGWMLHYFPFFLMGRILYFHHYFPAMLFSSMLTGILWDTLLRLCAWGLAPSPLGRRIHAVGILSLLLTTAYSFYLFHPLAYGMVGPLAQEPESPMAGLRWLESWDF", "length": 820 }, "evidence": [ { "id": "45230257", "url": "http://www.informatics.jax.org/homology/45230257", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UKY4-1", "protein_name": "Protein O-mannosyl-transferase 2", "gene_name": "POMT2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPPATGGGLAESELRPRRGRCGPQAARAAGRDVAAEAVARSPKRPAWGSRRFEAVGWWALLALVTLLSFATRFHRLDEPPHICWDETHFGKMGSYYINRTFFFDVHPPLGKMLIGLAGYLSGYDGTFLFQKPGDKYEHHSYMGMRGFCAFLGSWLVPFAYLTVLDLSKSLSAALLTAALLTFDTGCLTLSQYILLDPILMFFIMAAMLSMVKYNSCADRPFSAPWWFWLSLTGVSLAGALGVKFVGLFIILQVGLNTIADLWYLFGDLSLSLVTVGKHLTARVLCLIVLPLALYTATFAVHFMVLSKSGPGDGFFSSAFQARLSGNNLHNASIPEHLAYGSVITVKNLRMAIGYLHSHRHLYPEGIGARQQQVTTYLHKDYNNLWIIKKHNTNSDPLDPSFPVEFVRHGDIIRLEHKETSRNLHSHYHEAPMTRKHYQVTGYGINGTGDSNDFWRIEVVNRKFGNRIKVLRSRIRFIHLVTGCVLGSSGKVLPKWGWEQLEVTCTPYLKETLNSIWNVEDHINPKLPNISLDVLQPSFPEILLESHMVMIRGNSGLKPKDNEFTSKPWHWPINYQGLRFSGVNDTDFRVYLLGNPVVWWLNLLSIALYLLSGSIIAVAMQRGARLPAEVAGLSQVLLRGGGQVLLGWTLHYFPFFLMGRVLYFHHYFPAMLFSSMLTGILWDTLLRLCAWGLASWPLARGIHVAGILSLLLGTAYSFYLFHPLAYGMVGPLAQDPQSPMAGLRWLDSWDF", "length": 750 }, "evidence": [ { "id": "45230257", "url": "http://www.informatics.jax.org/homology/45230257", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "dolichyl-phosphate-mannose-protein mannosyltransferase activity", "id": "GO:0004169", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004169", "evidence": [ { "database": "UniProtKB", "id": "Q14U74", "url": "https://www.uniprot.org/uniprot/Q14U74" } ], "pmid": "" }, { "name": "mannosyltransferase activity", "id": "GO:0000030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000030", "evidence": [ { "database": "UniProtKB", "id": "Q14U74", "url": "https://www.uniprot.org/uniprot/Q14U74" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "positive regulation of protein O-linked glycosylation", "id": "GO:1904100", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904100", "evidence": [ { "database": "UniProtKB", "id": "Q14U74", "url": "https://www.uniprot.org/uniprot/Q14U74" } ], "pmid": "" }, { "name": "protein O-linked mannosylation", "id": "GO:0035269", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035269", "evidence": [ { "database": "UniProtKB", "id": "Q14U74", "url": "https://www.uniprot.org/uniprot/Q14U74" } ], "pmid": "" }, { "name": "dentate gyrus development", "id": "GO:0021542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021542", "evidence": [ { "database": "UniProtKB", "id": "Q14U74", "url": "https://www.uniprot.org/uniprot/Q14U74" } ], "pmid": "" }, { "name": "basement membrane organization", "id": "GO:0071711", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071711", "evidence": [ { "database": "UniProtKB", "id": "Q14U74", "url": "https://www.uniprot.org/uniprot/Q14U74" } ], "pmid": "" }, { "name": "reactive gliosis", "id": "GO:0150103", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150103", "evidence": [ { "database": "UniProtKB", "id": "Q14U74", "url": "https://www.uniprot.org/uniprot/Q14U74" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q14U74", "url": "https://www.uniprot.org/uniprot/Q14U74" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q14U74", "url": "https://www.uniprot.org/uniprot/Q14U74" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q14U74", "url": "https://www.uniprot.org/uniprot/Q14U74" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q14U74", "url": "https://www.uniprot.org/uniprot/Q14U74" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 168, "end_pos": 170, "annotation": "n_glycosylation_sequon" }, { "start_pos": 376, "end_pos": 378, "annotation": "n_glycosylation_sequon" }, { "start_pos": 400, "end_pos": 402, "annotation": "n_glycosylation_sequon" }, { "start_pos": 515, "end_pos": 517, "annotation": "n_glycosylation_sequon" }, { "start_pos": 598, "end_pos": 600, "annotation": "n_glycosylation_sequon" }, { "start_pos": 653, "end_pos": 655, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17377", "name": "", "equation": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q99PR0-1", "Q14U74-1", "Q9UKY4-1", "Q9Y6A1-1", "Q5T4D3-1", "Q8IUR5-5", "Q8N394-1", "Q6ZXV5-1", "Q9NX78-1", "Q8R2R1-1", "Q8BGQ4-1", "Q8BG19-1", "Q8BRH0-1", "Q56A06-1", "Q3UV71-1", "Q8BMD6-1", "P31382-1", "P46971-1", "P33775-1", "P47190-1", "P52867-1", "P42934-1", "Q06644-1", "Q8MXQ3-1", "Q9W5D4-1", "Q7K4B6-1", "Q9V3X5-1", "Q9VF81-1", "Q9VQE9-1", "Q9VTK2-1" ], "evidence": [ { "id": "17377", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17377" } ] }, { "id": "53396", "name": "", "equation": "a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q99PR0-1", "Q14U74-1", "Q9UKY4-1", "Q9Y6A1-1", "Q5T4D3-1", "Q8IUR5-5", "Q8N394-1", "Q6ZXV5-1", "Q9NX78-1", "Q8R2R1-1", "Q8BGQ4-1", "Q8BG19-1", "Q8BRH0-1", "Q56A06-1", "Q3UV71-1", "Q8BMD6-1", "P31382-1", "P46971-1", "P33775-1", "P47190-1", "P52867-1", "P42934-1", "Q06644-1", "Q8MXQ3-1", "Q9W5D4-1", "Q7K4B6-1", "Q9V3X5-1", "Q9VF81-1", "Q9VQE9-1", "Q9VTK2-1" ], "evidence": [ { "id": "53396", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53396" } ] }, { "id": "R-RNO-5615637", "name": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane", "input_participant_list": [ "R-RNO-8931890" ], "output_participant_list": [ "R-RNO-5615647" ], "enzyme_list": [ "Q14U74-1", "Q99PR0-1" ], "evidence": [ { "id": "R-RNO-5615637", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5615637" } ] } ], "reaction_participants": [ { "participant_id": "R-RNO-5615647", "participant_name": "Dag1 [endoplasmic reticulum lumen]", "crossref": [ { "id": "F1M8K0", "database": "UniProt", "url": "" }, { "id": "621890", "database": "RGD", "url": "" }, { "id": "NP_446149.1", "database": "RefSeq", "url": "" }, { "id": "ENSRNOP00000026327", "database": "Ensembl", "url": "" }, { "id": "ENSRNOG00000019400", "database": "Ensembl", "url": "" }, { "id": "ENSRNOT00000026327", "database": "Ensembl", "url": "" } ] }, { "participant_id": "R-RNO-8931890", "participant_name": "Dag1 [endoplasmic reticulum lumen]", "crossref": [ { "id": "ENSRNOG00000019400", "database": "Ensembl", "url": "" }, { "id": "F1M8K0", "database": "UniProt", "url": "" }, { "id": "NP_446149.1", "database": "RefSeq", "url": "" }, { "id": "ENSRNOT00000026327", "database": "Ensembl", "url": "" }, { "id": "ENSRNOP00000026327", "database": "Ensembl", "url": "" }, { "id": "621890", "database": "RGD", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "P31382", "gene_name": "PMT2", "activity": [ { "ec_number": "2.4.1.109", "activity": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+).", "evidence": [ { "id": "P31382", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31382" } ] }, { "ec_number": "2.4.1.109", "activity": "", "evidence": [ { "id": "P31382", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31382" } ] } ] }, { "uniprot_ac": "P33775", "gene_name": "PMT1", "activity": [ { "ec_number": "2.4.1.109", "activity": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+).", "evidence": [ { "id": "P33775", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33775" } ] }, { "ec_number": "2.4.1.109", "activity": "", "evidence": [ { "id": "P33775", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33775" } ] } ] }, { "uniprot_ac": "P42934", "gene_name": "PMT6", "activity": [ { "ec_number": "2.4.1.109", "activity": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+).", "evidence": [ { "id": "P42934", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42934" } ] }, { "ec_number": "2.4.1.109", "activity": "", "evidence": [ { "id": "P42934", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42934" } ] } ] }, { "uniprot_ac": "P46971", "gene_name": 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